Thailand achieved most MDG targets early in the 2000s through sustainable health system development and investments in infrastructure, health workforce, and financial risk protection. This success was due to political and financial commitments to health, continuity of pro-poor policies across governments, rapid economic growth, and effective generation and use of evidence to guide policies and implementation. Thailand then introduced a national "MDG Plus" agenda to move beyond global targets and ensure more equitable progress, focusing on poorer areas. Maintaining these achievements and embracing emerging issues like non-communicable diseases will be important beyond 2015.