The document provides an overview of the key factors that led to the rise of the Renaissance in Western Europe between 1300-1600 CE. It discusses how increased trade and the growth of powerful city-states in Italy, new forms of stronger central government, changes in the power and influence of the Catholic Church, and the impact of the Black Death plague all contributed to the transition from the medieval period and the "rebirth" of interest in classical Greco-Roman thought and emphasis on human potential and secular achievements that characterized the Renaissance.