Taxoids
•Download as PPTX, PDF•
0 likes•936 views
Taxoids, also known as paclitaxel, are derivatives from taxol, an early potent anticancer compound extracted from Pacific yew (Taxus brevifolia Nutt).
Report
Share
Report
Share
Recommended
Taxol and Tamoxifen
This document discusses two chemotherapy drug treatments for breast cancer: Tamoxifen and Taxol. Tamoxifen is a selective estrogen receptor modulator that sits in estrogen receptors in breast cells to block the effects of estrogen and prevent cancer growth. Taxol is a mitotic inhibitor that interferes with cell division by inhibiting microtubule polymerization, thereby stopping rapidly dividing cancer cells from replicating and causing cell death. Both drugs are evaluated for their effects on patients with breast cancer.
Tamoxifen and taxol
This document evaluates the effects of tamoxifen and paclitaxel (taxol) in treating breast cancer. It begins with background on breast anatomy and cancer types. Tamoxifen is a selective estrogen receptor modulator that blocks estrogen's effects in breast tissue. Paclitaxel disrupts microtubule function, inhibiting cell division. The document reviews literature on paclitaxel's mechanism of action and structure. It will present results from a study on tamoxifen and paclitaxel's effects, and discuss methodology, interpretation and conclusions.
Taxol
- Taxol is a potent anticancer compound obtained from the Pacific yew tree. It was first isolated in 1971 and has the generic name paclitaxel.
- Due to the tree's slow growth, industrial production of taxol involves extraction from tree bark or semi-synthesis from related compounds like 10-deacetylbaccatin III from European yew.
- Taxol is used to treat cancers like ovarian cancer, breast cancer, and lung cancer. It works by stabilizing microtubules to inhibit cancer cell growth. While initially challenging to source, taxol production is now sustainable through extraction and semi-synthesis.
Hina isolation, elicitation and mechanism of anti cancerous activity of taxol
In this presentation, i will be talk about Taxol that is a chemotherapeutic drug.
how it is isolate, elicititate and their anti-cancerous mechanism.
Taxol and Derivatives In Therapy
This document discusses taxol and its derivatives used in cancer therapy. It provides background on the isolation of taxol from yew trees and the development of docetaxel as a semi-synthetic analogue. It describes the mechanism of action of taxanes as microtubule stabilizers, inhibiting cell division. Side effects and clinical uses of paclitaxel and docetaxel are outlined. Factors complicating treatment include drug resistance, debilitating side effects, and high costs.
Anticancer DRUG
This document summarizes several classes of anticancer drugs, including taxanes like paclitaxel and docetaxel, and podophyllotoxins like etoposide and teniposide. It notes the limitations of paclitaxel including its poor solubility and limited supply, and how docetaxel was developed to address these issues. The document also discusses the biosynthesis of paclitaxel from precursors like baccatin III, as well as podophyllotoxin derivatives and their mechanisms of inhibiting DNA synthesis.
TAXANES AND PODOPHYLLOTOXINS
TAXANES AND PODOPHYLLOTOXINSCollege of Pharmacy,Sri Ramakrishna Institute of Paramedical Sciences,Coimbatore
The document discusses natural products taxanes and podophyllotoxins that have led to new anti-cancer drugs. It describes how over 60% of anti-cancer drugs originate from natural products. Taxanes such as paclitaxel and docetaxel stabilize microtubules, preventing cell division and causing cancer cell death. Podophyllotoxins like etoposide and teniposide inhibit topoisomerase and DNA synthesis in cancer cells. Both classes are effective against various cancer types with side effects like low blood counts and hair loss that require careful treatment. Natural products continue providing leads for developing new anti-cancer pharmaceuticals.Anticancer drugs
This document discusses several classes of natural anticancer drugs derived from plants, including their plant sources, mode of action, and clinical uses. It describes vinca alkaloids from Catharanthus roseus that block microtubule assembly; podophyllotoxins from Podophyllum species that inhibit topoisomerase; taxanes from Taxus species that interfere with microtubule disassembly; and camptothecins from Camptotheca acuminata that inhibit topoisomerase I. The document concludes that plants have been a major source of effective anticancer drugs and that natural agents show promise as sources of new inhibitors for cancer treatment.
Recommended
Taxol and Tamoxifen
This document discusses two chemotherapy drug treatments for breast cancer: Tamoxifen and Taxol. Tamoxifen is a selective estrogen receptor modulator that sits in estrogen receptors in breast cells to block the effects of estrogen and prevent cancer growth. Taxol is a mitotic inhibitor that interferes with cell division by inhibiting microtubule polymerization, thereby stopping rapidly dividing cancer cells from replicating and causing cell death. Both drugs are evaluated for their effects on patients with breast cancer.
Tamoxifen and taxol
This document evaluates the effects of tamoxifen and paclitaxel (taxol) in treating breast cancer. It begins with background on breast anatomy and cancer types. Tamoxifen is a selective estrogen receptor modulator that blocks estrogen's effects in breast tissue. Paclitaxel disrupts microtubule function, inhibiting cell division. The document reviews literature on paclitaxel's mechanism of action and structure. It will present results from a study on tamoxifen and paclitaxel's effects, and discuss methodology, interpretation and conclusions.
Taxol
- Taxol is a potent anticancer compound obtained from the Pacific yew tree. It was first isolated in 1971 and has the generic name paclitaxel.
- Due to the tree's slow growth, industrial production of taxol involves extraction from tree bark or semi-synthesis from related compounds like 10-deacetylbaccatin III from European yew.
- Taxol is used to treat cancers like ovarian cancer, breast cancer, and lung cancer. It works by stabilizing microtubules to inhibit cancer cell growth. While initially challenging to source, taxol production is now sustainable through extraction and semi-synthesis.
Hina isolation, elicitation and mechanism of anti cancerous activity of taxol
In this presentation, i will be talk about Taxol that is a chemotherapeutic drug.
how it is isolate, elicititate and their anti-cancerous mechanism.
Taxol and Derivatives In Therapy
This document discusses taxol and its derivatives used in cancer therapy. It provides background on the isolation of taxol from yew trees and the development of docetaxel as a semi-synthetic analogue. It describes the mechanism of action of taxanes as microtubule stabilizers, inhibiting cell division. Side effects and clinical uses of paclitaxel and docetaxel are outlined. Factors complicating treatment include drug resistance, debilitating side effects, and high costs.
Anticancer DRUG
This document summarizes several classes of anticancer drugs, including taxanes like paclitaxel and docetaxel, and podophyllotoxins like etoposide and teniposide. It notes the limitations of paclitaxel including its poor solubility and limited supply, and how docetaxel was developed to address these issues. The document also discusses the biosynthesis of paclitaxel from precursors like baccatin III, as well as podophyllotoxin derivatives and their mechanisms of inhibiting DNA synthesis.
