The document summarizes recommendations for human papillomavirus (HPV) vaccination from the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. It recommends routine HPV vaccination for females and males aged 11-12 to help reduce cancers and genital warts caused by HPV. Two HPV vaccines are approved and have shown to be highly effective and safe when administered before the onset of sexual activity according to clinical trials. Obstetrician-gynecologists should educate patients about HPV vaccination.
HPV Vaccination, Cerviocal Cancer : Do we need it
for Prevention of cervical cancer &
other HPV related diseasesm,
Presentation Outlines
Cervical cancer disease burden
Prevention with HPV vaccination
Vaccination of sexually active women
Opportunity of Postpartum HPV vaccination
Importance of genital warts prevention
Real world effectiveness data
Safety of HPV vaccine
HPV Vaccination, Cerviocal Cancer : Do we need it
for Prevention of cervical cancer &
other HPV related diseasesm,
Presentation Outlines
Cervical cancer disease burden
Prevention with HPV vaccination
Vaccination of sexually active women
Opportunity of Postpartum HPV vaccination
Importance of genital warts prevention
Real world effectiveness data
Safety of HPV vaccine
UPDATE HPV Vaccination IN Cervical Cancer Prevention Dr Sharda Jain Lifecare Centre
Cervical Cancer In India: A Preventable Tragedy That Requires Urgent Attention
It is estimated that in India, about 160 million women aged 30-59 years are at risk of developing cervical cancer, with fatality rate of 50 per cent
The United States Congress designated January as Cervical Health Awareness Month.
CANSA places the focus on Cervical Cancer during the month of September. Cervical Cancer is the 2nd most common cancer among South African women.
Sources: http://www.cansa.org.za/womens-health/
PANEL DISCUSSION
MODERATOR: DR. RUPAM ARORA / Dr. Sharda Jain
PANELISTS:
DR. ARUNA SAXENA
DR. DEEPTI NABH
DR. ILA GUPTA
DR. JYOTI AGARWAL
DR. RAJ BOKADIA
DR. RENU CHAWLA
Is cervical cancer common
Human papillomavirus (HPV) causes cervical cancer being the fourth most common cancer in women. 99% of all cervical cancer cases are related to genital infection with HPV. HPV Vaccines are now available and are the springboard for a change by primary prevention of this threatening situation.
HPV Diseases More Than Cervical Cancer, Dr. Sharda Jain Lifecare Centre
HPV Disease . Cervical cancer , prevention cervical cancer , HPV prevention , cancer prevention , Human Papillomavirus (HPV), cervical cancer prevention
Cancer Biomarkers Research, HPV and Cancer, HPV VaccineJames Lyons-Weiler
An overview of advances in cancer biomarker research strategies, the pathogenesis of HPV virus and a focus on the HPV vaccine with an analysis of evidence of type replacement.
HPV Infection , HPV Vaccination , Cervical cancer , Cancer in India , Dr. SHA...Lifecare Centre
HPV inefection , HPV disease prevention, Cervical cancer prevention , Cervical cancer treatment, Female cancer , Female cancer prevention , Uterine cancer , Cancer in india
UPDATE HPV Vaccination IN Cervical Cancer Prevention Dr Sharda Jain Lifecare Centre
Cervical Cancer In India: A Preventable Tragedy That Requires Urgent Attention
It is estimated that in India, about 160 million women aged 30-59 years are at risk of developing cervical cancer, with fatality rate of 50 per cent
The United States Congress designated January as Cervical Health Awareness Month.
CANSA places the focus on Cervical Cancer during the month of September. Cervical Cancer is the 2nd most common cancer among South African women.
Sources: http://www.cansa.org.za/womens-health/
PANEL DISCUSSION
MODERATOR: DR. RUPAM ARORA / Dr. Sharda Jain
PANELISTS:
DR. ARUNA SAXENA
DR. DEEPTI NABH
DR. ILA GUPTA
DR. JYOTI AGARWAL
DR. RAJ BOKADIA
DR. RENU CHAWLA
Is cervical cancer common
Human papillomavirus (HPV) causes cervical cancer being the fourth most common cancer in women. 99% of all cervical cancer cases are related to genital infection with HPV. HPV Vaccines are now available and are the springboard for a change by primary prevention of this threatening situation.
