The graph at right represents the frequency of a neutral allele (A_1) in a population as it becomes fixed. If the allele is neutral, what effect will natural selection have on it? Would you predict that this will become fixed or be lost? Did the population size change during the time period covered by the graph? How do you know? Solution a) neutral gene in the organism will not change the fitness for survival and reproduction in the habitat and hence there will be no role played by natural selection on them. b) the expression of the allele depends on the chances of survival. natural selection theory hold good when the survival of the fittest happens of the organism due to the presence of the allele and hence the number of those organisms increases. so the natural selection only can decide about the allelic frequency (retained or lost). c) according to the graph the frequency of the allele has shown variable ups and downs but if we focus from start to end, the two end points denote the raise in frequency. this means if the frequency of the allele is more, it is favoured by nature and hence the population size is more. the times in between you can see the downfall in the frequency is the time when this allele was not favoured by nature and the population size went low..