Venlafaxine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Venlafaxine Dosage & Rx Info | Venlafaxine Uses, Side Effects -: Indications, Side Effects, Warnings, Venlafaxine - Drug Information - Taj Pharma, Venlafaxine dose Taj pharmaceuticals Venlafaxine interactions, Taj Pharmaceutical Venlafaxine contraindications, Venlafaxine price, Venlafaxine Taj Pharma Venlafaxine 75mg tablets SMPC- Taj Pharma . Stay connected to all updated on Venlafaxine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Diazepam 5mg tablets smpc taj pharmaceuticalsTaj Pharma
Diazepam Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Diazepam Dosage & Rx Info | Diazepam Uses, Side Effects -: Indications, Side Effects, Warnings, Diazepam - Drug Information - Taj Pharma, Diazepam dose Taj pharmaceuticals Diazepam interactions, Taj Pharmaceutical Diazepam contraindications, Diazepam price, Diazepam Taj Pharma Diazepam 5mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Diazepam Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Olanzapine 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Olanzapine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Olanzapine Dosage & Rx Info | Olanzapine Uses, Side Effects -: Indications, Side Effects, Warnings, Olanzapine - Drug Information - Taj Pharma, Olanzapine dose Taj pharmaceuticals Olanzapine interactions, Taj Pharmaceutical Olanzapine contraindications, Olanzapine price, Olanzapine Taj Pharma Olanzapine 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Olanzapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Clonazepam 500mcg tablets smpc taj pharmaceuticalsTaj Pharma
Clonazepam Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Clonazepam Dosage & Rx Info | Clonazepam Uses, Side Effects -: Indications, Side Effects, Warnings, Clonazepam - Drug Information - Taj Pharma, Clonazepam dose Taj pharmaceuticals Clonazepam interactions, Taj Pharmaceutical Clonazepam contraindications, Clonazepam price, Clonazepam Taj Pharma Clonazepam 500mcg Tablets SMPC- Taj Pharma . Stay connected to all updated on Clonazepam Taj Pharmaceuticals Taj pharmaceuticals Hyderabad
Treat Premature Ejaculation With Generic Dapoxetine Hydrochloride Tablets The Swiss Pharmacy
Generic Dapoxetine Hydrochloride (Everlast and Poxet Tablets) is used to treat premature ejaculation in adult men aged 18 to 64 years.
Generic Dapoxetine increases the time it takes to ejaculate and can improve the control over the ejaculation.
Diazepam 5mg tablets smpc taj pharmaceuticalsTaj Pharma
Diazepam Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Diazepam Dosage & Rx Info | Diazepam Uses, Side Effects -: Indications, Side Effects, Warnings, Diazepam - Drug Information - Taj Pharma, Diazepam dose Taj pharmaceuticals Diazepam interactions, Taj Pharmaceutical Diazepam contraindications, Diazepam price, Diazepam Taj Pharma Diazepam 5mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Diazepam Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Olanzapine 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Olanzapine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Olanzapine Dosage & Rx Info | Olanzapine Uses, Side Effects -: Indications, Side Effects, Warnings, Olanzapine - Drug Information - Taj Pharma, Olanzapine dose Taj pharmaceuticals Olanzapine interactions, Taj Pharmaceutical Olanzapine contraindications, Olanzapine price, Olanzapine Taj Pharma Olanzapine 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Olanzapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Clonazepam 500mcg tablets smpc taj pharmaceuticalsTaj Pharma
Clonazepam Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Clonazepam Dosage & Rx Info | Clonazepam Uses, Side Effects -: Indications, Side Effects, Warnings, Clonazepam - Drug Information - Taj Pharma, Clonazepam dose Taj pharmaceuticals Clonazepam interactions, Taj Pharmaceutical Clonazepam contraindications, Clonazepam price, Clonazepam Taj Pharma Clonazepam 500mcg Tablets SMPC- Taj Pharma . Stay connected to all updated on Clonazepam Taj Pharmaceuticals Taj pharmaceuticals Hyderabad
Treat Premature Ejaculation With Generic Dapoxetine Hydrochloride Tablets The Swiss Pharmacy
Generic Dapoxetine Hydrochloride (Everlast and Poxet Tablets) is used to treat premature ejaculation in adult men aged 18 to 64 years.
Generic Dapoxetine increases the time it takes to ejaculate and can improve the control over the ejaculation.
Sildenafil 50 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Sildenafil Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Sildenafil Dosage & Rx Info | Sildenafil Uses, Side Effects -: Indications, Side Effects, Warnings, Sildenafil - Drug Information - Taj Pharma, Sildenafil dose Taj pharmaceuticals Sildenafil interactions, Taj Pharmaceutical Sildenafil contraindications, Sildenafil price, Sildenafil Taj Pharma Sildenafil 50 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Sildenafil Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Zolpiderm tartrate 5mg and 10mg tablets pil, taj pharmaceuticals.Taj Pharma
Zolpidem Tartrate - Drug Information - Taj Pharma, Zolpidem Tartrate dose Taj pharmaceuticals Zolpidem Tartrate interactions, Taj Pharmaceutical Zolpidem Tartrate contraindications, Zolpidem Tartrate price, Zolpidem Tartrate , Taj Pharma Zolpidem Tartrate 5mg & 10mg Tablets - Taj Pharma . Stay connected to all updated on Zolpidem Tartrate Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
They are specific 5-HT and various degrees NE reuptake inhibition.
Venlafaxine, at lower doses (75–100 mg/day) acts as SSRI. As the dose increases it inhibit NE reuptake (& 2ry ↓ DA reuptake in prefrontal cortex, which lacks DAT→ ↑ DA).
Promethazine 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Promethazine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Promethazine hydrochloride Dosage & Rx Info | Promethazine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Promethazine hydrochloride - Drug Information - Taj Pharma, Promethazine hydrochloride dose Taj pharmaceuticals Promethazine hydrochloride interactions, Taj Pharmaceutical Promethazine hydrochloride contraindications, Promethazine hydrochloride price, Promethazine hydrochloride Taj Pharma Promethazine hydrochloride 10 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Promethazine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Diazepam is used to treat anxiety, alcohol withdrawal, and seizures. It is also used to relieve muscle spasms and to provide sedation before medical ..
New Treatment Devices and Clinical Trials jgreenberger
Dr. Kathryn Davis from Penn Epilepsy Center present on new treatment devices and clinical trials for epilepsy. From the 2014 Epilepsy Education Exchange.
Generic Zyprexa (Olanzapine Tablets) is used for the treatment of schizophrenia as well as acute treatment of manic or mixed episodes associated with bipolar I disorder and maintenance treatment of bipolar I disorder.
Chlordiazepoxide 5mg and 10mg capsules pil, taj pharmaceuticals.Taj Pharma
Chlordiazepoxide 5mg and 10mg Capsules Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Chlordiazepoxide Dosage & Rx Info | Chlordiazepoxide Uses, Side Effects , Chlordiazepoxide 5mg and 10mg Capsules: Indications, Side Effects, Warnings, Chlordiazepoxide - Drug Information - Taj Pharma, Chlordiazepoxide dose Taj pharmaceuticals Chlordiazepoxide interactions, Taj Pharmaceutical Chlordiazepoxide contraindications, Chlordiazepoxide price, Chlordiazepoxide , Taj Pharma Chlordiazepoxide 5mg and 10mg Capsules - Taj Pharma . Stay connected to all updated on Chlordiazepoxide Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
Lariago (Generic Chloroquine Phosphate tablets) is used for the suppressive treatment and for the treatment of acute attacks of Malaria. This medicine is also used for the treatment of extraintestinal amebiasis, amoebic hepatitis and abscess, discoid and systemic lupus erythematosus and rheumatoid arthritis.
