This document summarizes a study examining the role of genetic factors in hypertension among Iraqi citizens. The study included 140 patients divided into a case group of 120 hypertensive patients and a control group of 30 normotensive patients. Data on demographics, family history, blood pressure, and other medical variables were collected and analyzed. Statistical analysis found a significant relationship between genetic factors and hypertension, with a p-value of 0.001. Patients with a positive family history of hypertension in a first-degree relative had 3.98 times higher odds of having hypertension themselves. The study concluded that genetics play an important role in hypertension risk among Iraqi citizens.
Epidemiology of Hypertension among Adults in Al-Azhary Area in Khartoum-State...inventionjournals
Hypertension (HT) is one of the most important risk factors in cardiovascular disease which causes early death in adults. Hypertension is a common disease associated with high mortality and morbidity. Hypertension a silent killer as it is symptomless and remains undiagnosed, and not controlled if diagnosed. This is a descriptive cross - sectional community based study was conducted in Al-Azhary area in Khartoum StateSudan, with aim to estimate the prevalence of hypertension and to identify the possible risk factors associated with hypertension among adults. Data were collected from 303 participants (53.5% females and 46.5% males) using structured pretested questionnaire and blood pressure. The prevalence of hypertension was 19.1% (95% CI 0.61-1.93).There was no significant sex difference in the prevalence rate OR 1.09 (95% CI 0.61-1.93, P = 0.767). The results showed there was strong association between age group and hypertension (P = 0.0001), also there was statistical association between marital status, family history and hypertension positivity P.values =(0.0001 and 0.027) respectively. There was a significantly higher prevalence of hypertension among participants with diabetes, Vascular diseases and kidneys problems OR= (5.44(95% CI 1.89- 15.69, P = 0.017), 4.4(95% CI 0.86 - 2.39, P = 0.074) and 3.56 (95% CI 0.92-13.68, P = 0.05) respectively. Conclusion: one out of every five respondents of the study had hypertensive (19.1%). Age group, marital status, family history, history of (diabetes, vascular diseases and kidneys problems)were statistically significant predictors of hypertension positivity.
Hemorheological indexes, living habits, medical history and genetics factor are primary risk factors in Coronary Heart Disease (CHD). In the present study the relation of all factors to the severity of CHD was examined. The data of 282 patients (mean age: 60±9 years) diagnosed with CHD and 229 healthy controls (mean age: 59±7 years) from Wenzhou Medical University were analyzed.
Association of Hypertension with Behavioural Risk Factors in Adults in a Rura...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Epidemiology of Hypertension among Adults in Al-Azhary Area in Khartoum-State...inventionjournals
Hypertension (HT) is one of the most important risk factors in cardiovascular disease which causes early death in adults. Hypertension is a common disease associated with high mortality and morbidity. Hypertension a silent killer as it is symptomless and remains undiagnosed, and not controlled if diagnosed. This is a descriptive cross - sectional community based study was conducted in Al-Azhary area in Khartoum StateSudan, with aim to estimate the prevalence of hypertension and to identify the possible risk factors associated with hypertension among adults. Data were collected from 303 participants (53.5% females and 46.5% males) using structured pretested questionnaire and blood pressure. The prevalence of hypertension was 19.1% (95% CI 0.61-1.93).There was no significant sex difference in the prevalence rate OR 1.09 (95% CI 0.61-1.93, P = 0.767). The results showed there was strong association between age group and hypertension (P = 0.0001), also there was statistical association between marital status, family history and hypertension positivity P.values =(0.0001 and 0.027) respectively. There was a significantly higher prevalence of hypertension among participants with diabetes, Vascular diseases and kidneys problems OR= (5.44(95% CI 1.89- 15.69, P = 0.017), 4.4(95% CI 0.86 - 2.39, P = 0.074) and 3.56 (95% CI 0.92-13.68, P = 0.05) respectively. Conclusion: one out of every five respondents of the study had hypertensive (19.1%). Age group, marital status, family history, history of (diabetes, vascular diseases and kidneys problems)were statistically significant predictors of hypertension positivity.
Hemorheological indexes, living habits, medical history and genetics factor are primary risk factors in Coronary Heart Disease (CHD). In the present study the relation of all factors to the severity of CHD was examined. The data of 282 patients (mean age: 60±9 years) diagnosed with CHD and 229 healthy controls (mean age: 59±7 years) from Wenzhou Medical University were analyzed.
Association of Hypertension with Behavioural Risk Factors in Adults in a Rura...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
IDENTIFICATION OF SOCIOECONOMIC VARIABLES RESPONSIBLE FOR HYPERTENSIVE KIDNEY...hiij
The study was conducted to identify some socioeconomic variables responsible for the prevalence of
hypertensive kidney disease among Bangladeshi adults of 18 years and above. For this, 498 males and 497
females, totalling 995 adults of both urban and rural localities were investigated. In the sample there were
17.6% hypertensive adults and 18.9% of them were suffering from hypertension and kidney disease
simultaneously. Beside other percentages of respondents, there were 19.6% elderly people of ages 50 years
and above, 30.2% obese adults, 67.0% diabetic patients, 44.4% involved in sedentary activity and 33.1%
smokers. The overall percentage of hypertensive kidney patients was 3.3. These group of patients were
discriminated from the remaining 96.7% adults. During discrimination duration of diabetes was identified
as most responsible variable followed by age, body mass index, sedentary activity, smoking habit, etc. The
risk of prevalence of hypertensive kidney disease was 12.25 times in diabetic patients suffering for 15 years
and above compared to the risk of prevalence in other adults. The risk was 8.43 times in elderly people,
16.80 times in obese adults, 2.50 times in adults involved in sedentary activity, and 1.91 times in smoker
adults. Higher risk rate was also observed in adults of lower economic group of families.
IDENTIFICATION OF SOCIOECONOMIC VARIABLES RESPONSIBLE FOR HYPERTENSIVE KIDNEY...hiij
The study was conducted to identify some socioeconomic variables responsible for the prevalence of
hypertensive kidney disease among Bangladeshi adults of 18 years and above. For this, 498 males and 497
females, totalling 995 adults of both urban and rural localities were investigated. In the sample there were
17.6% hypertensive adults and 18.9% of them were suffering from hypertension and kidney disease
simultaneously. Beside other percentages of respondents, there were 19.6% elderly people of ages 50 years
and above, 30.2% obese adults, 67.0% diabetic patients, 44.4% involved in sedentary activity and 33.1%
smokers. The overall percentage of hypertensive kidney patients was 3.3. These group of patients were
discriminated from the remaining 96.7% adults. During discrimination duration of diabetes was identified
as most responsible variable followed by age, body mass index, sedentary activity, smoking habit, etc. The
risk of prevalence of hypertensive kidney disease was 12.25 times in diabetic patients suffering for 15 years
and above compared to the risk of prevalence in other adults. The risk was 8.43 times in elderly people,
16.80 times in obese adults, 2.50 times in adults involved in sedentary activity, and 1.91 times in smoker
adults. Higher risk rate was also observed in adults of lower economic group of families.
Systematic literature review services | Cardiovascular research | Bariatric s...Pubrica
Pubrica provides support with medical data collection project work, Comprehensive Review Of Medical Data Collection Systems For Efficient Patient Health Care.
