In Bangladesh, the incidence of cervical cancer is about 13,000 and around 6600 women dies from cervical cancer each year [1]. Cervical cancer constitutes 22-29% of the female cancer in Bangladesh [2,3]. Diagnosis and treatment of CIN through population-based screening programs has lead to 50-80% reduction in deaths from cervical cancer in various developed countries
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In Bangladesh, the incidence of cervical cancer is about 13,000 and around 6600 women dies from cervical cancer each year [1]. Cervical cancer constitutes 22-29% of the female cancer in Bangladesh [2,3]. Diagnosis and treatment of CIN through population-based screening programs has lead to 50-80% reduction in deaths from cervical cancer in various developed countries
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Prepared By Roman Sharkar and Mir Tasfiq Alam. Both of them are students of the B.Pharm Program in Bangladesh. They prepared this ppt file from their choice of interest which is Genomic Medicine. Hope this will handly to the others who are interested in this topic !!
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Differences in microRNA expression during tumor development in the transition...Enrique Moreno Gonzalez
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Clinical and experimental studies regarding the expression and diagnostic val...Enrique Moreno Gonzalez
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Analysis of NCCN
guideline, RTOG study,
NCDB [national cancer
database] and Cancer
Network Review
4th International Conference on Biomarkers & Clinical Research, will be organized around the theme "Impact of Biomarker Developments in Health Diagnostics and Clinical Research."
Multicentric and multifocal versus unifocal breast cancer: differences in the...Enrique Moreno Gonzalez
The aim of this study was to evaluate the expression of the cell adhesion-related glycoproteins MUC-1, β-catenin and E-cadherin in multicentric/multifocal breast cancer in comparison to unifocal disease in order to identify potential differences in the biology of these tumor types.
Differences in microRNA expression during tumor development in the transition...Enrique Moreno Gonzalez
The prostate is divided into three glandular zones, the peripheral zone (PZ), the transition zone (TZ), and the central zone. Most prostate tumors arise in the peripheral zone (70-75%) and in the transition zone (20-25%) while only 10% arise in the central zone. The aim of this study was to investigate if differences in miRNA expression could be a possible explanation for the difference in propensity of tumors in the zones of the prostate.
Nuclear TK1 expression is an independent prognostic factor for survival in pr...Enrique Moreno Gonzalez
TK1 expression was determined by immunohistochemistry in cervical lesions (cervical intraepithelial neoplasia (CIN), n = 216; invasive cervical carcinoma, n = 84). TK1 and Ki-67
expressions and pathological/FIGO stages and age were correlated with 5-year survival by Kaplan-Meier, log rank and COX hazard uni- and multivariate analyses.
Ulo Palm, American Society for Quality (ASQ), ASQ Food, Drug & Cosmetic Division (FD&C) - Speaker at the marcus evans Evolution Summit 2012, held in Wheeling, IL, April 30 - May 2, 2012, delivered his presentation on Lack of Reproducibility in Biomedical Research – How a Common Quality Standard for Non-Regulated Biomedical Research Could Change the Trend
Application of Microarray Technology and softcomputing in cancer BiologyCSCJournals
DNA microarray technology has emerged as a boon to the scientific community in understanding the growth and development of life as well as in widening their knowledge in exploring the genetic causes of anomalies occurring in the working of the human body. microarray technology makes biologists be capable of monitoring expression of thousands of genes in a single experiment on a small chip. Extracting useful knowledge and info from these microarray has attracted the attention of many biologists and computer scientists. Knowledge engineering has revolutionalized the way in which the medical data is being looked at. Soft computing is a branch of computer science capable of analyzing complex medical data. Advances in the area of microarray –based expression analysis have led to the promise of cancer diagnosis using new molecular based approaches. Many studies and methodologies have come up which analyszes the gene espression data by using the techniques in data mining such as feature selection, classification, clustering etc. emboiding the soft computing methods for more accuracy. This review is an attempt to look at the recent advances in cancer research with DNA microarray technology , data mining and soft computing techniques.
