Michael Braxenthaler, president of the Pistoia Alliance, introduces the concept of the information ecosystem in life science research and discusses the role the Pistoia Alliance can play within this ecosystem. The workshop occurred in October 2011.
Emerging Life Sciences Collaboration on Common Service SpecificationPistoia Alliance
Presentation by Pistoia Alliance reps Ian Harrow (Pfizer) and Nick Lynch (AstraZeneca) at the International Conference on Trends for Scientific Information Professionals, October 2010.
Emerging Life Sciences Collaboration on Common Service SpecificationPistoia Alliance
Presentation by Pistoia Alliance reps Ian Harrow (Pfizer) and Nick Lynch (AstraZeneca) at the International Conference on Trends for Scientific Information Professionals, October 2010.
The Status of CCS 2011 Report - Victor Der - Global CCS Institute – Nov 2011 ...Global CCS Institute
As a part of the Institute's strategic focus on assisting CCS projects through knowledge sharing, three North American roadshow events will help the industry share project experiences and knowledge about CCS. Taking place in the US and Canada, the three events include:
• Austin, Texas on November 8, 2011;
• Calgary, Canada on 10 November, 2011; and
• Washington, D.C. on 19 January, 2012.
The first roadshow focused on sharing project experiences and knowledge from the projects in North America but also brought in projects from Europe (Don valley) and Australia (Callide) so that regionally diverse experiences could be shared amongst a global audience.
Attendance at the event was around 30 to 35 which allowed open and frank discussions around technical, management, and regulatory issues and how these challenges can impact on a project’s advancement and decision making processes.
TransAlta Corporation – Project Pioneer CCS in the Power Sector – Don Wharton...Global CCS Institute
As a part of the Institute's strategic focus on assisting CCS projects through knowledge sharing, three North American roadshow events will help the industry share project experiences and knowledge about CCS. Taking place in the US and Canada, the three events include:
• Austin, Texas on November 8, 2011;
• Calgary, Canada on 10 November, 2011; and
• Washington, D.C. on 19 January, 2012.
The first roadshow focused on sharing project experiences and knowledge from the projects in North America but also brought in projects from Europe (Don valley) and Australia (Callide) so that regionally diverse experiences could be shared amongst a global audience.
Attendance at the event was around 30 to 35 which allowed open and frank discussions around technical, management, and regulatory issues and how these challenges can impact on a project’s advancement and decision making processes.
The Pistoia Alliance Biology Domain Strategy April 2011Pistoia Alliance
Michael Braxenthaler (Roche and external liaison officer for Pistoia) describes the Pistoia Alliance biology domain strategy at the first Pistoia Alliance Conference in April 2011.
Notes taken to support breakout discussion of possible business models necessary to support the information ecosystem in life science R&D during the Pistoia Alliance Information Ecosystem Workshop in October 2011.
David Klatte (Pfizer) presented on this potential new working group during the "Dragons' Den" portion of the Pistoia Alliance Conference in Boston, MA, on April 24, 2012.
Resource Description Framework Approach to Data Publication and FederationPistoia Alliance
Bob Stanley, CEO, IO Informatics, explains the utility to RDF as a standard way of defining and redefining data that could have utility in managing life science information.
The Pistoia Alliance: Strategy, Progress, MomentumPistoia Alliance
Pistoia Alliance Board Member Ramesh Durvasula of BMS provides an overview of the Pistoia Alliance and project status at the BioITWorld Expo in Boston on April 13, 2011.
The Pistoia Alliance: Update on Strategy and ProgressPistoia Alliance
Ramesh Durvasula, Pistoia Alliance board member, discusses the Pistoia Alliance mission and recaps activities in 2011-12, with particular emphasis on the successful completion of the Sequence Squeeze Competition and Sequence Services Phase 2. The presentation was delivered at BioITWorld in Boston in April 2012.