Visit us for high quality research services @ https://pubrica.com/services/research-services/
Contact us @ sales@pubrica.com
A Comparative Study of Anthropometric Characteristics and Blood Pressure betw...ijtsrd
Background Hypertension is a frequently encountered multifactorial disorder and its prevalence is reported to increase in postmenopausal females. Cardiovascular disease is the leading cause of death in women. Furthermore, there is evidence that hormonal changes also leads to anthropometric changes associated with hypertension.Aim - To compare the anthropometric measures and blood pressure of pre and post menopausal women and find the association between anthropometric measures and hypertension.Methodology - A comparative study was conducted on 50 pre and 50 post menopausal women. The sampling method was purposive sampling and conducted in Goyala Vihar of Delhi. The door to door survey was conducted and data was collected using kobo tool. The measurements of BP, weight, height, hip and waist circumference was done following the protocols. The data was analysed using SPSS software.Result and conclusion - The result was significant for all variables Age, Wt, BMI, HC, WC, WHR and BAI except Ht. Independent T test was used to compare. Correlation and regression depicted that age is the predictor for diastolic blood pressure in pre menopausal women and for post menopausal women age, Ht, Wt, BMI, WC and HC are predictor of diastolic blood pressure. Women in post menopausal stage were at high risk of HTN compared to pre menopausal women. Jyoti Yadav "A Comparative Study of Anthropometric Characteristics and Blood Pressure between Pre and Post - Menopausal Women in Poor Urban Area, Goyala Vihar, Delhi" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-4, August 2023, URL: https://www.ijtsrd.com/papers/ijtsrd59641.pdf Paper Url:https://www.ijtsrd.com/other-scientific-research-area/other/59641/a-comparative-study-of-anthropometric-characteristics-and-blood-pressure-between-pre-and-post---menopausal-women-in-poor-urban-area-goyala-vihar-delhi/jyoti-yadav
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
IOSR journal of VLSI and Signal Processing (IOSRJVSP) is an open access journal that publishes articles which contribute new results in all areas of VLSI Design & Signal Processing. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced VLSI Design & Signal Processing concepts and establishing new collaborations in these areas.
RunningHead: PICOT Question 1
RunningHead: PICOT Question 7
PICOT Question
Avery Bryan
NRS-433V
Professor Christine Vannelli
May 19, 2019
Clinical Problem
A report from the Center for Disease Control and Prevention in 2015 revealed that (9.4%) 30.3 million Americans are diabetic and 84.1 million have prediabetes. This is a total population of over 100 million is at risk of developing type 2 diabetes which is a growing health problem being the seventh leading cause of death in the U.S. An estimated 1.5 million new cases were among 18-year old bracket and the rates of diagnosed diabetes increased proportionally to age. Below 44 years accounted for 4%, below 64 years at 17 % and 25% for those above 65 years across both genders. One-third of adults in America has prediabetes but sadly, they are unaware despite reports released by The National Diabetes Statistics Report every year. These reports elaborate on prevalence and incidence, prediabetes, long-term complications, risk factors, mortality, and cost. Diabetes poses the risk of serious complications like death, blindness, stroke, kidney disorders, cardiac diseases and health problems that lead to amputation of legs. However, the risks can be mitigated through physical body activities, proper dieting and prescribed use of insulin and other related measures to control the blood sugar levels. Diabetes Prevention Program was funded by NIH to research a yearly evidence-based program to improve healthy weight loss through diet and physical activities. There also efforts to determine the effectiveness of public service campaigns in improving the real-life experience in the diagnosis and treatment of diabetes.
PICOT Question.
The population affected by diabetes cuts across all ages, gender, race, and ethnicity. The prevalence is significantly high from 18 years and it increases with age to about 25% above 65 years. In terms of gender, men are at higher risk accounting for 37% while women are at 30% across races and educational levels. On races, the rates were higher among Indians/Alaska natives at 15%, non-Hispanic blacks at 12.7% and Hispanics at 12%. Among Asians, the rates were lower at 8% and 7.4% for non-Hispanic whites.
Intervention indicator for diabetes shows that individuals who do not observe a healthy diet are more exposed to the disease. Some risk behaviors include lack of exercise and excessive intake of junk foods that lead to obesity and increased blood sugar levels. Diabetes prevalence varied according to education levels were those with less than high school education at 12.6% and 7.2% for those higher than high school education.
Comparison and use of a control group from the popularity of Complementary and Alternative Medicine and Traditional Chinese Medicine showed distinct knowledge of diabetes, blood sugar control, and self-care. The experimental group received education through interactive multimedia for three months while the control group received.
CARDIOVASCULAR DISEASE
CARDIOVASCULAR DISEASE
Cardiovascular Disease
Introduction
Cardiovascular disease posits a major cause of premature deaths and disability throughout the world and contributes to a significant increase in healthcare costs, particularly in medication, healthcare services, and production loss. Specifically, heart diseases and stroke accommodate the highest prevalence rate in the USA; accommodate an average of 610,000 and 365,000 annual deaths from CVD (CDC, 2015). Similarly, every year, CVD causes the USA approximately, $207 billion for medication, healthcare services, and productivity loss. Noteworthy, heart diseases and stroke incidences vary with factors such as ethnicity, gender, age, and individuals with certain disorders. Similarly, the project accommodates notable articulations on intervention, comparison, outcome, and time as a fundamental consideration in heart diseases and stroke in the USA. Thus, an enriched articulation on heart diseases and stroke are underscoring for the project presentation.
Definition
According to (Mayo Clinic, 2018), Heart disease describes a condition that affects the heart; including blood vessels diseases arrhythmias, and other heart defects. Significantly, the heart disease is interchangeable for the CVD, articulating on the infections involving narrowed or blocked blood vessels, causing a heart attack, chest pain, and stroke, among other clinical presentations. Similarly, (Mayo Clinic, 2018) acknowledges that many CVD is preventable and treatable with healthy lifestyle choices.
Epidemiology
Cardiovascular diseases posits an undying cause of death in the USA, projected at 840, 678 deaths in 2016, averagely one in three deaths (Salim et al. 2020). Similarly, between 2013 and 2016 121.5 million adults Americans presented notable for of the CVD. Notably, between 2013 and 2015 direct and indirect costs of managing the CVD in the USA, recorded $213.8 billion and $137.4 billion respectively. Statistically, between 2013 and 2016, 57.1% of non-HN black females and 60.1% of non-HN black males presenting CVD manifestations (Salim et al. 2020). According to the researcher causes of the CVD Include atherosclerosis resulting from an unhealthy diet, lacking exercise, overweight, and smoking. In the epistemology studies, risk factors such as age, sex, family history, smoking, chemotherapy and radiation drugs, high blood pressure, poor diet, obesity, physical inactivity, stress, and poor hygiene are underscoring risk factors in the CVD (Mayo Clinic, 2018). Thus, heart disease epistemological indicates the patterns, causes, risk factors, and specific populations in the USA.
Clinical Presentations
Cardiovascular disease acclaims clinical presentations that may differ between men and women. According to (Mayo Clinic, 2018), men present significant chest pain that women and women clinical presentations such as shortness in breathing, nausea, and fatigue are more evident than in men. Admi ...
A comparative analysis of biochemical and hematological parameters in diabeti...amsjournal
This study evaluated the biochemical and the hematological parameters in diabetic and non- diabetic patients. The measured biochemical parameters were fasting blood sugar, serum alanine aminotransferase (SGPT/ALT), total cholesterol, urea, creatinine and hematological parameters were hemoglobin, total white blood cell, neutrophil, lymphocyte,monocyte, eosinophil and ESR. There were 403 diabetic and 320 non-diabetic subjects included in this study and the study was carried out in BIRDEM (Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders) General Hospital). It was observed that the mean values of SGPT/ALT (p<0.001),><0.001)><0.001)><0.001),><0.004),><0.001) of hematological parameters were significantly higher in diabetic patients than in the non-diabetic patients. In univariate analysis, all biochemical parameters and only four hematological parameters were found significantly associated with fasting blood sugar after adjusted with age and sex. The fasting blood sugar correlates highly with the other biochemical parameters but less or none with the hematological parameters. Our findings demonstrated that control of increased biochemical parameters and abnormal hematological levels in the early stage of diabetes mellitus may help the patients to raise quality of life.