HPV Diseases More Than Cervical Cancer, Dr. Sharda Jain Lifecare Centre
HPV Disease . Cervical cancer , prevention cervical cancer , HPV prevention , cancer prevention , Human Papillomavirus (HPV), cervical cancer prevention
Cancer Biomarkers Research, HPV and Cancer, HPV VaccineJames Lyons-Weiler
An overview of advances in cancer biomarker research strategies, the pathogenesis of HPV virus and a focus on the HPV vaccine with an analysis of evidence of type replacement.
HPV Infection , HPV Vaccination , Cervical cancer , Cancer in India , Dr. SHA...Lifecare Centre
HPV inefection , HPV disease prevention, Cervical cancer prevention , Cervical cancer treatment, Female cancer , Female cancer prevention , Uterine cancer , Cancer in india
Where traditional and tech meet: How banks and marketplace lenders can partne...Craig Schleicher
While marketplace lenders are often seen as disruptive competitors to banks, complementary attributes open up the opportunity for true strategic partnership between traditional and marketplace lenders. Partnerships can take many potential forms, such as referrals, white labeling, joint product development, and lending-as-a-service. This paper focuses on how marketplace lending platforms can assess potential partnership opportunities and prepare to partner successfully.
Wondering facts hpv vaccines are reducing infections, warts and probably cancer.Root India Healthcare
Wondering facts hpv vaccines are reducing infections, warts and probably cancer. Top OPD Health card for you available at www.rihl.in and medsill.com, Buy it Today !!!
Human PapillomavirusVaccineUSU, FNP 590 Health Promotion, EdNarcisaBrandenburg70
Human Papillomavirus
Vaccine
USU, FNP 590 Health Promotion, Education, and Disease Prevention Across the Lifespan
Our Group 2 presentation is on the Human Papilloma Virus Vaccine. We will talk about what the HPV virus is, how you contact the virus and can prevent getting the virus, some information about the vaccine which includes some pros/cons and the issues and controversy surrounding it.
1
HPV is a group of approximately 150 related viruses that can lead up to 6 different types of cancers later on in life.
HPV is the most common sexually transmitted infection.
HPV appears as skin or mucous membrane growths on the vagina, cervix, rectum, anus, penis, and scrotum.
What is Human Papilloma Virus (HPV)?
HPV is spread from skin to skin sexual contact with someone who has the virus.
HPV is the most common STD. Most people do not know they have it unless they feel or see the skin irritation and see their physician for diagnosis but the lesions usually go away on their own.
How do you get HPV?
The best way to prevent contracting HPV is to avoid sexual contact with someone who has the virus.
The HPV vaccine significantly reduces your chances of contracting the virus.
Prevention of HPV
HPV vaccination
-The vaccine is recommended for children at age 11-12 years old.
-Most children only require two doses of the vaccine when vaccinated before age 15.
-Studies suggest that the protection provided by the HPV vaccine is long lasting. Data from patients followed for 10 years substantiates protection has remained high in those individuals. There has been no evidence of the protection decreasing over time.
-Over 120 million doses of the HPV vaccine have been distributed since the vaccine was licensed, and data continue to show the vaccine is safe and effective.
-HPV infections, genital warts, and cervical pre-cancers have dropped significantly since the vaccine has been in use in the United States.
-Studies indicate there have been reductions of HPV cases due to vaccines:
* 86% among teenage girls
* 71% among adult young women
* 40% among women
The HPV vaccine is recommended for boys and girls at 11-12 years of age but can be given as young as 9 and up to 14 years of age and in 2 doses that are 6-12 months apart. If the vaccine is given after age 15 up through the age of 26, there are 3 doses required. The vaccine is not recommended for people over the age of 26 but can be a discussion with their doctor if they were never vaccinated at a younger age to discuss their risk for contracting HPV and the possible benefits to receiving the vaccine at this time.