TAXANES AND PODOPHYLLOTOXINS
TAXANES AND PODOPHYLLOTOXINSCollege of Pharmacy,Sri Ramakrishna Institute of Paramedical Sciences,Coimbatore
The document discusses natural products taxanes and podophyllotoxins that have led to new anti-cancer drugs. It describes how over 60% of anti-cancer drugs originate from natural products. Taxanes such as paclitaxel and docetaxel stabilize microtubules, preventing cell division and causing cancer cell death. Podophyllotoxins like etoposide and teniposide inhibit topoisomerase and DNA synthesis in cancer cells. Both classes are effective against various cancer types with side effects like low blood counts and hair loss that require careful treatment. Natural products continue providing leads for developing new anti-cancer pharmaceuticals.Anticancer drugs
This document discusses several classes of natural anticancer drugs derived from plants, including their plant sources, mode of action, and clinical uses. It describes vinca alkaloids from Catharanthus roseus that block microtubule assembly; podophyllotoxins from Podophyllum species that inhibit topoisomerase; taxanes from Taxus species that interfere with microtubule disassembly; and camptothecins from Camptotheca acuminata that inhibit topoisomerase I. The document concludes that plants have been a major source of effective anticancer drugs and that natural agents show promise as sources of new inhibitors for cancer treatment.
Anti cancer drugs
Anti cancer drugs obtained from plant sources,classifications, mechanism of action, clinical uses, clinical trails, uses etc....
Anticancer
The presentation discusses cancer, including its causes, classification of anticancer drugs, and recent developments. It covers milestones in cancer discovery such as imatinib mesylate in 2001 and recent FDA-approved drugs. Phytochemicals from fruits and vegetables that are being studied for cancer prevention are mentioned. Research is exploring the anticancer effects of compounds from pomegranates, bromelain from pineapples, and curcumin from turmeric. Targeted drug delivery approaches to tumor vasculature are also discussed.
Medicinal plants and cancer A series of Presentation By Mr. Allah Dad Khan ...
A series of Presentation By Mr. Allah Dad Khan Former DG Agriculture Extension KP Province and Visiting Professor the University of Agriculture Peshawar Pakistan allahdad52@gmail.com
Anticancer drugs
Anticancer Drugs
Brief of Cancer
Cancer starts when cells in a part of the body start to grow out of control. Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells continue to grow and form new, abnormal cells. Cancer cells can also invade (grow into) other tissues, something that normal cells can’t do. Growing out of control and invading other tissues are what makes a cell a cancer cell.
Cells become cancer cells because of DNA damage. DNA is in every cell and it directs all its actions. In a normal cell, when DNA is damaged the cell either repairs the damage or dies. In cancer cells, the damaged DNA is not repaired, but the cell doesn’t die like it should. Instead, the cell goes on making new cells that the body doesn’t need. These new cells all have the same damaged DNA as the first abnormal cell does.
People can inherit abnormal DNA (it’s passed on from their parents), but most often DNA damage is caused by mistakes that happen while the normal cell is reproducing or by something in the environment. Sometimes the cause of the DNA damage may be something obvious like cigarette smoking or sun exposure.
In most cases, the cancer cells form a tumor. Over time, the tumors can replace normal tissue, crowd it, or push it aside. Some cancers, like leukemia, rarely form tumors.
"Drivers" of Cancer
The genetic changes that contribute to cancer tend to affect three main types of genes…. proto-oncogenes, tumor suppressor genes and DNA repair genes. These changes are sometimes called “drivers” of cancer.
Proto-oncogenes are involved in normal cell growth and division. However, when these genes are altered in certain ways or are more active than normal, they may become cancer-causing genes (or oncogenes), allowing cells to grow and survive when they should not.
Tumor suppressor genes are also involved in controlling cell growth and division. Cells with certain alterations in tumor suppressor genes may divide in an uncontrolled manner.
DNA repair genes are involved in fixing damaged DNA. Cells with mutations in these genes tend to develop additional mutations in other genes. Together, these mutations may cause the cells to become cancerous.
How cancer spreads?
Cancer cells often travel to other parts of the body where they can grow and form new tumors. This happens when the cancer cells get into the body’s bloodstream or lymph vessels. The process of cancer spreading is called metastasis.
Herbal anticancer drugs
This document discusses herbal anti-cancer drugs. It defines cancer and anti-cancer drugs as drugs used to inhibit or kill cancer cells. Several classes of anti-cancer drugs derived from plants are described, including vinca alkaloids from Catharanthus roseus, podophyllotoxins from Podophyllum hexandrum, camptothecins from Camptotheca acuminata, and taxanes from Taxus brevifolia. The document explains the mode of action of these natural anti-cancer drugs, noting they may inhibit microtubules, topoisomerases, or other targets. Recent advances in natural anti-cancer agents include developing new compounds with low toxicity and novel mechanisms of action.
cancer
The document discusses several plants that have potential anticancer properties, including their uses, mechanisms of action, and effects on specific cancer types. It provides details on Ashwagandha, Manjistha, Chitraka, Daruhaldi, and Katuki - describing their geographical sources, morphologies, chemical constituents, and roles in treating cancers like colon, breast, lung, blood, prostate, and more. The key mechanisms discussed include inducing apoptosis, inhibiting angiogenesis, suppressing metastasis, and modulating critical signaling pathways.
Chemotherapy
Paul Ehrlich was a German scientist considered the father of chemotherapy. He developed the "magic bullet" concept of targeting drugs specifically to diseased cells without harming healthy cells. Chemotherapy involves using cytotoxic drugs to treat cancer by targeting rapidly dividing cells, though it also affects other fast-dividing normal cells causing side effects like hair loss and reduced blood cell production. There are over 100 chemotherapy drugs classified into groups like alkylating agents, antimetabolites, and microtubule inhibitors that work by crosslinking DNA, blocking metabolites, or stabilizing microtubules to damage cancer cells and trigger cell death. The goals of chemotherapy include eliminating cancer, shrinking tumors, preventing spread, and relieving symptoms.