The Statutory Interpretation of Renewable Energy Based on Syllogism of Britis...AI Publications
The current production for energy consumption generates harmful impacts of carbon dioxide to the environment causing instability to sustainable development goals. The constitutional reforms of British Government serve to be an important means of resolving any encountered incompatibilities to political environment. This study aims to evaluate green economy using developed equation for renewable energy towards political polarization of corporate governance. The Kano Model Assessment is used to measure the equivalency of 1970 Patents Act to UK Intellectual Property tabulating the criteria for the fulfillment of sustainable development goals in respect to the environment, artificial intelligence, and dynamic dichotomy of administrative agencies and presidential restriction, as statutory interpretation development to renewable energy. The constitutional forms of British government satisfy the sustainable development goals needed to fight climate change, advocate healthy ecosystem, promote leadership of magnates, and delegate responsibilities towards green economy. The presidential partisanship must be observed to delineate parties of concerns and execute the government prescriptions in equivalence to the dichotomous relationship of technology and the environment in fulfilling the rights and privileges of all citizens. Hence, the political elites can execute corporate governance towards sustainable development of renewable energy promoting environmental parks and zero emission target of carbon dioxide discharges. The economic theory developed in statutory interpretation for renewable energy serves as a tool to reduce detrimental impacts of carbon dioxide to the environment, mitigate climate change, and produce artefacts of bioenergy and artificial intelligence promoting sustainable development. It is suggested to explore other vulnerabilities of artificial intelligence to prosper economic success.
Enhancement of Aqueous Solubility of Piroxicam Using Solvent Deposition SystemAI Publications
Piroxicam is a non-steroidal anti-inflammatory drug that is characterized by low solubility-high permeability. The present study was designed to improve the dissolution rate of piroxicam at the physiological pH's through its increased solubility by using solvent deposition system.
More Related Content
Similar to The role of genetic factors in Hypertension among Iraqi citizens
IDENTIFICATION OF SOCIOECONOMIC VARIABLES RESPONSIBLE FOR HYPERTENSIVE KIDNEY...hiij
The study was conducted to identify some socioeconomic variables responsible for the prevalence of
hypertensive kidney disease among Bangladeshi adults of 18 years and above. For this, 498 males and 497
females, totalling 995 adults of both urban and rural localities were investigated. In the sample there were
17.6% hypertensive adults and 18.9% of them were suffering from hypertension and kidney disease
simultaneously. Beside other percentages of respondents, there were 19.6% elderly people of ages 50 years
and above, 30.2% obese adults, 67.0% diabetic patients, 44.4% involved in sedentary activity and 33.1%
smokers. The overall percentage of hypertensive kidney patients was 3.3. These group of patients were
discriminated from the remaining 96.7% adults. During discrimination duration of diabetes was identified
as most responsible variable followed by age, body mass index, sedentary activity, smoking habit, etc. The
risk of prevalence of hypertensive kidney disease was 12.25 times in diabetic patients suffering for 15 years
and above compared to the risk of prevalence in other adults. The risk was 8.43 times in elderly people,
16.80 times in obese adults, 2.50 times in adults involved in sedentary activity, and 1.91 times in smoker
adults. Higher risk rate was also observed in adults of lower economic group of families.
IDENTIFICATION OF SOCIOECONOMIC VARIABLES RESPONSIBLE FOR HYPERTENSIVE KIDNEY...hiij
The study was conducted to identify some socioeconomic variables responsible for the prevalence of
hypertensive kidney disease among Bangladeshi adults of 18 years and above. For this, 498 males and 497
females, totalling 995 adults of both urban and rural localities were investigated. In the sample there were
17.6% hypertensive adults and 18.9% of them were suffering from hypertension and kidney disease
simultaneously. Beside other percentages of respondents, there were 19.6% elderly people of ages 50 years
and above, 30.2% obese adults, 67.0% diabetic patients, 44.4% involved in sedentary activity and 33.1%
smokers. The overall percentage of hypertensive kidney patients was 3.3. These group of patients were
discriminated from the remaining 96.7% adults. During discrimination duration of diabetes was identified
as most responsible variable followed by age, body mass index, sedentary activity, smoking habit, etc. The
risk of prevalence of hypertensive kidney disease was 12.25 times in diabetic patients suffering for 15 years
and above compared to the risk of prevalence in other adults. The risk was 8.43 times in elderly people,
16.80 times in obese adults, 2.50 times in adults involved in sedentary activity, and 1.91 times in smoker
adults. Higher risk rate was also observed in adults of lower economic group of families.
Systematic literature review services | Cardiovascular research | Bariatric s...Pubrica
Pubrica provides support with medical data collection project work, Comprehensive Review Of Medical Data Collection Systems For Efficient Patient Health Care.
Visit us for high quality research services @ https://pubrica.com/services/research-services/
Contact us @ sales@pubrica.com
A Comparative Study of Anthropometric Characteristics and Blood Pressure betw...ijtsrd
Background Hypertension is a frequently encountered multifactorial disorder and its prevalence is reported to increase in postmenopausal females. Cardiovascular disease is the leading cause of death in women. Furthermore, there is evidence that hormonal changes also leads to anthropometric changes associated with hypertension.Aim - To compare the anthropometric measures and blood pressure of pre and post menopausal women and find the association between anthropometric measures and hypertension.Methodology - A comparative study was conducted on 50 pre and 50 post menopausal women. The sampling method was purposive sampling and conducted in Goyala Vihar of Delhi. The door to door survey was conducted and data was collected using kobo tool. The measurements of BP, weight, height, hip and waist circumference was done following the protocols. The data was analysed using SPSS software.Result and conclusion - The result was significant for all variables Age, Wt, BMI, HC, WC, WHR and BAI except Ht. Independent T test was used to compare. Correlation and regression depicted that age is the predictor for diastolic blood pressure in pre menopausal women and for post menopausal women age, Ht, Wt, BMI, WC and HC are predictor of diastolic blood pressure. Women in post menopausal stage were at high risk of HTN compared to pre menopausal women. Jyoti Yadav "A Comparative Study of Anthropometric Characteristics and Blood Pressure between Pre and Post - Menopausal Women in Poor Urban Area, Goyala Vihar, Delhi" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-4, August 2023, URL: https://www.ijtsrd.com/papers/ijtsrd59641.pdf Paper Url:https://www.ijtsrd.com/other-scientific-research-area/other/59641/a-comparative-study-of-anthropometric-characteristics-and-blood-pressure-between-pre-and-post---menopausal-women-in-poor-urban-area-goyala-vihar-delhi/jyoti-yadav
Dr. ihsan edan abdulkareem alsaimary
PROFESSOR IN MEDICAL MICROBIOLOGY AND MOLECULAR IMMUNOLOGY
ihsanalsaimary@gmail.com
mobile : 009647801410838
university of basrah - college of medicine - basrah -IRAQ
IOSR journal of VLSI and Signal Processing (IOSRJVSP) is an open access journal that publishes articles which contribute new results in all areas of VLSI Design & Signal Processing. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced VLSI Design & Signal Processing concepts and establishing new collaborations in these areas.
RunningHead: PICOT Question 1
RunningHead: PICOT Question 7
PICOT Question
Avery Bryan
NRS-433V
Professor Christine Vannelli
May 19, 2019
Clinical Problem
A report from the Center for Disease Control and Prevention in 2015 revealed that (9.4%) 30.3 million Americans are diabetic and 84.1 million have prediabetes. This is a total population of over 100 million is at risk of developing type 2 diabetes which is a growing health problem being the seventh leading cause of death in the U.S. An estimated 1.5 million new cases were among 18-year old bracket and the rates of diagnosed diabetes increased proportionally to age. Below 44 years accounted for 4%, below 64 years at 17 % and 25% for those above 65 years across both genders. One-third of adults in America has prediabetes but sadly, they are unaware despite reports released by The National Diabetes Statistics Report every year. These reports elaborate on prevalence and incidence, prediabetes, long-term complications, risk factors, mortality, and cost. Diabetes poses the risk of serious complications like death, blindness, stroke, kidney disorders, cardiac diseases and health problems that lead to amputation of legs. However, the risks can be mitigated through physical body activities, proper dieting and prescribed use of insulin and other related measures to control the blood sugar levels. Diabetes Prevention Program was funded by NIH to research a yearly evidence-based program to improve healthy weight loss through diet and physical activities. There also efforts to determine the effectiveness of public service campaigns in improving the real-life experience in the diagnosis and treatment of diabetes.
PICOT Question.
The population affected by diabetes cuts across all ages, gender, race, and ethnicity. The prevalence is significantly high from 18 years and it increases with age to about 25% above 65 years. In terms of gender, men are at higher risk accounting for 37% while women are at 30% across races and educational levels. On races, the rates were higher among Indians/Alaska natives at 15%, non-Hispanic blacks at 12.7% and Hispanics at 12%. Among Asians, the rates were lower at 8% and 7.4% for non-Hispanic whites.
