A novel approach of treatment.

1. Transdermal Drug
Delivery System
Presented By : Samir Goel
M Pharm. Pharmaceutics
1st Year
Presented To : Dr Rajeshwar Sir
Professor : Pharmaceutics
Kumaun University
Department of Pharmaceutical Sciences

2. Presentation Flow
• Introduction
• Structure of skin
• Penetration Process
• Factors influencing absorption through skin
• Components of TDDS
• Mechanism of action of TDDS
• Types of TDDS
• Evaluation Method
• Application
• Advantages
• Disadvantage

3. Introduction

4. Introduction

5. Introduction

6. Structure of Skin

7. Penetration Process
Process
Transcorneal
Intracellular Intercellular
Transappendageal

8. Intracellular Administration

9. Intercellular

11. Transappendageal

13. Factors influencing absorption through
skin

14. Components of TDDS
•Polymer Matrix- Gelatin, Cellulose, Chitosan etc
•Drug/API- low melting point, short half life, low molecular weight, solubility in
water and oil
•Permeation Enhancer- Surfactants, Fatty Acids, Cyclodextrin etc
•Adhesive- Polyacrylate, Polyisobutylene , Silicones
•Backing lamination- Polyesters, Elastomers
•Release Liner

15. Mechanism of action of TDDS

17. Mechanism of action of TDDS

19. Mechanism of action of TDDS

21. Mechanism of action of TDDS

23. Types of TDDS
•Drug in Adhesive System
•Reservoir System
•Matrix System
•Micro- reservoir System

24. Types of
TDDS

25. Types of
TDDS

26. Types of
TDDS

27. Types of
TDDS

28. Types of
TDDS

29. Evaluation Method
• Thickness
• Uniformity of weight- Random checking of batches
• Drug content determination
• Content uniformity
• Moisture content- % moisture content=initial wt- final wt x 100
• Moisture Uptake
• Folding endurance
• Rolling ball test
• Invitro test- Franz diffusion cell

30. Application

32. Advantages
• Avoid first pass effect
• Consistent serum level of drug
• Non invasive
• Choice of termination
• Novel option
• Self administration
• Gastrointestinal upsets avoided
• Narrow therapeutic window
• Extended therapy
• Continued Drug administration

33. Disadvantages
• Skin irritation and hypersensitivity
• Slow permeation of hydrophilic property
• Not suitable for high drug doses
• Not suitable for low potent drugs
• High cost