Off-Label indications include the treatment of corona virus disease 2019 (COVID-19) and severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) infection.
Risperidone 2mg, 4mg Film coated Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Risperidone Dosage & Rx Info | Risperidone Uses, Side Effects - Risperidone : Indications, Side Effects, Warnings, Risperidone - Drug Information - Taj Pharma, Risperidone dose Taj pharmaceuticals Risperidone interactions, Taj Pharmaceutical Risperidone contraindications, Risperidone price, Risperidone Taj Pharma anti-psychotics Schizophrenia Risperidone 2mg, 4mg Film coated Tablets PIL- Taj Pharma . Stay connected to all updated on Risperidone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
Vemurafenib 240 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Vemurafenib Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Vemurafenib Dosage & Rx Info | Vemurafenib Uses, Side Effects -: Indications, Side Effects, Warnings, Vemurafenib - Drug Information - Taj Pharma, Vemurafenib dose Taj pharmaceuticals Vemurafenib interactions, Taj Pharmaceutical Vemurafenib contraindications, Vemurafenib price, Vemurafenib Taj Pharma Vemurafenib 240mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Vemurafenib Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Ranolazine Tablets 500mg, 750mg, 1000mg Taj Pharma SmPCTajPharmaQC
Ranolazine Tablets 500mg, 750mg, 1000mg Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ranolazine Dosage & Rx Info | Ranolazine Uses, Side Effects, Anti-anginal, Ranolazine : Indications, Side Effects, Warnings, Ranolazine - Drug Information - Taj Pharma, Ranolazine dose Taj pharmaceuticals Ranolazine interactions, Taj Pharmaceutical Ranolazine contraindications, Ranolazine price, Ranolazine Taj Pharma Anti-anginal Ranolazine Powder for Tablets SmPC.
Sildenafil 50 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Sildenafil Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Sildenafil Dosage & Rx Info | Sildenafil Uses, Side Effects -: Indications, Side Effects, Warnings, Sildenafil - Drug Information - Taj Pharma, Sildenafil dose Taj pharmaceuticals Sildenafil interactions, Taj Pharmaceutical Sildenafil contraindications, Sildenafil price, Sildenafil Taj Pharma Sildenafil 50 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Sildenafil Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Zolpiderm tartrate 5mg and 10mg tablets pil, taj pharmaceuticals.Taj Pharma
Zolpidem Tartrate - Drug Information - Taj Pharma, Zolpidem Tartrate dose Taj pharmaceuticals Zolpidem Tartrate interactions, Taj Pharmaceutical Zolpidem Tartrate contraindications, Zolpidem Tartrate price, Zolpidem Tartrate , Taj Pharma Zolpidem Tartrate 5mg & 10mg Tablets - Taj Pharma . Stay connected to all updated on Zolpidem Tartrate Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
They are specific 5-HT and various degrees NE reuptake inhibition.
Venlafaxine, at lower doses (75–100 mg/day) acts as SSRI. As the dose increases it inhibit NE reuptake (& 2ry ↓ DA reuptake in prefrontal cortex, which lacks DAT→ ↑ DA).
Promethazine 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Promethazine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Promethazine hydrochloride Dosage & Rx Info | Promethazine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Promethazine hydrochloride - Drug Information - Taj Pharma, Promethazine hydrochloride dose Taj pharmaceuticals Promethazine hydrochloride interactions, Taj Pharmaceutical Promethazine hydrochloride contraindications, Promethazine hydrochloride price, Promethazine hydrochloride Taj Pharma Promethazine hydrochloride 10 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Promethazine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Diazepam is used to treat anxiety, alcohol withdrawal, and seizures. It is also used to relieve muscle spasms and to provide sedation before medical ..
New Treatment Devices and Clinical Trials jgreenberger
Dr. Kathryn Davis from Penn Epilepsy Center present on new treatment devices and clinical trials for epilepsy. From the 2014 Epilepsy Education Exchange.
Generic Zyprexa (Olanzapine Tablets) is used for the treatment of schizophrenia as well as acute treatment of manic or mixed episodes associated with bipolar I disorder and maintenance treatment of bipolar I disorder.
Chlordiazepoxide 5mg and 10mg capsules pil, taj pharmaceuticals.Taj Pharma
Chlordiazepoxide 5mg and 10mg Capsules Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Chlordiazepoxide Dosage & Rx Info | Chlordiazepoxide Uses, Side Effects , Chlordiazepoxide 5mg and 10mg Capsules: Indications, Side Effects, Warnings, Chlordiazepoxide - Drug Information - Taj Pharma, Chlordiazepoxide dose Taj pharmaceuticals Chlordiazepoxide interactions, Taj Pharmaceutical Chlordiazepoxide contraindications, Chlordiazepoxide price, Chlordiazepoxide , Taj Pharma Chlordiazepoxide 5mg and 10mg Capsules - Taj Pharma . Stay connected to all updated on Chlordiazepoxide Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
Lariago (Generic Chloroquine Phosphate tablets) is used for the suppressive treatment and for the treatment of acute attacks of Malaria. This medicine is also used for the treatment of extraintestinal amebiasis, amoebic hepatitis and abscess, discoid and systemic lupus erythematosus and rheumatoid arthritis.
Off-Label indications include the treatment of corona virus disease 2019 (COVID-19) and severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) infection.
Risperidone 2mg, 4mg Film coated Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Risperidone Dosage & Rx Info | Risperidone Uses, Side Effects - Risperidone : Indications, Side Effects, Warnings, Risperidone - Drug Information - Taj Pharma, Risperidone dose Taj pharmaceuticals Risperidone interactions, Taj Pharmaceutical Risperidone contraindications, Risperidone price, Risperidone Taj Pharma anti-psychotics Schizophrenia Risperidone 2mg, 4mg Film coated Tablets PIL- Taj Pharma . Stay connected to all updated on Risperidone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
Vemurafenib 240 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Vemurafenib Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Vemurafenib Dosage & Rx Info | Vemurafenib Uses, Side Effects -: Indications, Side Effects, Warnings, Vemurafenib - Drug Information - Taj Pharma, Vemurafenib dose Taj pharmaceuticals Vemurafenib interactions, Taj Pharmaceutical Vemurafenib contraindications, Vemurafenib price, Vemurafenib Taj Pharma Vemurafenib 240mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Vemurafenib Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Ranolazine Tablets 500mg, 750mg, 1000mg Taj Pharma SmPCTajPharmaQC
Ranolazine Tablets 500mg, 750mg, 1000mg Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Ranolazine Dosage & Rx Info | Ranolazine Uses, Side Effects, Anti-anginal, Ranolazine : Indications, Side Effects, Warnings, Ranolazine - Drug Information - Taj Pharma, Ranolazine dose Taj pharmaceuticals Ranolazine interactions, Taj Pharmaceutical Ranolazine contraindications, Ranolazine price, Ranolazine Taj Pharma Anti-anginal Ranolazine Powder for Tablets SmPC.