Study the anticancer effect of lepidium sativum leaves extract
The International Institute for Science, Technology and Education (IISTE). Science, Technology and Medicine Journals Call for Academic Manuscripts
Herbal anti cancer drugs
Cancer is abnormal cell growth that can spread if untreated. It is caused by factors like chemicals, alcohol, smoking, viruses and genetics. Symptoms include fatigue, nausea, and weight loss. Treatments include surgery, chemotherapy, radiation, and targeted therapies. Many plants have compounds that may treat cancer by inhibiting cell proliferation or inducing cell death. Examples discussed include vinca alkaloids from Catharanthus roseus, taxanes from Taxus brevifolia, and camptothecin from Camptotheca acuminata. Curcumin, flavonoids, polyphenols from foods like berries and tea may also have anticancer effects. As conventional treatments do not always work, herbal medicines provide a
potential of plant in cancer
Potential plants molecule in cancer disease. The document discusses several herbal plants that show anticancer activity, including their mechanisms of action. It summarizes that Camptotheca acuminata contains camptothecin which inhibits topoisomerase I and DNA replication. Podophyllum contains podophyllotoxin and related compounds that inhibit topoisomerase II. Periwinkle contains alkaloids vinblastine and vincristine which prevent microtubule assembly. Taxus brevifolia contains taxol and related compounds that stabilize microtubules. Curcuma longa contains curcumin which has anti-inflammatory and apoptotic effects. Many herbal compounds show promise for cancer treatment but developing safe, economic anticancer drugs remains a
Anticancer drugs: Classification , general toxicity and Alkylating agents.
Neoplasm or cancer is one of the dangerous condition. Here we discuss about cancer and it's drug classification, general toxicity and brief description about Alkylating agents.
Anti neoplastic agents
This document discusses anti-neoplastic agents used to treat cancer. It begins by introducing malignant disease and cancer treatment options such as surgery, radiotherapy, chemotherapy, immunotherapy and gene therapy. It then categorizes anti-cancer drugs according to their chemical structure, mechanism of action, and cell cycle specificity. Examples of major drug classes discussed include alkylating agents, platinum compounds, antimetabolites, and plant extracts. Common mechanisms of action and adverse effects are also summarized for several representative drugs.
Antineoplastic agent
This document discusses antineoplastic agents, which are used to treat malignant diseases like cancer. It describes the main types of anticancer therapies as ionizing radiation, surgery, and chemotherapeutic agents. The document then classifies chemotherapeutic agents into several categories based on their mechanism of action, including alkylating agents, antimetabolites, antibiotics, hormones, plant products, and miscellaneous compounds. Examples are provided for each category of anticancer drug.
Introduction to Chemotherapy in a Gyn/Onc Context
A good review of common GYN/ONC chemotherapy agents, especially for residents. Given at Wake Forest. Thanks to Dr. Michael Kelly for contributing and reviewing.
Vinca Alkaloids as Anticancer Agents (Looking back and peering ahead)
This document discusses Vinca alkaloids, which are anti-cancer agents originally isolated from the Madagascar periwinkle plant. It covers the structure, mechanism of action, applications, and total synthesis of major Vinca alkaloids like vinblastine and vincristine. The document also summarizes emerging vinblastine-related compounds through modifications to the catharanthine and vindoline nuclei. Finally, it discusses drug targeting approaches for Vinca alkaloids like conjugating vinblastine to folic acid to selectively target cancer cells overexpressing folate receptors.
Advanced study of natural sources of anti-cancer
This document discusses natural sources of anti-cancer agents. It notes that plant-based drug discovery has resulted in important anticancer agents derived from plants, marine organisms, and microorganisms. It also outlines numerous phytochemicals found in fruits and vegetables that can be used in anticancer therapy, including curcumin, resveratrol, genistein, and compounds from garlic, soybeans, tomatoes, and other foods. The review suggests that active principles from natural products represent an opportunity to discover novel anticancer agents and mechanisms of action.
Natural products as leads for new pharmaceuticals
THE LEADS FOR NEW PHARMACEUTICALS ARE DIFFICULT TO COLLECT BUT WE HAVE TRIED BEST TO EXPLAIN AND COVER THE MOST.
Anti cancer thesis
Studies that examined the therapeutic potential of plants leaf extracts
Plant Scientific Name Common Name Type of extraction Proposed active material
1. Solanum viarum Tropical Soda Apple Ether Solasodine glycoalkaloid
2. Acanthus illicifolious Harkucha Kanta Methanol Triterpenoids,Flavonoids,
Alkaloids
3. Annona squamosa Custard Apple Ethyl acetate Acetogenins,Alkaloids,
Dofamine
4 Alstonia scholaris. Chatium Methanol Alkaloids,Flavonoids
5. Calotropis gigantea Akanda Ethanol Triterpenoids,Flavonol
Glycosides
Advances in research on the anticancer mechanism of the natural compound cucu...
The document reviews the anticancer mechanisms of the natural compound cucurbitacin from Cucurbitaceae plants. It summarizes that cucurbitacins induce tumor cell apoptosis through multiple pathways, including the STAT3, MAPK, NF-κB, and PI3K/AKT signaling pathways. It also discusses how cucurbitacins promote cytoskeletal destruction and cell cycle arrest. Studies show cucurbitacins exert anticancer effects by multi-targeting various cancer-related signaling pathways and have potential as anticancer drugs.
The flavonoid quercetin transientyly inhibits the activity of taxol and nocod...
This study examined the effects of the flavonoid quercetin on cancer cell viability and cell cycle progression when administered alone or in combination with the microtubule-targeting drugs taxol and nocodazole. The researchers found that while quercetin induced cancer cell death in a dose-dependent manner, lower doses of quercetin protected cancer cells from the G2/M cell cycle arrest induced by taxol and nocodazole. Specifically, quercetin delayed cell cycle progression, inhibited the accumulation of cyclin B1 at the microtubule organizing center, and partially restored viability of drug-treated cells for up to 72 hours. However, long-term exposure to quercetin still suppressed cancer cell proliferation and
Antimicrotubules kiran
Antimicrotubule agents such as paclitaxel and docetaxel are microtubule-stabilizing drugs that directly bind to tubulin. They profoundly alter microtubule dynamics and suppress microtubule depolymerization, leading to mitotic arrest. Peripheral neuropathy is a common side effect due to their effects on microtubules in neurons. Paclitaxel and docetaxel are effective in treating several types of cancer but require premedication to reduce hypersensitivity reactions and have dose-limiting toxicities of neutropenia and neuropathy.
Adele- URECA Poster Presentation
1. The document describes the synthesis and biological evaluation of SB-T-1216, a potent second-generation taxoid.
2. Enantiopure β-lactam is prepared via chiral ester-enolate imine cyclocondensation and Staudinger cycloaddition, then coupled to a modified baccatan.
3. SB-T-1216 shows greater efficacy than paclitaxel against drug-resistant cancer cell lines, with IC50 values over 100-fold lower for resistant cell lines. It induces microtubule bundling and cell death at lower concentrations than paclitaxel.
More Related Content
What's hot
Anti cancer drugs
Anti cancer drugs obtained from plant sources,classifications, mechanism of action, clinical uses, clinical trails, uses etc....