The Status of CCS 2011 Report - Victor Der - Global CCS Institute – Nov 2011 ...Global CCS Institute
As a part of the Institute's strategic focus on assisting CCS projects through knowledge sharing, three North American roadshow events will help the industry share project experiences and knowledge about CCS. Taking place in the US and Canada, the three events include:
• Austin, Texas on November 8, 2011;
• Calgary, Canada on 10 November, 2011; and
• Washington, D.C. on 19 January, 2012.
The first roadshow focused on sharing project experiences and knowledge from the projects in North America but also brought in projects from Europe (Don valley) and Australia (Callide) so that regionally diverse experiences could be shared amongst a global audience.
Attendance at the event was around 30 to 35 which allowed open and frank discussions around technical, management, and regulatory issues and how these challenges can impact on a project’s advancement and decision making processes.
TransAlta Corporation – Project Pioneer CCS in the Power Sector – Don Wharton...Global CCS Institute
As a part of the Institute's strategic focus on assisting CCS projects through knowledge sharing, three North American roadshow events will help the industry share project experiences and knowledge about CCS. Taking place in the US and Canada, the three events include:
• Austin, Texas on November 8, 2011;
• Calgary, Canada on 10 November, 2011; and
• Washington, D.C. on 19 January, 2012.
The first roadshow focused on sharing project experiences and knowledge from the projects in North America but also brought in projects from Europe (Don valley) and Australia (Callide) so that regionally diverse experiences could be shared amongst a global audience.
Attendance at the event was around 30 to 35 which allowed open and frank discussions around technical, management, and regulatory issues and how these challenges can impact on a project’s advancement and decision making processes.
The Pistoia Alliance Biology Domain Strategy April 2011Pistoia Alliance
Michael Braxenthaler (Roche and external liaison officer for Pistoia) describes the Pistoia Alliance biology domain strategy at the first Pistoia Alliance Conference in April 2011.
Notes taken to support breakout discussion of possible business models necessary to support the information ecosystem in life science R&D during the Pistoia Alliance Information Ecosystem Workshop in October 2011.
David Klatte (Pfizer) presented on this potential new working group during the "Dragons' Den" portion of the Pistoia Alliance Conference in Boston, MA, on April 24, 2012.
Resource Description Framework Approach to Data Publication and FederationPistoia Alliance
Bob Stanley, CEO, IO Informatics, explains the utility to RDF as a standard way of defining and redefining data that could have utility in managing life science information.
The Pistoia Alliance: Strategy, Progress, MomentumPistoia Alliance
Pistoia Alliance Board Member Ramesh Durvasula of BMS provides an overview of the Pistoia Alliance and project status at the BioITWorld Expo in Boston on April 13, 2011.
The Pistoia Alliance: Update on Strategy and ProgressPistoia Alliance
Ramesh Durvasula, Pistoia Alliance board member, discusses the Pistoia Alliance mission and recaps activities in 2011-12, with particular emphasis on the successful completion of the Sequence Squeeze Competition and Sequence Services Phase 2. The presentation was delivered at BioITWorld in Boston in April 2012.
Pistoia Alliance SESL pilot Bio IT World Hanover 12 Oct 2011Ian Harrow
Towards a brokering framework for knowledge-based services: learning from the Pistoia Alliance SESL pilot
Ian Harrow PhD for the Pistoia Alliance
This presentation describes a pilot project to determine the feasibility of biomedical knowledge brokering. It shows query across multiple disparate data sources through a brokering demonstrator built from RDF triple store technology. The learning from this pilot is contributing to larger scale projects such as the Innovative Medicines Initiative, OpenPFACTs.
Towards a brokering framework for knowledge-based services: Learning from the...Pistoia Alliance
Ian Harrow, co-leader of the Pistoia Alliance SESL pilot, describes the vision for the SESL pilot, the outcomes, and the project's future. The presentation at the 2011 BioITWorld Conference and Expo included a link to the SESL public demonstrator.