It is recommended to receive the vaccine at the younger age prior to becoming sexually active.
The vaccine should not be given to people that have had a prior allergic reaction to vaccines or who are pregnant.
There are 3 different vaccines but the Gardasil 9 is the one given in the United States.
As healthcare pro ...
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
Vacunacion pvh
1. 712 VOL. 123, NO. 3, MARCH 2014 OBSTETRICS & GYNECOLOGY
Human Papillomavirus Vaccination
ABSTRACT: The Advisory Committee on Immunization Practices of the Centers for Disease Control and
Prevention recommends that human papillomavirus (HPV) vaccination routinely be targeted to females and males
aged 11 years or 12 years as part of the adolescent immunization platform to help reduce the incidence of ano-
genital cancers and genital warts associated with HPV infection. The quadrivalent HPV vaccine is approved for
use in males and females, whereas the bivalent HPV vaccine is approved for use only in females. For those not
vaccinated at the target age, catch-up vaccination is recommended up to age 26 years. The American College of
Obstetricians and Gynecologists endorses these recommendations. Although obstetrician–gynecologists are not
likely to care for many patients in the initial HPV vaccination target group, they have the opportunity to educate
mothers about the importance of vaccinating their children at the recommended age and are critical to vaccinating
adolescent girls and young women during the catch-up period. Obstetrician–gynecologists should advise patients
and parents that HPV vaccines are most effective in preventing genital cancers when administered before the
onset of sexual activity. However, sexually active individuals can receive some benefit from the vaccination
because exposure to all HPV types prevented by the vaccines is unlikely in persons aged 13 years through 26
years. Although HPV vaccination in pregnancy is not recommended, neither is routine pregnancy testing before
vaccination. Lactating women can receive either HPV vaccine. The need for ongoing cervical cytology screening
should be emphasized in all women aged 21 years and older, even those who received HPV vaccination before
the onset of sexual activity.
Human papillomavirus (HPV) is a group of more than
120 different viruses. Infection with HPV is associated
with the development of anogenital cancers (including
cervical, vaginal, vulvar, and anal), oropharyngeal cancer,
and genital warts. Approximately 40 HPV genotypes are
primarily sexually transmitted from person to person (eg,
genital–genital contact, oral–genital contact, and sexual
intercourse) and infect the oral, anal, or genital areas of
men and women. However, only 13 genotypes have been
shown to cause cervical cancer (1). Approximately 70% of
all cases of cervical cancer are caused by HPV genotypes
16 and 18, and 90% of cases of genital warts are caused by
HPV genotypes 6 and 11 (2).
Each year in the United States, cervical cancer is
diagnosed in more than 12,000 women, and nearly 4,000
die from the disease (3). In addition, there are more than
1 million cases of abnormal cytology screening results that
require evaluation (4, 5). Although the implementation
of cervical cytology screening programs and treatment
of precancerous lesions has led to a decrease in deaths
from cervical cancer in the United States, such deaths
still occur. Approximately one half of all cases of cervical
cancer are found in women who have never had a Pap test,
and another 10% occur in patients who have not had one
within the past 5 years (6). Both ongoing cervical cytology
screening and HPV vaccination are needed to help reduce
these deaths.
Human papillomavirus vaccination can also help
reduce the incidence of other anogenital cancers and
genital warts and may decrease the incidence of oropha-
ryngeal cancer. Each year in the United States, HPV is
believed to cause approximately 2,600 cases of vulvar and
vaginal cancer, 4,300 cases of anal cancer, 360,000 cases of
genital warts, and more than 8,400 cases of oropharyngeal
COMMITTEE OPINION
Number 588 • March 2014 (Replaces Committee Opinion Number 467, September 2010)
Committee on Adolescent Health Care
This Committee Opinion was developed with the assistance of the Immunization Expert Work Group. The document reflects emerging
clinical and scientific advances as of the date issued and is subject to change. This information should not be construed as dictating an
exclusive course of treatment or procedure to be followed.