Sertraline 50 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Sertalin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Sertalin Dosage & Rx Info | Sertalin Uses, Side Effects -: Indications, Side Effects, Warnings, Sertalin - Drug Information - Taj Pharma, Sertalin dose Taj pharmaceuticals Sertalin interactions, Taj Pharmaceutical Sertalin contraindications, Sertalin price, Sertalin Taj Pharma Sertalin 50mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Sertalin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Levosimendan for Injection Taj Pharma SmPCTajPharmaQC
Levosimendan for Injection 12.5mg, 25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Levosimendan Dosage & Rx Info | Levosimendan Uses, Side Effects Levosimendan: Indications, Side Effects, Warnings, Levosimendan -Drug Information –Taj Pharma, Levosimendan dose Taj pharmaceuticals Levosimendan interactions, Taj Pharmaceutical Levosimendan contraindications, Levosimendan price, Levosimendan Taj Pharma Levosimendan SmPC-Taj Pharma Stay connected to all updated on Levosimendan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Simvastatin 20 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Simvastatin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Simvastatin Dosage & Rx Info | Simvastatin Uses, Side Effects -: Indications, Side Effects, Warnings, Simvastatin - Drug Information - Taj Pharma, Simvastatin dose Taj pharmaceuticals Simvastatin interactions, Taj Pharmaceutical Simvastatin contraindications, Simvastatin price, Simvastatin Taj Pharma Simvastatin 20mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Simvastatin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Decitabine for Injection Taj Pharma SmPCTajPharmaQC
Decitabine for Injection 50mg/Vial Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Decitabine Dosage & Rx Info | Decitabine Uses, Side Effects Decitabine: Indications, Side Effects, Warnings, Decitabine -Drug Information –Taj Pharma, Decitabine dose Taj pharmaceuticals Decitabine interactions, Taj Pharmaceutical Decitabine contraindications, Decitabine price, Decitabine Taj Pharma Decitabine SmPC-Taj Pharma Stay connected to all updated on Decitabine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Everolimus Tablets 5mg, 10mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Everolimus Dosage & Rx Info | Everolimus Uses, Side Effects Everolimus: Indications, Side Effects, Warnings, Everolimus -Drug Information –Taj Pharma, Everolimus dose Taj pharmaceuticals Everolimus interactions, Taj Pharmaceutical Everolimus contraindications, Everolimus price, Everolimus Taj Pharma Everolimus SmPC-Taj Pharma Stay connected to all updated on Everolimus Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Fluoxetine Capsules USP SmPC Taj PharmaceuticalsTajPharmaQC
Fluoxetine Capsules USP 10mg, 20mg, 40mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Fluoxetine Dosage & Rx Info | Fluoxetine Uses, Side Effects Fluoxetine: Indications, Side Effects, Warnings, Fluoxetine -Drug Information –Taj Pharma, Fluoxetine dose Taj pharmaceuticals Fluoxetine interactions, Taj Pharmaceutical Fluoxetine contraindications, Fluoxetine price, Fluoxetine Taj Pharma Fluoxetine SmPC- Taj Pharma Stay connected to all updated on Fluoxetine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Levocetirizine dihydrochloride 5 mg film coated tablets smpc- taj pharmaceuti...Taj Pharma
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Quetiapine 25mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Quetiapine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Quetiapine Dosage & Rx Info | Quetiapine Uses, Side Effects -: Indications, Side Effects, Warnings, Quetiapine - Drug Information - Taj Pharma, Quetiapine dose Taj pharmaceuticals Quetiapine interactions, Taj Pharmaceutical Quetiapine contraindications, Quetiapine price, Quetiapine Taj Pharma Cancer, oncologyQuetiapine 25mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Quetiapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Mirtazapine 30mg tablets smpc taj pharmaceuticalsTaj Pharma
Mirtazapine 30mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Mirtazapine Dosage & Rx Info | Mirtazapine Uses, Side Effects - Mirtazapine: Indications, Side Effects, Warnings, Mirtazapine - Drug Information - Taj Pharma, Mirtazapine dose Taj pharmaceuticals Mirtazapine interactions, Taj Pharmaceutical Mirtazapine contraindications, Mirtazapine price, Mirtazapine Taj Pharma Mirtazapine 30mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Mirtazapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Amitriptyline 25mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
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Everolimus 2.5 mg, 5mg tablets smpc taj pharmaceuticalsTaj Pharma
EVEROLIMUS Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, EVEROLIMUS Dosage & Rx Info | EVEROLIMUS Uses, Side Effects -: Indications, Side Effects, Warnings, EVEROLIMUS - Drug Information - Taj Pharma, EVEROLIMUS dose Taj pharmaceuticals EVEROLIMUS interactions, Taj Pharmaceutical EVEROLIMUS contraindications, EVEROLIMUS price, EVEROLIMUS Taj Pharma Cancer, oncologyEverolimus 2.5 mg, 5mg, 10mg tablets SMPC- Taj Pharma
Aceclofenac 100 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
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Enalapril maleate 5 mg tablets smpc taj pharmaceuticalsTaj Pharma
Enalapril maleate Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Enalapril maleate Dosage & Rx Info | Enalapril maleate Uses, Side Effects -: Indications, Side Effects, Warnings, Enalapril maleate - Drug Information - Taj Pharma, Enalapril maleate dose Taj pharmaceuticals Enalapril maleate interactions, Taj Pharmaceutical Enalapril maleate contraindications, Enalapril maleate price, Enalapril maleate Taj Pharma Enalapril maleate 5 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Enalapril maleate Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Quinine sulfate 200mg tablets smpc taj pharmaceuticalsTaj Pharma
QUININE SULFATE - Drug Information - Taj Pharma, QUININE SULFATE dose Taj pharmaceuticals QUININE SULFATE interactions, Taj Pharmaceutical QUININE SULFATE contraindications, QUININE SULFATE price, QUININE SULFATE Taj Pharma QUININE SULFATE TABLETS 200mg SMPC- Taj Pharma . Stay connected to all updated on QUININE SULFATE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Zolpidem tartrate 5 mg tablets smpc taj pharmaceuticalsTaj Pharma
Zolpidem Tartrate - Drug Information - Taj Pharma, Zolpidem Tartrate dose Taj pharmaceuticals Zolpidem Tartrate interactions, Taj Pharmaceutical Zolpidem Tartrate contraindications, Zolpidem Tartrate price, Zolpidem Tartrate Taj Pharma Zolpidem Tartrate 5 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Zolpidem Tartrate Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Tramadol 50mg per ml solution for injection or infusion smpc taj pharmaceuti...Taj Pharma
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Tetracycline hydrochloride 250mg tablets smpc taj pharmaceuticalsTaj Pharma
Tetracycline hydrochloride - Drug Information - Taj Pharma, Tetracycline hydrochloride dose Taj pharmaceuticals Tetracycline hydrochloride interactions, Taj Pharmaceutical Tetracycline hydrochloride contraindications, Tetracycline hydrochloride price, Tetracycline hydrochloride Taj Pharma Tetracycline hydrochloride 250mg TabletsSMPC- Taj Pharma . Stay connected to all updated on Tetracycline hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Tetracycline 250mg tablets pil taj pharmaceuticalsTaj Pharma
Tetracycline - Drug Information - Taj Pharma, Tetracycline dose Taj pharmaceuticals Tetracycline interactions, Taj Pharmaceutical Tetracycline contraindications, Tetracycline price, Tetracycline , Taj Pharma Tetracycline tablets 250mg PIL- Taj Pharma . Stay connected to all updated on Tetracycline Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
Tadalafil 20 mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Drug Information - Taj Pharma, Tadalafil dose Taj pharmaceuticals Tadalafil interactions, Taj Pharmaceutical Tadalafil contraindications, Tadalafil price, Tadalafil Taj Pharma Tadalafil 20 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Tadalafil Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Tadalafil 10 mg film coated tablets pil, taj pharmaceuticals.Taj Pharma
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Sodium feredetate 190mg per 5ml oral solution smpc taj pharmaceuticalsTaj Pharma