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Adenocarcinoma of the pancreas (PDAC) accounts for 2.4% of all cancers diagnosed and is the fourth leading cause of cancer death, with almost equal rates of incidence and mortality [1]. By 2030, pancreatic cancer is projected to be the second leading cause of cancer-related death [2], surpassing breast, prostate and colorectal cancer. The overall survival at 5 years of around 7.2% as the majority of patients present with advanced disease at diagnosis. Patients with localized disease are treated with surgery, with or without neoadjuvant chemotherapy/ radiotherapy, followed by adjuvant chemotherapy. The majority (around 80%) of patients are treated only with chemotherapy as they have an advanced disease. Patients are treated in the first line with gemcitabine-abraxane or Folfirinox and with Naliri plus 5FU in the second line. There have been few clinical advances in PDAC treatment over the last 20 years and chemotherapy is the only treatment option available for the majority of patients. These tumours are also resistant to many targeted therapies such as anti-EGFR therapy like cetuximab [3] due to the presence of a KRAS mutation in the majority of primary tumors. Personalized medicine strategies have not yet been established in pancreatic cancer as in other more common tumour types. Thus, novel anti-tumour strategies are an important clinical need in order to improve survival rates.
Clinical and experimental studies regarding the expression and diagnostic val...Enrique Moreno Gonzalez
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Prostate Cancer -A Brief
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The LANCET Oncology is the world-leading clinical oncology research journal globally (2021 Journal Citation Reports®, Clarivate 2022) With an Impact Factor of 54·433.
Publisher: Elsevier's Oncology Journal Network
Total Indexing – 11
Some Indexing sites are – Scopus , MEDLINE ,PubMed , Chemical Abstracts , Essential Science Indicators ,etc .
Editor :David Collingridge, Editor-in-Chief , gained a PhD in Tumour Biology from the Gray Cancer Institute/University College London (UK) and held research posts in the Department of Therapeutic Radiology, Yale University (USA) and in the PET Oncology Group, Imperial College School of Medicine, Hammersmith Hospital (UK)
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The unique prophetic calling of the Lord on dr.Owuor
1. THE UNIQUE PROPHETIC CALLING OF THE LORD ON DR. OWUOR
Dr. Owuor Dr. Owuor was born in 1966 in Bondo District in Kenya. Having studied in Makerere
University, (Uganda); Uni-versity of Nairobi, (Kenya); Ben Gurion University of the Negev,
(Israel), University of Haifa, (Israel), and University of Giessen, Institute for Genetics,
(Germany), he specialized in molecular genetic engineering, examining DNA cloning and
nucleotide sequence analysis for medical drug design and discovery. His interest in this
speciality was driven by the advent of human genom mapping which opened up a great treasure
in
molecular medicine for future disease therapy, especially in cancer and HIV/AIDS. This is an area that has
attracted interest among pharmaceutical companies especially when he was examining transcriptional
factors for the regulation of gene expression in medical intervention through delivery of small DNA
molecules and proteins for medicine among patients.
Upon completion of his Doctorate from Mount Carmel, Haifa, (Israel) Dr, Owuor joined the University of
Illinois at Chicago Medical Center (UIC), Center for Pharmaceutical Biotechnology as a Post Doctoral Fellow
specialising in signal transduction by Cancer Chemotherapeutic drugs. During this time, he examined the
role of tamoxifen as a chemotherapeutic drug targetting breast cancer and the signalling pathways that are
involved. He also lectured to Ph.D graduate students in the Pharmaceutics & Pharmacodynamics and Drug
Metabolism by Cancer Chemotherapeutic and Chemoprevention Drugs Programme of the UIC Medical
Center. He specialised in teaching Onco-protein networks and especially mitogen activated protein Kinase
networks as potential drug targets in future anti-cancer drug design.