Richard Bolton (GSK and Pistoia's ELN query services workstream coordinator) discusses the Alliance's chemistry strategy, which includes ELN query standards, hosted ELN, and chemistry externalization faciliation
Sources of innovations have considerably changed in the past. How can policy makers react? What are the key desing features of new innovation support schemes. Based on the so called ANIS approach, regional innovation systems can be analysed and appropriate innovation support schemes developed.
Open Entrepreneurship_Teigland, Di Gangi, YetisRobin Teigland
Our presentation at the Innovation and Market Creation in and around Virtual Worlds in May 2012 at Copenhagen Business School. More information here: http://nordicworlds.net/2012/04/13/innovation-and-market-creation-in-and-around-virtual-worlds-2/.
PPP in Research Development and Innovation for the Southern MediterraneanWesley Schwalje
The European Investment Bank used our research as background for its presentation on PPPs in Research Development and Innovation for the Southern Mediterranean region citing our work as the rationale for improved skill creation; increased technology transfer through FDI; employment creation; and enhanced regulatory framework for business.
Similar to The Pistoia Alliance Information Ecosystem Workshop (20)
Fairification experience clarifying the semantics of data matricesPistoia Alliance
This webinar presents the Statistics Ontology, STATO which is a semantic framework to support the creation of standardized analysis reports to help with review of results in the form of data matrices. STATO includes a hierarchy of classes and a vocabulary for annotating statistical methods used in life, natural and biomedical sciences investigations, text mining and statistical analyses.
Innovation applications of microphysiological systems (MPS) have been growing over the past decade, especially with respect to the use of complex human tissues for assessing safety of drug candidates – but broad industry adoption of MPS methods has not yet become a reality.
This webinar addresses some recent advances in MPS development and begins to explore the barriers to increased incorporation of MPS to improve drug safety assessment and to provide safer, more effective drugs into the clinical pipeline.
Federated Learning (FL) is a learning paradigm that enables collaborative learning without centralizing datasets. In this webinar, NVIDIA present the concept of FL and discuss how it can help overcome some of the barriers seen in the development of AI-based solutions for pharma, genomics and healthcare. Following the presentation, the panel debate on other elements that could drive the adoption of digital approaches more widely and help answer currently intractable science and business questions.
It seems that AI is also becoming a buzzword, like design thinking. Everyone is talking about AI or wants to have AI, and sees all the ideas and benefits – that’s fine, but how do you get started? But what’s different now? Three innovations have finally put AI on the fast track: Big Data, with the internet and sensors everywhere; massive computing power, especially through the Cloud; and the development of breakthrough algorithms, so computers can be trained to accomplish more sophisticated tasks on their own with deep learning. If you use new technology, you need to explore and know what’s possible. With design thinking, it aids to outline the steps and define the ways in which you’re going to create the solution. Starting with mapping the customer journey, defining who will be using that service enhanced with intelligent technology, or who will benefit and gain value from it. We discuss how these two worlds are coming together, and how you get started to transform your venture with Artificial Intelligence using Design Thinking.
Speaker: Claudio Mirti, Principal Solution Specialist – Data & AI, Microsoft
Themes and objectives:
To position FAIR as a key enabler to automate and accelerate R&D process workflows
FAIR Implementation within the context of a use case
Grounded in precise outcomes (e.g. faster and bigger science / more reuse of data to enhance value / increased ability to share data for collaboration and partnership)
To make data actionable through FAIR interoperability
Speakers:
Mathew Woodwark,Head of Data Infrastructure and Tools, Data Science & AI, AstraZeneca
Erik Schultes, International Science Coordinator, GO-FAIR
Georges Heiter, Founder & CEO, Databiology
Knowledge graphs ilaria maresi the hyve 23apr2020Pistoia Alliance
Data for drug discovery and healthcare is often trapped in silos which hampers effective interpretation and reuse. To remedy this, such data needs to be linked both internally and to external sources to make a FAIR data landscape which can power semantic models and knowledge graphs.