Intervention indicator for diabetes shows that individuals who do not observe a healthy diet are more exposed to the disease. Some risk behaviors include lack of exercise and excessive intake of junk foods that lead to obesity and increased blood sugar levels. Diabetes prevalence varied according to education levels were those with less than high school education at 12.6% and 7.2% for those higher than high school education.
Comparison and use of a control group from the popularity of Complementary and Alternative Medicine and Traditional Chinese Medicine showed distinct knowledge of diabetes, blood sugar control, and self-care. The experimental group received education through interactive multimedia for three months while the control group received.
CARDIOVASCULAR DISEASE
CARDIOVASCULAR DISEASE
Cardiovascular Disease
Introduction
Cardiovascular disease posits a major cause of premature deaths and disability throughout the world and contributes to a significant increase in healthcare costs, particularly in medication, healthcare services, and production loss. Specifically, heart diseases and stroke accommodate the highest prevalence rate in the USA; accommodate an average of 610,000 and 365,000 annual deaths from CVD (CDC, 2015). Similarly, every year, CVD causes the USA approximately, $207 billion for medication, healthcare services, and productivity loss. Noteworthy, heart diseases and stroke incidences vary with factors such as ethnicity, gender, age, and individuals with certain disorders. Similarly, the project accommodates notable articulations on intervention, comparison, outcome, and time as a fundamental consideration in heart diseases and stroke in the USA. Thus, an enriched articulation on heart diseases and stroke are underscoring for the project presentation.
Definition
According to (Mayo Clinic, 2018), Heart disease describes a condition that affects the heart; including blood vessels diseases arrhythmias, and other heart defects. Significantly, the heart disease is interchangeable for the CVD, articulating on the infections involving narrowed or blocked blood vessels, causing a heart attack, chest pain, and stroke, among other clinical presentations. Similarly, (Mayo Clinic, 2018) acknowledges that many CVD is preventable and treatable with healthy lifestyle choices.
Epidemiology
Cardiovascular diseases posits an undying cause of death in the USA, projected at 840, 678 deaths in 2016, averagely one in three deaths (Salim et al. 2020). Similarly, between 2013 and 2016 121.5 million adults Americans presented notable for of the CVD. Notably, between 2013 and 2015 direct and indirect costs of managing the CVD in the USA, recorded $213.8 billion and $137.4 billion respectively. Statistically, between 2013 and 2016, 57.1% of non-HN black females and 60.1% of non-HN black males presenting CVD manifestations (Salim et al. 2020). According to the researcher causes of the CVD Include atherosclerosis resulting from an unhealthy diet, lacking exercise, overweight, and smoking. In the epistemology studies, risk factors such as age, sex, family history, smoking, chemotherapy and radiation drugs, high blood pressure, poor diet, obesity, physical inactivity, stress, and poor hygiene are underscoring risk factors in the CVD (Mayo Clinic, 2018). Thus, heart disease epistemological indicates the patterns, causes, risk factors, and specific populations in the USA.
Clinical Presentations
Cardiovascular disease acclaims clinical presentations that may differ between men and women. According to (Mayo Clinic, 2018), men present significant chest pain that women and women clinical presentations such as shortness in breathing, nausea, and fatigue are more evident than in men. Admi ...
A comparative analysis of biochemical and hematological parameters in diabeti...amsjournal
This study evaluated the biochemical and the hematological parameters in diabetic and non- diabetic patients. The measured biochemical parameters were fasting blood sugar, serum alanine aminotransferase (SGPT/ALT), total cholesterol, urea, creatinine and hematological parameters were hemoglobin, total white blood cell, neutrophil, lymphocyte,monocyte, eosinophil and ESR. There were 403 diabetic and 320 non-diabetic subjects included in this study and the study was carried out in BIRDEM (Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders) General Hospital). It was observed that the mean values of SGPT/ALT (p<0.001),><0.001)><0.001)><0.001),><0.004),><0.001) of hematological parameters were significantly higher in diabetic patients than in the non-diabetic patients. In univariate analysis, all biochemical parameters and only four hematological parameters were found significantly associated with fasting blood sugar after adjusted with age and sex. The fasting blood sugar correlates highly with the other biochemical parameters but less or none with the hematological parameters. Our findings demonstrated that control of increased biochemical parameters and abnormal hematological levels in the early stage of diabetes mellitus may help the patients to raise quality of life.
The Statutory Interpretation of Renewable Energy Based on Syllogism of Britis...AI Publications
The current production for energy consumption generates harmful impacts of carbon dioxide to the environment causing instability to sustainable development goals. The constitutional reforms of British Government serve to be an important means of resolving any encountered incompatibilities to political environment. This study aims to evaluate green economy using developed equation for renewable energy towards political polarization of corporate governance. The Kano Model Assessment is used to measure the equivalency of 1970 Patents Act to UK Intellectual Property tabulating the criteria for the fulfillment of sustainable development goals in respect to the environment, artificial intelligence, and dynamic dichotomy of administrative agencies and presidential restriction, as statutory interpretation development to renewable energy. The constitutional forms of British government satisfy the sustainable development goals needed to fight climate change, advocate healthy ecosystem, promote leadership of magnates, and delegate responsibilities towards green economy. The presidential partisanship must be observed to delineate parties of concerns and execute the government prescriptions in equivalence to the dichotomous relationship of technology and the environment in fulfilling the rights and privileges of all citizens. Hence, the political elites can execute corporate governance towards sustainable development of renewable energy promoting environmental parks and zero emission target of carbon dioxide discharges. The economic theory developed in statutory interpretation for renewable energy serves as a tool to reduce detrimental impacts of carbon dioxide to the environment, mitigate climate change, and produce artefacts of bioenergy and artificial intelligence promoting sustainable development. It is suggested to explore other vulnerabilities of artificial intelligence to prosper economic success.
Enhancement of Aqueous Solubility of Piroxicam Using Solvent Deposition SystemAI Publications
Piroxicam is a non-steroidal anti-inflammatory drug that is characterized by low solubility-high permeability. The present study was designed to improve the dissolution rate of piroxicam at the physiological pH's through its increased solubility by using solvent deposition system.
Analysis of Value Chain of Cow Milk: The Case of Itang Special Woreda, Gambel...AI Publications
Ethiopia has a long and rich history of dairy farming, which was mostly carried out by small and marginal farmers who raised cattle, camels, goats, and sheep, among other species, for milk. Finding the Itang Special Woreda cow milk value chain is the study's main goal. In order to gather primary data, 204 smallholder dairy farmer households were randomly selected, and the market concentration ratio was calculated using 20 traders. Descriptive statistics, econometric models, and rank analysis were used to achieve the above specified goals. Out of all the participants in the milk value chain, producers, cafés, hotels, and dairy cooperatives had the largest gross marketing margins, accounting for 100% of the consumer price in channels I and II, 55% in channels III and V, and 25.5% in channels V. The number of children under five, the number of milking cows owned, the amount of money from non-dairy sources, the frequency of extension service contacts, the amount of milk produced each day, and the availability of market information were found to have an impact on smallholders' involvement in the milk market. Numerous obstacles also limited the amount of milk produced and marketed. The poll claims that general health issues, sickness, predators, and a lack of veterinary care are plaguing farmers. In order to address the issue of milk perishability, the researchers recommended the host community and organization to construct an agro milk processor, renovate the dairy cooperative in the study region, and restructure the current conventional marketing to lower the transaction and cost of milk marketing.
