The document discusses the muscular system, describing the three main types of muscle tissue - skeletal, smooth, and cardiac muscle - and their functions. It examines the structure of skeletal muscle from the organ level down to the molecular level. Key concepts covered include muscle contraction, the roles of actin and myosin fibers, energy sources for muscle work, and effects of aging on muscle mass, fiber number and size, motor units, and performance.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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2. Introduction
2
Three (3) Types of Muscle Tissues
• Skeletal Muscle
• Usually attached to bones
• Under conscious control
(Voluntary)
• Somatic
• Striated
•Smooth Muscle
• Walls of most viscera, blood
vessels and skin
• Not under conscious control
(involuntary)
• Autonomic
• Not striated
• Cardiac Muscle
• Wall of heart
• Not under conscious control
• Autonomic
• Striated
4. Functions of the Muscular
System
Through sustained contraction or alternating contraction and relaxation,
muscle tissue has three key functions:
1. Producing motion
2. Providing stabilization (standing or sitting)
3. Generating heat (generation of heat)
4
5. 1. Motion: Motion is obvious in movements such as walking and running,
and in localized movements, such as grasping a pencil or nodding the
head. These movements rely on the integrated functioning of bones,
joints, and skeletal muscles.
2. Stabilizing body positions and regulating the volume of cavities in the
body: Postural muscles display sustained contractions when a person is
awake, for example, partially contracted neck muscles hold the head
upright. In addition, the volumes of the body cavities are regulated
through the contractions of skeletal muscles. For example muscles of
respiration regulate the volume of the thoracic cavity during the process
of breathing.
3. Thermo genesis : As skeletal muscle contracts to perform work, a by-
product is heat. Much of the heat released by muscle is used to maintain
normal body temperature. Muscle contractions are thought to generate
as much as 85% of all body heat.
5
Functions of the Muscular
System
6. Physiologic Characteristics of
Muscle Tissue
Muscle tissue has four principal characteristics that enable it to carry
out its functions and thus contribute to homeostasis.
1. Excitability (irritability)
2. Contractility
3. Extensibility
4. Elasticity
6
19. Types of contractions
19
• Isotonic: when a muscle contracts and its ends are
pulled closer together.
• Isometric: when a muscle contracts but attachments do
net move.
• Isokinetic: when the force a muscle generates is less
than that required to move or lift an object, the
contraction is called isokinetic.
24. 24
Muscle Fatigue
• Inability to contract muscle
• Commonly caused from:
• Decreased blood flow
• Ion imbalances across the sarcolemma
• Accumulation of lactic acid
• Cramp – sustained, involuntary muscle contraction
• Physiological vs. psychological fatigue
25. The Effects of Ageing
25
• Age-related reductions in muscle mass are a direct cause of
declines in muscle strength with aging. This reduction in muscle
strength is a major cause of disability in the older adult since
strength and power are major components of posture, balance, and
the ability to walk.
26. The Effects of Ageing
26
• Reductions in Muscle Mass
Aging is associated with decreases in total muscle cross-sectional area,
amounting to approximately 40% between the ages of 20 and 80
years.
• Reduction in Muscle Fiber Number
The total number of muscle fibers is significantly reduced with age,
beginning at about 25 years and progressing at an accelerated rate
thereafter. The decline in muscle cross-sectional area is most likely due
to decreases in total fiber number, especially type II fast-twitch
glycolytic fibers. The loss of muscle fibers is followed by a replacement
with fat and fibrous tissue and a gradual increase in non-muscle tissue.
27. The Effects of Ageing
27
• Changes in Muscle Fiber Size
• Motor Unit Number and Size
The average motor neuron loss from the second to tenth decade is
approximately 25%
• Age-Related Changes in Muscle Performance
Including Strength, Power, Endurance
• Blood Flow and Capillarity
The reduction in capillarity has major importance for the ability of
muscle to sustain power output over time.