Anticancer
The presentation discusses cancer, including its causes, classification of anticancer drugs, and recent developments. It covers milestones in cancer discovery such as imatinib mesylate in 2001 and recent FDA-approved drugs. Phytochemicals from fruits and vegetables that are being studied for cancer prevention are mentioned. Research is exploring the anticancer effects of compounds from pomegranates, bromelain from pineapples, and curcumin from turmeric. Targeted drug delivery approaches to tumor vasculature are also discussed.
Medicinal plants and cancer A series of Presentation By Mr. Allah Dad Khan ...
A series of Presentation By Mr. Allah Dad Khan Former DG Agriculture Extension KP Province and Visiting Professor the University of Agriculture Peshawar Pakistan allahdad52@gmail.com
Anticancer drugs
Anticancer Drugs
Brief of Cancer
Cancer starts when cells in a part of the body start to grow out of control. Cancer cell growth is different from normal cell growth. Instead of dying, cancer cells continue to grow and form new, abnormal cells. Cancer cells can also invade (grow into) other tissues, something that normal cells can’t do. Growing out of control and invading other tissues are what makes a cell a cancer cell.
Cells become cancer cells because of DNA damage. DNA is in every cell and it directs all its actions. In a normal cell, when DNA is damaged the cell either repairs the damage or dies. In cancer cells, the damaged DNA is not repaired, but the cell doesn’t die like it should. Instead, the cell goes on making new cells that the body doesn’t need. These new cells all have the same damaged DNA as the first abnormal cell does.
People can inherit abnormal DNA (it’s passed on from their parents), but most often DNA damage is caused by mistakes that happen while the normal cell is reproducing or by something in the environment. Sometimes the cause of the DNA damage may be something obvious like cigarette smoking or sun exposure.
In most cases, the cancer cells form a tumor. Over time, the tumors can replace normal tissue, crowd it, or push it aside. Some cancers, like leukemia, rarely form tumors.
"Drivers" of Cancer
The genetic changes that contribute to cancer tend to affect three main types of genes…. proto-oncogenes, tumor suppressor genes and DNA repair genes. These changes are sometimes called “drivers” of cancer.
Proto-oncogenes are involved in normal cell growth and division. However, when these genes are altered in certain ways or are more active than normal, they may become cancer-causing genes (or oncogenes), allowing cells to grow and survive when they should not.
Tumor suppressor genes are also involved in controlling cell growth and division. Cells with certain alterations in tumor suppressor genes may divide in an uncontrolled manner.
DNA repair genes are involved in fixing damaged DNA. Cells with mutations in these genes tend to develop additional mutations in other genes. Together, these mutations may cause the cells to become cancerous.
How cancer spreads?
Cancer cells often travel to other parts of the body where they can grow and form new tumors. This happens when the cancer cells get into the body’s bloodstream or lymph vessels. The process of cancer spreading is called metastasis.
Herbal anticancer drugs
This document discusses herbal anti-cancer drugs. It defines cancer and anti-cancer drugs as drugs used to inhibit or kill cancer cells. Several classes of anti-cancer drugs derived from plants are described, including vinca alkaloids from Catharanthus roseus, podophyllotoxins from Podophyllum hexandrum, camptothecins from Camptotheca acuminata, and taxanes from Taxus brevifolia. The document explains the mode of action of these natural anti-cancer drugs, noting they may inhibit microtubules, topoisomerases, or other targets. Recent advances in natural anti-cancer agents include developing new compounds with low toxicity and novel mechanisms of action.
cancer
The document discusses several plants that have potential anticancer properties, including their uses, mechanisms of action, and effects on specific cancer types. It provides details on Ashwagandha, Manjistha, Chitraka, Daruhaldi, and Katuki - describing their geographical sources, morphologies, chemical constituents, and roles in treating cancers like colon, breast, lung, blood, prostate, and more. The key mechanisms discussed include inducing apoptosis, inhibiting angiogenesis, suppressing metastasis, and modulating critical signaling pathways.
Chemotherapy
Paul Ehrlich was a German scientist considered the father of chemotherapy. He developed the "magic bullet" concept of targeting drugs specifically to diseased cells without harming healthy cells. Chemotherapy involves using cytotoxic drugs to treat cancer by targeting rapidly dividing cells, though it also affects other fast-dividing normal cells causing side effects like hair loss and reduced blood cell production. There are over 100 chemotherapy drugs classified into groups like alkylating agents, antimetabolites, and microtubule inhibitors that work by crosslinking DNA, blocking metabolites, or stabilizing microtubules to damage cancer cells and trigger cell death. The goals of chemotherapy include eliminating cancer, shrinking tumors, preventing spread, and relieving symptoms.
Study the anticancer effect of lepidium sativum leaves extract
The International Institute for Science, Technology and Education (IISTE). Science, Technology and Medicine Journals Call for Academic Manuscripts
Herbal anti cancer drugs
Cancer is abnormal cell growth that can spread if untreated. It is caused by factors like chemicals, alcohol, smoking, viruses and genetics. Symptoms include fatigue, nausea, and weight loss. Treatments include surgery, chemotherapy, radiation, and targeted therapies. Many plants have compounds that may treat cancer by inhibiting cell proliferation or inducing cell death. Examples discussed include vinca alkaloids from Catharanthus roseus, taxanes from Taxus brevifolia, and camptothecin from Camptotheca acuminata. Curcumin, flavonoids, polyphenols from foods like berries and tea may also have anticancer effects. As conventional treatments do not always work, herbal medicines provide a
potential of plant in cancer
Potential plants molecule in cancer disease. The document discusses several herbal plants that show anticancer activity, including their mechanisms of action. It summarizes that Camptotheca acuminata contains camptothecin which inhibits topoisomerase I and DNA replication. Podophyllum contains podophyllotoxin and related compounds that inhibit topoisomerase II. Periwinkle contains alkaloids vinblastine and vincristine which prevent microtubule assembly. Taxus brevifolia contains taxol and related compounds that stabilize microtubules. Curcuma longa contains curcumin which has anti-inflammatory and apoptotic effects. Many herbal compounds show promise for cancer treatment but developing safe, economic anticancer drugs remains a
Anticancer drugs: Classification , general toxicity and Alkylating agents.
Neoplasm or cancer is one of the dangerous condition. Here we discuss about cancer and it's drug classification, general toxicity and brief description about Alkylating agents.
Anti neoplastic agents
This document discusses anti-neoplastic agents used to treat cancer. It begins by introducing malignant disease and cancer treatment options such as surgery, radiotherapy, chemotherapy, immunotherapy and gene therapy. It then categorizes anti-cancer drugs according to their chemical structure, mechanism of action, and cell cycle specificity. Examples of major drug classes discussed include alkylating agents, platinum compounds, antimetabolites, and plant extracts. Common mechanisms of action and adverse effects are also summarized for several representative drugs.
