Complementary therapies are widespread but controversial. We aim to provide a
comprehensive collection and a summary of systematic reviews of clinical trials in three major
complementary therapies (acupuncture, herbal medicine, homeopathy). This article is dealing with
homeopathy. Potentially relevant reviews were searched through the register of the Cochrane
Complementary Medicine Field, the Cochrane Library, Medline, and bibliographies of articles and
books. To be included articles had to review prospective clinical trials of homeopathy; had to
describe review methods explicitly; had to be published; and had to focus on treatment effects.
Information on conditions, interventions, methods, results and conclusions was extracted using a
pretested form and summarized descriptively.
Randomised placebo-controlled trials of individualised homeopathic treatment:...home
Conclusions: Medicines prescribed in individualised homeopathy may have small, specific treatment effects.
Findings are consistent with sub-group data available in a previous ‘global’ systematic review. The low or unclear
overall quality of the evidence prompts caution in interpreting the findings. New high-quality RCT research is
necessary to enable more decisive interpretation.
A systematic review of the quality of homeopathic clinical trialshome
While a number of reviews of homeopathic clinical trials have been done, all have
used methods dependent on allopathic diagnostic classifications foreign to homeopathic practice.
In addition, no review has used established and validated quality criteria allowing direct comparison
of the allopathic and homeopathic literature.
Observations about controlled clinical trials expressed by Max Haidvogl
in the book Ultra High Dilution (1994) have been appraised from a perspective two
decades later. The present commentary briefly examines changes in homeopathy
research evidence since 1994 as regards: the published number of randomised controlled
trials (RCTs), the use of individualised homeopathic intervention, the ‘proven efficacy of
homeopathy’, and the quality of the evidence.
Randomised placebo-controlled trials of individualised homeopathic treatment:...home
Conclusions: Medicines prescribed in individualised homeopathy may have small, specific treatment effects.
Findings are consistent with sub-group data available in a previous ‘global’ systematic review. The low or unclear
overall quality of the evidence prompts caution in interpreting the findings. New high-quality RCT research is
necessary to enable more decisive interpretation.
A systematic review of the quality of homeopathic clinical trialshome
While a number of reviews of homeopathic clinical trials have been done, all have
used methods dependent on allopathic diagnostic classifications foreign to homeopathic practice.
In addition, no review has used established and validated quality criteria allowing direct comparison
of the allopathic and homeopathic literature.
Observations about controlled clinical trials expressed by Max Haidvogl
in the book Ultra High Dilution (1994) have been appraised from a perspective two
decades later. The present commentary briefly examines changes in homeopathy
research evidence since 1994 as regards: the published number of randomised controlled
trials (RCTs), the use of individualised homeopathic intervention, the ‘proven efficacy of
homeopathy’, and the quality of the evidence.
Homeopathic treatment of patients with chronic sinusitis: A prospective obser...home
This observational study showed relevant improvements that persisted for 8 years
in patients seeking homeopathic treatment because of sinusitis. The extent to which the observed
effects are due to the life-style regulation and placebo or context effects associated with the
treatment needs clarification in future explanatory studies.
OMICS Publishing Group, Journal of Clinical Pharmacology & Biopharmaceutics (CPB) emphasizes the phases of drug development from absorption, disposition, metabolism, excretion interactions and rational design of drug products to deliver the drug at a specific rate to the body in order to optimize the therapeutic effect and minimize any adverse effects. The CPB acts as an interface between academics, those in research and developments, explicates the research on various developmental applications for contemporary drug development and utilization.
Homeopathy in the treatment of fibromyalgia A comprehensive literature-review...home
Given the low number and included trials and the lowmethodological quality, any conclusion based on the resultsof this review have to be regarded as preliminary. However,as single case studies and clinical trials indicate a positiveeffect, homeopathy could be considered a complementarytreatment for patients with fibromyalgia
Freshers in clinical research and regulatory affairs must go through this presentation. It will help you to understand the basis of clinical trial design as per European guidelines, which is the most preferred reference guideline. Initially, I also faced many problems to understand this concept. A student who is studying a clinical research diploma can also use this presentation for their basic understanding.
Trends in management of rheumatoid arthritis Dr.Neena Mehan
Rheumatoid Arthritis (RA) is an auto-immune disease in which body mistakenly considers some parts of its own system as pathogens and attacks them.