2020.04.07 automated molecular design and the bradshaw platform webinarPistoia Alliance
This presentation described how data-driven chemoinformatics methods may automate much of what has historically been done by a medicinal chemist. It explored what is reasonable to expect “AI” approaches might achieve, and what is best left with a human expert. The implications of automation for the human-machine interface were explored and illustrated with examples from Bradshaw, GSK’s experimental automated design environment.
This presentation reviewed the challenges in identifying, acquiring and utilizing research data in relation to an evolving data market. Strategic solutions were examined in which the FAIR principles play a key role in the future of data management.
Dr. Dennis Wang discusses possible ways to enable ML methods to be more powerful for discovery and to reduce ambiguity within translational medicine, allowing data-informed decision-making to deliver the next generation of diagnostics and therapeutics to patients quicker, at lowered costs, and at scale.
The talk by Dr. Dennis Wang was followed by a panel discussion with Mr. Albert Wang, M. Eng., Head, IT Business Partner, Translational Research & Technologies, Bristol-Myers Squibb.
With the explosion of interest in both enhanced knowledge management and open science, the past few years have seen considerable discussion about making scientific data “FAIR” — findable, accessible, interoperable, and reusable. The problem is that most scientific datasets are not FAIR. When left to their own devices, scientists do an absolutely terrible job creating the metadata that describe the experimental datasets that make their way in online repositories. The lack of standardization makes it extremely difficult for other investigators to locate relevant datasets, to re-analyse them, and to integrate those datasets with other data. The Center for Expanded Data Annotation and Retrieval (CEDAR) has the goal of enhancing the authoring of experimental metadata to make online datasets more useful to the scientific community. The CEDAR work bench for metadata management will be presented in this webinar. CEDAR illustrates the importance of semantic technology to driving open science. It also demonstrates a means for simplifying access to scientific data sets and enhancing the reuse of the data to drive new discoveries.
Open interoperability standards, tools and services at EMBL-EBIPistoia Alliance
In this webinar Dr Henriette Harmse from EMBL-EBI presents how they are using their ontology services at EMBL-EBI to scale up the annotation of data and deliver added value through ontologies and semantics to their users.
Fair webinar, Ted slater: progress towards commercial fair data products and ...Pistoia Alliance
Elsevier is a global information analytics business that helps institutions and professional’s
advance healthcare and open science to improve performance for the benefit of humanity.
In this webinar, we discuss how Elsevier is increasingly leveraging the FAIR Guiding Principles to improve its products and services to better serve the scientific community.
Application of recently developed FAIR metrics to the ELIXIR Core Data ResourcesPistoia Alliance
The FAIR (Findable, Accessible, Interoperable and Reusable) principles aim to maximize the discovery and reuse of digital resources. Using recently developed software and metrics to assess FAIRness and supported through an ELIXIR Implementation Study, Michel worked with a subset of ELIXIR Core Data Resources to apply these technologies. In this webinar, he will discuss their approach, findings, and lessons learned towards the understanding and promotion of the FAIR principles.
Implementing Blockchain applications in healthcarePistoia Alliance
Blockchain technology can revolutionise the way information is exchanged between parties by bringing an unprecedented level of security and trust to these transactions. The technology is finding its way into multiple use cases but we are yet to see full adoption and real-world business implementation in the Healthcare industry.
In this webinar we will explore the main challenges and considerations for the implementation of Blockchain technology in Healthcare use cases. This is the third webinar in our Blockchain Education series.
Building trust and accountability - the role User Experience design can play ...Pistoia Alliance
In this webinar our panel of UX specialists give a brief introduction to User Experience before presenting the design opportunities UX can bring to AI. We all know that AI has great potential but has some significant hurdles to overcome not least so the human aspect of trust and ethical considerations when designing in the life sciences.