The American College of
Obstetricians and Gynecologists
WOMEN’S HEALTH CARE PHYSICIANS
2. VOL. 123, NO. 3, MARCH 2014 Committee Opinion Human Papillomavirus Vaccination 713
cancer (7). Approximately 35% of all cases of anal cancer
and 80% of all cases of oropharyngeal cancer are in men
(7).
Human Papillomavirus Vaccines
The U.S. Food and Drug Administration (FDA) has
approved two vaccines shown to be effective at prevent-
ing HPV infection. The quadrivalent HPV vaccine is indi-
cated to prevent cancers and intraepithelial neoplasias
of the cervix, anus, vulva, and vagina and genital warts
associated with HPV genotypes 6, 11, 16, and 18 (8). The
FDA has approved administration of the quadrivalent
three-dose vaccine to females and males aged 9–26 years.
The bivalent three-dose HPV vaccine has FDA approval
for administration to females aged 9–25 years for the
prevention of cervical cancer, cervical intraepithelial neo-
plasia (CIN) 2 or worse and adenocarcinoma in situ, and
CIN 1 caused by oncogenic HPV genotypes 16 and 18 (9).
Efficacy
Studies of the quadrivalent HPV vaccine have shown that
among participants who were naive to the vaccine geno-
types and who followed protocol, the vaccine was nearly
100% effective in preventing CIN 2, CIN 3, and condy-
lomatous vulvar disease related to the HPV genotypes
covered by the vaccine (8). Similarly, clinical trials in men
showed an efficacy of 90.4% in preventing external geni-
tal lesions associated with the HPV genotypes covered
by the vaccine (10). In a substudy of men who have sex
with men, the quadrivalent vaccine was 77.5% effective in
preventing anal intraepithelial neoplasia related to HPV
genotypes 6, 11, 16, and 18, leading to FDA approval of
the quadrivalent vaccine for the prevention of anal cancer
and associated precancerous lesions that are caused by
these HPV genotypes (11). Results of studies of the biva-
lent HPV vaccine indicate that it offers protection similar
to the quadrivalent vaccine against CIN 2 and CIN 3 in
adolescent and young women who are naive to the vac-
cine’s HPV genotypes 16 and 18 (12, 13). The bivalent
vaccine does not protect against lower genital tract con-
dyloma caused by low-risk HPV genotypes 6 and 11 (ie,
associated with genital warts). There is evidence that each
vaccine provides some minor degree of cross-protection
against other nonvaccine HPV genotypes that are associ-
ated with disease (14).
To be maximally effective, vaccination with either
vaccine should be given during the target ages (11 years
and 12 years) or before the onset of sexual activity. If the
vaccine is given after the onset of sexual activity, patients
may have already been infected with HPV. Data from
Australia, where coverage is more than 75% in the target
age group (females only), showed that the diagnosis of
genital warts in females decreased by 73% within 3 years
of vaccine introduction (13). There also was a significant
decrease in the diagnosis of genital warts in heterosexual
men, suggesting herd immunity. In Sweden, data that
linked multiple population registers showed that vaccine
effectiveness in preventing genital warts was 93% among
girls vaccinated between ages 10 years and 13 years com-
pared with 48% and 21% if vaccinated at ages 20–22 years
and 23–26 years, respectively (15). Data from the United
States show that 1 month after the completion of HPV
vaccination, girls aged 10–14 years generally have higher
antibody levels than young women aged 15–26 years and
retain these higher levels for several years (16, 17). All of
these findings underscore the importance of vaccination
during the target age or before the onset of sexual activity.