Homeopathic and conventional treatment for acute respiratory and ear complain...home
This comparative cohort study, involving more than
1,500 patients in primary care practices of at least 6 different
European countries, demonstrates that homeopathic
treatment for acute respiratory and ear complaints was not
inferior to conventional treatment. Although no firm conclusions
can be drawn about the efficacy of homeopathic
treatment, these results certainly contribute to the growing
evidence that homeopathy is a safe and beneficial
treatment strategy for acute diseases in primary care settings.
Homeopathic treatment of patients with chronic sinusitis: A prospective obser...home
This observational study showed relevant improvements that persisted for 8 years
in patients seeking homeopathic treatment because of sinusitis. The extent to which the observed
effects are due to the life-style regulation and placebo or context effects associated with the
treatment needs clarification in future explanatory studies.
OMICS Publishing Group, Journal of Clinical Pharmacology & Biopharmaceutics (CPB) emphasizes the phases of drug development from absorption, disposition, metabolism, excretion interactions and rational design of drug products to deliver the drug at a specific rate to the body in order to optimize the therapeutic effect and minimize any adverse effects. The CPB acts as an interface between academics, those in research and developments, explicates the research on various developmental applications for contemporary drug development and utilization.
Homeopathy in the treatment of fibromyalgia A comprehensive literature-review...home
Given the low number and included trials and the lowmethodological quality, any conclusion based on the resultsof this review have to be regarded as preliminary. However,as single case studies and clinical trials indicate a positiveeffect, homeopathy could be considered a complementarytreatment for patients with fibromyalgia
Freshers in clinical research and regulatory affairs must go through this presentation. It will help you to understand the basis of clinical trial design as per European guidelines, which is the most preferred reference guideline. Initially, I also faced many problems to understand this concept. A student who is studying a clinical research diploma can also use this presentation for their basic understanding.
Trends in management of rheumatoid arthritis Dr.Neena Mehan
Rheumatoid Arthritis (RA) is an auto-immune disease in which body mistakenly considers some parts of its own system as pathogens and attacks them.
Homeopathic and conventional treatment for acute respiratory and ear complain...home
This comparative cohort study, involving more than
1,500 patients in primary care practices of at least 6 different
European countries, demonstrates that homeopathic
treatment for acute respiratory and ear complaints was not
inferior to conventional treatment. Although no firm conclusions
can be drawn about the efficacy of homeopathic
treatment, these results certainly contribute to the growing
evidence that homeopathy is a safe and beneficial
treatment strategy for acute diseases in primary care settings.
Homeopathic and conventional treatment for acute respiratory and ear complain...home
Data of 1,577 patients were evaluated in the full analysis set of which 857 received homeopathic (H) and 720
conventional (C) treatment. The majority of patients in both groups reported their outcome after 14 days of treatment
as complete recovery or major improvement (H: 86.9%; C: 86.0%; p = 0.0003 for non-inferiority testing). In the perprotocol
set (H: 576 and C: 540 patients) similar results were obtained (H: 87.7%; C: 86.9%; p = 0.0019). Further
subgroup analysis of the full analysis set showed no differences of response rates after 14 days in children (H: 88.5%; C:
84.5%) and adults (H: 85.6%; C: 86.6%). The unadjusted odds ratio (OR) of the primary outcome criterion was 1.40
(0.89–2.22) in children and 0.92 (0.63–1.34) in adults. Adjustments for demographic differences at baseline did not
significantly alter the OR. The response rates after 7 and 28 days also showed no significant differences between both
treatment groups. However, onset of improvement within the first 7 days after treatment was significantly faster upon
homeopathic treatment both in children (p = 0.0488) and adults (p = 0.0001). Adverse drug reactions occurred more
frequently in adults of the conventional group than in the homeopathic group (C: 7.6%; H: 3.1%, p = 0.0032), whereas in
children the occurrence of adverse drug reactions was not significantly different (H: 2.0%; C: 2.4%, p = 0.7838).
Homeopathy for allergic rhinitis: protocol for a systematic reviewhome
This will be the first systematic review of all types of
homeopathy for allergic rhinitis. We have attempted to
design a robust protocol which should result in an objective
and adequate summary of the available evidence
in this area of research. The review is not limited to
studies published in the English language: such limitation
might have excluded several studies that met all
other inclusion criteria. The selected databases index a
large number of CAM journals and the search strategy
is expected to identify most of the relevant studies that
exist.
