1) The document discusses recent technological advances in pharmaceutical dosage form design, including fluidized bed processing, microencapsulation, and spray drying. 2) It provides an overview of the concepts of pre-formulation, types of tablet formulations, granulation processes, and applications of fluidized bed processors. 3) Key advances discussed are quality by design principles, 3D printing, co-processing of excipients, and microencapsulation techniques like spray drying for controlled release products and inhalation applications.

1. P R E S E N T E D B Y
M R . R A J E N D R A K . S U R A W A S E
Technological Advances in
Pharmaceutical Dosage form
Designing
Department of Pharmaceutics
Loknete Dr. J. D. Pawar College of Pharmacy
Manur, Kalwan, Nashik (M.S)
2/3/2020
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R. K. Surawase

2. Content
 Concept of Preformulation
 Recent trends in drug delivery Development
 Types of tablet Formulations
 Conventional Method of tablet Manufacturing
 Recent advances in granulation process
 Concept of Microencapsulation
 Applications & Fundamentals of FBP
 Processing Variables of FBP
 Spray Drying
 Critical elements of Spray drying
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3. Introduction
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PharmaceuticsDrug Dosage
Forms
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4. Concept of Pre-formulation
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Preformulation testing is the first step in the rational development
of dosage forms of a drug substance.
 It can be defined as study of physico-chemical properties of a
drug substance alone and combined with excipients.
 The overall objective of Preformulation study is to generate
information useful to the formulator in developing stable and
efficient, qualitative dosage forms.
R. K. Surawase

5. Preformulation Process
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 Physicochemical property:
 Organoleptic Property
 Particle characteristics
 Crystallinity
 Polymorphism
 Hygroscopicity
 Solubility analysis
 Thermal analysis
 Physicomechanical property:
 Flow property
 Angle of repose
 Percent compressibility
 Bulk density
 Spectroscopic method:
 Assay development:
 Stability testing:
R. K. Surawase

6. Recent Trends in Drug Delivery
Development
Recent
Trends
3 D
Printing
Technology
Co-
processing
of
Excipients
Quality by
Design &
DoE
Fluidized
Bed
Processing
Nanotechn-
ology
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7. Types of Tablet Formulation
 Compressed tablet
 Sugar coated tablet
 Film coated
 Effervescent tablet
 Chewable tablet
 Mouth dissolving tablet
 Dispersible tablet
 Multilayer tablet
 Sublingual tablet
 Buccal tablet
 Micro tablet / Mini Tablet
 Osmoticaly active tablet (osmotic
Pump)
 3 D tablet
 SR/ CR tablet
 Fast disintegrating SR tablet
 Colon targeted Tablet
 Floating tablet
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8. Conventional methods of tablet
Manufacturing
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WetGranulation
• Raw material
• Weigh
• Screen
• Mix
• Wet mass
• Mill
• Dry
• Mill
• Mix
• Compress
DirectCompression
• Raw material
• Weigh
• Screen
• Compress
DryGranulation
• Raw material
• Weigh
• Screen
• Mix
• Slug
• Mill
• Mix
• Compress
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9. Recent advancement in granulation
process
 Pneumatic Dry Granulation
 Steam granulation
 Melt granulation
 Moisture activated dry granulation
 Thermal adhesion granulation process
 Foam granulation
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10. Microencapsulation
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Microencapsulation is a means of applying thin uniform
coatings to microparticles of core material in solid or
liquid droplets.
Fundamental of Microencapsulation:
Core Material
Coating Material
Manufacturing Vehicle Phase
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11. Microencapsulation methods
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1. Air suspension
2. Coacervation-phase separation
3. Spray drying
4. Congealing
5. Pan coating
6. Solvent evaporation techniques
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12. Microencapsulation Processes and
their Applicability
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Approximate Particle Size
(µm)
Applicable Core
Material
Microencapsulation
Process
35-5000SolidsAir suspension
600-5000SolidsPan coating
1-5000Solids & liquidsMultiorifice centrifugal
2-5000Solids & liquidsCoacervation-phase
separation
5-5000Solids & liquidsSolvent evaporation
600Solids & liquidsSpray drying and congealing
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13. Fluidized Bed Processor
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Microencapsulation by air suspension techniques using Fluidized
Bed Processor:
 Control panel
 Coating chamber
 Particles being treated
 Process airflow
 Air distribution plate
 Nozzle for applying film coatings
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14. Fluidized Bed Processor
Reduced
time
Cost
Processing
steps
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15. Applications of FBP
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16. Fundamentals on the Processes
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Fluid Bed Drying
Fluid Bed Granulation
Fluid Bed Coating
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17. Fluid Bed Coating (Air Suspension)
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18. Advantages
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Rapid mixing
Liquid like behavior, easy to control
Applicable for large or small scale operation
Continuous operation
Ease of process control due to stable condition
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19. Disadvantages
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Pipe and vessel walls erode due to collisions by
particles.
Particle breakup is common
Difficult to predict non- uniform flow pattern
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20. Processing Variables
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 Density, surface area, melting point, solubility, crystalline nature,
flowability of core material.
 Coating material concentration
 Coating material concentration rate
 Volume of air required
 Inlet and outlet temperature
 Viscosity of coating solution
 Atomization pressure / Droplet size
 Position of Nozzle
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21. Industrial Applications
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Fluidized
Bed
Coating
Snack
Detregent
Enteric
coated
Formulation
Batery
Fertilizer
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22. Spray Drying
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Critical elements of spray drying:
 Atomizers
 Air flow
Co-current flow
Counter-current flow
Mixed flow
 Spray drying chamber

23. Critical Parameters of Spray Drying
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 Inlet temperature of air
 Outlet temperature of air
 Viscosity
 Atomization pressure
 Feed temperature
 Nozzle material

24. Application of Spray Drying in
Pharmaceutical Field
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 Powder properties
 Granulation
 Bioavailability
 Encapsulation
 Inhalation
 Controlled release product

25. 2/3/2020
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Thank You
R. K. Surawase