Minds and Machines: Impact of Emotional Intelligence on Investment Decisions ...AI Publications
In the evolving landscape of financial decision-making, this study delves into the intricate relationships among Emotional Intelligence (EI), Artificial Intelligence (AI), and Investment Decisions (ID). By scrutinizing the direct influence of human emotional intelligence on investment choices and elucidating the mediating role of AI in this process, our research seeks to unravel the complex interplay between minds and machines. Through empirical analysis, we reveal that EI not only directly impacts ID but also exerts its influence indirectly through AI-mediated pathways. The findings underscore the pivotal role of emotional awareness in investor decision-making, augmented by the technological capabilities of AI. It suggests that most investors are influenced by the identified emotional intelligence when making investment decisions. Furthermore, AI substantially impacts investors' decision-making process when it comes to investing; nevertheless, AI partially mediates the relationship between emotional intelligence and investment decisions. This nuanced understanding provides valuable insights for financial practitioners, policymakers, and researchers, emphasizing the need for holistic strategies that integrate emotional and technological dimensions in navigating the intricacies of modern investment landscapes. As the synergy between human intuition and artificial intelligence becomes increasingly integral to financial decision-making, this study contributes to the ongoing discourse on the symbiotic relationship between minds and machines in investments.0
Bronchopulmonary cancers are common cancers with a poor prognosis. It is the leading cause of death by cancer in Algeria and in the world. Behind this unfavorable prognosis hides numerous disparities according to age, sex, and exposure to risk factors, ranking 4th among incident cancers and developing countries including Algeria, all sexes combined. It ranks 2nd cancers in men and 3rd among women. Whatever the age observed, the incidence of this cancer is higher in men than in women, however the gap is narrowing to the detriment of the latter. The results of scientific research agree to relate trends in incidence and mortality rates to tobacco consumption, including passive smoking. Furthermore, other risk factors are mentioned such as exposure to asbestos in the workplace or to radon for the general population, or even genetic predisposition. However, the weight of these etiological and/or predisposing factors is in no way comparable to that of tobacco in the genesis of lung cancer and the resulting mortality. We provide a literature review in our article on the descriptive and analytical epidemiology of lung cancer.
Further analysis on Organic agriculture and organic farming in case of Thaila...AI Publications
The objective of this paper is to present Further analysis on Organic agriculture and organic farming in case of Thailand agriculture and enhancing farmer productivity. In view of the demand for organic fertilizers, efforts should also be made to enhance and to develop more effective of compost, bio-fertilizer, and bio-pesticides currently used by farmers. Likewise, emphasis should also be laid on the cultivation of legumes and other crops that can enhance the fertility of the soil, as practiced by farmers in many developing countries to fertilize their lands. On the other hand, most of the farmers who practice this farm system found that they are adopting a number of SLMs and interested in joining the meeting or training to gain more and more knowledge.
Current Changes in the Role of Agriculture and Agri-Farming Structures in Tha...AI Publications
The objective os this study is to present Current Changes in the Role of Agriculture and Agri-Farming Structures in Thailand and Vietnam with SLM practices. Farmer’s adoption and investment in SLM is a key for controlling land degradation, enhancing the well-being of society, and ensuring the optimal use of land resources for the benefit of present and future generations (World Bank, 2006; FAO, 2018). And agriculture remains an essential element of lives of many farmers in term of the strong cultural and symbolic values that attach current working generation to do and to spend time for it but not intern of income generating.
Growth, Yield and Economic Advantage of Onion (Allium cepa L.) Varieties in R...AI Publications
Haphazard and low soil fertility, low yielding verities and poor agronomic practices are among the major factors constraining onion production in the central rift valley of Ethiopia. Therefore, a field experiment was conducted in East Showa Zone of Adami Tulu Jido Combolcha district in central rift valley areas at ziway from October 2021 to April 2022 to identify appropriate rate of NPSB fertilizer and planting pattern of onion varieties. The experiment was laid out in split plot design of factorial arrangement in three replications. The main effect of NPSB blended fertilizer rates and varieties (red coach and red king) significantly (p<0.01) influenced plant height, leaf length, leaf diameter, leaf number and fresh leaf weight, shoot dry matter per plant, and harvest index. Total dry biomass, bulb diameter, neck diameter, average fresh bulb weight, bulb dry matter, marketable bulb yield, and total bulb yield were significantly (p<0.01) influenced only by the main effect of NPSB blended fertilizer rates. In addition, unmarketable bulb yield was statistically significantly affected (p≥0.05) by the blended fertilizer rates and planting pattern. Moreover, days to 90% maturity of onion was affected by the main factor of NPSB fertilizer rate, variety and planting pattern. The non-fertilized plants in the control treatment were inferior in all parameters except unmarketable bulb yield and harvest index. Significantly higher marketable bulb yield (41 t ha-1) and total bulb yield (41.33 t ha-1) was recorded from 300 kg ha-1 NPSB blended fertilizer rate applied. Double row planting method and hybrid red coach onion variety had also gave higher growth and yields. The study revealed that the highest net benefit of Birr, 878,894 with lest cost of Birr 148,006 by the combinations of 150 kg blended NPSB ha-1 with double row planting method (40cm*20cm*7cm) and red coach variety which can be recommendable for higher marketable bulb yield and economic return of hybrid onion for small scale farmers in the study area. Also, for resource full producers (investors), highest net benefit of Birr 1,205,372 with higher cost (159,628 Birr) by application of 300 kg NPSB ha-1 is recommended as a second option. However, the research should be replicated both in season and areas to more verify the recommendations.
Evaluation of In-vitro neuroprotective effect of Ethanolic extract of Canariu...AI Publications
The ethanolic extract of canarium solomonense leaves (ecsl) was studied for its neuroprotective activity. The neuroprotective activity of ECSL was found to have a significant impact on neuronal cell death triggered by hydrogen peroxide (MTT assay) in human SH-SY5Y neuroblastoma cells. Scopolamine, a muscarinic receptor blocker, is frequently used to induce cognitive impairment in laboratory animals. Injections of scopolamine influence multiple cognitive functions, including motor function, short-term memory, and attention. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, memory enhancing activity in scopolamine-induced amnesic rats was evaluated. Using the Morris water maze, the Y maze, and the passive avoidance paradigm, ECSL was found to have a substantial effect on the memory of scopolamine- induced amnesic rats. Our experimental data indicated that ECSL can reverse scopolamine induced amnesia and assist with memory issues.
The goal of neuroprotection is to shield neurons against damage, whether that damage is caused by environmental factors, pathogens, or neurodegenerative illnesses. Inhibiting protein-based deposit buildup, oxidative stress, and neuroinflammation, as well as rectifying abnormalities of neurotransmitters like dopamine and acetylcholine, are some of the ways in which medicinal herbs have neuroprotective effects [1-3]. This review will focus on the ways in which medicinal herbs may protect neurons.
A phytochemical and pharmacological review on canarium solomonenseAI Publications
The genus Canarium L. consists of 75 species of aromatic trees which are found in the rainforests of tropical Asia, Africa and the Pacific. The medicinal uses, botany, chemical constituents and pharmacological activities are now reviewed. Various compounds are tabulated according to their classes their structures are given. Traditionally canarium solomonense have been used to treat a broad array of illnesses. Pharmacological actions for canarium solomonense as discussed in this review include antibacterial, antimicrobial, antioxidant, anti-inflammatory, hepatoprotective and antitumor activity.
Influences of Digital Marketing in the Buying Decisions of College Students i...AI Publications
This research investigates the influence of digital marketing channels on purchasing decisions among college students in Ramanathapuram District. The study highlights that social media marketing, online advertising, and mobile marketing exhibit substantial positive effects on purchase decisions. However, email marketing's impact appears to be more complex. Moreover, the study explores how demographic variables like gender and academic level shape these effects. Notably, freshman students display varying susceptibility to specific digital marketing messages compared to their junior, senior, or graduate counterparts. These findings offer crucial insights for marketers aiming to tailor their strategies effectively to the preferences and behaviors of college students. By understanding the differential impacts of various digital marketing channels and considering demographic nuances, marketers can refine their approaches, optimize engagement, and ultimately enhance the effectiveness of their campaigns in targeting this demographic.
A Study on Performance of the Karnataka State Cooperative Agriculture & Rural...AI Publications
The Karnataka State Co-operative Agriculture and Rural Development Bank Limited is the apex bank of all the primary co-operative agriculture and rural development banks in the state. All the PCARD Banks in the state are affiliated to it. The KSCARD Bank provides financial accommodation to the PCARD Banks for their lending operations. In order to quick sanction and disbursement of loans and supervision over the PCARD Banks the KSCARD Bank has opened district level branches. Bank has established Women Development Cell to promote entrepreneurship among women in 2005. The Bank is identifying women borrowers in the rural areas by assigning suitable projects to motivate their self-confidence to lead independent life. Progress made in financing women entrepreneurs women.