Homeopathic treatment of elderly patients - a prospective observational study...home
The severity of disease showed marked and sustained improvements under homeopathic treatment,
but this did not lead to an improvement of quality of life. Our findings might indicate that homeopathic medical
therapy may play a beneficial role in the long-term care of older adults with chronic diseases and studies on
comparative effectiveness are needed to evaluate this hypothesis.
Efficacy of individualized homeopathic treatment and fluoxetine for moderate ...home
his study is the first trial of classical homeopathy that will evaluate the efficacy of homeopathic
individualized treatment using C-potencies versus placebo or fluoxetine in peri- and postmenopausal women with
moderate to severe depression. It is an attempt to deal with the obstacles of homeopathic research due to the
need for individual prescriptions in one of the most common psychiatric diseases.
Clinical trial of homeopathy in rheumatoid arthritishome
The conclusion of the study that the effect was due to
‘consultation’ and not to the homeopathic remedy appears
to be biased for two reasons:
There was no substantial amelioration of the pathology
in any group to compare and on which to base conclusions.
The placebo effect in such deep pathology cases is superficial
and transient as the patient remains in essence with
the same frame of pathology.
A protocol for a trial of homeopathic treatment for irritable bowel syndromehome
Irritable bowel syndrome is a chronic condition with no known cure. Many sufferers seek
complementary and alternative medicine including homeopathic treatment. However there is much controversy as
to the effectiveness of homeopathic treatment. This three-armed study seeks to explore the effectiveness of
individualised homeopathic treatment plus usual care compared to both an attention control plus usual care and
usual care alone, for patients with irritable bowel syndrome.
P04.17. Adverse effects of homeopathy, what do we know? A systematic reviewhome
In order to prevent serious events as a consequence of
homeopathic treatment, the identification of an unwanted
adverse event is of critical importance. A differentiation of
adverse events and homeopathic aggravations, which is
accepted as a concept in homeopathy, should be a part of
a reporting system where risk and safety are assessed. This
is of particular significance in a treatment system like
homeopathy, which is in most European countries regulated
as an alternative treatment and as such not included
in the supervision system of health care.
Homeopathy – what are the active ingredients? An exploratory study using the ...home
This study has has identified, using primary consultation and other data, a range of
factors that might account for the effectiveness of homeopathic care. Some of these, such as
empathy, are non-specific. Others, such as the remedy matching process, are specific to
homeopathy. These findings counsel against the use of placebo-controlled RCT designs in which
both arms would potentially be receiving specific active ingredients. Future research in homeopathy
should focus on pragmatic trials and seek to confirm or refute the therapeutic role of constructs
such as patient "openness", disclosure and homeopathicity
Homeopathy – what are the active ingredients? An exploratory study using the ...home
This study has has identified, using primary consultation and other data, a range of
factors that might account for the effectiveness of homeopathic care. Some of these, such as
empathy, are non-specific. Others, such as the remedy matching process, are specific to
homeopathy. These findings counsel against the use of placebo-controlled RCT designs in which
both arms would potentially be receiving specific active ingredients. Future research in homeopathy
should focus on pragmatic trials and seek to confirm or refute the therapeutic role of constructs
such as patient "openness", disclosure and homeopathicity.
Homeopahty, el proyecto de un Sistema de Salud, protagonistas, fundadores, ideólogos históricos, las iniciativas de Medicina Alternativa Complementaria CAM.
Homeopathy—quackery or a key to the future of medicine?home
When cholera first invaded Europe in 1831, the
mortality throughout Europe was generally between
40% and 60%. To the surprise of many, mortality
rates reported by homeopathic physicians was generally
below 10%, and commonly under 4%. Let me
present two typical cholera reports, which have a
stamp of officialdom. The first one comes from the
territory of Raab in Hungary where in 1831 a
Dr Joseph Bakody treated 223 patients with mild to
severe cholera, 14 of which were in a state of collapse .
He lost a total of 8 patients, a mortality of 3.6%. A
similar situation occurred in Cincinnati in 1849. The
Board of Health issued an order calling for physicians
to report all cases of cholera. Reports of a high
mortality rate were received by the Board from the city
hospital and allopathic physicians. However, six
homeopathic physicians attracted national attention
when they reported not a single death out of their first
350 cases of cholera. Two of these homeopathic
physicians, Dr Pulte and Ehrmann would eventually
report treating 2646 cases with 35 deaths, or a
mortality rate of 1.3%. Allopaths reported fatal
outcomes in about 50% of their cases.
