Understanding fibrosis in the kidney presentation
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Renal fibrosis is a major cause of kidney disease where the body forms excessive fibrous tissue in the kidneys, resulting in scarring that can destroy the nephron and impair kidney function. Dr. Dix P. Poppas is researching ways to inhibit and reverse fibrosis in obstructed kidneys, with the goal of providing hope to those with or at risk of kidney fibrosis.
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Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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- 1. Understanding Fibrosis in the Kidney
- 2. • An acquired lesion that necessitates kidney transplants or dialysis, renal fibrosis is a major cause for alarm in kidney disease patients. • Fibrosis involves the body forming excessive fibrous connective tissue within tissues or organs during reactive or reparative processes.
- 3. • Fibrosis takes the form of scarring, which destroys underlying tissues or organ structures. • Fibrosis in the kidney can affect the reabsorptive or filtering integrity of the nephron, the kidney's functional unit.
- 4. • This, in turn, can lead to further kidney dysfunction or failure. • Dix P. Poppas, M.D., is currently engaged in investigations to better understand the mechanisms of inhibiting and reversing fibrosis in the obstructed kidney.
- 5. • Dr. Poppas's work may provide new hope to patients living with, or in danger of developing, fibrosis in the kidney. • Selected by New York Magazine as one of the Top 100 Minimally Invasive Surgeons in New York, Dix P. Poppas, M.D., is a Richard Rodgers Family Professor of Pediatric Urology at Weill Cornell Medical College.
- 6. • Dr. Poppas's work may provide new hope to patients living with, or in danger of developing, fibrosis in the kidney. • Selected by New York Magazine as one of the Top 100 Minimally Invasive Surgeons in New York, Dix P. Poppas, M.D., is a Richard Rodgers Family Professor of Pediatric Urology at Weill Cornell Medical College.