Antineoplastic agent
This document discusses antineoplastic agents, which are used to treat malignant diseases like cancer. It describes the main types of anticancer therapies as ionizing radiation, surgery, and chemotherapeutic agents. The document then classifies chemotherapeutic agents into several categories based on their mechanism of action, including alkylating agents, antimetabolites, antibiotics, hormones, plant products, and miscellaneous compounds. Examples are provided for each category of anticancer drug.
Introduction to Chemotherapy in a Gyn/Onc Context
A good review of common GYN/ONC chemotherapy agents, especially for residents. Given at Wake Forest. Thanks to Dr. Michael Kelly for contributing and reviewing.
Vinca Alkaloids as Anticancer Agents (Looking back and peering ahead)
This document discusses Vinca alkaloids, which are anti-cancer agents originally isolated from the Madagascar periwinkle plant. It covers the structure, mechanism of action, applications, and total synthesis of major Vinca alkaloids like vinblastine and vincristine. The document also summarizes emerging vinblastine-related compounds through modifications to the catharanthine and vindoline nuclei. Finally, it discusses drug targeting approaches for Vinca alkaloids like conjugating vinblastine to folic acid to selectively target cancer cells overexpressing folate receptors.
Advanced study of natural sources of anti-cancer
This document discusses natural sources of anti-cancer agents. It notes that plant-based drug discovery has resulted in important anticancer agents derived from plants, marine organisms, and microorganisms. It also outlines numerous phytochemicals found in fruits and vegetables that can be used in anticancer therapy, including curcumin, resveratrol, genistein, and compounds from garlic, soybeans, tomatoes, and other foods. The review suggests that active principles from natural products represent an opportunity to discover novel anticancer agents and mechanisms of action.
Natural products as leads for new pharmaceuticals
THE LEADS FOR NEW PHARMACEUTICALS ARE DIFFICULT TO COLLECT BUT WE HAVE TRIED BEST TO EXPLAIN AND COVER THE MOST.
Anti cancer thesis
Studies that examined the therapeutic potential of plants leaf extracts
Plant Scientific Name Common Name Type of extraction Proposed active material
1. Solanum viarum Tropical Soda Apple Ether Solasodine glycoalkaloid
2. Acanthus illicifolious Harkucha Kanta Methanol Triterpenoids,Flavonoids,
Alkaloids
3. Annona squamosa Custard Apple Ethyl acetate Acetogenins,Alkaloids,
Dofamine
4 Alstonia scholaris. Chatium Methanol Alkaloids,Flavonoids
5. Calotropis gigantea Akanda Ethanol Triterpenoids,Flavonol
Glycosides
Advances in research on the anticancer mechanism of the natural compound cucu...
The document reviews the anticancer mechanisms of the natural compound cucurbitacin from Cucurbitaceae plants. It summarizes that cucurbitacins induce tumor cell apoptosis through multiple pathways, including the STAT3, MAPK, NF-κB, and PI3K/AKT signaling pathways. It also discusses how cucurbitacins promote cytoskeletal destruction and cell cycle arrest. Studies show cucurbitacins exert anticancer effects by multi-targeting various cancer-related signaling pathways and have potential as anticancer drugs.
The flavonoid quercetin transientyly inhibits the activity of taxol and nocod...
This study examined the effects of the flavonoid quercetin on cancer cell viability and cell cycle progression when administered alone or in combination with the microtubule-targeting drugs taxol and nocodazole. The researchers found that while quercetin induced cancer cell death in a dose-dependent manner, lower doses of quercetin protected cancer cells from the G2/M cell cycle arrest induced by taxol and nocodazole. Specifically, quercetin delayed cell cycle progression, inhibited the accumulation of cyclin B1 at the microtubule organizing center, and partially restored viability of drug-treated cells for up to 72 hours. However, long-term exposure to quercetin still suppressed cancer cell proliferation and
What's hot (20)
Medicinal plants and cancer A series of Presentation By Mr. Allah Dad Khan ...
Medicinal plants and cancer A series of Presentation By Mr. Allah Dad Khan ...
Study the anticancer effect of lepidium sativum leaves extract
Study the anticancer effect of lepidium sativum leaves extract
Anticancer drugs: Classification , general toxicity and Alkylating agents.
Anticancer drugs: Classification , general toxicity and Alkylating agents.
Vinca Alkaloids as Anticancer Agents (Looking back and peering ahead)
Vinca Alkaloids as Anticancer Agents (Looking back and peering ahead)
Advances in research on the anticancer mechanism of the natural compound cucu...
Advances in research on the anticancer mechanism of the natural compound cucu...
The flavonoid quercetin transientyly inhibits the activity of taxol and nocod...
The flavonoid quercetin transientyly inhibits the activity of taxol and nocod...
Similar to Taxoids
Antimicrotubules kiran
Antimicrotubule agents such as paclitaxel and docetaxel are microtubule-stabilizing drugs that directly bind to tubulin. They profoundly alter microtubule dynamics and suppress microtubule depolymerization, leading to mitotic arrest. Peripheral neuropathy is a common side effect due to their effects on microtubules in neurons. Paclitaxel and docetaxel are effective in treating several types of cancer but require premedication to reduce hypersensitivity reactions and have dose-limiting toxicities of neutropenia and neuropathy.
Adele- URECA Poster Presentation
1. The document describes the synthesis and biological evaluation of SB-T-1216, a potent second-generation taxoid.
2. Enantiopure β-lactam is prepared via chiral ester-enolate imine cyclocondensation and Staudinger cycloaddition, then coupled to a modified baccatan.
3. SB-T-1216 shows greater efficacy than paclitaxel against drug-resistant cancer cell lines, with IC50 values over 100-fold lower for resistant cell lines. It induces microtubule bundling and cell death at lower concentrations than paclitaxel.
Ovarian damage from chemotherapy and current approaches to its protection.
1) Chemotherapy drugs like cyclophosphamide, cisplatin, and doxorubicin can damage the ovaries and reduce female fertility by inducing follicle loss and early menopause.
2) Potential methods to protect the ovaries include using tamoxifen to reduce cyclophosphamide-induced damage, using luteinizing hormone to protect from cisplatin toxicity, and using bortezomib to reduce doxorubicin-induced DNA damage.
3) Further research into ovarian protection methods is needed to preserve fertility for women undergoing chemotherapy.
MA et al. 2017_SciReps
1. Several Pancratistatin (PST) analogs, including SVTH-7, SVTH-6, and SVTH-5, were found to have potent anti-cancer activity greater than PST and standard chemotherapeutics in a medium-throughput screen of various cancer cell lines.
2. The PST analogs disrupted mitochondrial function, activated the intrinsic apoptotic pathway, and reduced tumor growth in vivo. Inhibition of mitochondrial complexes II and III abrogated the pro-apoptotic effects of SVTH-7, suggesting it exploits a mitochondrial vulnerability.