In the late Fall and Winter of 2018, the Pistoia Alliance in cooperation with Elsevier and charitable organizations Cures within Reach and Mission: Cure ran a datathon aiming to find drugs suitable for treatment of childhood chronic pancreatitis, a rare disease that causes extreme suffering. The datathon resulted in identification of four candidate compounds in a short time frame of just under three months. In this webinar our speakers discuss the technologies that made this leap possible
PA webinar on benefits & costs of FAIR implementation in life sciences Pistoia Alliance
The slides from the Pistoia Alliance Debates Webinar where a panel of experts from technology support providers and the biopharma industry, who have been invited to share their views on the "Benefits and costs of FAIR Implementation for life science industry".
Creating novel drugs is an extraordinarily hard and complex problem.
One of the many challenges in drug design is the sheer size of the search space for novel chemical compounds. Scientists need to find molecules that are active toward a biological target or pathway and at the same time have acceptable ADMET properties.
There is now considerable research going on using various AI and ML approaches to tackle these challenges.
Our distinguished speakers, Drs. Alex Tropsha and Ola Engkvist, will discuss their recent work in Drug Design involving Deep Reinforcement Learning and Neural Networks, and will answer questions from the audience on the current state of the research in the field.
Speakers:
Prof Alex Tropsha, Professor at University of North Carolina at Chapel Hill, USA
Dr. Ola Engkvist, Associate Director at AstraZeneca R&D, Gothenburg, Sweden
GraphSummit Singapore | The Future of Agility: Supercharging Digital Transfor...Neo4j
Leonard Jayamohan, Partner & Generative AI Lead, Deloitte
This keynote will reveal how Deloitte leverages Neo4j’s graph power for groundbreaking digital twin solutions, achieving a staggering 100x performance boost. Discover the essential role knowledge graphs play in successful generative AI implementations. Plus, get an exclusive look at an innovative Neo4j + Generative AI solution Deloitte is developing in-house.
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
Elevating Tactical DDD Patterns Through Object CalisthenicsDorra BARTAGUIZ
After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
SAP Sapphire 2024 - ASUG301 building better apps with SAP Fiori.pdfPeter Spielvogel
Building better applications for business users with SAP Fiori.
• What is SAP Fiori and why it matters to you
• How a better user experience drives measurable business benefits
• How to get started with SAP Fiori today
• How SAP Fiori elements accelerates application development
• How SAP Build Code includes SAP Fiori tools and other generative artificial intelligence capabilities
• How SAP Fiori paves the way for using AI in SAP apps
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...SOFTTECHHUB
The choice of an operating system plays a pivotal role in shaping our computing experience. For decades, Microsoft's Windows has dominated the market, offering a familiar and widely adopted platform for personal and professional use. However, as technological advancements continue to push the boundaries of innovation, alternative operating systems have emerged, challenging the status quo and offering users a fresh perspective on computing.
One such alternative that has garnered significant attention and acclaim is Nitrux Linux 3.5.0, a sleek, powerful, and user-friendly Linux distribution that promises to redefine the way we interact with our devices. With its focus on performance, security, and customization, Nitrux Linux presents a compelling case for those seeking to break free from the constraints of proprietary software and embrace the freedom and flexibility of open-source computing.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Climate Impact of Software Testing at Nordic Testing DaysKari Kakkonen
My slides at Nordic Testing Days 6.6.2024
Climate impact / sustainability of software testing discussed on the talk. ICT and testing must carry their part of global responsibility to help with the climat warming. We can minimize the carbon footprint but we can also have a carbon handprint, a positive impact on the climate. Quality characteristics can be added with sustainability, and then measured continuously. Test environments can be used less, and in smaller scale and on demand. Test techniques can be used in optimizing or minimizing number of tests. Test automation can be used to speed up testing.