Homeopathy as replacement to antibiotics in the case of Escherichia coli diar...home
The use of antibiotics in the livestock sector is increasing to such an extent
that it threatens negative consequences for human health, animal health and the environment.
Homeopathy might be an alternative to antibiotics. It has therefore been tested in
a randomised placebo-controlled trial to prevent Escherichia coli diarrhoea in neonatal
piglets.
Multidrugresistant tuberculosis
Among the most menacing forms of MDR is multidrug
resistant tuberculosis (MDR-TB). WHO estimates that
were about 450,000 new cases and 170,000 deaths from
MDR-TB in 2012. The number of cases reported to
WHO rose by an alarming 35% between 2011 and 2012,
although this probably mostly reflects increased recognition
and reporting. Over half the new cases were in India,
China or the Russian Federation.3
This issue of Homeopathy features a paper by Dr Kusum
Chand and colleagues reporting a randomized, double blind,
placebo-controlled clinical trial of individualized homeopathic
treatment or placebo in addition to standard antituberculous
chemotherapy as specified by the Indian Revised
National Tuberculosis Control Program, for MDR-TB
articleHealth professionals’ and families’ understanding of the role ofindivi...home
This paper draws on a mixed methods study that examined the feasibility of conducting a randomised controlled trial of individualisedhomeopathy plus usual care, compared to usual care alone, for children aged 7–14 with moderate to severe asthma recruited from secondary care.It draws on qualitative interviews with participants in the feasibility study that investigated families’ and professionals’ views and experiences ofasthma, homeopathy and study participation
Cutting Edge Research in Homeopathy: HRI’s second international research conf...home
Rome, 3rde5th June 2015, was the setting for the Homeopathy Research Institute’s (HRI)
second conference with the theme ‘Cutting Edge Research in Homeopathy’. Attended by
over 250 delegates from 39 countries, this event provided an intense two and a half day
programme of presentations and a forum for the sharing of ideas and the creation of international
scientific collaborations. With 35 oral presentations from leaders in the field,
the scientific calibre of the programme was high and the content diverse. This report
summarises the key themes underpinning the cutting edge data presented by the
speakers, including six key-note presentations, covering advancements in both basic
and clinical research. Given the clear commitment of the global homeopathic community
to high quality research, the resounding success of both Barcelona 2013 and
Rome 2015 HRI conferences, and the dedicated support of colleagues, the HRI moves
confidently forward towards the next biennial conference
CORE-Hom: A powerful and exhaustive database of clinical trials in homeopathyhome
The CORE-Hom database was created to answer the need for a reliable and publicly available
source of information in the field of clinical research in homeopathy. As of May 2014
it held 1048 entries of clinical trials, observational studies and surveys in the field of homeopathy,
including second publications and re-analyses. 352 of the trials referenced in
the database were published in peer reviewed journals, 198 of which were randomised
controlled trials. The most often used remedies were Arnica montana (n = 103) and
Traumeel (n = 40). The most studied medical conditions were respiratory tract infections
(n = 126) and traumatic injuries (n = 110). The aim of this article is to introduce
the database to the public, describing and explaining the interface, features and content
of the CORE-Hom database.
Blisters and homeopathy: case reports and differential diagnosishome
Blisters are skin lesions characterized by accumulation of fluid between the layers of the
skin. Their severity varies from the common blisters caused by friction to severe autoimmune
and congenital bullous disorders, some of themcurrently without treatment in conventional
medicine or requiring drugs with potentially severe side-effects. This article
reports cases of blistering diseases successfully treated with homeopathic medicines,
which represent an alternative for the treatment of such disorders.
A short history of the development of homeopathy in Indiahome
Homeopathy was introduced in India the early 19th century. It flourished in Bengal at first,
and then spread all over India. In the beginning, the system was extensively practised by
amateurs in the civil and military services and others. Mahendra Lal Sircar was the first
Indian who became a homeopathic physician. A number of allopathic doctors started
homeopathic practice following Sircar’s lead. The ‘Calcutta Homeopathic Medical
College’, the first homeopathic medical college was established in 1881. This institution
took on a major role in popularising homeopathy in India.
