Use Of Terlipressin In Septic Shock
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The document examines the role of Terlipressin in treating refractory septic shock. It discusses how Terlipressin, a vasopressin analogue, has been used to treat conditions like variceal bleeding and hepatorenal syndrome. Some studies have found Terlipressin effective for septic shock resistant to norepinephrine. However, the evidence is limited and more large randomized controlled trials are needed before recommending regular use of Terlipressin for septic shock.
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Use Of Terlipressin In Septic Shock
- 1. To examine the role of Terlipressin in the management of patients with refractory septic shock.
Editor's Notes
- Septic shock is a distributive type of shock where there is widespread vasodilatation following sepsis (Leone and Martin, 2006). Due to the distributive nature of the shock, vigorous resuscitation measures may fail. In those cases, cardio-stimulants and vasopressors are widely used namely noradrenalin (NE), dopamine, dobutamine etc. (Claessens et al. 2007). Nonetheless, the responsiveness of the blood vessels to these drugs gradually fades away resulting in fatalities (Goncalves et al. 1998, Landry and Oliver, 2001, Bennett et al. 2004). Terlipressin (TP) is an analogue of AVP that has been used primarily in the management of variceal bleeding, diabetes insipidus and hepatorenal syndrome (Soederlund, 1993). However, its use in the management of patients with refractory septic shock has been documented revealing its certain advantages over other drugs like longer duration of action and less side effects (O’Brien et al, 2002, ).
- As a physician working in the Emergency Medicine and Critical Care the author comes across patients with septic shock who do not respond to conventional treatment with intravenous fluids, antibiotics, steroids and catecholamines.
- RCT= Randomised controlled trials