Alt. GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using ...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
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The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
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Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
GridMate - End to end testing is a critical piece to ensure quality and avoid...ThomasParaiso2
End to end testing is a critical piece to ensure quality and avoid regressions. In this session, we share our journey building an E2E testing pipeline for GridMate components (LWC and Aura) using Cypress, JSForce, FakerJS…
Communications Mining Series - Zero to Hero - Session 1DianaGray10
This session provides introduction to UiPath Communication Mining, importance and platform overview. You will acquire a good understand of the phases in Communication Mining as we go over the platform with you. Topics covered:
• Communication Mining Overview
• Why is it important?
• How can it help today’s business and the benefits
• Phases in Communication Mining
• Demo on Platform overview
• Q/A
5. Life Science Information Landscape
A rapidly evolving ecosystem
Yesterday Today Tomorrow
Big Life
Science
Company
Yesterday Today Tomorrow
Innovation Innovation inside Searching for Innovation Heterogeneity of collaborations. Part
of the wider ecosystem
Model
IT Internal apps & data Struggling with change Cloud/Services
Security and Trust
Data Mostly inside In and Out Distributed
Portfolio Internally driven and owned Partially shared Shared portfolio
5
6. The Pistoia Mission
Lowering the barriers to
innovation
by improving inter-operability of
R&D business processes
through pre competitive
collaboration
6
7. The Role of Pistoia: Node or ”Glue”?
Proprietary
• Pistoia is not a node in
content
Public provider its own right
content
provider • Pistoia supports the
connections between
the nodes
CRO • Pistoia‟s strength is its
diversity of
Regulatory members, representing
authorities substantial parts of this
Academic ecosystem
group
Service provider
Software vendor
7
9. Pistoia Project Portfolio Questionnaire – Summary
Contribute Users Contribute a
Contribute
Analysis out of 22 Question # Interested? to define Project
Funding?
Requirements? Manager?
Chemistry - Collaboration
2 15 8 1 1
Backbone
Chemistry - (Hosted) Ordering
3 9 4 3 1
/ Requesting Services
Chemistry - Hosted ELN and
4 12 6 1 1
Services
Chemistry - Collaboration
5 9 5 0 1
Brokering
Chemistry - Analytical Data
6 11 7 1 2
Standards
Chemistry - Hosted
7 12 4 1 0
Registration Services
Life Sciences - Information
Ecosystem Workshop
8 19 13 8 2
Projects which are important
9 7 1 1 1
to you /your company.
10. Workshop Agenda and Deliverables Outline
Morning session: Afternoon session:
What is the IES? What should it be? How do we get there?
Develop common understanding on what Develop a roadmap of projects and
the IES should deliver activities
White Paper: IES Roadmap:
The Key Concepts Projects and
of the Information Ecosystem Follow-up activities
More info at http://pistoiaalliance.org/2011-Events/infoecoworkshop.html
11. Morning Session
Overarching theme:
Develop a shared understanding of the problem space:
What does ‘information ecosystem’ mean?
What are the current shortcomings?
What should it look like to help us solve our problems?
• Workgroup 1: The industry/academic collaboration space
• Workgroup 2: Information exchange with CROs – discovery/chemistry
• Workgroup 3: Information exchange with CROs – biology/NCD
• Workgroup 4: Integration of public and proprietary content
• Workgroup 5: The Standards Landscape
12. AM Workgroup 1
The industry/academic collaboration space
• Increasing number of bi- and multilateral collaborations between
life science companies and academic groups.
• Need for collaboration space
– Not just sharing and exchange of documents and data
– Secure, „science-aware‟ collaboration environment
– Allows collaborative data analysis and discussion
– Easy and fast way to spin up and turn off instances
What would such a space ideally look like?
What are the minimal and optimal requirements for such a space?