In 1973, the Government of India recognised homeopathy as one of the national systems of
medicine and set up the Central Council of Homeopathy (CCH) to regulate its education
and practice. Now, only qualified registered homeopaths can practice homeopathy in
India. At present, in India, homeopathy is the third most popular method of medical treatment
after allopathy and Ayurveda. There are over 200,000 registered homeopathic doctors
currently, with approximately 12,000 more being added every year.
Utilization of complementary and alternative medicine (CAM) among children fr...home
A homeopathy user utilized on average homeopathic remedies worth EUR 15.28. The corresponding figure for herbal
drug users was EUR 16.02, and EUR 18.72 for overall medicinal CAM users.
CAM use among 15-year-old children in the GINIplus cohort is popular, but decreased noticeably compared
with children from the same cohort at the age of 10 years. This is possibly mainly because German health legislation
normally covers CAM for children younger than 12 years only.
Complementary medical health services: a cross sectional descriptive analysis...home
The clinic attracts people from a wide area in the metropolitan Toronto and surrounding region with
health concerns and diagnoses that are consistent with primary care, providing health education and addressing
acute and chronic health conditions. Further explorations into health services delivery from the broader
naturopathic or other complementary/alternative medical professions would provide greater context to these
findings and expand understanding of the patients and type of care being provided by these health professionals.
Prayer-for-health and complementary alternative medicine use among Malaysian ...home
CAM use was prevalent among breast cancer patients. Excluding PFH from the definition of CAM
reduced the prevalence of overall CAM use. Overall, CAM use was associated with higher education levels and
household incomes, advanced cancer and lower chemotherapy schedule compliance. Many patients perceived
MBP to be beneficial for improving overall well-being during chemotherapy. These findings, while preliminary,
clearly indicate the differences in CAM use when PFH is included in, and excluded from, the definition of CAM
Extreme sensitivity of gene expression in human SH-SY5Y neurocytes to ultra-l...home
The study shows that Gelsemium s., a medicinal plant used in traditional remedies and
homeopathy, modulates a series of genes involved in neuronal function. A small, but statistically significant,
response was detected even to very low doses/high dilutions (up to 30c), indicating that the human neurocyte
genome is extremely sensitive to this regulation.
Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner ...home
These observations delineate the significance of immuno-modulatory circuit during calcarea carbonicamediated
tumor apoptosis. The molecular mechanism identified may serve as a platform for involving calcarea
carbonica into immunotherapeutic strategies for effective tumor regression
P05.39. Clinical experiences of homeopaths participating in a study of the ho...home
Homeopathic medications and dietary protocols were
found to be easily adapted for use in a clinical trial. These
observations provide insights for future research in the
area of homeopathic treatment (for ADHD in particular
and of homeopathy in general) and provide insights for
the potential integration of homeopathic practice into conventional
settings.
P04.71. Acupuncture, self-care homeopathy, and practitioner-based homeopathy:...home
The relationship between acupuncture use and depression
deserves further investigation. Given high levels of
concern about overuse of antibiotics in respiratory infections,
further research into the efficacy and cost-effectiveness
of homeopathy for these conditions is
warranted. Hopefully, future versions of NHIS-CAM
will provide more realistic estimates of expenditures.
P02.167. Long term evaluation of homeopathy on post treatment impairment of p...home
Homeopathy is effective in improving lung capacity and
health status. Benefits remain evident after a year. This
suggests that homeopathy could make an important
contribution to post treatment tuberculosis pulmonary
impairment
OA15.04. Accelerating the healing of bone fracture using homeopathy: a prospe...home
In clinical practice, homeopathy is widely used in the
fracture-repair process, which accelerates the healing of
fractures, enhances callus formation and reduces pain.
But there is no anatomical or scientific evidence yet to
prove that. Therefore, the current study was undertaken
to test the efficacy of homoeopathy in bone fracture
healing.
Commentary on Mathie RT et al. Method for appraising model validity of random...home
Although many researchers agree that applying conventional drug-trial quality criteria to CAM studies lacks
plausibility, few take on the burden of devising alternative criteria in a specific area of CAM. This commentary
points out strengths and weaknesses in the approach taken in the work of Mathie and colleagues to do this for
homeopathy
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
2. BMC Complementary and Alternative Medicine (2001) 1:4 http://www.biomedcentral.com/1472-6882/1/4
in South America, India or Pakistan [3]. This widespread
use is in strong contrast with the position held by many
in scientific medicine that homeopathy has no effect be-
yond placebo [4].