Sodium Feredetate - Drug Information - Taj Pharma, Sodium Feredetate dose Taj pharmaceuticals Sodium Feredetate interactions, Taj Pharmaceutical Sodium Feredetate contraindications, Sodium Feredetate price, Sodium Feredetate Taj Pharma Sodium Feredetate 190mg/5ml Oral Solution SMPC- Taj Pharma . Stay connected to all updated on Sodium Feredetate Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Pyrimethamine 25 mg tablets smpc taj pharmaceuticalsTaj Pharma
Pyrimethamine - Drug Information - Taj Pharma, Pyrimethamine dose Taj pharmaceuticals Pyrimethamine interactions, Taj Pharmaceutical Pyrimethamine contraindications, Pyrimethamine price, Pyrimethamine Taj Pharma Pyrimethamine 25 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Pyrimethamine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Prednisolone acetate 1% eye drops suspension smpc taj pharmaceuticalsTaj Pharma
Prednisolone acetate - Drug Information - Taj Pharma, Prednisolone acetate dose Taj pharmaceuticals Prednisolone acetate interactions, Taj Pharmaceutical Prednisolone acetate contraindications, Prednisolone acetate price, Prednisolone acetate Taj Pharma Prednisolone acetate 1% w/v, Eye Drops SuspensionSMPC- Taj Pharma . Stay connected to all updated on Prednisolone acetate Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Piperaquine tetraphosphate 320 mg and dihydroartemisinin 40 mg film coated ta...Taj Pharma
Drug Information - Taj Pharma, dose Taj interactions, Taj Pharmaceutical Piperaquine tetraphosphate and dihydroartemisinin contraindications Taj Pharma Piperaquine tetraphosphate 320 mg and dihydroartemisinin 40 mg film coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Piperaquine tetraphosphate and dihydroartemisinin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Paracetamol and ibuprofen 500 mg and 150 mg film coated tablets smpc taj pha...Taj Pharma
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Venlafaxine 75mg tablets smpc taj pharmaceuticals
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RX
VENLAFAXINE TABLETS
75MG
1.NAME OF THE MEDICINAL PRODUCT
Venlafaxine 75mg Tablets
2. QUALITATIVE AND QUANTITATIVE
COMPOSITION
Each Venlafaxine 75mg Tablet contains 75mg
venlafaxine as venlafaxine hydrochloride
Excipients: Lactose monohydrate and Sunset
Yellow (E110)
For a full list of excipients, see section 6.1
3. PHARMACEUTICAL FORM
Film coated tablets
Orange, 10 mm round biconvex, scored film-
coated tablets.
4. CLINICAL PARTICULARS
4.1 Therapeutic indications
Treatment of major depressive episodes.
For prevention of recurrence of major depressive
episodes.
4.2 Posology and method of administration
Major depressive episodes
The recommended starting dose of immediate-
release venlafaxine is 75mg/day in two or three
divided doses taken with food. Patients not
responding to the initial 75mg/day dose may
benefit from dose increases up to a maximum
dose of 375mg/day. Dosage increases can be
made at intervals of 2 weeks or more. If
clinically warranted due to symptom severity,
dose increases can be made at more frequent
intervals, but not less than 4 days.
Because of the risk of dose-related adverse
effects, dose increments should be made only
after a clinical evaluation (see section 4.4). The
lowest effective dose should be maintained.
Patients should be treated for a sufficient period
of time, usually several months or longer.
Treatment should be reassessed regularly on a
case-by-case basis. Longer-term treatment may
also be appropriate for prevention of recurrence
of major depressive episodes (MDE). In most of
the cases, the recommended dose in prevention
of recurrence of MDE is the same as the one
used during the current episode.
Antidepressive medicinal products should
continue for at least six months following
remission.
Use in elderly patients
No specific dose adjustments of venlafaxine are
considered necessary based on patient age alone.
However, caution should be exercised in treating
the elderly (e.g., due to the possibility of renal
impairment, the potential for changes in
neurotransmitter sensitivity and affinity
occurring with aging). The lowest effective dose
should always be used, and patients should be
carefully monitored when an increase in the dose
is required.
Use in children and adolescents under the age
of 18 years
Venlafaxine is not recommended for use in
children and adolescents.
Controlled clinical studies in children and
adolescents with major depressive disorder
failed to demonstrate efficacy and do not support
the use of venlafaxine in these patients (see
sections 4.4 and 4.8).
The efficacy and safety of venlafaxine for other
indications in children and adolescents under the
age of 18 have not been established.
Use in patients with hepatic impairment
In patients with mild and moderate hepatic
impairment, in general a 50% dose reduction
should be considered. However, due to inter-
individual variability in clearance,
individualisation of dosage may be desirable.
There are limited data in patients with severe
hepatic impairment. Caution is advised, and a
dose reduction by more than 50% should be
considered. The potential benefit should be
weighed against the risk in the treatment of
patients with severe hepatic impairment.
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Use in patients with renal impairment
Although no change in dosage is necessary for
patients with glomerular filtration rate (GFR)
between 30-70ml/minute, caution is advised. For
patients that require haemodialysis and in
patients with severe renal impairment (GFR <
30ml/min), the dose should be reduced by 50%.
Because of inter-individual variability in
clearance in these patients, individualisation of
dosage may be desirable.
Withdrawal symptoms seen on
discontinuation of venlafaxine
Abrupt discontinuation should be avoided.
When stopping treatment with venlafaxine, the
dose should be gradually reduced over a period
of at least one to two weeks in order to reduce
the risk of withdrawal reactions (see sections 4.4
and 4.8). If intolerable symptoms occur
following a decrease in the dose or upon
discontinuation of treatment, then resuming the
previously prescribed dose may be considered.
Subsequently, the physician may continue
decreasing the dose, but at a more gradual rate.
For oral use.
It is recommended that venlafaxine immediate-
release tablets be taken with food, at
approximately the same time each day.
Patients treated with venlafaxine immediate-
release tablets may be switched to venlafaxine
prolonged-release capsules at the nearest
equivalent daily dosage. For example,
venlafaxine immediate-release tablets 37.5mg
twice daily may be switched to venlafaxine
prolonged-release capsules 75mg once daily.
Individual dosage adjustments may be
necessary.
4.3 Contraindications
• Hypersensitivity to venlafaxine or to any of the
excipients.
• Concomitant treatment with irreversible
monoamine oxidase inhibitors (MAOIs) is
contraindicated due to the risk of serotonin
syndrome with symptoms such as agitation,
tremor and hyperthermia.
• Venlafaxine must not be initiated for at least
14 days after discontinuation of treatment with
an irreversible MAOI.
• Venlafaxine must be discontinued for at least 7
days before starting treatment with an
irreversible MAOI (see sections 4.4 and 4.5).
4.4 Special Warnings and precautions for use
• Suicide/suicidal thoughts or clinical
worsening:
Depression is associated with an increased risk
of suicidal thoughts, self harm and suicide
(suicide-related events).
This risk persists until significant remission
occurs. As improvement may not occur during
the first few weeks or more of treatment,
patients should be closely monitored until such
improvement occurs. It is general clinical
experience that the risk of suicide may increase
in the early stages of recovery. Other psychiatric
conditions for which venlafaxine is prescribed
can also be associated with an increased risk of
suicide related events. In addition, these
conditions may be co-morbid with major
depressive disorder. The same precautions
observed when treating patients with major
depressive disorder should therefore be observed
when treating patients with other psychiatric
disorders.
Patients with a history of suicide-related events,
or those exhibiting a significant degree of
suicidal ideation prior to commencement of
treatment, are known to be at greater risk of
suicidal thoughts or suicide attempts, and should
receive careful monitoring during treatment. A
meta-analysis of placebo-controlled clinical
trials of antidepressant drugs in adult patients
with psychiatric disorders showed an increased
risk of suicidal behaviour with antidepressants
compared to placebo in patients less than 25
years old.