In the United States, the prevalence of vaccine-type
HPV has decreased 56% among females aged 14–19 years
since the quadrivalent vaccine was introduced in 2006
(18). The observed decrease in vaccine-associated HPV
prevalence is likely due to the protection induced by a
single vaccine dose, at least in the short term. According
to the Centers for Disease Control and Prevention
(CDC), slightly more than 50% of 13–17-year-olds in the
United States have received at least one vaccine dose, and
only 33% have received all three doses (19). Recent data
demonstrate that individuals who received two doses of
the quadrivalent vaccine at 0 and 6 months had similar
antibody responses within 6 months as those receiving
three doses (16). However, at 24–36 months, those who
received two doses showed a lower level of antibody
response than those who received three doses (16). Thus,
reduced dose schedules are not currently recommended.
The need for booster doses remains to be demon-
strated but is unlikely (13). The current three-dose vac-
cine series is designed to maximize the primary immune
response and enhance long-term protection. The dura-
bility of the immune response (ie, how long protection
lasts) is being monitored in various long-term studies,
and there is currently no indication for a booster vaccine.
Safety
Safety data for both HPV vaccines are reassuring.
According to the Vaccine Adverse Events Reporting
System, more than 57 million doses of HPV vaccine have
been distributed, and there are no data to suggest that
there are any severe side effects or adverse reactions linked
to vaccination (20). Ongoing surveillance of HPV vaccine
side effects—which include syncope, nausea, headache,
dizziness, and local pain and redness—shows no new,
unexpected adverse reactions (20). Although there was an
observed increase of venous thromboembolism in those
vaccinated, on review it was determined that this finding
was not statistically significant because all five patients had
prior known risks of venous thromboembolism (21). The
CDC continues to consider HPV vaccines safe.
Vaccination of Specific Populations
The following are recommendations for HPV vaccination
of specific groups. Testing for HPV DNA is not required
or recommended before vaccination in any group. If
the patient is tested for HPV DNA and the results are
positive, vaccination is still recommended because the
3. 714 Committee Opinion Human Papillomavirus Vaccination OBSTETRICS & GYNECOLOGY
warts associated with HPV infection. The quadrivalent
HPV vaccine is approved for use in males and females,
whereas the bivalent HPV vaccine is approved for use
only in females. Depending on the circumstances, the
vaccine can be given to individuals as young as 9 years.
For those not vaccinated at the target age, catch-up vac-
cination is recommended up to age 26 years (see Box 1)
(2). Once the vaccination series has begun, there is no
evidence to suggest that the series needs to be restarted if
there is a delay in administration of subsequent vaccine
doses.
The American College of Obstetricians and Gyne-
cologists endorses these recommendations. During a
health care visit with a girl, adolescent, or a young woman
in the age range for vaccination, obstetrician–gynecolo-
gists should assess the patient’s HPV vaccine status, dis-
cuss HPV and the potential benefit of HPV vaccination,
offer vaccination as needed, and document this informa-
tion in the patient’s medical record.
chance that the patient has been exposed to all vaccine-
preventable HPV genotypes is low.
In all states, minors are allowed to give consent for
the diagnosis and treatment of sexually transmitted infec-
tions. However, many of the laws that authorize them to
provide such consent may only permit it after they have
reached a specific age. Furthermore, these laws do not
mention vaccinations (22). Clinicians should be familiar
with state and local statutes regarding the rights of minors
to consent to health care services and the federal and state
laws that affect confidentiality.
Girls and Boys, Adolescents, and Young
Women and Men
The Advisory Committee on Immunization Practices of
the CDC recommends that HPV vaccination routinely be
targeted to females and males aged 11 years or 12 years
as part of the adolescent immunization platform to help
reduce the incidence of anogenital cancer and genital
Box 1. Key Information Regarding the Bivalent and
Quadrivalent Human Papillomavirus Vaccines* ^
Dosage
Administered intramuscularly as three separate 0.5-mL doses based on the following schedule:
1. First dose: at elected date
2. Second dose: 1–2 months after the first dose
3. Third dose: 6 months after the first dose
Minimum interval between first and second dose is 4 weeks, between second and third dose is 12 weeks, and between first and
third dose is 24 weeks. If the vaccine schedule is interrupted, the series does not need to be restarted, regardless of the length
of time between doses. Whenever possible, the same vaccine product should be used for all doses in the series.