The basic principle of homeopathy is the principle of
similars: A patient with a specific pattern of symptoms is
best treated by a remedy which causes the same or a very
similar pattern in healthy subjects. Homoeopathic reme-
dies are often prescribed in high dilutions some of which
are unlikely to contain any molecules of the originally di-
luted agents. In consequence, homoeopathic remedies –
at least when applied in high dilutions – cannot act by
pharmacological means. Theories for a potential mecha-
nism of action, therefore, postulate the storage of infor-
mation in the dilution process by physical means [5].
Methods
A detailed description of the methods used in this review
of reviews is given in the first part of this series [6]. As a
specific intervention-related inclusion criterion we re-
quired that reports reviewed prospective (not necessarily
controlled) clinical trials of homoeopathic medicines in
humans.
Results
From a total of 22 potentially relevant reviews identified
in the literature screening, 18 reviews published in 19 pa-
pers met the inclusion criteria [7–25] (see table 1). Four
papers were excluded as they were only subgroup or
methodological analyses of previously published papers
[26–29].
Three quantitative meta-analyses addressed the general
question whether homeopathy is different from placebo
by pooling highly heterogeneous study samples [7–9].
Study samples and meta-analytic methods differed con-
siderably (total number of trials covered 97). While two
reviews reported significant effects of homeopathy [7,8]
a third found no effect over placebo in the main analysis
[9]. Several years before the publication of these studies
a meta-analytic approach had already been tried in a the-
sis [10]. However, this review is mainly dealing with the
problems encountered when trying to pool the data and
cannot be interpreted meaningfully with respect to the
effectiveness of homeopathy. Two older reviews included
both placebo-controlled trials and comparisons with
standard treatment [11,12] (total number of trials cov-
ered 107). Results were classified in a vote count as posi-
tive and negative. The majority of the studies had
reported positive results. The conclusions were positive
with reservations in one review and ambiguous in the
other.
Two reviews focused on individualized homeopathy but
were not restricted in terms of conditions investigated. A
review of comparisons of individualized homoeopathic
and conventional treatment found that only few trials of
low quality exist [13]. The other review included mainly
placebo-controlled trials [14]. Overall, the results sug-
gested that individualized homeopathy is superior to pla-
cebo but when the analysis was limited to studies of
better quality the difference was no longer significant.
Four reviews focused on a single condition or a group of
conditions but included a variety of homoeopathic treat-
ments [15–18]. Positive results have been reported for
the treatment of postoperative ilues and asthma but de-
finitive conclusions are not possible.
Arnica is the most often investigated homoeopathic rem-
edy. Typically it is used in conditions involving tissue
trauma. Two reviews with slightly different inclusion cri-
teria have been published [19,20] (total number of trials
covered 37). While the results of the available trials seem
to be contradictory the more comprehensive of the two
reviews had slightly more favorable conclusions.
Systematic reviews addressing more focused questions
are available for the use of isopathic nosodes (diluted al-
lergens) in allergic conditions, Oscillococcinum for influ-
enza-like syndromes, individualized homeopathy for
headache and galphimia for pollinosis [21–25]. Signifi-
cant differences over placebo were reported for all but
the headache review.
3. BMC Complementary and Alternative Medicine (2001) 1:4 http://www.biomedcentral.com/1472-6882/1/4
Table 1: Systematic reviews of clinical trials of homoeopathy
Features
Author Year Indication Homoeopathy/ Studies 1 / 2 / 3 / Results Conclusion
Control 4 / 5
All homoeopathy in all conditions
Cucherat all all/placebo 17 RCT y / y / y / Combined p value for an effect There is some evidence that
2000 [7] n /y over placebo p = 0.000036, for homoeopathy is more than place-
bo.
best trials only p = 0.08 Studies of high quality more likely
to be
negative
Linde 97 [8] all all/placebo 89 RCT y / y / y / OR of all trials over placebo 2.45 Results not compatbile with the
y /y (95%CI 2.05; 2.93), in better trials hypothesis that all homeo-pathy is
1.66 (1.33; 2.08) placebo. No firm evidence for any
single condition
Walach 97 all all/placebo, 41 RCT y / p / y / Random effect size g = 0.259 The effects of homoeopathy are
not
[9] conventional y / y (95%CI -0.319; 0.837), fixed different from placebo on a statis-
tical
effects 0.295 (0.223; 0.366) level
Lutz 93 [10] all all/placebo, 21
RCT/
CCT
? / n / y / Results of available studies No clear conclusions drawn.