He further joined the Department of Pharmaceutics, Earnest Mario School of Pharmacy, The State University
of New Jersey (Rutgers) and Environmental and Occupational Health Sciences Institute, (EOSHI) of the
University of Medicine and Dentistry of New Jersey (UMDNJ) where he looked at the relationship between
green tea Polyphenols and Phenethylisothiocyanate (PEITCs) in Apoptosis (self-suicide) and Cancer
Chemoprevention. Dr. Owuor also examined the role of nuclear related transcriptional Factor-2 (NrF2) in the
regulation of phase 2 drug metabolizing enzymes and cellular defensive mechanism in humans. He
developed research interest in examining the role phosphorylation of the newly discovered Extra-cellular
Regulated Kinase 5, a sister pathway to the ErK1,2 pathway necessary for tumor proliferation. During this
time, Dr. Owuor was able to elucidate the link between p38 cell death and suicide pathways, and especially
the MKK6 oncoprotein and ErK5 defensive mechanism. To put it in lay man's terms, this kind of cross-talk
between defensive and cell death genes, complicates cancer therapy and leads to the death of cancer patients.
This cross-talk also results into cancer drug resistance and therapeutic by-pass, therefore making this a very
significant finding in cancer research. He also collaborated with several pharmaceutical companies. In one
such collaboration with Centacor in PA while examining the drug quinacrine and its potential to target
cervical cancer in humans, he discovered the signalling pathway leading to the death of cervical cancer cells.
This has a great significance in cancer therapy since quinacrine had only been used as an anti-malarial drug
used as a chemotherapeutic adjuvant.
Dr. Owuor was further appointed Research Teaching Specialist in the Division of Surgical Oncology, The
Department of Surgery, the Cancer Institute of New Jersey (CINJ)-UMDNJ-RobertWood Johnson Medical
School). After this he was appointed a Consultant Specialist in cDNA micro array analysis, in Forensic
Toxicology and Aircraft Accident of the Civil Aerospace Medical Institute (CAMI). During this time, Dr.
Owuor was more interested in developing fine molecular signatures for normal and impaired human
physiological performance in the cockpit during operation of an aircraft. He also examined the role of alcohol
and drugs abuse in impairing human physiological performance in the operation of an aircraft by commercial
airline pilots in Civil Aviation. At the CAMI, Dr. Owuor published in international medical peer review
journals such as Aero Space Medical Research R&D Bulletin, carcinogenesis, Journal for biological
Chemistry, Pharmaceutical Research Journal of the American Association of Pharmaceutical Scientists,
Biochemical Pharmacology, among others. (see website for the Journal for Biochemichal Pharmacology,
Journal for Biological Chemistry; jbc.org, carcinogenesis, pubmed, Ncbi the Journal for The American
Association for Pharmaceutical Scientist, Korean Pharmaceutical Society.
http://acb100.tc.Faa.gov/docs/R&D_review/rdreview_v02_104.pdf, www.ncbi.n/m.n,h.gov/entrez,
http://stinet.dtic.m.mil/oai)
It was during this time that The LORD GOD called Dr. Owuor to serve King Jesus. The LORD called Dr.
Owuor from his job to tell the four corners of the earth to turn away from sin and prepare the way for the
Second Coming of Christ, The Lamb of God. He has given various major prophesies which have come to pass
and changed the course of events on this planet earth. The last one being an Asteroid that was coming
close to the earth which Dr. Owuor prophesied on February 9th 2009 and aired it live on JESUS
IS LORD Radio in Kenya. This mighty prophecy was promptly fulfilled twenty-one days later on
March 2nd 2009. It was astonishing to see Asteroid 2009 DD45 covered by all Global News
Networks on Monday, March 2nd 2009 having passed within 38,000 miles of earth, which was
far too close to the earth. The prophecy specifically mentioned that the Asteroid was going to
be clearly visible from Australia by name and shockingly, the Asteroid discovery was made in
Page 1 of 1zimsite : Message: THE UNIQUE PROPHETIC CALLING OF THE LORD ON DR. ...
22/10/2011http://groups.yahoo.com/group/zimsite/message/39926