Recommended Age
• Target population: females and males†
aged 11 years or 12 years (can be started as early as age 9 years)
• Females and males†
who did not receive the vaccination at the target age can be vaccinated from age 13 years through 26
years
Contraindications
Individuals who develop symptoms indicative of hypersensitivity to the active substances or to any of the components of either
vaccine after receiving a dose of vaccine should not receive further doses of the product. Safety and effectiveness of the two
formulations have not been established in pregnant women. Any exposure to it during pregnancy should be reported to the
manufacturer by calling 1-877-888-4231 for the quadrivalent vaccine and 1-888-452-9622 for the bivalent vaccine.
Precautions
As with any vaccine, vaccination may not protect all vaccine recipients. Neither vaccine is intended to be used for treatment
of active disease (ie, genital warts, cervical cancer, cervical intraepithelial neoplasia, vulvar intraepithelial neoplasia, or
vaginal intraepithelial neoplasia). Human papillomavirus (HPV) vaccines can be administered simultaneously or at any time
before or after a different inactivated or live vaccine administration. Because vaccinated individuals may develop syncope,
sometimes resulting in falling with injury, health care providers should consider observing patients for 15 minutes after vaccine
administration.
Storage
Both formulations should be refrigerated at 2–8°C (36–46°F), should not be frozen, and should be protected from light.
Vaccine Adverse Event Reporting
To report an adverse event associated with administration, go to http://vaers.hhs.gov.
(continued)
4. VOL. 123, NO. 3, MARCH 2014 Committee Opinion Human Papillomavirus Vaccination 715
vaccination. Currently, there are few data on HPV vac-
cine administration in pregnancy; however, the available
safety data regarding the inadvertent administration
of the vaccine during pregnancy are reassuring (25,
26). In clinical studies, the proportion of pregnancies
with adverse outcomes was comparable in women who
received the HPV vaccine and in women who received
a placebo (9, 27). However, it is wise to remind patients
to use contraception during the period when they are
receiving the vaccination series. The manufacturer should
be contacted if pregnancy is detected during the vaccina-
tion schedule (see Box 1). Completion of the vaccine
series should be delayed until pregnancy is completed.
Lactating women can receive either HPV vaccine because
inactivated vaccines, such as these vaccines, do not affect
the safety of breastfeeding for mothers or infants (28).
Immunosuppressed Patients
The presence of immunosuppression, like that experi-
enced in patients with HIV infection or organ transplan-
tation, is not a contraindication to HPV vaccination.
However, the immune response may be less robust in the
immunocompromised patient (29).
Women Older Than 26 Years
Human papillomavirusvaccinesarenot currentlylicensed
in the United States for women older than 26 years. Off-
label use may be indicated on a case-by-case basis because
vaccination may provide some marginal benefit (16).
Patient Education and Vaccination
Efforts
Obstetrician–gynecologists are encouraged to discuss
the benefits of HPV vaccination with patients aged
Sexually Active Adolescents and Young Women
Sexually active adolescents and young women can receive
either the quadrivalent or bivalent HPV vaccine. These
patients should be counseled that the vaccine may be less
effective in individuals who have been exposed to HPV
before vaccination than in individuals who were HPV
naive at the time of vaccination (8, 12). However, sexually
active individuals can receive some benefit from the vac-
cination because exposure to all HPV types prevented by
the vaccines is unlikely in persons aged 13 years through
26 years. The need for ongoing cervical cytology screen-
ing should be emphasized in all women aged 21 years and
older, even those vaccinated before the onset of sexual
activity.