Close supervision of patients and in particular
those at high risk should accompany drug
therapy especially in early treatment and
following dose changes. Patients (and caregivers
of patients) should be alerted about the need to
monitor for any clinical worsening, suicidal
behaviour or thoughts and unusual changes in
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behaviour and to seek medical advice
immediately if these symptoms present.
• Use in children and adolescents under 18
years of age.
Venlafaxine Tablets should not be used in the
treatment of children and adolescents under the
age of 18 years. Suicide-related behaviours
(suicide attempt and suicidal thoughts), and
hostility (predominantly aggression,
oppositional behaviour and anger) were more
frequently observed in clinical trials among
children and adolescents treated with
antidepressants compared to those treated with
placebo. If, based on clinical need, a decision to
treat is nevertheless taken, the patient should be
carefully monitored for the appearance of
suicidal symptoms. In addition, long-term safety
data in children and adolescents concerning
growth, maturation and cognitive and
behavioural development are lacking.
• Serotonin syndrome
As with other serotonergic agents, serotonin
syndrome, a potentially life-threatening
condition, may occur with venlafaxine
treatment, particularly with concomitant use of
other agents, such as MAOinhibitors, that may
affect the serotonergic neurotransmitter systems
(see sections 4.3 and 4.5).
Serotonin syndrome symptoms may include
mental status changes (e.g., agitation,
hallucinations, coma), autonomic instability
(e.g., tachycardia, labile blood pressure,
hyperthermia), neuromuscular aberrations (e.g.,
hyperreflexia, incoordination) and/or
gastrointestinal symptoms (e.g., nausea,
vomiting, diarrhoea).
• Narrow-angle glaucoma
Mydriasis may occur in association with
venlafaxine. It is recommended that patients
with raised intraocular pressure or patients at
risk for acute narrow-angle glaucoma (angle-
closure glaucoma) be closely monitored.
• Blood pressure
Dose-related increases in blood pressure have
been commonly reported with venlafaxine. In
some cases, severely elevated blood pressure
requiring immediate treatment has been reported
in postmarketing experience. All patients should
be carefully screened for high blood pressure
and preexisting hypertension should be
controlled before initation of treatment. Blood
pressure should be reviewed periodically, after
initiation of treatment and after dose increases.
Caution should be exercised in patients whose
underlying conditions might be compromised by
increases in blood pressure, e.g., those with
impaired cardiac function.
• Heart rate
Increases in heart rate can occur, particularly
with higher doses. Caution should be exercised
in patients whose underlying conditions might
be compromised by increases in heart rate.
• Cardiac disease and risk of arrhythmia
Venlafaxine has not been evaluated in patients
with a recent history of myocardial infarction or
unstable heart disease. Therefore, it should be
used with caution in these patients.
In postmarketing experience, fatal cardiac
arrhythmias have been reported with the use of
venlafaxine, especially in overdose. The balance
of risks and benefits should be considered before
prescribing venlafaxine to patients at high risk of
serious cardiac arrhythmia.
• Convulsions
Convulsions may occur with venlafaxine
therapy. As with all antidepressants, venlafaxine
should be introduced with caution in patients
with a history of convulsions, and concerned
patients should be closely monitored. Treatment
should be discontinued in any patient who
develops seizures.
• Hyponatraemia
Cases of hyponatraemia and/or the Syndrome of
Inappropriate Antidiuretic Hormone (SIADH)
secretion may occur with venlafaxine. This has
most frequently been reported in volume-
depleted or dehydrated patients. Elderly patients,
patients taking diuretics, and patients who are
otherwise volume-depleted may be at greater
risk for this event.
• Abnormal bleeding
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Medicinal products that inhibit serotonin uptake
may lead to reduced platelet function. The risk
of skin and mucous membrane bleeding,
including gastrointestinal haemorrhage, may be
increased in patients taking venlafaxine. As with
other serotonin-reuptake inhibitors, venlafaxine
should be used cautiously in patients
predisposed to bleeding, including patients on
anticoagulants and platelet inhibitors.
• Serum cholesterol
Clinically relevant increases in serum
cholesterol were recorded in 5.3% of
venlafaxine-treated patients and 0.0% of
placebo-treated patients treated for at least 3
months in placebo-controlled clinical trials.
Measurement of serum cholesterol levels should
be considered during long-term treatment.
• Co-administration with weight loss agents
The safety and efficacy of venlafaxine therapy in
combination with weight loss agents, including
phentermine, have not been established.
Co-administration of venlafaxine and weight
loss agents is not recommended. Venlafaxine is
not indicated for weight loss alone or in
combination with other products.
• Mania/hypomania
Mania/hypomania may occur in a small
proportion of patients with mood disorders who
have received antidepressants, including
venlafaxine. As with other antidepressants,
venlafaxine should be used cautiously in patients
with a history or family history of bipolar
disorder.
• Aggression
Aggression may occur in a small number of
patients who have received antidepressants,
including venlafaxine. This has been reported
under initiation, dose changes and
discontinuation of treatment.
As with other antidepressants, venlafaxine
should be used cautiously in patients with a
history of aggression.
• Discontinuation of treatment
Withdrawal symptoms when treatment is
discontinued are common, particularly if
discontinuation is abrupt (see section 4.8). In
clinical trials, adverse events seen on treatment
discontinuation (tapering and post-tapering)
occurred in approximately 31% of patients
treated with venlafaxine and 17% of patients
taking placebo.
The risk of withdrawal symptoms may be
dependent on several factors, including the
duration and dose of therapy and the rate of dose
reduction. Dizziness, sensory disturbances
(including paraesthesia), sleep disturbances
(including insomnia and intense dreams),
agitation or anxiety, nausea and/or vomiting,
tremor and headache are the most commonly
reported reactions. Generally, these symptoms
are mild to moderate; however, in some patients
they may be severe in intensity.
They usually occur within the first few days of
discontinuing treatment, but there have been
very rare reports of such symptoms in patients
who have inadvertently missed a dose.
Generally, these symptoms are self-limiting and
usually resolve within 2 weeks, though in some
individuals they may be prolonged (2-3 months
or more). It is therefore advised that venlafaxine
should be gradually tapered when discontinuing
treatment over a period of several weeks or
months, according to the patient's needs (see
section 4.2).
• Akathisia/psychomotor restlessness
The use of venlafaxine has been associated with
the development of akathisia, characterised by a
subjectively unpleasant or distressing
restlessness and need to move often
accompanied by an inability to sit or stand still.
This is most likely to occur within the first few
weeks of treatment. In patients who develop
these symptoms, increasing the dose may be
detrimental.
• Dry mouth
Dry mouth is reported in 10% of patients treated
with venlafaxine. This may increase the risk of
caries, and patients should be advised upon the
importance of dental hygiene.
• Diabetes
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In patients with diabetes, treatment with an SSRI
or venlafaxine may alter glycaemic control.
Insulin and/or antidiabetic dosage may need to
be adjusted.
• Excipients of known effect
Patients with rare hereditary problems of
galactose intolerance, the Lapp lactase
deficiency or glucose-galactose malabsorption
should not take this medicine.
The colouring sunset yellow FCF (E110) may
cause allergic reactions.
4.5 Interaction with other medicinal
products and other forms of interaction
Monoamine Oxidase Inhibitors (MAOI)
Irreversible non-selective MAOIs
Venlafaxine must not be used in combination
with irreversible non-selective MAOIs.
Venlafaxine must not be initiated for at least 14
days after discontinuation of treatment with an
irreversible non-selective MAOI. Venlafaxine
must be discontinued for at least 7 days before
starting treatment with an irreversible non-
selective MAOI (see sections 4.3 and 4.4).
