Biosynthesis of fatty acids & eicosanoidsMeghanasweetie1
This presentation provides the knowledge about Biosynthesis of Fatty acids & eicosanoids, Pathways, De novo fatty acid Synthesis, Advantages, Significance, Pharmacological Applications.
Metabolic engineering for oil quality improvementSenthil Natesan
The most important oilseed crops are Oil palm, Soybeans, Rapeseed and Sunflower,which together account for ≈ 79% of the total production of oils.Oils that are low in palmitic acid and rich in either oleic acid or stearic acid are novel oils. Selective breeding utilizing natural variants or induced mutations has been used to develop a range of improved oils. The vegetable oil is used for different applications as renewable sources of food used for frying, baking, processed foods,Fuel (Biodiesel),medicine and can be used as industrial raw material for preparation of soaps, detergents, paints, lubricants etc.
The recommended ratio of omega6/omega3 fatty acids in the human diet is approximately 2:1 to 6:1 (Simopoulos., 2000; Wijendran and Hayes., 2004) and the much higher ratio of omega 6 fatty acids in the typical Western diet (approximately 20:1) is thought to be a major contributor to cardiovascular disease (Simopoulos., 2000).
For metabolic engineering of oil quality improvement fatty acid composition and enzymes involved are very important so we can reduce expression of endogenous enzymes by adding new enzyme ,overexpressing existing enzyme and by using antisense RNA. It proved that genes for membrane-bound fatty acid-modifying enzymes not only from plants but also from bacterial,animal,yeast have been shown to function in transgenic plants.The enzymes such as Fatty acid synthase ,Thioesterases ,Elongases ,Desaturases ,Stearoyl-ACP desaturase ,Δ12-desaturase, , Δ15-Desaturase ,Acyltransferases and Hydroxylases are important in fatty acid manipulation.Suppression of the oleate D12-desaturase gene (which normally converts 18:1 to 18:2) in soybean, sunflower, cotton and canola has resulted in the production of oils with a high oleic acid content, which have greater oxidative stability and improved performance in high-temperature cooking applications. (Metzger and Bornscheuer., 2006).
English:
Caution: This slide contains images of animate beings which are used for scientific purposes only.
Hadith:
Sahih Al Bukhari Chapter 89:
Narrated Muslim:
We were with Masruq at the house of Yasar bin Numair. Masruq saw pictures on his terrace and said, "I heard `Abdullah saying that he heard the Prophet (ﷺ) saying, "The people who will receive the severest punishment from Allah will be the picture makers.'"
Bahasa Indonesia:
Perhatian: Slide ini mengandung gambar makhluk bernyawa yang hanya digunakan untuk tujuan ilmu pengetahuan saja.
1.FATTY ACID SYNTHESIS FOR MBBS, LABORATORY MEDICINEAND BDS.pptRajendra Dev Bhatt
Lipid metabolism is the processing of lipids for energy use, energy storage, and structural component (Cholesterol & lipoproteins) production. Lipids are digested by lipase enzymes in the GI tract (with the help of bile acids) and are absorbed directly through the cell membrane. Free fatty acids are then resynthesized into triacylglycerols (TAGs) in the enterocytes. Finally, lipid components are repackaged into chylomicrons and transported throughout the body for use or storage.
Biosynthesis of fatty acids & eicosanoidsMeghanasweetie1
This presentation provides the knowledge about Biosynthesis of Fatty acids & eicosanoids, Pathways, De novo fatty acid Synthesis, Advantages, Significance, Pharmacological Applications.
Metabolic engineering for oil quality improvementSenthil Natesan
The most important oilseed crops are Oil palm, Soybeans, Rapeseed and Sunflower,which together account for ≈ 79% of the total production of oils.Oils that are low in palmitic acid and rich in either oleic acid or stearic acid are novel oils. Selective breeding utilizing natural variants or induced mutations has been used to develop a range of improved oils. The vegetable oil is used for different applications as renewable sources of food used for frying, baking, processed foods,Fuel (Biodiesel),medicine and can be used as industrial raw material for preparation of soaps, detergents, paints, lubricants etc.
The recommended ratio of omega6/omega3 fatty acids in the human diet is approximately 2:1 to 6:1 (Simopoulos., 2000; Wijendran and Hayes., 2004) and the much higher ratio of omega 6 fatty acids in the typical Western diet (approximately 20:1) is thought to be a major contributor to cardiovascular disease (Simopoulos., 2000).
For metabolic engineering of oil quality improvement fatty acid composition and enzymes involved are very important so we can reduce expression of endogenous enzymes by adding new enzyme ,overexpressing existing enzyme and by using antisense RNA. It proved that genes for membrane-bound fatty acid-modifying enzymes not only from plants but also from bacterial,animal,yeast have been shown to function in transgenic plants.The enzymes such as Fatty acid synthase ,Thioesterases ,Elongases ,Desaturases ,Stearoyl-ACP desaturase ,Δ12-desaturase, , Δ15-Desaturase ,Acyltransferases and Hydroxylases are important in fatty acid manipulation.Suppression of the oleate D12-desaturase gene (which normally converts 18:1 to 18:2) in soybean, sunflower, cotton and canola has resulted in the production of oils with a high oleic acid content, which have greater oxidative stability and improved performance in high-temperature cooking applications. (Metzger and Bornscheuer., 2006).
English:
Caution: This slide contains images of animate beings which are used for scientific purposes only.
Hadith:
Sahih Al Bukhari Chapter 89:
Narrated Muslim:
We were with Masruq at the house of Yasar bin Numair. Masruq saw pictures on his terrace and said, "I heard `Abdullah saying that he heard the Prophet (ﷺ) saying, "The people who will receive the severest punishment from Allah will be the picture makers.'"