Adolescents and Young Women With Previous
Cervical Intraepithelial Neoplasia or Genital
Warts
The HPV vaccines can be given to patients with previ-
ous CIN or genital warts. Health care providers need to
emphasize that the benefits may be limited and cervi-
cal cytology screening and corresponding management
based on College recommendations must continue. The
HPV vaccines are not intended to be treatment for cervi-
cal cytologic abnormalities, genital warts, or a positive
HPV DNA test result. Patients with these conditions
should undergo the appropriate evaluation and treat-
ment (23, 24).
Pregnant and Lactating Women
Both the quadrivalent and bivalent HPV vaccines have
been classified by the FDA as pregnancy category B.
Although HPV vaccination in pregnancy is not recom-
mended, neither is routine pregnancy testing before
Box 1. Key Information Regarding the Bivalent and
Quadrivalent Human Papillomavirus Vaccines* (continued)
Advisory Committee on Immunization Practices Recommendations
For current recommendations by the Advisory Committee on Immunization Practices, go to http://www.cdc.gov/vaccines/recs/
acip/default.htm.
Current Procedural Terminology Code‡
The American Medical Association has established a Current Procedural Terminology code of 90649 for quadrivalent HPV
vaccination and 90650 for bivalent HPV vaccine.
*Note that the U.S. Food and Drug Administration labeling for the bivalent vaccine indicates it is for use in females aged 9–25 years. In addi-
tion, the U.S. Food and Drug Administration approved dosage intervals for the quadrivalent and bivalent vaccines to be 0 months, 2 months,
and 6 months and 0 months, 1 month, and 6 months, respectively.
†
The U.S. Food and Drug Administration has approved the quadrivalent vaccine for use in males aged 9–26 years for the prevention of genital
warts.
‡
Current Procedural Terminology (CPT) copyright 2012 American Medical Association. All rights reserved. CPT is a registered trademark of
the American Medical Association.
Data from Centers for Disease Control and Prevention. FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use
in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP). MMWR Morb
Mortal Wkly Rep 2010;59:626–9.
5. 716 Committee Opinion Human Papillomavirus Vaccination OBSTETRICS & GYNECOLOGY
Pamphlet AP073. Washington, DC: American College of
Obstetricians and Gynecologists; 2013.
American College of Obstetricians and Gynecologists.
Infeccion del virus del papiloma humano [Spanish].Patient
Education Pamphlet SP073. Washington, DC: American
College of Obstetricians and Gynecologists; 2013.
American College of Obstetricians and Gynecologists.
Human papillomavirus. In: Tool kit for teen care. 2nd ed.
Washington, DC: ACOG; 2009.
American College of Obstetricians and Gynecologists.
Immunization for women. Available at: http://www.
immunizationforwomen.org. Retrieved January 10, 2013.
Screening for cervical cancer. Practice Bulletin No. 131.
American College of Obstetricians and Gynecologists.
Obstet Gynecol 2012;120:1222–38.
Other Resources
The following list is for information purposes only. Referral to these sources
and web sites does not imply the endorsement of the American College of
Obstetricians and Gynecologists. This list is not meant to be comprehensive.
The exclusion of a source or web site does not reflect the quality of that
source or web site. Please note that web sites are subject to change without
notice.
