The document reviews tissue engineering's implications in dentistry, summarizing 15 studies on its application for regenerating oral tissues, including the development of engineered teeth. It discusses key components such as dental stem cells, growth factors, scaffolds, and bioreactors, while highlighting the successes and challenges in research and ethical considerations. The team presented their findings at the 1st IADSR International Dental Conference, where they placed 11th out of 53 teams.

2. Our Team
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› Dr. M. Amber Fareed
› Dr. Nauman A. Noor
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Our Task
Asim W.
Sara I.
Fatima A. A.
Faculty Advisors:-
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A critical review of tissue engineering and its
impact on dentistry, presented as a scientific
poster at the 1st IADSR International Dental
Conference.
Participation in the scientific poster competition.

3. A review of 15 different studies
conducted by eminent researchers in
the field of tissue engineering.
 A brief introduction to tissue engineering,
and the creation of a diagram illustrating
its basic principles.
 A discussion of its therapeutic viability
and an evaluation of its future prospects.
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4. Tissue Engineering: an interdisciplinary field that applies the knowledge
of engineering, life sciences, cells culture, biomaterials and suitable
biochemical factors toward the development of biological substitutes to
regenerate or create damaged tissues and artificial organs and tissues[1].
Dental TE relies on the in-vitro recreation of the genetic odontogenic
programme using stem cells approaches

5. Dental stem cells
(SCs): undifferentiated
totipotent, pluripotent or
multipotent cells of
mesenchymal or
epithelial origin.[4]
Growth Factors:
regulatory substances
that stimulate cell
growth, proliferation and
differentiation; examples
include bone
morphogenic proteins. [5]
Scaffold: an artificial
structure capable of
supporting 3-D tissue
formation. [6]
Bioreactor: any
engineered device or
system that supports a
biologically active
environment.

6. Current research efforts focus on the characterization
and identification of dental stem cell population,
development of scaffold materials and growth factor
release technologies, and experimental design.
 Researchers have seeded cultured tooth germ cells
on bio-degradable scaffolds which were then
implanted to bioengineer tooth tissues [2].
 Animal trials have been highly successful though
human trials have met with limited success.
 Ethical issues may arise concerning the source of
cells (patient’s own vs. donated cells) and the type
of cells (adult-donor vs. fetal cells). In addition, there
is a real possibility that dental tissue engineering will
be achievable to allow individuals to grow teeth insitu.
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7. 
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TE principles are being
applied to the
regeneration of nearly
all oral tissues, including
periodontal tissues.
Scientists have been
able to generate tooth
structures from nondental mesenchymal
cells placed in contact
with embryonic oral
epithelium and
transplanted to an
ectopic site [3] .
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Test-tube teeth may
become the first
completely engineered
human organs.
It is expected that in a
few decades rapid
scientific and
technological
advancements will
provide new solutions to
allow tissue engineered
tooth a routine practice
for missing teeth.

8. 
Selected for a consolation prize [placed
11th] out of 53 undergrad and postgrad
teams from all over Pakistan.

9. Development as
future dental
professionals, and as
scientists.
 Insight into Research
 Expansion of
Knowledge Base
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
Skill Development
› Presentation Skills
› Communication
Skills
› Research Skills
› IT Skills

Team Work

10. 
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[1]. Langer R, Vancanti JP. Tissue Engineering ; Science 1993;260:9920
[2]. Duailibi M, Duailibi S, et al. Bioengineered teeth from cultured rat tooth
bud cells. J Dent Res. 2004;83:523
[3]. Ohazama A, Modino SAC. Stem-cell-based tissue engineering of murine
teeth. J Dent Res. 2004;83:518–522
[4] Huang YH, Yang JC, at al. Dental Stem Cells & Tooth Banking for
Regenerative Medicine. J Exp Clin Med.2010;2:111
[5] Lin Y, Yelick PC, Dental Tissue Engineering. Therapeutic application- tissue
therapy. 2007
[6]. Liu C, Xia Z. Design & Development of Three Dimensional Scaffolds for
tissue engineering. Che Eng Res Desi. 2007;85(A7): 1051
[7]. Kaigler D, Mooney D. Tissue Engineering’s Impact on Dentistry. Critical
Review Oral Med Biology.2001;12:456