This systematic review examines the relationship between temporomandibular disorders (TMD) and malocclusions. The review identified 9 studies that provided moderately strong evidence. These studies found that large overjets were associated with higher prevalence of TMD symptoms, though specific malocclusions could not be definitively linked to TMD. Longitudinal studies observing subjects from teenage years to age 30 showed reduction in most TMD signs over time. Psychological health and muscle strength may be as associated with TMD as malocclusion. More research is still needed, especially longitudinal studies observing subjects before and after treatment.