Reversible, selective MAO-A inhibitor
(moclobemide)
Due to the risk of serotonin syndrome, the
combination of venlafaxine with a reversible and
selective MAOI, such as moclobemide, is not
recommended. Following treatment with a
reversible MAO-inhibitor, a shorter withdrawal
period than 14 days may be used before
initiation of venlafaxine treatment. It is
recommended that venlafaxine should be
discontinued for at least 7 days before starting
treatment with a reversible MAOI (see section
4.4).
Reversible, non-selective MAOI (linezolid)
The antibiotic linezolid is a weak reversible and
non-selective MAOI and should not be given to
patients treated with venlafaxine (see section
4.4).
Severe adverse reactions have been reported in
patients who have recently been discontinued
from an MAOI and started on venlafaxine, or
have recently had venlafaxine therapy
discontinued prior to initiation of an MAOI.
These reactions have included tremor,
myoclonus, diaphoresis, nausea, vomiting,
flushing, dizziness, and hyperthermia with
features resembling neuroleptic malignant
syndrome, seizures, and death.
Serotonin syndrome
As with other serotonergic agents, serotonin
syndrome may occur with venlafaxine treatment,
particularly with concomitant use of other agents
that may affect the serotonergic neurotransmitter
system (including triptans, SSRIs, SNRIs,
lithium, sibutramine, tramadol, or St. John's
Wort [Hypericum perforatum]), with medicinal
agents which impair metabolism of serotonin
(including MAOIs), or with serotonin precursors
(such as tryptophan supplements).
If concomitant treatment of venlafaxine with an
SSRI, an SNRI or a serotonin receptor agonist
(triptan) is clinically warranted, careful
observation of the patient is advised, particularly
during treatment initiation and dose increases.
The concomitant use of venlafaxine with
serotonin precursors (such as tryptophan
supplements) is not recommended (see section
4.4).
CNS-active substances
The risk of using venlafaxine in combination
with other CNS-active substances has not been
systematically evaluated. Consequently, caution
is advised when venlafaxine is taken in
combination with other CNS-active substances.
Ethanol
Venlafaxine has been shown not to increase the
impairment of mental and motor skills caused by
ethanol. However, as with all CNS-active
substances, patients should be advised to avoid
alcohol consumption.
Effect of other medicinal products on
venlafaxine
Ketoconazole (CYP3A4 inhibitor)
A pharmacokinetic study with ketoconazole in
CYP2D6 extensive (EM) and poor metabolisers
(PM) resulted in higher AUC of venlafaxine
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(70% and 21% in CYP2D6 PM and EM
subjects, respectively) and O-
desmethylvenlafaxine (33% and 23% in
CYP2D6 PM and EM subjects, respectively)
following administration of ketoconazole.
Concomitant use of CYP3A4 inhibitors (e.g.,
atazanavir, clarithromycin, indinavir,
itraconazole, voriconazole, posaconazole,
ketoconazole, nelfinavir, ritonavir, saquinavir,
telithromycin) and venlafaxine may increase
levels of venlafaxine and O-
desmethylvenlafaxine. Therefore, caution is
advised if a patient's therapy includes a CYP3A4
inhibitor and venlafaxine concomitantly.
Effect of venlafaxine on other medicinal
products
Lithium
Serotonin syndrome may occur with the
concomitant use of venlafaxine and lithium (see
Serotonin syndrome).
Diazepam
Venlafaxine has no effects on the
pharmacokinetics and pharmacodynamics of
diazepam and its active metabolite,
desmethyldiazepam. Diazepam does not appear
to affect the pharmacokinetics of either
venlafaxine or O-desmethylvenlafaxine. It is
unknown whether a pharmacokinetic and/or
pharmacodynamic interaction with other
benzodiazepines exists.
Imipramine
Venlafaxine did not affect the pharmacokinetics
of imipramine and 2-OH-imipramine. There was
a dose-dependent increase of 2-OH-desipramine
AUC by 2.5 to 4.5-fold when venlafaxine 75mg
to 150mg daily was administered. Imipramine
did not affect the pharmacokinetics of
venlafaxine and O-desmethylvenlafaxine. The
clinical significance of this interaction is
unknown. Caution should be exercised with co-
administration of venlafaxine and imipramine.
Haloperidol
A pharmacokinetic study with haloperidol has
shown a 42% decrease in total oral clearance, a
70% increase in AUC, an 88% increase in Cmax,
but no change in half-life for haloperidol. This
should be taken into account in patients treated
with haloperidol and venlafaxine concomitantly.
The clinical significance of this interaction is
unknown.
Risperidone
Venlafaxine increased the risperidone AUC by
50%, but did not significantly alter the
pharmacokinetic profile of the total active
moiety (risperidone plus 9-hydroxyrisperidone).
The clinical significance of this interaction is
unknown.
Metoprolol
Concomitant administration of venlafaxine and
metoprolol to healthy volunteers in a
pharmacokinetic interaction study for both
medicinal products resulted in an increase of
plasma concentrations of metoprolol by
approximately 30-40% without altering the
plasma concentrations of its active metabolite,
α-hydroxymetoprolol. The clinical relevance of
this finding in hypertensive patients is unknown.
Metoprolol did not alter the pharmacokinetic
profile of venlafaxine or its active metabolite, O-
desmethylvenlafaxine. Caution should be
exercised with co-administration of venlafaxine
and metoprolol.
Indinavir
A pharmacokinetic study with indinavir has
shown a 28% decrease in AUC and a 36%
decrease in Cmax for indinavir. Indinavir did not
affect the pharmacokinetics of venlafaxine and
O-desmethylvenlafaxine. The clinical
significance of this interaction is unknown.
4.6 Fertility, pregnancy and lactation
Pregnancy
Pregnancy
There are no adequate data from the use of
venlafaxine in pregnant women.
Studies in animals have shown reproductive
toxicity (see section 5.3). The potential risk for
humans is unknown. Venlafaxine must only be
administered to pregnant women if the expected
benefits outweigh any possible risk.
As with other serotonin reuptake inhibitors
(SSRIs/SNRIs), discontinuation symptoms may
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occur in the newborns if venlafaxine is used
until or shortly before birth. Some newborns
exposed to venlafaxine late in the third trimester
have developed complications requiring tube-
feeding, respiratory support or prolonged
hospitalisation. Such complications can arise
immediately upon delivery.
The following symptoms may be observed in
neonates if the mother has used an SSRI/SNRI
late in pregnancy: irritability, tremor, hypotonia,
persistent crying, and difficulty in sucking or in
sleeping.
These symptoms may be due to either
serotonergic effects or exposure symptoms. In
the majority of cases, these complications are
observed immediately or within 24 hours after
partus.
Epidemiological data have suggested that the
use of SSRIs in pregnancy, particularly in late
pregnancy, may increase the risk of persistent
pulmonary hypertension in the newborn
(PPHN). Although no studies have investigated
an association of PPHN to SNRI treatment, this
potential risk cannot be ruled out with
venlafaxine taking into account the related
mechanism of action (inhibition of the re-uptake
of serotonin).
Lactation
Venlafaxine and its active metabolite, O-
desmethylvenlafaxine, are excreted in breast
milk. There have been post-marketing reports of
breast-fed infants who experienced crying,
irritability, and abnormal sleep patterns.
Symptoms consistent with venlafaxine drug
discontinuation have also been reported after
stopping breast-feeding. A risk to the suckling
child cannot be excluded. Therefore, a decision
to continue/discontinue breast-feeding or to
continue/discontinue therapy with venlafaxine
should be made, taking into account the benefit
of breast-feeding to the child and the benefit of
venlafaxine therapy to the woman.
