Transducers use the piezoelectric effect to measure physiological variables in medical instrumentation. The piezoelectric effect occurs in certain natural and man-made crystals, where an electric charge is produced when mechanical stress is applied. Piezoelectric transducers are used as microphones to detect heart sounds and in ultrasound devices due to their ability to convert mechanical energy to electrical signals. The capacitive properties of piezoelectric transducers interact with the input impedance of amplifiers, affecting the transducer response. Piezoelectric constitutive equations describe the relationships between stress, strain, electric field, and electric charge in piezoelectric materials.