3. This work identifies several PST analogs with high therapeutic potential and provides insight into distinct mitochondrial features of cancer
5cancer
Nanotechnology shows promise for improving cancer treatment. Nanoparticles can be engineered to selectively target tumors using passive and active targeting methods. Passive targeting relies on the enhanced permeability and retention effect whereby nanoparticles accumulate in leaky tumor vasculature and are trapped there. Drugs encapsulated in nanoparticles like Doxil have shown improved efficacy with less toxicity compared to free drugs due to passive targeting. Active targeting attaches molecules to nanoparticles that bind specific cellular receptors overexpressed on cancer cells. Many nanotherapies are in clinical trials including PET imaging agents and immune-stimulating adenovirus nanoparticles.
Vital Signs Edition #2
The document discusses evidence that calls into question the theory that Avastin works as an anti-angiogenic drug by cutting off blood supply to tumors. Some studies show Avastin is more effective when added to weaker chemotherapy regimens, suggesting it may work by depleting the stromal layer surrounding tumors and allowing more chemotherapy to reach cancer cells. The debate over Avastin's mechanism of action will continue. The document also provides updates on clinical trials investigating drugs for lung cancer and pancreatic cancer that target the stromal tissue surrounding tumors.
Tubulysin
Tubulysins, originally isolated from myxobacteria, are a series of antimitotic tetrapeptides discovered by Hofle and co-workers in 2000. Functionally similar to dolastatins, tubulysins are among the most powerful cell division inhibitors reported until now. Due to their ability to inhibit tubulin polymerization, tubulysins exert a potent anti-proliferative activity against human cancer cells, even the drug-resistant cancer cells.
Aimee Skrei Melendy Poster
The document describes research into creating an antibody-drug conjugate (ADC) to treat metastatic triple negative breast cancer. Key points:
- Researchers developed an antibody that recognizes HSPG2, a biomarker expressed on metastatic breast cancer cells, and aims to link this antibody to the chemotherapy drug paclitaxel.
- The ADC would be synthesized by modifying the antibody with thiol groups and paclitaxel with maleimide groups, allowing them to conjugate.
- While the antibody thiolation was successful, complications arose in activating paclitaxel for conjugation. Other drug molecules will be explored to complete the ADC synthesis.
Spindle MT Dynamics
1. The document discusses microtubule organization in the mitotic spindle apparatus, which involves both centrosome-based nucleation and acentrosomal branching microtubule nucleation.
2. Using Xenopus egg extracts and total internal reflection microscopy, the study directly observed branching microtubule nucleation from existing microtubules.
3. The study found that RanQ69L and its effector protein TPX2 have an activating effect on branching microtubule nucleation and daughter microtubules maintain polarity. Components of the γ-TuRC and augmin complexes and the RanGTP signaling pathway were found to be involved in primary and branching nucleation, respectively.
RoswellResearchPoster2015-ver2smaller-1
- Ovarian cancer cell growth is markedly reduced by inhibitors of the TAK1-IKK pathway, suggesting TAK1 signaling drives ovarian cancer progression.
- Matrix Metalloproteinase-9 (MMP9) secretion is stimulated by TGF-β and TNF-α in some ovarian cancer cell lines, and this secretion may depend on TAK1 signaling.
- Motility of ovarian cancer cells is increased by TNF-α but decreased by TAK1-IKK pathway inhibitors, indicating TAK1-IKK signaling plays a role in ovarian cancer cell invasion.
Current Perspective of Natural Alkaloid Carbazole and its Derivatives as Anti...
This document summarizes research on natural and synthetic carbazole alkaloids and their potential as antitumor agents. Several studies are described that tested various carbazole derivatives for cytotoxicity against different cancer cell lines. Many of the carbazole compounds showed cytotoxicity in the low micromolar or nanomolar range against cell lines like MCF-7, A549, HCT-116, and others. The carbazoles are proposed to exert their antitumor effects through mechanisms like DNA intercalation or inhibition of DNA-dependent enzymes. The review concludes that natural carbazole alkaloids and their derivatives show promise as antitumor agents and warrant further investigation.
A Comprehensive Guide to ADC Payload Classes.pdf
ADC payloads are critical components of the ADC structure, and their selection and design are crucial for achieving optimal therapeutic efficacy and minimizing toxicity.
Cytokine Immunotherapy: A Forthcoming Visible Feature in Cancer Therapeutics
The document discusses cytokine immunotherapy as a promising approach for cancer treatment. It notes that cytokines can stimulate the immune system to fight tumors, but that mono-cytokine therapy has limitations. Combined cytokine therapy or cytokine therapy combined with other treatments may be more effective by creating a specific immune response. The document advocates focusing research on combination therapies to help overcome drawbacks of traditional cancer treatments.
CHEMISTRY OF PACLITAXEL( NATURAL CHEMISTRY).pptx
Paclitaxel is a chemotherapy medication used to treat various types of cancer, including ovarian, breast, lung, and pancreatic cancer. It is a natural product derived from the bark of the Pacific yew tree, Taxus brevifolia.
Paclitaxel works by inhibiting the growth and spread of cancer cells by interfering with the normal function of microtubules, which are necessary for cell division. By disrupting microtubule function, paclitaxel prevents cancer cells from dividing and replicating, ultimately leading to their death.
Paclitaxel is administered intravenously and is usually given in combination with other chemotherapy drugs. It can cause side effects such as hair loss, fatigue, nausea, vomiting, and low blood cell counts. However, these side effects are often temporary and can be managed with supportive care.
Despite its side effects, paclitaxel has been shown to be an effective treatment for many types of cancer, and has helped to improve the survival rates of cancer patients.
PaperRozenchan 2015
This research article examines the expression of RhoA and Rac1 in fibroblasts found at primary breast tumor sites and corresponding lymph node metastases. Immunohistochemistry on tissue microarrays revealed that 59% of fibroblasts at primary tumors and 41% at lymph node metastases expressed RhoA. Similarly, 57.1% at primary tumors and 42.9% at lymph node metastases expressed Rac1. Since expression levels were similar between primary and metastatic sites, the researchers suggest that fibroblasts actively participate in cancer cell invasion to lymph nodes and that metastatic cells continue relying on their microenvironment. Primary cell cultures were used to validate differences in focal adhesion pathways between carcinoma-associated fibroblasts and normal fibroblasts previously found via genomic profiling.