13. AM Workgroup 2
Information exchange with CROs – discovery/chemistry
• See use case “Research Externalization on a Collaborative
Framework”
14. Use Case “Research Externalization
on a Collaborative Framework”
Introduction:
Declining R&D productivity, rising costs of commercialization &
shorter exclusivity period have driven up the average cost of
launching a successful new drug to US $ 1.7 billion. To facilitate drug
development & to lower the cost & risk of launching new drugs on
their own, pharmaceutical companies have increasingly turned to
alliances for outsourcing.
Actors:
Pharmaceutical Company, Scientist, Regulatory body, Discovery
CRO, Chemistry service providers, Biology service provider, assay
development, screening, lead optimization & other vendors.
14
15. Use Case “Research Externalization
on a Collaborative Framework” (cont‟d - 1)
Scenario:
Target molecule has been discovered & validated by pharmaceutical
company‟s internal R&D department. Lead identification requires
expertise, specialized skills, and heavy investments on resources/technology.
There already exist vendors in the market with
resources/technology/expertise in dedicated areas. Hence the
pharmaceutical company decides to externalize the different components of
lead identification process to multiple capable vendors, thereby resulting in
reduced cost, time and overcoming lack of in-house expertise/resources.
The diagram below depicts a scenario indicating a transition from a
siloed/fully internal approach to a collaborative model which enables
multiple pharma‟s to externalize their research activities to multiple
organizations in a secured manner.
15
16. Use Case “Research Externalization
on a Collaborative Framework” (cont‟d – 2)
Pharma
Design synthesize Register Distribute Assay Report
Fully Internal Model
CRO
Pharma
1 Design Distribute
Pharma 1
CRO Chem
CRO
Synthesize
2
Pharma 2
CRO
Bio
Assay
CRO
Pharma 3 3
Data
CRO
Register Report
CRO
4
Selectively Integrated Model
16
17. Use Case “Research Externalization
on a Collaborative Framework” (cont‟d - 3)
The current industry challenges to execute the above scenario on
a collaborative framework are:
• Secured real time information exchange
• IP Protection & infringement
• Process & Data harmonization
• Lack of standard data formats
• Lack of regulatory guidelines around collaboration & networking
Summary:
This collaborative model would not only drive seamless research
externalization, but also enable access to information/experts, real time
learning‟s, reuse/sharing of internal assets, increase research
productivity, focused approach, effective process tracking, shared workspace
for secured communication and risk mitigation.
17
18. AM Workgroup 3
Information exchange with CROs – biology/NCD
• Currently, data exchange between life science companies and CROs
requires substantial manual involvement
– data formatting issues
– meta data and context for interpretation
• Many areas in the R&D process affected
– Genotyping, NGS, Proteomics, Metabolomics, Preclinical Safety - Animal Studies
What would the ideal exchange environment look like?
• Are data and meta data standards sufficient?
• Or would this environment benefit from a collaboration space
allowing collaborative data access for QC and interpretation?
19. AM Workgroup 4
Integration of public and proprietary content
• Increasingly large volumes of relevant data for life science R&D are
available in the public domain.
• Tendency increasing in volume, complexity, and
geographic/organizational distribution
• Conventional approach to bring all relevant data in-house for
integration and analysis will not be feasible in the future
What are sustainable models for environments which enable
integrated analysis and interpretation of distributed complex data?
See also use case “Disease Explorer”
20. Use Case “Disease Explorer”
There is a need to be able to "peel away" layers of information around a
disease. For example:
• For a given indication, what are the higher-level pathophysiological processes?
• For each process, what are the cells, tissues and events within?
• To what elements of the disease does each process contribute
(initiation, progression, exacerbation etc.)
• How does this then break down into molecular pathways?
• Where are current therapies targetted?
• Are we all targeting the same few pathways in the same process?
• Are there processes that are completely untested?
• How does the literature map onto this?
• Where are the new emerging areas?
• Where are the overlaps between diseases? Aan obvious example being the
repurposing of viagra due to the enzyme, PDE5 s control of cyclic GMP, and that
cGMP is involved in sleeping, diabetes etc.)
