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Update on breast cancer english presentation
- 1. Vida! Educational Series – Promoting Good Health Welcome! - We will begin shortly If viewing by internet: for technical help: 520-626-0167 Please complete surveys: http://streaming.biocom.arizona.edu/
- 2. Update in Breast Cancer Ana Maria Lopez, MD, MPH, FACP Associate Dean, Outreach and Multicultural Affairs Professor of Medicine and Pathology Medical Director, Arizona Telemedicine Program
- 3. Educational Objectives 1. Learn what is breast cancer 2. Discuss risks to breast cancer 3. Outline prevention measures for breast cancer
- 4. What is breast cancer?
- 9. What causes breast cancer? • Causes and risk factors
- 10. Risk Factors • Age: • 95% in women 40yo + • highest in 70-74 yo • FH • Personal history • Genetic risk: • BRCA 1/2, TP 53, ATM • Nulliparous • 1st full term pregnancy after 35 yo • No lactation • HRT • Alcohol • Overweight/obesity • Physical inactivity
- 11. 70% of breast cancers are in patients without identifiable risk factors
- 13. Hereditary Breast Cancer Risks 5-10% of all breast cancers • Ashkenazi Jewish descent • 3 or more 1st or 2nd degree relatives • 1st degree relative with bilateral breast cancer • 2 or more 1st or 2nd degree relatives with ovarian cancer • Male breast cancer
- 14. BRCA 1 and BRCA 2 • Code for DNA repair • Presence of gene, increases the risk of getting breast cancer up to 80% in her lifetime • BRCA1 or BRCA2 mutations make up about half of all cases of inherited breast cancer • associated with ovarian cancer and prostate cancer • can be inherited either from the mother or the father.
- 15. Other Inherited Genes • TP53 gene • codes for the tumor suppressor protein p53 • Mutations cause Li-Fraumeni syndrome: associated with early onset breast cancer • Ataxia Telangiectasia (ATM) gene Females with one defective copy of the ATM gene and one normal copy of the gene are at increased risk for breast cancer.
- 19. presstv.ir
- 23. Prevention
- 24. Prevention: saves us from the pain of being sick --Unknown
- 25. health.usf.edu
- 26. Prevention Studies • Tamoxifen • Raloxifen: STAR (Study of Tamoxifen and Raloxifene) • Raloxifene is as effective as tamoxifen in reducing invasive but not nonivasive (DCIS) BC risk • Both drugs reduce invasive BC risk by about 50% • Raloxifene: 36% fewer uterine cancers, 29% fewer blood clots • Both increase blood clots.
- 27. Aspirin • In an epidemiologic study, aspirin appeared to lower breast cancer risk • Need prospective trial
- 28. Vitamin D • Helps with calcium absorption to maintain bone density • In clinical trials
- 29. Fat • WINS • Low fat diet (< 30%) • 5Y FU: new breast cancers--9.8% low-fat diet; 12.4% standard diet (24% reduction) • largest risk reduction – 42%--in ER negative tumors
- 30. What about soy? Flax? Phytoestrogens? • Eat what you like! • Eat healthy! • Do not change your diet drastically to include phytoestrogens. • There may be safety concerns re: pharmaceutically concentrated soy products
- 31. Lifestyle • Maintain a healthy weight • Decrease intake overall. Increase vegetables in specific (2/3 of plate) • Increase activity: 3-4 hours of exercise per week • Decrease alcohol intake
- 32. Early Detection
- 35. Treatment
- 39. dailymail.co.uk
Editor's Notes
- National Cancer Institute and the National Surgical Adjuvant Breast and Bowel Project