Claudin 1 expression in basal-like breast cancer is related to patient age
Defects in tight junctions, gate-keepers of the integrity of the epidermal barrier function, are known to contribute to cancer development. As such, enhancing our understanding of how the expression of proteins involved in these junctions is regulated in cancer, remains a priority. Although the expression of one of these proteins, claudin 1, is down regulated in most invasive human breast cancers (HBC), we have recently shown that high levels of claudin 1, characterized tumors belonging to the very aggressive basal-like breast cancer (BLBC) subtype. In these tumors, the claudin 1.
Similar to Taxoids (16)
Ovarian damage from chemotherapy and current approaches to its protection.
Ovarian damage from chemotherapy and current approaches to its protection.
Current Perspective of Natural Alkaloid Carbazole and its Derivatives as Anti...
Current Perspective of Natural Alkaloid Carbazole and its Derivatives as Anti...
Cytokine Immunotherapy: A Forthcoming Visible Feature in Cancer Therapeutics
Cytokine Immunotherapy: A Forthcoming Visible Feature in Cancer Therapeutics
Claudin 1 expression in basal-like breast cancer is related to patient age
Claudin 1 expression in basal-like breast cancer is related to patient age
More from Creative Biolabs
What is oncolytic virus
Recently, the development of molecular biotechnology allows modifications of viral genomes genetically and optimizes the transformation of available viruses with weak pathogenicity. These methods are used to enhance the oncolytic effect and reduce adverse reactions to maximize both efficacy and safety. Indeed, the oncolytic virus can stimulate a pro-inflammatory tumor environment by enhancing antigen recognition and robust immune responses. It overcomes the immune evasiveness and escape of malignant cells to eliminate the tumor cells.
https://www.creative-biolabs.com/oncolytic-virus/definition-of-an-oncolytic-virus.htm
What is oncolytic virus therapy
An oncolytic virus is a form of promising therapeutic tool for the treatment of malignant tumors, which uses viruses to selectively infect and kill tumor cells and further to induce or boost specific antitumor immunity. https://www.creative-biolabs.com/oncolytic-virus/definition-of-an-oncolytic-virus.htm
Reporter-encoding Oncolytic Virus
Oncolytic viruses encoding reporter genes utilized for in vivo molecular imaging are useful to locate the distribution of oncolytic viruses in pre-clinical tests. Optical detection methods mainly include green fluorescent protein (GFP), enhanced GFP (eGFP), discosoma red fluorescent protein (DsRed), and bioluminescence imaging (BLI), which utilizes luciferases. Reporter-encoding oncolytic viruses, including vaccinia virus, adenovirus, herpes simplex virus and vesicular stomatitis virus, allow accurate tracking of gene expression, tumor metastases, viral infection as well as assessment of gene therapy.
https://www.creative-biolabs.com/oncolytic-virus/category-reporter-encoding-oncolytic-virus-293.htm
Pre-made Oncolytic VACV
Vaccinia virus can accommodate more than 30 kb of foreign DNA. Foreign genes can be stably integrated into the viral genome, resulting in efficient and long-term gene expression. The deletion of the viral genes of thymidine kinase (TK) and vaccinia growth factors (VGF) results in enhanced tumor-selectively and antitumor activity, and reduced virus virulence. https://www.creative-biolabs.com/oncolytic-virus/category-pre-made-oncolytic-vaccinia-virus-291.htm
Pre-made Oncolytic Vaccinia Virus
Oncolytic viruses are a class of antitumor agents that selectively kill tumor cells without affecting normal cells. Vaccinia virus (VACV) is a large, enveloped virus that is considered as the most potential live biotherapeutic agent because of its strong oncolytic efficacy and potent antigen presentation capability that can combine well with its natural oncolytic activities for cancer immunotherapy. Many types of modified vaccinia virus have been used for in vitro and in vivo studies, as well as clinical trials.https://www.creative-biolabs.com/oncolytic-virus/category-pre-made-oncolytic-vaccinia-virus-291.htm
Pre-made Oncolytic HSV
Partial deletion of the HSV gene results in superior packaging capacity of >30 kb foreign DNA with low toxicity as an expression vector. Multiple modified purified oncolytic herpes simplex virus (oHSV) products can avoid evading the host immune response and reduce toxicity by gene knock-out, such as ICP0, ICP4, ICP22, ICP27 or ICP47.https://www.creative-biolabs.com/oncolytic-virus/category-pre-made-oncolytic-herpes-simplex-virus-290.htm
Pre-made Oncolytic Herpes Simplex Virus
Oncolytic viruses are using for the treatment of cancer due to the specific antitumor activity in tumor cells. Herpes simplex virus (HSV) is a human neurogenic dsDNA virus that has the characteristic of life-long latent infection of neurons and allows for long-term transgene expression.https://www.creative-biolabs.com/oncolytic-virus/category-pre-made-oncolytic-herpes-simplex-virus-290.htm
Oncolytic Virus Delivery
Oncolytic viruses have the potential to powerfully and selectively kill cancer cells and have shown impressive efficacy in preclinical and clinical settings. However, their potential can be restricted by inefficient delivery into the complex tumor environment. Thus, the efficient delivery of oncolytic viruses remains a significant challenge in the field of oncology, limiting their therapeutic effect. https://www.creative-biolabs.com/oncolytic-virus/approaches-to-delivery-of-oncolytic-viruses.htm
Oncolytic Virus Application
Numerous viruses are being developed pre-clinically and clinically. An investigation of all registered clinical trials in 2017 demonstrates 78 interventional trials regarding OVs. This ability for near-universal therapeutic impact in cancer makes OVs a popular therapeutic tool. Today, both preclinical and early-stage clinical trials are intensively investigating the approach to improve oncolytic virotherapy.