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21. Use Case “Disease Explorer” (cont‟d)
Conclusion:
• We should have information systems able to explore disease through
different levels of resolution and map databases accordingly.
• This requires a functioning information eco-system, where the data is
mapped to standards that facilitate this exploration and there is a wide
body of developers producing elements of this "browser".
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22. AM Workgroup 5
The Standards Landscape
• Many standards exist or are being developed in the life science
information space
• At the same time there are many calls for standards to enable
information exchange/sharing/integration
What does the current standards landscape look like?
What are the key issues with the current standard landscape?
Too many? (where?)
Missing? (where?)
Problems with agreement/adoption?
23. Pistoia Project Portfolio Questionnaire – Summary
Contribute Users Contribute a
Contribute
Analysis out of 22 Question # Interested? to define Project
Funding?
Requirements? Manager?
Chemistry - Collaboration
2 15 8 1 1
Backbone
Chemistry - (Hosted) Ordering
3 9 4 3 1
/ Requesting Services
Chemistry - Hosted ELN and
4 12 6 1 1
Services
Chemistry - Collaboration
5 9 5 0 1
Brokering
Chemistry - Analytical Data
6 11 7 1 2
Standards
Chemistry - Hosted
7 12 4 1 0
Registration Services
Life Sciences - Information
Ecosystem Workshop
8 19 13 8 2
Projects which are important
9 7 1 1 1
to you /your company.
24. Open Question - 9
At GQ we believe that both sequencing and sequencing analysis/data management are pre-competitive. To date,
Pistoia has focused only on basic sequence analysis. I know Integration the sequence piece will include NGS.
that phase II of of public
1
However, I like the way you outlined the chemistry piece above, much more life-cycle centric. I’d argue you
should do the same with NGS Sequencing and NGS Informatics.
and proprietary
content
2 Interested in the Semantic Web
It’s important that Pistoia picks a few key projects and nails them now, so a general steer would be not to dilute
3 efforts or become over ambitious now. Put maximum energy and resource into a small number of projects and
ensure success to ‘prove’ Pistoia works.
Information
Multi-party collaboration, project management, reporting tools including hosted, cloud-based or internal platforms.
Multi-vendor integration approaches. Multi-discipline datawith CROs
exchange integration.
4
5 Pharma is moving towards externalization and the key to success is a standardized, scalable collaboration backbone.
6 Platform for sharing in-house code externally
7
Standards
SEND (the CDISC standard for non-clinical data) Tox/DMPK area - Archiving
8
(Pistoia certification?)
Standardisation of clinical data format (by this comment was meant the exchange of information with CROs)
9 Standards are important to us, as are projects involving making data more accessible to end users.
We are very interested in external collaborative systems. However our current focus is to 'find' a vendor already in
Information
this space and ensure that the Vendor is driven by open standards (where they exist). I hope that Pistoia will
exchange with CROs
eventually lead to a standards body for data sharing formats. Perhaps our goal should be to have Vendors proud to
10
bear the mark 'Verified by Pistoia'. I wonder where this fits into the various standards coming from W3C? The list
above does not yet seem to ask questions regarding data formats for Assay/Protocol transfer. I think this is a
critical issue when collaborating with multiple organisations. Is there a project looking into this?
11 We focus on services around workflows for data integration/analysis, moving towards self-service workflows.
25. Afternoon Session
Overarching theme:
Develop solution outlines to address the current problems:
Proposals for short term projects and mid term activities
Looking beyond the scientific-technical horizon: Economic
feasibility and viable business models
• Workgroups 1 and 2: Low-hanging fruit – What can we tackle right away
within a 1-year time frame?
• Workgroup 3: Continuing focus areas and mid-term activities – How do
we approach more complex problems?
• Workgroup 4: The Standards Landscape – What needs to be done?
• Workgroup 5: Business Models – Rethinking the game
26. Let‟s go!
Time to break up into groups and
get our hands dirty…
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