Excitability (irritability)a property of both muscle and nerve cells (neurons), is the ability to respond to certain stimuli by producing electrical signal called action potentials (impulses). For example, the stimuli that trigger action potentials are chemicals-neurotransmitters, released by neurons, hormones distributed by the blood.
2. Contractility is the ability of muscle tissue to shorten and thicken (contract), thus generating force to do work. Muscles contract in response to one or more muscle action potentials.
3. Extensibility means that the muscle can be extended (stretched) without damaging the tissue. Most skeletal muscles are arranged in opposing pairs. While one is contracting, the other not only relaxed but also usually is being stretched.
4. Elasticity means that muscle tissue tends to return to its original shape after contraction or extension.
A. Connective Tissue Component A skeletal muscle is an organ composed mainly of striated muscle cells and connective tissue. Each skeletal muscle has two parts; the connective tissue sheath that extend to form specialized structures that aid in attaching the muscle to bone and the fleshy part the belly or gaster. The extended specialized structure may take the form of a cord, called a tendon; alternatively, a broad sheet called an aponeurosis may attach muscles to bones or to other muscles, as in the abdomen or across the top of the skull. A connective tissue sheath called facia surrounds and separates muscles (Figure 6-1). Connective tissue also extends into the muscle and divides it into numerous muscle bundles (fascicles). There are three connective tissue components that cover a skeletal muscle tissue. These are: 1. Epimysium─a connective tissue sheath that surrounds and separates muscle. 2. Perimysium─a connective tissue that surrounds and holds fascicles together. 3. Endomysium─a connective tissue that surrounds each muscle fibre
Microscopic structures The muscle bundles are composed of many elongated muscle cells called muscle fibres. Each muscle fibre is a cylindrical cell containing several nuclei located immediately beneath the cell membrane (sarcolemma). The cytoplasm of each muscle fibre (sarcoplasm) is filled with myofibrils. Each myofibril is a thread-like structure that extends from one end of the muscle fibre to the other. Myofibrils consist of two major kinds of protein fibres: actins or thin myofilaments, and myosin or thick myofilaments. The actins and myosin myofilaments form highly ordered units called sarcomers, which are joined end-to-end to form the myofibrils (see Figure 6-1). Sarcomere is a structural and functional unit of muscle tissue. The ends of a sarcomere are a network of protein fibres, which form the Z-lines when the sarcomere is viewed from side. The Z-lines form an attachment site for actins myofilaments. The arrangement of the actin and myosin myofilaments in a sarcomere gives the myofibril a banded appearance because the myofibril appears darker where the actin and myosin myofilaments overlap. The alternating light (I-band) and dark (A-band) areas of the sarcomers are responsible for striation (banding pattern) seen in skeletal muscle cells observed through the microscope. The sarcolemma of a muscle fibre forms blind-ended sacs or T-tubules which penetrate the cell and lie in the spaces between the myofibrils. The T-tubules contain interstitial fluid and do not open into the interior of the muscle fibre. Within the sarcoplasm of the muscle fibre there is an extensive network of branching and anastomosing channels, which forms the sarcoplasmic reticulum (this structure is a modified endoplasmic reticulum). The channels of the sarcoplasmic reticulum lay in close contact around the ends of T-tubules, and contain stores of calcium.