https://www.creative-biolabs.com/oncolytic-virus/applications-of-oncolytic-viruses-in-cancer-treatment.htm
Oncolytic Virus Animal Model
To fully optimize oncolytic virotherapy and provide meaningful mechanistic insight, it is important to have representative animal models of oncolysis in various tumor types. https://www.creative-biolabs.com/oncolytic-virus/animal-models-for-oncolytic-virus-study.htm
Abciximab mechanism of action
Abciximab (also known as abcixifiban or c7E3 Fab), is the Fab fragment of the chimeric human-murine, monoclonal antibody 7E3. It is composed of murine variable regions and human constant regions.https://www.creativebiolabs.net/abciximab-overview.htm
Abagovomab mechanism of action
Abagovomab is a murine monoclonal anti-idiotypic antibody (MW: 165-175 kDa), produced by a mouse hybridoma and generated against OC125, which serves to functionally imitate the human cancer antigen 125 (CA-125). https://www.creativebiolabs.net/abagovomab-overview.htm
Wnt Pathway
Wnt comprises a diverse family of secreted lipid-modified signaling glycoproteins that are 350-400 amino acids in length. Wnt is an acronym in the field of genetics that stands for 'Wingless/Integrated'.https://www.creativebiolabs.net/wnt-signaling-pathway.htm
TNF Pathway
TNF works through two receptors, TNFR1 and TNFR2. TNFR1 is the major signal receptor of TNF-α. TNFR2, which mediates limited biological responses, binds to TNF-α and TNF-β. TNF signaling transduction through TNFR1 and TNFR2 can induce a variety of cellular responses, which depends on many factors, including the metabolic state of the cell and the adaptor proteins present in the cell.https://www.creativebiolabs.net/tnf-signaling-pathway.htm
TLR Pathway
Innate immune receptors, also known as pattern recognition receptors (PRRs), have been identified in the serum, on the cell surface, in endosomes, and in the cytoplasm. Toll-like receptors (TLRs) is one of the particularly important groups of PRRs.https://www.creativebiolabs.net/tlr-signal-pathway.htm
TGF-β Pathway
Transforming growth factor beta (TGF-β) is a cytokine that participates in both physiological and pathological processes.https://www.creativebiolabs.net/tgf-beta-signaling-pathway.htm
TCR Pathway
T-cell receptor (TCR) is a heterodimers composed of α and β peptide chains. TCR is mainly responsible for recognizing the antigens presented by major histocompatibility complex (MHC) molecules on the surface of antigen presenting cells (APC).https://www.creativebiolabs.net/tcr-signal-pathway.htm
RAS Pathway
Ras, which is a low-molecular-weight GDP/GTP-binding guanine triphosphatase, is the prototypical member of the Ras superfamily of proteins. https://www.creativebiolabs.net/ras-signaling-pathway.htm
PPAR Pathway
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors, which are responsible for regulating gene expression.https://www.creativebiolabs.net/ppar-signaling-pathway.htm
VPI3K-AKT Pathway
PI3K-Akt signaling pathway is one of the important signal transduction pathways in cells. It is involved in regulating cell metabolism, growth, proliferation, survival, transcription and protein synthesis by affecting the activation of downstream effector molecules. https://www.creativebiolabs.net/pi3k-akt-signaling-pathway.htm
More from Creative Biolabs (20)
Recently uploaded
NVBDCP.pptx Nation vector borne disease control program
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
STIs may cause PID. For the both disease, herbal medicine Fuyan Pill can be a solution.
Non-respiratory Functions of the Lungs.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Novas diretrizes da OMS para os cuidados perinatais de mais qualidadeProf. Marcus Renato de Carvalho
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Role of Mukta Pishti in the Management of Hyperthyroidism
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Journal Article Review on Rasamanikya
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
A Classical Text Review on Basavarajeeyam
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Adhd Medication Shortage Uk - trinexpharmacy.com
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
PPT RELATED TO ARTHROLOGY ACCORDING TO NCISM AYURVEDA
The Best Ayurvedic Antacid Tablets in India
Treat the symptoms of indigestion, heartburn and stomach reflux with the 10 Best Ayurvedic Antacid Tablets in India.
#cALL# #gIRLS# In Dehradun ꧁❤8107221448❤꧂#cALL# #gIRLS# Service In Dehradun W...
#cALL# #gIRLS# In Dehradun ꧁❤8107221448❤꧂#cALL# #gIRLS# Service In Dehradun W...chandankumarsmartiso
#cALL# #gIRLS# In Dehradun ꧁❤8107221448❤꧂#cALL# #gIRLS# Service In Dehradun Women Seeking Service
Physiology of Chemical Sensation of smell.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recently uploaded (20)
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
Thyroid Gland- Gross Anatomy by Dr. Rabia Inam Gandapore.pptx
NVBDCP.pptx Nation vector borne disease control program
NVBDCP.pptx Nation vector borne disease control program
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
CHEMOTHERAPY_RDP_CHAPTER 6_Anti Malarial Drugs.pdf
Tests for analysis of different pharmaceutical.pptx
Tests for analysis of different pharmaceutical.pptx
#cALL# #gIRLS# In Dehradun ꧁❤8107221448❤꧂#cALL# #gIRLS# Service In Dehradun W...
#cALL# #gIRLS# In Dehradun ꧁❤8107221448❤꧂#cALL# #gIRLS# Service In Dehradun W...
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Vestibulocochlear Nerve by Dr. Rabia Inam Gandapore.pptx
Taxoids
- 2. Taxoids • Taxoids, also known as paclitaxel, are derivatives from taxol, an early potent anticancer compound extracted from Pacific yew (Taxus brevifolia Nutt). Taxiods was first discovered and named by Wall et al. in 1966 and their cytotoxcicity was later demonstrated in 9 KB cancer cell and tissue culture. Since then, taxiods have been documented to show anti-cancer activity against leukemia and murine melanoma cell cultures, as well as various xenograft mouse models bearing MX1 (breast), CX1 (colon) and LX1 (lung) carcinomas.
- 3. • Taxiods were shown to function as microtubule- stabilizing agents to expedit tubulin polymerization. They have generated a remarkable impact on current cancer chemotherapy against breast, ovary, and lung cancers. • Additionally, taxoids have also been used in the form of conjugates with different tumor-targeting modules including polyunsaturated fatty acids (PUFAs) and monoclonal antibodies, etc. to further enhance their anti- cancer activities and to increase their theraputic windows.
- 4. The structure of taxol (paclitaxel), a powerful anti-cancer agent (J Med Chem, 2010).
- 5. LOREM IPSUM DOLOR Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.
- 6. Content 2 Ta x o i d s - b a s e d a n t i b o d y - d r u g c o n j u g a t e s 1 Taxoids mode of action (MOA)
- 7. At clinically interrelated concentrations (1–10 nM), taxoids (paclitaxel) reveal their efficacy by inhibiting microtubule dynamics. Taxoids bind to the tubulin heterodimer at its β-tubulin subunit, and they have been shown to change microtubule morphology, resulting in a decreased number of protofilaments in microtubules. Taxoids (paclitaxel) mainly bind to microtubules rather than individual tubulin dimers and cause protofilament reduction within second in preformed microtubules. Taxoids mode of action (MOA)
- 8. Clinical analysis have revealed taxoids’ significant efficacy against advanced solid tumors, such as breast and ovarian cancer. However, taxoids are still highly toxic and they often present with poor solubility. A novel strategy of the taxoids delivering, taxoid-antibody conjugates, has arisen to circumvent these limitations. The antibody’s targeting function is usually not compromized by the chemical coupling of a taxoid-linker complex and the antibody deliver the drug into the tumor cells via receptor mediated endocytosis upon target receptor binding. Taxoids-based antibody-drug conjugates
- 9. Contact Us 45-1 Ramsey Road, Shirley, NY 11967, USA Tel: 1-631-619-7922 Fax: 1-631-207-8356 Email: marketing@creative- biolabs.com
- 10. THANK YOU