This document discusses research on food factors that can improve obesity and metabolic disorders. It describes how tomato-derived oxo-octadecadienoic acids (ODAs) and fenugreek-derived diosgenin activate or inhibit nuclear receptors like PPARα and LXR to reduce lipid accumulation and improve fatty liver. Mice fed high-fat diets supplemented with 9-oxo-ODA or fenugreek showed decreased hepatic triglyceride levels and increased fatty acid oxidation gene expression compared to controls. In cell studies, 9-oxo-ODA and diosgenin also reduced lipid accumulation and modulated nuclear receptor pathways involved in lipid metabolism. The findings suggest certain food compounds can help prevent and
This document discusses research on food factors that can improve obesity and metabolic disorders. It describes how tomato-derived oxo-octadecadienoic acids (ODAs) and fenugreek-derived diosgenin activate or inhibit nuclear receptors like PPARα and LXR to reduce lipid accumulation and improve fatty liver. Mice fed high-fat diets supplemented with 9-oxo-ODA or fenugreek showed decreased hepatic triglyceride levels and increased fatty acid oxidation gene expression compared to controls. In cell studies, 9-oxo-ODA and diosgenin also reduced lipid accumulation and modulated nuclear receptor pathways involved in lipid metabolism. The findings suggest certain food compounds can help prevent and