Breast hamartoma is a rare, well-circumscribed, benign lesion made up of a variable quantity of glandular, adipose and fibrous tissue. This is a lesion that can affect women at any age from puberty. With the increasingly frequent use of imaging methods such as mammography and ultrasound as well as breast biopsy, cases of hamartoma diagnosed are increasing. The diagnosis of these lesions is made by mammography. The histological and radiological aspects are variable and depend on its adipose tissue content. The identification of these lesions is important in order to avoid surgical excisions. We report radio-clinical and pathological records of breast hamartoma.
A retrospective study on ovarian cancer with a median follow-up of 36 months ...AI Publications
Ovarian cancer is relatively common but serious and has a poor prognosis. The aim of this study is to highlight the epidemiological, diagnostic, therapeutic and evolutionary aspects of this malignant pathology managed at the Bejaia university hospital center. This is a retrospective and descriptive study over a period of 3 years (2019 - 2022) carried out on 20 patients who developed ovarian cancer. The average age of the patients was 50 years old, 53.23% of whom were over 45 years old. The CA-125 blood test was positive in 18 out of 20 patients. The tumors were discovered on ultrasound in 87.10% of cases and at laparotomy in 12.90%. Total hysterectomy with bilateral adnexectomy was the most performed procedure (64.52%). The early postoperative course was simple. 15 patients underwent second look surgery (16.13%) for locoregional recurrences. Epithelial tumors were the most frequent histological type (93.55%), including 79% in the advanced stage ( IIIc -IV) and 21% in the early stage (Ia- Ib ). Adjuvant chemotherapy was administered in 80% of patients. With a median follow-up of 36 months, 2 patients were lost to follow-up. The evolution was favorable in 27.42% and in 25.81% deaths occurred late postoperatively. Ovarian cancer is not common but serious given the advanced stages and the high rate of late postoperative deaths which were largely observed in patients deprived of adequate neoadjuvant or adjuvant chemotherapy.
More analysis on environment protection and sustainable agriculture - A case ...AI Publications
This study presents a case of tea and coffee crops , esp. environment protection and sustainable agriculture in Son La and Thai Nguyen of Vietnam. Research results show us that The process of having an agricultural product goes through many steps such as planting, planning, harvesting, packing, transporting, storing and distributing. - The State adopts policies to encourage innovation of agricultural production models and methods towards sustainability, adapting to climate change, saving water, and limiting the use of inorganic fertilizers and pesticides. chemicals and products for environmental treatment in agriculture; develop environmentally friendly agricultural models. Our research limitation is that we can expand for other crops, industries and markets as well.
Assessment of Growth and Yield Performance of Twelve Different Rice Varieties...AI Publications
The present investigation entitled “Assessment of growth and yield performance of twelve different rice varieties under north Konkan coastal zone of Maharashtra” was carried out during the kharif season of the year 2021 and 2022 on the field of ASPEE, Agricultural Research and Development Foundation, Tansa Farm, At Nare, Taluka Wada, District Palghar, Maharashtra, India. The experiment was laid out in Randomized Block Design (RBD). The twelve varieties namely Zini, Jaya, Dandi, Rahghudya, Govindbhog, Dangi, Gurjari, VNR-7, VNR-8, VNR-9, Karjat-3, and Karjat-5 were replicated thrice. The plant height (cm), number of tillers per plant, number of panicles per plant, number of panicles (m²), and length of panicle (cm) were noted to the maximum with cv. “VNR-7”. The highest number of seeds per panicle, test weight (gm), grain yield (q/ha), and straw yield (q/ha) were recorded with the cv. “VNR-7”. While the lowest number of days to 50% flowering was also recorded with cv. “VNR-7” during the year 2021 and 2022.
Cultivating Proactive Cybersecurity Culture among IT Professional to Combat E...AI Publications
In the current digital landscape, cybercriminals continually evolve their techniques to execute successful attacks on businesses, thus posing a great challenge to information technology (IT) professionals. While traditional cybersecurity approaches like layered defense and reactive security have helped IT professionals cope with traditional threats, they are ineffective in dealing with evolving cyberattacks. This paper focuses on the need for a proactive cybersecurity culture among IT professionals to enable them combat evolving threats. The paper emphasis that building a proactive security approach and culture can help among IT professionals anticipate, identify, and mitigate latent threats prior to them exploiting existing vulnerabilities. This paper also points out that as IT professionals use reactive security when dealing with traditional attacks, they can use it collaboratively with proactive security to effectively protect their networks, data, and systems and avoid heavy costs of dealing with cyberattack’s aftermaths and business recovery.
The Impacts of Viral Hepatitis on Liver Enzymes and BilrubinAI Publications
Viral hepatitis is an infection that causes liver inflammation and damage. Several different viruses cause hepatitis, including hepatitis A, B, C, D, and E. The hepatitis A and E viruses typically cause acute infections. The hepatitis B, C, and D viruses can cause acute and chronic infections. Hepatitis A causes only acute infection and typically gets better without treatment after a few weeks. The hepatitis A virus spreads through contact with an infected person’s stool. Protection by getting the hepatitis A vaccine. Hepatitis E is typically an acute infection that gets better without treatment after several weeks. Some types of hepatitis E virus are spread by drinking water contaminated by an infected person’s stool. Other types are spread by eating undercooked pork or wild game. Hepatitis B can cause acute or chronic infection. Recommendation for screening for hepatitis B in pregnant women or in those with a high chance of being infected. Protection from hepatitis B by getting the hepatitis B vaccine. Hepatitis C can cause acute or chronic infection. Doctors usually recommend one-time screening of all adults ages 18 to 79 for hepatitis C. Early diagnosis and treatment can prevent liver damage. The hepatitis D virus is unusual because it can only infect those who have a hepatitis B virus infection. A coinfection occurs when both hepatitis D and hepatitis B infections at the same time. A superinfection occurs already have chronic hepatitis B and then become infected with hepatitis D. The aim of this study is to find the effect of each type of viral hepatitis on the bilirubin (TB , DSB) , and liver enzymes; AST, ALT, ALP,GGT among viral hepatitis patients. 200 patients were selected from the viral hepatitis units in the central public health laboratory in Baghdad city, all the chosen cases were confirmed as a positive samples , they are classified into four equal group each with fifty individual and with a single serological viral hepatitis type either; anti-HAV( IgM ) , HBs Ag , anti-HCV ,or anti-HEV(IgM ). All patients were tested for; serum bilirubin ( TB ,D.SB ) , AST , ALT , ALP , GGT. Another fifty quite healthy and normal person was selected as a control group for comparison. . Liver enzymes and bilirubin changes are more pronounced in HAV, HEV than HCV and HBVAST and ALT lack some sensitivity in detecting HCV ,HBV and mild elevations of ALT or AST in asymptomatic patients can be evaluated efficiently by considering ,hepatitis B, hepatitis C. ALT is generally a more sensitive indicator of acute liver cell damage than AST, It is relatively specific for hepatocyte necrosis with a marked elevations in viral hepatitis. Liver enzymes and bilirubin changes are more pronounced in HAV, HEV than HCV and HBV.AST and ALT lack some sensitivity in detecting HCV ,HBV and mild elevations of ALT or AST in asymptomatic patients can be evaluated efficiently by considering ,hepatitis B, hepatitis C. ALT is generally a more sensitive indicator of acute liver
Determinants of Women Empowerment in Bishoftu Town; Oromia Regional State of ...AI Publications
The purpose of this study was to determine the status of women's empowerment and its determinants using women's asset endowment and decision-making potential as indicators. To determine representative sample size, this study used a two-stage sampling technique, and 122 sample respondents were selected at random. To analyze the data in this study, descriptive statistics and a probit model were used. The average women's empowerment index was 0.41, indicating a relatively lower status of women's empowerment in the study area. According to the study's findings, only 40.9% of women were empowered, while the remaining 59.1% were not. The probit model results show that women's access to the media, women's income, and their husbands' education status have a significant and positive impact on the status of women's empowerment, while the family size of households has a negative impact. As a result, it is important to enhance women's access to the media and income, promote family planning and contraception, and improve men's educational status in order to improve the status of women's empowerment.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. Ismael et al./ The role of genetic factors in Hypertension among Iraqi citizens
Int. J. Med. Phar. Drug Re. 2022 2
Vol-6, Issue-6; Online Available at: https://www.aipublications.com/ijmpd/
number of publications on HT or other diseases in which
HT is present has increased dramatically [13,14,15].
