The document discusses multiple factors that contributed to the decline of Venice: 1) Foreign threats from involvement in mainland conflicts, the Ottoman Empire, and the League of Cambrai weakened Venice militarily and economically. 2) Increased maritime competition as new sea routes were discovered and other nations began direct trade with Asia challenged Venice's trade monopoly. 3) Political challenges including incapable leaders, corruption, and overreliance on mercenaries undermined Venice's governance. 4) Social changes such as Venetian nobles pursuing leisure over affairs of state further hastened Venice's decline.