4.7 Effects on ability to drive and use
machines
Any psychoactive medicinal product may impair
judgment, thinking, and motor skills. Therefore,
any patient receiving venlafaxine should be
cautioned about their ability to drive or operate
hazardous machinery.
4.8 Undesirable Effects
The most commonly (>1/10) reported adverse
reactions in clinical studies were nausea, dry
mouth, headache and sweating (including night
sweats).
Adverse reactions are listed below by system
organ class and frequency.
Frequencies are defined as: very common
(≥1/10), common (≥1/100 to <1/10), uncommon
(≥1/1,000 to <1/100), rare (≥1/10,000 to
<1/1,000), not known (cannot be estimated from
the available data).
Body
System
Very
Comm
on
Common Uncommo
n
Rare Not Known
Haematol
ogical /
Lymphati
c
Ecchymosis
,
Gastrointes
tinal
haemorrha
ge
Mucous
membrane
bleeding,
Prolonged
bleeding
time,
Thrombocyt
opaenia,
Blood
dyscrasias,
(including
agranulocyt
osis,
aplastic
anaemia,
neutropaeni
a and
pancytopae
nia)
Metabolic
/
Nutritiona
l
Serum
cholesterol
increased,
Weight loss
Weight gain Abnormal
liver
function
tests,
Hyponatrae
mia,
Hepatitis,
Syndrome
of
Inappropriat
e
Antidiuretic
Hormone
Secretion
(SIADH),
Prolactin
increased
Nervous Dry
mouth
(10.0%
),
Heada
che
(30.3%
)*
Abnormal
dreams,
Decreased
libido,
Dizziness,
Increased
muscle tonus
(hypertonia),
Insomnia,
Nervousness
,
Paresthesia,
Sedation,
Apathy,
Hallucinatio
ns,
Myoclonus,
Agitation,
Impaired
coordinatio
n and
balance
Akathisia/
Psychomotor
restlessness,
Convulsion,
Manic
reaction
Neuroleptic
Malignant
Syndrome
(NMS),
Serotonergi
c
syndrome,
Delirium,
Extrapyrami
dal
reactions
(including
dystonia
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Tremor,
Confusion,
Depersonalis
ation
and
dyskinaesia
),
Tardive
dyskinaesia
,
Suicidal
ideation
and
behaviours*
*
Vertigo,
Aggression
***
Special
Senses
Abnormality
of
accommodati
on,
Mydriasis,
Visual
disturbance
Altered
taste
sensation,
Tinnitus
Angle-
closure
glaucoma
Cardiova
scular
Hypertension
,
Vasodilatatio
n (mostly hot
flashes/flush
es),
Palpitations
Postural
hypotensio
n,
Syncope,
Tachycardi
a
Hypotensio
n,
QT
prolongatio
n,
Ventricular
fibrillation,
Ventricular
tachycardia
(including
torsade de
pointes)
Respirato
ry
Yawning Pulmonary
eosinophilia
Digestive Nause
a
(20.0%
)
Appetite
decreased
(anorexia),
Constipation,
Vomiting
Bruxism,
Diarrhoea
Pancreatitis
Skin Sweati
ng
(includi
ng
night
sweats
)
[12.2%]
Rash,
Alopecia
Erythema
multiforme,
Toxic
epidermal
necrolysis,
Stevens-
Johnson
syndrome,
Pruritus,
Urticaria
Musculos
keletal
Rhabdomy
olysis
Urogenita
l
Abnormal
ejaculation/or
gasm
(males),
Anorgasmia,
Erectile
dysfunction
(impotence),
Urination
impaired
(mostly
hesitancy),
Menstrual
disorders
associated
with
increased
bleeding or
increased
irregular
bleeding
(e.g.,
Abnormal
orgasm
(females),
Urinary
retention
Urinary
incontinence
Urogenital
menorrhagia,
metrorrhagia
),
Pollakiuria
Body as
a Whole
Asthenia
(fatigue),
Chills
Angioedem
a,
Photosensit
ivity
reaction
Anaphylaxi
s
*In pooled clinical trials, the incidence of
headache was 30.3% with venlafaxine versus
31.3% with placebo.
**Cases of suicidal ideation and suicidal
behaviours have been reported during
venlafaxine therapy or early after treatment
discontinuation (see section 4.4).
*** See section 4.4.
Discontinuation of venlafaxine (particularly
when abrupt) commonly leads to withdrawal
symptoms.
Dizziness, sensory disturbances (including
paraethesia), sleep disturbances (including
insomnia and intense dreams), agitation or
anxiety, nausea and/or vomiting, tremor,
Vertigo, headache and flu syndrome are the
most commonly reported reactions. Generally,
these events are mild to moderate and are self-
limiting; however, in some patients, they may be
severe and/or prolonged. It is therefore advised
that when venlafaxine treatment is no longer
required, gradual discontinuation by dose
tapering should be carried out (see sections 4.2
and 4.4).
Paediatric patients
In general, the adverse reaction profile of
venlafaxine (in placebo-controlled clinical trials)
in children and adolescents (ages 6 to 17) was
similar to that seen for adults. As with adults,
decreased appetite, weight loss, increased blood
pressure, and increased serum cholesterol were
observed (see section 4.4).
In paediatric clinical trials the adverse reaction
suicidal ideation was observed. There were also
increased reports of hostility and, especially in
major depressive disorder, self-harm.
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Particularly, the following adverse reactions
were observed in paediatric patients: abdominal
pain, agitation, dyspepsia, ecchymosis, epistaxis,
and myalgia.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after
authorisation of the medicinal product is
important. It allows continued monitoring of the
benefit/risk balance of the medicinal product.
4.9 Overdose
In postmarketing experience, overdose with
venlafaxine was reported predominantly in
combination with alcohol and/or other medicinal
products. The most commonly reported events in
overdose include tachycardia, changes in level
of consciousness (ranging from somnolence to
coma), mydriasis, convulsion, and vomiting.
Other reported events include
electrocardiographic changes (e.g., prolongation
of QT interval, bundle branch block, QRS
prolongation), ventricular tachycardia,
bradycardia, hypotension, vertigo, and death.
Published retrospective studies report that
venlafaxine overdosage may be associated with
an increased risk of fatal outcomes compared to
that observed with SSRI antidepressant
products, but lower than that for tricyclic
antidepressants. Epidemiological studies have
shown that venlafaxine treated patients have a
higher burden of suicide risk factors than SSRI
patients. The extent to which the finding of an
increased risk of fatal outcomes can be attributed
to the toxicity of venlafaxine in overdosage, as
opposed to some characteristics of venlafaxine-
treated patients, is not clear.
Prescriptions for venlafaxine should be written
for the smallest quantity of the medicinal
product consistent with good patient
management in order to reduce the risk of
overdose.
Recommended treatment
General supportive and symptomatic measures
are recommended; cardiac rhythm and vital
signs must be monitored. When there is a risk of
aspiration, induction of emesis is not
recommended. Gastric lavage may be indicated
if performed soon after ingestion or in
symptomatic patients. Administration of
activated charcoal may also limit absorption of
the active substance. Forced diuresis, dialysis,
hemoperfusion and exchange transfusion are
unlikely to be of benefit. No specific antidotes
for venlafaxine are known.
5. PHARMACOLOGICAL PROPERTIES
5.1 Pharmacodynamic properties
Pharmacotherapeutic group: Other
antidepressants - ATC code: NO6A X16.