The presence of arterial hypertension in close relatives is
an important risk factor for the development of arterial
hypertension. First-degree relatives are especially at high
risk [16,17,18,19].
As the degree of relationship decreases, so does the degree
of genetic risk. [20,21] The younger the patient's age at
which he developed arterial hypertension, the higher the
risk of developing the disease in family members. The
genetic predisposition appears especially in puberty, youth,
and maturity. In people over 70 years of age, the genetic
risk of developing the disease is significantly reduced and
practically approaches of the general population [22].
Genetic predisposition to disease development is achieved
under the influence of environmental factors, but
recognition of the role of external factors in increasing the
incidence of arterial hypertension does not reduce the
important role of genetic risk factors. [23]
Genetic predisposition to hypertension Arterial
hypertension is the most common disease in the adult
population of the developed world. In Iraq, hypertension
occurs in 39.2% of men and 41.1% of women, and 12-15%
of patients develop persistent hypertension.
The frequency of arterial hypertension increases markedly
with age - for example, hypertension is observed in 4% of
people aged 20-23 years and reaches 50% or more at the
age of 50-70 years. [24]
II. MATERIAL AND METHOD
A cross-sectional study was conducted to know the role
and contribution of genetic factors in arterial hypertension
among Iraqi citizens, where 140 patients were collected
from different hospitals in Iraq.
This study was designed through cooperation with the
hospital for the purpose of withdrawing the information
found in the electronic record to patients, which includes
primary information from demographic data (age - gender
- body mass index - blood samples - smoking - alcohol -
clinical history - genetic history and blood pressure levels
were defined as follows
1) Normal blood pressure: systolic blood pressure of less
than 120 mmHg and diastolic blood pressure of less than
80 mmHg.
2) Pre-hypertension condition: in which the blood pressure
is higher than normal, but it is not sufficient to diagnose
high blood pressure, and the person with it becomes more
likely to develop the hypertensive disease. Prehypertension
occurs with systolic pressure between 120-139 mmHg or
diastolic pressure between 80-89 mmHg.
3) Hypertension disease: The disease is diagnosed after
taking several blood pressure measurements over several
sessions, in which the systolic blood pressure is greater
than or
equal to 140 mmHg, or the diastolic blood pressure is
greater than or equal to 90 mmHg.
Statistical Analysis
The data and demographic information related to the
patients were analyzed by relying on the statistical analysis
program IBM soft SPSS 22, where the chi-square value
was extracted to know the differences in the patients' ages.
The type of relationship between genetic factors and
hypertension by extracted p-value with 0.05 and then
logistic regression value was calculated to know the
factors that constituted the risk to the patients
III. RESULTS
Table 1- Characteristics baseline demographic results of
the patient
Variable Value p-value
Age (MEAN±SD)
years
45.2±15.3 0.66
BMI (kg/m2)
(MEAN±SD)
29.34±3.9 0.87
Smokers (%) 69 (49.2) 0.74
Alcohol N (%) 10 (7.1) 0.001
cardiovascular
disease N (%)
55 (39) 0.44
DBP (mmHg) 85±8.8 0.5
SBP (mmHg) 140±10.1 0.79
Sex
Male N (%) 60 (42)
Female N (%) 80 (57.1) 0.32
Education
Illiteracy N (%) 20 (14.2)
High School N (%) 40 (28.5)
College N (%) 60 (42.8) 0.45
High education N
(%)
20 (14.2)
Occupation
physical 33
mental 39
freelance 18 0.021
NO WORK 50
3. Ismael et al./ The role of genetic factors in Hypertension among Iraqi citizens
Int. J. Med. Phar. Drug Re. 2022 3
Vol-6, Issue-6; Online Available at: https://www.aipublications.com/ijmpd/
Table 2- Patients' laboratory results
mean sd
Blood glucose (mg/dl) 105 18.8
Total cholesterol (mg/dl) 212 29.9
Triglycerides (mg/dl) 133.3 87.9
HDL cholesterol (mg/dl) 50.5 8.8
LDL cholesterol (mg/dl) 139.3 33.1
S-potassium (mg/dl) 4.13 0.31
S-sodium (mg/dl) 139 1.8
Fig 1- Distribution of patients according to blood type
Fig 2- Proportion of Family History with Hypertension
patients
Table 3- A logistic analysis of the study of the association
between family history and hypertension.
Family history Case OR 95% CI
No positive result 30 1.00 0.88-1.11
positive result in
one generation
120 3.98 1.88–8.98
Fig 3- Genotyping results and their relationship to the risk of hypertension
IV. DISCUSSION
A retrospective study was conducted for the purpose of
a comprehensive evaluation of the various systemic factors
of Iraqi patients receiving dental implants.
V. DISCUSSION
In this study, 140 patients were collected, and they were
divided into two groups (120 patients and 30 control
groups). The average age in this study ranged from 25 to
65 years.
4. Ismael et al./ The role of genetic factors in Hypertension among Iraqi citizens
Int. J. Med. Phar. Drug Re. 2022 4
Vol-6, Issue-6; Online Available at: https://www.aipublications.com/ijmpd/
The mean S.D. to age was 45.2±15.3. It was also
observed that the body mass index increased for the ages
ranging from 50-60 years.
This study showed a high percentage of smokers, with
49.2% of cardiovascular disease 55 patients were found
with 39%.
Patients were distributed according to gender, and the
number of female patients was more than males, for 80
patients with 57.1% and 60 male patients with 42.8%, as
shown in Table 1.
Increased systolic pressure may play a greater role in
left ventricular hypertrophy and stroke than diastolic
hypertension, and there is significant evidence to support
that high systolic blood pressure may be a good indicator
of a patient's future cardiovascular risk.
As for isolated high diastolic pressure, there is little of
published evidence about the high risk posed by its
infection. It is also considered a low-value indicator in
predicting the risk of developing cardiovascular diseases in
the future, which has led to the suggestion not to measure
diastolic blood pressure, except for cases suspected of
having diastolic hypertension.
In the current study, we obtained data that confirms the
true role and genetic factors for patients with arterial
hypertension at ages ranging between 20-30 years in Iraq,
and Iraqi citizens have a genetic burden, according to
scientific studies that confirm the genetic role of evolution
The risk of developing high blood pressure in men at an
early age increases 2.5 times with the presence of those
with hypertension in a relative of the first generation
Among the many pathogenic mechanisms that can lead
to arterial hypertension, the main ones are those whose
effect is mediated through the renin-angiotensin-
aldosterone system. May affect the cardiovascular system
through vasoconstriction and water and sodium retention.
Renin acts on angiotensinogen (encoded by the AGT
gene) and converts it into angiotensin I. Moreover,
angiotensin-1 is exposed to angiotensin-converting
enzyme, which has effects intended to increase or maintain
blood pressure.
This protein acts through the angiotensin receptors, and
there are two types of receptors:
Angiotensin II plays an important role in the
pathogenesis of arterial hypertension, as it acts on the
smooth muscles of blood vessels, causing them to spasm,
increasing peripheral resistance, and in addition to causing
left ventricular hypertrophy in hypertension.
Thus, the genetic analysis that assesses the risk of
developing hypertension includes the study of genetic
markers, which allows to identify of a violation of the
regulation of blood pressure, myocardial activity, and
blood supply
The presence of arterial hypertension in close relatives
is an important risk factor for the development of arterial
hypertension, and this means that first-degree relatives
(e.g., father and son) are particularly at high risk.
As the relationship score decreases, the genetic risk
score also decreases. The younger the patient at which he
developed arterial hypertension, the higher the risk of
developing the disease in his family members.