Bahasa Indonesia:
Perhatian: Slide ini mengandung gambar makhluk bernyawa yang hanya digunakan untuk tujuan ilmu pengetahuan saja.
1.FATTY ACID SYNTHESIS FOR MBBS, LABORATORY MEDICINEAND BDS.pptRajendra Dev Bhatt
Lipid metabolism is the processing of lipids for energy use, energy storage, and structural component (Cholesterol & lipoproteins) production. Lipids are digested by lipase enzymes in the GI tract (with the help of bile acids) and are absorbed directly through the cell membrane. Free fatty acids are then resynthesized into triacylglycerols (TAGs) in the enterocytes. Finally, lipid components are repackaged into chylomicrons and transported throughout the body for use or storage.
PET CT beginners Guide covers some of the underrepresented topics in PET CTMiadAlsulami
This lecture briefly covers some of the underrepresented topics in Molecular imaging with cases , such as:
- Primary pleural tumors and pleural metastases.
- Distinguishing between MPM and Talc Pleurodesis.
- Urological tumors.
- The role of FDG PET in NET.
Empowering ACOs: Leveraging Quality Management Tools for MIPS and BeyondHealth Catalyst
Join us as we delve into the crucial realm of quality reporting for MSSP (Medicare Shared Savings Program) Accountable Care Organizations (ACOs).
In this session, we will explore how a robust quality management solution can empower your organization to meet regulatory requirements and improve processes for MIPS reporting and internal quality programs. Learn how our MeasureAble application enables compliance and fosters continuous improvement.
ALKAMAGIC PLAN 1350.pdf plan based of door to door delivery of alkaline water...rowala30
Alka magic plan 1350 -we deliver alkaline water at your door step and you can make handsome money by referral programme
we also help and provide systematic guideline to setup 1000 lph alkaline water plant
Rate Controlled Drug Delivery Systems, Activation Modulated Drug Delivery Systems, Mechanically activated, pH activated, Enzyme activated, Osmotic activated Drug Delivery Systems, Feedback regulated Drug Delivery Systems systems are discussed here.
Letter to MREC - application to conduct studyAzreen Aj
Application to conduct study on research title 'Awareness and knowledge of oral cancer and precancer among dental outpatient in Klinik Pergigian Merlimau, Melaka'
TEST BANK For Accounting Information Systems, 3rd Edition by Vernon Richardso...rightmanforbloodline
TEST BANK For Accounting Information Systems, 3rd Edition by Vernon Richardson, Verified Chapters 1 - 18, Complete Newest Version
TEST BANK For Accounting Information Systems, 3rd Edition by Vernon Richardson, Verified Chapters 1 - 18, Complete Newest Version
TEST BANK For Accounting Information Systems, 3rd Edition by Vernon Richardson, Verified Chapters 1 - 18, Complete Newest Version
Under Pressure : Kenneth Kruk's StrategyKenneth Kruk
Kenneth Kruk's story of transforming challenges into opportunities by leading successful medical record transitions and bridging scientific knowledge gaps during COVID-19.
13. TYPES OF FATTY ACIDS
Saturated Fats
Unsaturated Fats
NO double bonds
YES double bonds
14. TYPES OF FATTY ACIDS
Polyunsaturated
MULTIPLE double bonds
ESSENTIAL
15. ESSENTIAL FATTY ACIDS
• Polyunsaturated (>2 double bonds)
• Humans have limited ability in desaturating fatty acids
• Meaning it is NOT synthesized by the body
• Decrease the risk of Cardiovascular Disease/ Coronary Heart Disease
• These essential fatty acids give rise to eicosanoic (C20)
fatty acids, from which are derived families of
compounds known as eicosanoids.
• Eicosanoids include prostaglandins, prostacyclins,
thromboxanes, leukotriens, and lipoxins.
21. FATTY ACID SYNTHESIS
• Process by which the saturated Fatty Acid “Palmitate” is
formed
• Excess carbohydrates are converted to Fatty Acids, creating
a store of energy able to break down for future energy.
22. FATTY ACID SYNTHESIS
• Excess carbohydrates are converted to Fatty Acids, creating
a store of energy able to break down for future energy.
35. CLINICAL ASPECTS
Symptoms of Essential Fatty Acid Deficiency
in Humans Include Skin Lesions &
Impairment of Lipid Transport
In adults subsisting on ordinary diets, no signs of essential fatty
acid deficiencies have been reported. However, infants receiving
formula diets low in fat and patients who maintain for long periods
exclusively intravenous nutrition low in essential fatty acids show
deficiency symptoms that can be prevented by an essential fatty
acid intake of 1 – 2 % of the total caloric requirement.
36. CLINICAL ASPECTS
Abnormal Metabolism of Essential Fatty
Acids Occurs in Several Diseases
• Cystic fibrosis
• Acrodermatitis enteropathica
• Hepatorenal syndrome
• Sjogren-Larrson syndrome
• Multisystem neuronal degeneration
• Crohn’s disease
• Cirrhosis and alcoholism
• Reye’s syndrome
37. CLINICAL ASPECTS
Abnormal Metabolism of Essential Fatty
Acids Occurs in Several Diseases
Elevated levels of very-long-chain polyenoic acids have been
found in the brains of patients with Zellweger’s syndrome.
Diets with a high P:S(polyunsaturated:saturated fatty acid) ratio
reduce serum cholesterol levels and are considered to be
beneficial in terms of the risk of development of coronary heart
disease.
38. DOES OUR BODY NATURALLY
PRODUCE FATTY ACIDS?
Saturated Fatty Acids
X Essential Fatty Acids under
Unsaturated Fatty Acids