The mechanism of venlafaxine's antidepressant
action in humans is believed to be associated
with its potentiation of neurotransmitter activity
in the central nervous system. Preclinical studies
have shown that venlafaxine and its major
metabolite, O-desmethylvenlafaxine (ODV), are
inhibitors of serotonin and noradrenaline
reuptake. Venlafaxine also weakly inhibits
dopamine uptake. Venlafaxine and its active
metabolite reduce β-adrenergic responsiveness
after both acute (single dose) and chronic
administration. Venlafaxine and ODV are very
similar with respect to their overall action on
neurotransmitter reuptake and receptor binding.
Venlafaxine has virtually no affinity for rat brain
muscarinic, cholinergic, H1-histaminergic or α1-
adrenergic receptors in vitro. Pharmacological
activity at these receptors may be related to
various side effects seen with other
antidepressant medicinal products, such as
anticholinergic, sedative and cardiovascular side
effects.
Venlafaxine does not possess monoamine
oxidase (MAO) inhibitory activity.
In vitro studies revealed that venlafaxine has
virtually no affinity for opiate or benzodiazepine
sensitive receptors.
Major depressive episodes
The efficacy of venlafaxine immediate-release
as a treatment for major depressive episodes was
demonstrated in five randomised, double-blind,
placebo-controlled, short-term trials ranging
from 4 to 6 weeks duration, for doses up to
375mg/day. The efficacy of venlafaxine
prolonged-release as a treatment for major
depressive episodes was established in two
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placebo-controlled, short-term studies for 8 and
12 weeks duration, which included a dose range
of 75 to 225mg/day.
In one longer-term study, adult outpatients who
had responded during an 8-week open trial on
venlafaxine prolonged-release (75, 150, or
225mg) were randomised to continuation of
their same venlafaxine prolonged-release dose or
to placebo, for up to 26 weeks of observation for
relapse.
In a second longer-term study, the efficacy of
venlafaxine in prevention of recurrent depressive
episodes for a 12-month period was established
in a placebo-controlled double-blind clinical trial
in adult outpatients with recurrent major
depressive episodes who had responded to
venlafaxine treatment (100 to 200mg/day, on a
b.i.d. schedule) on the last episode of depression.
5.2 Pharmacokinetic properties
Venlafaxine is extensively metabolised,
primarily to the active metabolite, O-
desmethylvenlafaxine (ODV). Mean ± SD
plasma half-lives of venlafaxine and ODV are
5±2 hours and 11±2 hours, respectively. Steady-
state concentrations of venlafaxine and ODV are
attained within 3 days of oral multiple-dose
therapy. Venlafaxine and ODV exhibit linear
kinetics over the dose range of 75mg to
450mg/day.
Absorption
At least 92% of venlafaxine is absorbed
following single oral doses of immediate-release
venlafaxine.
Absolute bioavailability is 40% to 45% due to
presystemic metabolism. After immediate-
release venlafaxine administration, the peak
plasma concentrations of venlafaxine and ODV
occur in 2 and 3 hours, respectively. Following
the administration of venlafaxine prolonged-
release capsules, peak plasma concentrations of
venlafaxine and ODV are attained within 5.5
hours and 9 hours, respectively. When equal
daily doses of venlafaxine are administered as
either an immediate-release tablet or prolonged-
release capsule, the prolonged-release capsule
provides a slower rate of absorption, but the
same extent of absorption compared with the
immediate-release tablet. Food does not affect
the bioavailability of venlafaxine and ODV.
Distribution
Venlafaxine and ODV are minimally bound at
therapeutic concentrations to human plasma
proteins (27% and 30%, respectively). The
volume of distribution for venlafaxine at steady-
state is 4.4±1.6 L/kg following intravenous
administration.
Metabolism
Venlafaxine undergoes extensive hepatic
metabolism. In vitro and in vivo studies indicate
that venlafaxine is biotransformed to its major
active metabolite, ODV, by CYP2D6. In
vitro and in vivo studies indicate that venlafaxine
is metabolised to a minor, less active metabolite,
N-desmethylvenlafaxine, by CYP3A4. In
vitro and in vivo studies indicate that venlafaxine
is a weak inhibitor of CYP2D6. Venlafaxine did
not inhibit CYP1A2, CYP2C9, or CYP3A4.
Elimination
Venlafaxine and its metabolites are excreted
primarily through the kidneys. Approximately
87% of a venlafaxine dose is recovered in the
urine within 48 hours as either unchanged
venlafaxine (5%), unconjugated ODV (29%),
conjugated ODV (26%), or other minor inactive
metabolites (27%).
Mean ± SD plasma steady-state clearances of
venlafaxine and ODV are 1.3±0.6L/h/kg and
0.4±0.2L/h/kg, respectively.
Special populations
Age and gender
Subject age and gender do not significantly
affect the pharmacokinetics of venlafaxine and
ODV.
CYP2D6 extensive/poor metabolisers
Plasma concentrations of venlafaxine are higher
in CYP2D6 poor metabolisers than extensive
metabolisers. Because the total exposure (AUC)
of venlafaxine and ODV is similar in poor and
extensive metabolisers, there is no need for
different venlafaxine dosing regimens for these
two groups.
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Patients with hepatic impairment
In Child-Pugh A (mildly hepatically impaired)
and Child-Pugh B (moderately hepatically
impaired) subjects, venlafaxine and ODV half-
lives were prolonged compared to normal
subjects. The oral clearance of both venlafaxine
and ODV was reduced. A large degree of
intersubject variability was noted. There are
limited data in patients with severe hepatic
impairment (see section 4.2).
Patients with renal impairment
In dialysis patients, venlafaxine elimination half-
life was prolonged by about 180% and clearance
reduced by about 57% compared to normal
subjects, while ODV elimination half-life was
prolonged by about 142% and clearance reduced
by about 56%. Dosage adjustment is necessary
in patients with severe renal impairment and in
patients that require haemodialysis (see section
4.2).
5.3 Preclinical safety data
Studies with venlafaxine in rats and mice
revealed no evidence of carcinogenesis.
Venlafaxine was not mutagenic in a wide range
of in vitro and in vivo tests.
Animal studies regarding reproductive toxicity
have found in rats a decrease in pup weight, an
increase in stillborn pups, and an increase in pup
deaths during the first 5 days of lactation. The
cause of these deaths is unknown. These effects
occurred at 30mg/kg/day, 4 times the human
daily dose of 375mg of venlafaxine (on an
mg/kg basis). The no-effect dose for these
findings was 1.3 times the human dose. The
potential risk for humans is unknown.
Reduced fertility was observed in a study in
which both male and female rats were exposed
to ODV.
This exposure was approximately 1 to 2 times
that of a human venlafaxine dose of 375mg/day.
The human relevance of this finding is
unknown.
6. PHARMACEUTICAL PARTICULARS
6.1 List of excipients
ablet Core:
Lactose monohydrate
Microcrystalline cellulose
Croscarmellose sodium
Povidone K30
Magnesium stearate
Tablet Coating:
Opadry 03B23319 Orange containing;
Hypromellose 6 cP
Titanium dioxide (E171)
Macrogol / PEG 400
Sunset yellow FCF lake (E110)
6.2 Incompatibilities
Not applicable.
6.3 Shelf life
48 months
6.4 Special precautions for storage
No special precautions for storage
6.5 Nature and contents of container
Al/PVC Blister
HDPE Container with LDPE screw Cap
14, 28, 30, 42, 56 tablets
* Not all pack sizes may be marketed
6.6 Special precautions for disposal and
other handling
No special requirements
7. MANUFACTURER:
Manufactured in India by:
TAJ PHARMACEUTICALS LTD.
Mumbai, India
At:388/34, Changodar Industrial Estate
Changodar- 382 210
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Dist- Ahmedabad. Gujarat (India)