Genetic predisposition appears particularly in puberty,
youth and maturity.
In people over 70 years of age, the genetic risk of
developing the disease is significantly reduced and is
practically close to that of the general population.
Genetic predisposition to disease development is
realized under the influence of environmental factors, but
recognition of the role of external factors in the increased
incidence of arterial hypertension does not reduce the
important role of genetic risk factors.
Preventive genetic testing in the absence of traditional
risk factors would be beneficial for everyone because
genetic factors that lead to high blood pressure are very
common.
VI. CONCLUSION
Based on the results of a comprehensive study of 140
patients, which allows us to know the type of relationship
and the role of genetic factors in high blood pressure in
Iraqi citizens
Hypertension is one of the most important social
diseases associated with mutations in the human genome,
and this study identifying the genes associated with this
disease will provide a mechanism for classifying
hypertension phenotypes and will allow the creation of
diagnostic markers for individual patients and families.
REFERENCES
[1] Daniil G, Fernandes-Rosa FL, Chemin J, Blesneac I,
Beltrand J, Polak M, et al. CACNA1H mutations are
associated with different forms of primary aldosteronism.
EBioMedicine (2016) 13:225–36.
10.1016/j.ebiom.2016.10.002 [PMC free article] [PubMed]
[CrossRef] [Google Scholar]
[2] Wilson RC, Krozowski ZS, Li K, Obeyesekere VR,
Razzaghy-Azar M, Harbison MD, et al. A mutation in the
HSD11B2 gene in a family with apparent mineralocorticoid
excess. J Clin Endocrinol Metab (1995) 80:2263–6.
5. Ismael et al./ The role of genetic factors in Hypertension among Iraqi citizens
Int. J. Med. Phar. Drug Re. 2022 5
Vol-6, Issue-6; Online Available at: https://www.aipublications.com/ijmpd/
10.1210/jcem.80.7.7608290 [PubMed] [CrossRef] [Google
Scholar]
[3] Simonetti GD, Mohaupt MG, Bianchetti MG. Monogenic
forms of hypertension. Eur J Pediatr (2012) 171:1433–9.
10.1007/s00431-011-1440-7 [PubMed] [CrossRef] [Google
Scholar]
[4] Morineau G, Sulmont V, Salomon R, Fiquet-Kempf B,
Jeunemaître X, Nicod J, et al. Apparent mineralocorticoid
excess: report of six new cases and extensive personal
experience. J Am Soc Nephrol (2006) 17:3176–84.
10.1681/ASN.2006060570 [PubMed] [CrossRef] [Google
Scholar]
[5] Lavery GG, Ronconi V, Draper N, Rabbitt EH, Lyons V,
Chapman KE, et al. Late-onset apparent mineralocorticoid
excess caused by novel compound heterozygous mutations
in the HSD11B2 gene. Hypertension (2003) 42:123–9.
10.1161/01.HYP.0000083340.57063.35 [PubMed]
[CrossRef] [Google Scholar]
[6] Geller DS, Farhi A, Pinkerton N, Fradley M, Moritz M,
Spitzer A, et al. Activating mineralocorticoid receptor
mutation in hypertension exacerbated by pregnancy. Science
(2000) 289:119–23. 10.1126/science.289.5476.119
[PubMed] [CrossRef] [Google Scholar]
[7] White PC, Curnow KM, Pascoe L. Disorders of steroid 11
beta-hydroxylase isozymes. Endocr Rev (1994) 15:421–38.
10.1210/edrv-15-4-421 [PubMed] [CrossRef] [Google
Scholar]
[8] Rossier BC, Schild L. Epithelial sodium channel: Mendelian
versus essential hypertension. Hypertension (2008) 52:595–
600. 10.1161/HYPERTENSIONAHA.107.097147
[PubMed] [CrossRef] [Google Scholar]
[9] Yang C-L, Zhu X, Wang Z, Subramanya AR, Ellison DH.
Mechanisms of WNK1 and WNK4 interaction in the
regulation of thiazide-sensitive NaCl cotransport. J Clin
Invest (2005) 115:1379–87. 10.1172/JCI22452 [PMC free
article] [PubMed] [CrossRef] [Google Scholar]
[10] Kahle KT, Ring AM, Lifton RP. Molecular physiology of
the WNK kinases. Annu Rev Physiol (2008) 70:329–55.
10.1146/annurev.physiol.70.113006.100651 [PubMed]
[CrossRef] [Google Scholar]
[11] Gordon RD. Syndrome of hypertension and hyperkalemia
with normal glomerular filtration rate. Hypertension (1986)
8:93–102. [PubMed] [Google Scholar]
[12] Manning AK, LaValley M, Liu C-T, et al. Meta-analysis of
Gene-Environment interaction: joint estimation of SNP and
SNP×Environment regression coefficients. Genetic
Epidemiology. 2011;35 (1):11–18. doi: 10.1002/gepi.20546.
This paper lays the foundation for meta-analytic procedures
for genome-wide association studies to investigate gene-
environment interactions with a working application in type
2 diabetes research. [PMC free article] [PubMed]
[CrossRef] [Google Scholar]
[13] Thomas D. Gene-Environment-Wide Association Studies:
Emerging Approaches. Nature reviews Genetics. 2010;11
(4):259–272. doi: 10.1038/nrg2764. [PMC free article]
[PubMed] [CrossRef] [Google Scholar]
[14] Cox D. Interaction. International Statistical Review/Revue
Internationale De Statistique. 1984;52 (1):1–24.
http://www.jstor.org/stable/1403235. [Google Scholar]
[15] Ottman R. An Epidemiologic Approach to Gene-
Environment Interaction. Genetic epidemiology. 1990;7
(3):177. doi: 10.1002/gepi.1370070302. [PMC free article]
[PubMed] [CrossRef] [Google Scholar]
[16] Hunter DJ. Gene-environment interactions in human
diseases. Nat Rev Genet. 2005; 6:287–98. doi:
10.1038/nrg1578. [PubMed] [CrossRef] [Google Scholar]
[17] Engelman CD, Baurley JW, Chiu Y-F, et al. Detecting
Gene-Environment Interactions in Genome-Wide
Association Data. Genetic Epidemiology. 2009;33(Suppl
1):68–73. doi: 10.1002/gepi.20475. [PMC free article]
[PubMed] [CrossRef] [Google Scholar]
[18] Goldman D, Oroszi G, Ducci F. The genetics of addictions:
uncovering the genes. Nature Reviews Genetics. 2005;
6:521–532. [PubMed] [Google Scholar]
[19] Dudbridge F, Fletcher O. Gene-Environment Dependence
Creates Spurious Gene-Environment Interaction. American
Journal of Human Genetics. 2014;95 (3):301–307. doi:
10.1016/j.ajhg.2014.07.014. [PMC free article] [PubMed]
[CrossRef] [Google Scholar]
[20] García-Closas M, Thompson WD, Robins JM. Differential
misclassification and the assessment of gene-environment
interactions in case-control studies. Am J Epidemiol. 1998;
1475:426–433. [PubMed] [Google Scholar]
[21] Hein R, Beckmann L, Chang-Claude J. Sample size
requirements for indirect association studies of gene-
environment interactions (G × E) Genet Epidemiol. 2008;
32:235–245. [PubMed] [Google Scholar]
[22] Devlin B, Roeder K. Genomic Control for Association
Studies. Biometrics. 1999;55(4):997–1004. doi:
10.1111/j.0006-341X.1999.00997. x. [PubMed] [CrossRef]
[Google Scholar]
[23] Ioannidis JP, Trikalinos TA, Khoury MJ. Implications of
small effect sizes of individual genetic variants on the
design and interpretation of genetic association studies of
complex diseases. Am J Epidemiol. 2006; 164:609–614.
[PubMed] [Google Scholar]
[24] Becker BJ, Wu M-J. The Synthesis of Regression Slopes in
Meta-Analysis. Statistical Science. 2007;22 (3):414–429.
doi: 10.1214/07-STS243.
http://projecteuclid.org/euclid.ss/1199285041. [CrossRef]
[Google Scholar