INTRODUCTION:
The recent use of ultrasound imaging in peripheral regional anesthesia allows the operator to see neural structures, guide the needle under real-time visualization, navigate away from sensitive anatomy, and monitor the spread of local anesthetic.
INTRODUCTION:
The recent use of ultrasound imaging in peripheral regional anesthesia allows the operator to see neural structures, guide the needle under real-time visualization, navigate away from sensitive anatomy, and monitor the spread of local anesthetic.
Second year PG Resident of I Q City Medical College and Hospital, Durgapur, West Bengal.
Covers the scope and use of Imaging technology in Orthopaedics.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Second year PG Resident of I Q City Medical College and Hospital, Durgapur, West Bengal.
Covers the scope and use of Imaging technology in Orthopaedics.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
2. Principles of US guided regional
anesthesia
Four components
Image capture
Image optimization
Image interpretation
Needling technique
3. Image capture
Knowledge of Machine capabilities
Transducer characteristics
How to handle the transducer
Multifunctional, Range of transducer
frequencies, Doppler, Specific pre-sets
(Nerve & Vascular) & enhanced image
processing
4. Transducers
The most commonly used probe is a high-
frequency, linear array probe (5–10 MHz)
This gives good spatial resolution for the
nerves and plexuses, which are usually
superficial (1–5 cm deep)
A low frequency curvilinear probe (2–5
MHz) can be useful for deeper nerves and
plexuses,
but it is limited by its poor spatial
resolution at increasing depth.
5. Linear VS Curved Array
transducers
Transducer Frequency &
depth of view
Field of view Application
Linear Array 13 – 6MHz
6.0cm
Beam width
38mm
Rectangular
Field of view
Brachial Plexus
Femoral NB
Distal Sciatic
NB
Curved Array 5 – 2 MHz
30cm
Beam width
60mm
Wide field of
view
Sciatic NB
Spine
Lumbar Plexus
Infraclavicular
BPB
6. Scanning technique
Orient the transducer with screen
Orientation marker on the edge of the transducer
Highlighted green dot
Place the transducer lightly on the skin –
image display
Hand movement – PART
Pressure, Align, Rotate & Tilt
7. Hand Movement - PART
Pressure – Apply optimum pressure with
transducer on the skin
Ensure not to distort anatomy
Identification of blood vessels possible
Veins – Compressible
Arteries – Non- Compressible
8. Hand Movement - PART
Align (Slide) – Movement across the surface
of the skin
Follow the nerve and other structure – MCN
– Head of Humerous
Identify optimal entry point for injection
9. Hand Movement - PART
Rotate – twisting movement
Obtain short axis view
Tilt – Rocking hand movement (heal/toe)
Optimize the angle of insonation
(anisotropy)
Adjust for varying depth of the nerve
/structure
10. Planes of view
Short axis – Transverse
Long axis – Longitudinal
12. Image interpretation
“You only see what you know”
Understanding of different tissue
echogenicity
Recognition of artefacts
Effective use of Doppler
13. Peripheral nerves
Peripheral nerves consist of a collection of
axons arranged in to fascicles, within
variable amount of connective tissue
The amount of connective tissue increases
the more the distal the nerve from CNS –
alters the US appearance – Hyperechoeic
14. Peripheral nerves
Fascicles of peripheral nerves can be
detected with high-resolution ultrasound
imaging
This fascicular echotexture is the most
distinguishing feature of nerves
(“honeycomb” architecture)
15. More central nerves, such as the cervical
ventral rami, have fewer fascicles and
therefore can appear monofascicular on
ultrasound
Slide a broad linear transducer over the
known course of a peripheral nerve with the
nerve viewed in short axis
16.
17. Nerves can be round, oval, or triangular
Although nerve shape can change along the
nerve path, the cross-sectional nerve area
is constant in the absence of major
branching
Peripheral nerves are pathologically enlarged
by entrapment or in certain neuromuscular
disorders such as Charcot-Marie-Tooth
disease type IA
18. There is some evidence to suggest that
patients with diabetic neuropathy also have
enlarged peripheral nerves
19. Although direct nerve imaging has led to a
phenomenal increase in ultrasound-guided
regional anesthesia,
the identification of other nearby
structures (e.g., fascia and other
connective tissues) also is critical
20. Block Needles for Ultrasound-
Guided Procedures
Metal needles are hyperechoic and can
cause reverberation artefact
Needle tip visibility is best when the needle
path is parallel to the active face of the
transducer
In-plane (IP) or Out of –Plane (OOP)
21. In plane
Needle visualised in its entire length
Good visibility of Needle- Nerve interface
22.
23.
24.
25. Out of plane
Familiar needle insertion point
Short skin – nerve distance
Minimal intramuscular needle passage
Needle seen as a dot when in US beam (Be
aware tip and shaft is similar)
Editor's Notes
Ideal characteristics of the ultrasound machine
Gain – Brightness / Contrast
Sliding through the course of the nerve will identify the nerve
A, Fascicles of the median nerve in the forearm. In this sonogram the “honeycomb” appearance of a polyfascicular peripheral nerve is observed. B, Monofascicular echotexture of the brachial plexus in the neck
Sonogram of the popliteal fossa of a patient with Charcot-Marie-Tooth disease type 1A. The peripheral nerves are markedly enlarged because of the large fascicles
In this sonogram, the ulnar nerve and ulnar artery are viewed in short axis in the forearm. The nerve is surrounded with anechoic local anesthetic
The in plane approach appears easiest for clinicians starting US since the needle is easily visualised
Ilioinguinal block with ultrasound guidance (in-plane approach).
Abdominal wall imaging for ilioinguinal nerve block. A, In this sonogram, the external oblique, internal oblique, and transversus muscles are identified (the “three-layer cake” appearance). The ilioinguinal nerves are seen between the internal oblique and transversus muscles. B, The “kayak” sign of successful ilioinguinal injection. The fascia between the internal oblique and transversus muscles is split apart in the shape resembling a kayak
Abdominal wall imaging for ilioinguinal nerve block. A, In this sonogram, the external oblique, internal oblique, and transversus muscles are identified (the “three-layer cake” appearance). The ilioinguinal nerves are seen between the internal oblique and transversus muscles. B, The “kayak” sign of successful ilioinguinal injection. The fascia between the internal oblique and transversus muscles is split apart in the shape resembling a kayak
Axillary block with ultrasound guidance (out-of-plane approach). A, External photograph of the approach. B, Sonogram of the neurovascular bundle in short-axis view with the needle tip crossing the plane of imaging