American Cancer Society
250 Williams Street, NW
Atlanta, GA 30303
1-800-227-2345
http://www.cancer.org
American Sexual Health Association
PO Box 13827
Research Triangle Park, NC 27709
(919) 361-8400
http://www.ashastd.org
American Society for Colposcopy and Cervical
Pathology
1530 Tilco Drive, Suite C
Frederick, MD 21704
(301) 733-3640
1-800-787-7227
http://www.asccp.org
Center for Young Women’s Health
333 Longwood Avenue, 5th floor
Boston, MA 02115
(617) 355-2994
http://www.youngwomenshealth.org
Centers for Disease Control and Prevention
1600 Clifton Road
Atlanta, GA 30333
1-800-CDC-INFO (1-800-232-4636)
http://www.cdc.gov
Planned Parenthood Federation of America
434 West 33rd Street
New York, NY 10001
(212) 541-7800
1-800-230-7526
http://www.plannedparenthood.org
11–26 years and to offer initial vaccination and catch-up
vaccination as needed. Although obstetrician–gynecolo-
gists are not likely to care for many patients in the initial
HPV vaccination target group, they have the opportunity
to educate mothers about the importance of vaccinating
their children at the recommended age and are critical
to vaccinating adolescent girls and young women during
the catch-up period. It is important for health care pro-
viders to educate patients and parents of children in the
target age range for HPV vaccination about HPV-related
disease and be prepared to respond to questions regard-
ing HPV vaccination, including its benefits, limitations,
and safety, as discussed earlier. Studies have shown that
physicians’ recommendations play a crucial role in the
acceptance of HPV vaccination by patients and parents
of patients (30). Many parents think that HPV vaccina-
tion is not needed and are concerned about safety and
adverse reactions (31). Obstetrician–gynecologists should
advise patients and parents that HPV vaccines are most
effective in preventing genital cancers when administered
before the onset of sexual activity, although HPV can be
contracted without sexual activity. In addition, patients
and parents can be counseled that HPV vaccines are safe
and associated with few side effects, none of which are
severe. An additional concern among some parents is that
HPV vaccination may cause an increase in sexual activity
among adolescents. However, health care providers can
reassure parents that this is not the case. A study of 1,398
girls aged 11–12 years found that HPV vaccination was
not associated with increased sexual activity outcomes
that included pregnancy, sexually transmitted infection
testing or diagnosis, or contraceptive counseling (32).
According to the CDC, if health care providers
increase HPV vaccination coverage to 80%, it is estimated
that an additional 53,000 cases of cervical cancer could be
prevented during the lifetime of those younger than 12
years (19). Furthermore, for every year that coverage does
not increase, an additional 4,400 women will develop
cervical cancer. These data highlight the overwhelming
importance of HPV vaccination efforts, including discus-
sions with patients and parents of children and adoles-
cents about the benefit of HPV immunization for cancer
prevention (19).
American College of Obstetricians and
Gynecologists’ Resources
American College of Obstetricians and Gynecologists.
Cómo prevenir las enfermedades de transmisión sexual
[Spanish]. Patient Education Pamphlet SP009. Wash-
ington, DC: American College of Obstetricians and
Gynecologists; 2013.
American College of Obstetricians and Gynecologists.
How to prevent sexually transmitted diseases. Patient
Education Pamphlet AP009. Washington, DC: American
College of Obstetricians and Gynecologists; 2013.
American College of Obstetricians and Gynecologists.
Human papillomavirus infection. Patient Education
6. VOL. 123, NO. 3, MARCH 2014 Committee Opinion Human Papillomavirus Vaccination 717
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15. Leval A, Herweijer E, Ploner A, Eloranta S, Fridman Simard J,
Dillner J, et al. Quadrivalent human papillomavirus vac-
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17. Schwarz TF, Huang LM, Medina DM, Valencia A, Lin TY,
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J Adolesc Health 2012;50:187–94. [PubMed] [Full Text] ^
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McQuillan G, et al. Reduction in human papillomavirus
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22. Guttmacher Institute. An overview of minors’ consent
law. State Policies in Brief. New York (NY): GI; 2013.
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Society for Adolescent Health and Medicine
111 Deer Lake Road, Suite 100
Deerfield, IL 60015
(847) 753-5226
http://www.adolescenthealth.org
U.S. Food and Drug Administration
10903 New Hampshire Avenue
Silver Spring, MD 20993
1-888-INFO-FDA (1-888-463-6332)
http://www.fda.gov
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Copyright March 2014 by the American College of Obstetricians and
Gynecologists, 409 12th Street, SW, PO Box 96920, Washington, DC
20090-6920. All rights reserved.
Human papillomavirus vaccination. Committee Opinion No. 588. Amer-
ican College of Obstetricians and Gynecologists. Obstet Gynecol
2014;123:712–8