Muscle contractions The thick myofilaments are composed of a protein called myosin. Each myosin filament has small regular projections known as crossbridges. The crossbridges lie in a radial fashion around the long axis of the myofilament. The rounded heads of the crossbridges lie in apposition to the thin myofilaments. The thin myofilaments are composed of a complex protein called actin, arranged in a double stranded coil. The actin filaments also contain two additional proteins called troponin and tropomysinIn a resting muscle fibre the myosin crossbridges are prevented from combining with the actin filaments by the presence of troponin and tropomysin. When a nerve impulse reaches a muscle fibre it is conducted over the sarcolemma and in to the T-tubules, then to the sarcoplasmic reticulum. The sarcoplasmic reticulum releases calcium ions into the sacrcoplasm. The liberated calcium ions combine with troponin causing it to push tropomysin away from the receptor sites on the actins filaments. The myosin crossbridges interact with the actin receptor sites and pull the actins myofilaments toward the centre (H-zone) of each sarcomere. The bond between the myosin crossbridges and actin breaks down under the influence of enzymes and the crossbridges are then free to rejoin with other actin receptor sites. The actin filaments do not shorten but slide past the myosin filaments overlapping them so that the Z lines are drawn toward each other, shortening the sarcomere. As each sarcomere shortens the whole muscle fibre contracts. Relaxation of the muscle fibres occurs when the calcium ions are actively reabsorbed by the sarcoplasmic reticulum thus allowing troponin and tropomysin to again inhibit the interaction of the actins and myosin filaments (see Table 6-1 for summary of events in the contraction of a muscle fibre).
Energy Requirements for Muscle Contraction Contraction o skeletal muscle requires adenosine triphosphate (ATP). The ATP releases energy when it breaks down to adenosine diphosphate (ADP) and a phosphate (P), some of the energy is used to move the crossbridges and some of the energy is released as heat. ATP→ADP + P + Energy (for crossbridge movement) + Heat The ATP required for muscle contraction is produced primarily in numerous mitochondria located with in the muscle fibres. Because ATP is a very short-lived molecule and rapidly degenerates to the more stable ADP, it is necessary for muscle cells to constantly produce ATP. ATP is produced by anaerobic or aerobic respiration. Anaerobic respiration, which occurs in the absence of oxygen, results in the breakdown of glucose to yield ATP and lactic acid. Aerobic respiration requires oxygen and breaks down glucose to produce ATP, carbon dioxide, and water (figure 6-2). Compared with anaerobic respiration, aerobic respiration is much more efficient. The breakdown of glucose molecule by aerobic respiration theoretically can produce 19 times as much ATP as is produced by anaerobic respiration. In addition, aerobic respiration can utilize a greater variety of nutrient molecules to produce ATP than can anaerobic respiration. For example, aerobic respiration can use fatty acids to generate ATP. Although anaerobic respiration is less efficient than aerobic respiration, it can produce ATP when lack of oxygen limits aerobic respiration. By utilizing many glucose molecules, anaerobic respiration can rapidly produce much ATP, but only for a short period. Resting muscles or muscles undergoing long-term exercise such as a long-distance bicycling on level ground depend primarily on aerobic respiration for ATP synthesis. Although some glucose is used as an energy source, fatty acids are a more important energy source during sustained exercise as well as during resting conditions. On the other hand, during intense exercise such as riding a bicycle up a steep hill, anaerobic respiration provides enough ATP to support intense muscle Contractions for approximately 1 to 2 minutes. Anaerobic respiration is ultimately limited by depletion of glucose and a build up of lactic acid within the muscle fibre. Lactic acid can also irritate muscle fibres, causing short-term muscle pain. Muscle pain that lasts for a couple of days following exercise, however, results from damage to connective tissue and muscle fibres within the muscle. Muscle fatigue results when ATP is used during muscle contraction faster than it can be produced in the muscle cells, and lactic acid builds up faster than it can be removed. As a consequence, ATP levels are too low to sustain crossbridge movement and the contractions become weaker and weaker. For most of us, however, complete muscle fatigue is rarely the reason we stop exercising. Instead, we stop because of psychological fatigue, the feeling that the muscles have tired. A burst of activity in a tired athlete as a result of encouragement from spectators is an example of how psychological fatigue can be overcome. After intense exercise, the respiration rate remains elevated for a period. Even though oxygen is not needed for anaerobic production of ATP molecules for contraction, oxygen is needed to convert the lactic acid produced by anaerobic respiration back to glucose. The increased amount of oxygen needed in chemical reactions to convert lactic acid to glucose is the oxygen debt. After the oxygen debt is paid, respiration rate returns to normal.