Title: The Ondex Data Integration Framework Author: Jan Taubert

1. The ONDEX data integration framework BOSC2007, Vienna 20.07.2007 Jan Taubert ( [email_address] ) Rothamsted Research, UK

5. combine Large Experimental Data New Insights ONDEX Motivation 100‘s of Bio-Databases

6. … in which nodes and edges can have different properties. enzyme kinetics protein interactions metabolic pathways protein structure relation properties ontologies Everything is a network

7. ONDEX: Graph of Concepts and Relations Biology: Protein interaction network Ontology of Concept Classes, Relation Types and additional Properties Properties: compound name, protein sequence, protein structure, cellular component, KM-value, PH optimum … Protein – Ligand interaction network Protein Ligand interact Protein interact Concept Concept Concept Relation Relation Concept Class: Protein Protein Ligand Relation Type: interact interact Ontology based graph

9. Microarray experiment result analysis map 100‘s of Bio-Databases One example application

10. Comp Protein Gene Enzyme EC Treat- ment Reaction Pathway

11. Treatments from DRASTIC Pathways from KEGG

13. Good : Write Flatfile parser for ONDEX Better : Provide your database in OXL (see Taubert et al. (2007) “Exchange of integrated datasets – the OXL format”, in press, IB2007) Also welcome : Provide your database in another standard (BioPax, SBML, XGMML; but may result in loss of information) http://ondex.sourceforge.net What to contribute

14. Algorithms : Needed for the alignment of integrated data Core : Improve persistency layer of Ontology based graph Exporter : Provide your own exchange standard Webservices : Increase compatibility http://ondex.sourceforge.net What to contribute

15. http://ondex.sourceforge.net Support : OXL in your application Connect : Import from web service or directly from Core API Algorithms : Graph analysis using the ONDEX Visualisation and Analysis Tool Kit (OVTK) Feedback & Feature requests : Mailing lists and Sourceforge.net What to contribute

16. Jun 06 – Jun 07: 1828 Downloads, 15289 page views Current SF.net rank: 1074 Subversion Activity Jan 07 – Jun 07 8904 Reads 2072 Writes 4821 File Uploads Developer mailing list : [email_address] User mailing list : [email_address] Current release : 0.9alpha1 Sourceforge.net

17. J Taubert, R Winnenburg, M Hindle, J Weile, J Baumbach, S Philippi, C Rawlings and J Köhler (2007) “Data integration, information filtering and knowledge extraction with ONDEX”, Paper in preparation J Taubert, K P Sieren, M Hindle, B Hoekman, R Winnenburg, S Philippi, C Rawlings and J Köhler (2007) “Exchange of integrated datasets – the OXL format”, Submitted Paper, 4th integrative bioinformatics workshop (IB2007) Jacob Köhler, Stephan Philippi, Michael Specht and Alexander Rüeg (2006) "Ontology based text indexing and querying for the semantic web", Knowledge-Based Systems, Volume 19, Issue 8 Jacob Köhler, Jan Baumbach, Jan Taubert, Michael Specht, Andre Skusa, Alexander Rüegg, Chris Rawlings, Paul Verrier and Stephan Philippi (2006) "Graph-based analysis and visualization of experimental results with ONDEX", Bioinformatics 22(11) Skusa, A., Rüegg, A., Köhler, J. (2005) "Extraction of biological networks from scientific literature", Briefings in Bioinformatics 6(3) Köhler, J., Rawlings, C., Verrier, P., Mitchell, R., Skusa, A., Rüegg, A. and Philippi, S. (2004), "Linking experimental results, biological networks and sequence analysis methods using Ontologies and Generalized Data Structures", In Silico Biol, Volume 5, Special Issue: Ontology and Genome, Manuscript number in online journal: 0005. Publications

18. Centre for Mathematical and Computational Biology Department of Biomathematics and Bioinformatics Rothamsted Research Dr Jacob Köhler, Principle Investigator Prof Chris Rawlings, Head of Department Rothamsted Research is supported by the BBSRC Travel grants and scholarships by Acknowledgements

19. 4 th Integrative Bioinformatics workshop 10th to 12th September 2007 University of Ghent, Belgium http://www.rothamsted.bbsrc.ac.uk/bab/conf/ib07/ Invited speakers: Prof Carole Goble, School of Computer Science, University of Manchester, UK Prof Søren Brunak, BioCentrum-DTU, Technical University of Denmark, Denmark Dr David Searls, Senior Vice President, Informatics, GlaxoSmithKline Pharmaceuticals, USA Dr Luis Serrano, EMBL, Heidelberg, Germany Organising committee : Prof Ralf Hofestädt, University of Bielefeld, Germany (Co-chair) Dr Jacob Koehler, Rothamsted Research, UK (Co-chair) Prof Martin Kuiper, University of Ghent, Belgium (Local organisation) Paul Verrier, Rothamsted Research, UK (Local organisation) Poster submission deadline 27 th August 2007 Registration deadline 13 th August 2007