This document discusses various technological trends and disruptions that have occurred in recent years and will continue to accelerate. It notes that more change has happened in the last 3 years than the prior 30. Individuals and startups are now doing what large companies and countries used to do. Billions of customers are having incredible experiences through services like Uber and Airbnb that own no physical assets. The document also discusses trends in robotics, sensors/networks, machine learning/AI, and synthetic biology.