conventional y / p contradictory (Comment: thesis mainly discuss-
ing
problems of meta-analysis)
Kleijnen 91 all all/placebo, 107
CCT
y / p / y / 81 trials reported positive results. Available evidence positive but not
[11] conventional y / n Most trials low quality but many sufficient to draw definitive conclu-
sions
exceptions
Hill 90 [12] all all/placebo, 40 RCT n / p / y / The authors of half of the studies The results do not provide accept-
able
conventional y / n concluded that homoeopathy was evidence that homoeopathy treat-
ments
effective, further 7 promising are effective
Individualized homoeopathy in all conditions
Ernst 99 all individualized/ 3 RCT,
3 CCT
y / p / n / All trials were burdened with The relative efficacy of individual-
ized
[13] conventional y / n serious methodological flaws. homoeopathy compared to
Results non-uniform conventional treatments is not
known
Linde 98 all individualized/ 32 RCT y / y / y / Responder RR vs. placebo 1.62 Available evidence suggests effects
[14] placebo, convent. y / y (95%CI 1.17; 2.23), in better over placebo. Evidence not con-
vincing
quality trials 1.12 (0.87; 1.44) due to shortcomings and
inconsistencies
Various homoeopathic treatments in a single condition/area
Barnes 97 postoperative various/placebo 4 RCT,
2 CCT
y / y / y / Time to first flatus in homoeopathy Available evidence positive but
several
[15] ileus y / y significantly shorter. Best trial caveats preclude definitive conclu-
sions
negative
Ernst 98 delayed- various/placebo 8 dou-
ble-
blind
y / y / y / Most trials with severe flaws. The Published evidence does not sup-
port
[16] onset muscle trials (3 y / n 3 RCT showed no significant the hypothesis that homoeopathic
soreness explicit-
ly RCT)
effects over placebo remedies are effective for muscle
4. BMC Complementary and Alternative Medicine (2001) 1:4 http://www.biomedcentral.com/1472-6882/1/4
Discussion
Systematic reviews on homeopathy address, more often
than in other areas of complementary medicine, general
questions such as "is it more than placebo?" or "is it ef-
fective?" This is probably due to the fact that any effect of
homeopathy over placebo is considered scientifically im-
plausible. In consequence, the discussion does not pri-
marily focus on specific clinical problems but on whether
there is a real effect at all. While many overviews report
that the majority of trial results are positive conclusions
of reviewers are contradictory.
With few exceptions such as arnica for trauma or individ-
ualized homeopathy for headache, the reviews (and
probably the primary research) do not cover conditions
and treatment approaches which are relevant in homoe-
opathic practice. Self-medication with Oscillococcinum
for influenza-like syndromes is popular in several coun-
tries but cannot be considered representative practice.
We want to emphasize again that it was not our primary
objective to assess the effectiveness of homeopathy and
the other therapies included in our series but to provide
soreness
Jacobs 91*
rheumatic various/placebo 4 CCT p / y / n / 3 of 4 trials positive. Quality poor No specific conclusion on
[17] diseases y / n homoeopathy (generally: no con-
vincing
evidence for alternative therapies
in
rheumat.)
Linde 98 asthma various/placebo 3 RCT y / y / y / Trials highly heterogeneous. Two Currently available evidence insuf-
ficient
[18] y / n report statistically significant to assess the possible role of
effects homoeopathy in the treatment of
asthma
Arnica in various conditions (mainly various tissue traumata)
Lüdtke 99 all arnica/placebo, 23RCT,
14
y / y / y / Quality often low. 13 of 35 studies Available evidence suggests that
arnica
[19] no treatment CCT n / n vs. placebo with significant results, can be efficacious. Further rigor-
ous
10 with trend trials needed
Ernst 98 all (mainly arnica/placebo, 4 RCT,
4 CCT
y / y / y / 2 trials positive, 2 trials positive Claims that homoeopathic arnica is
[20] trauma) conventional y / n trend. Most studies with severe efficacious are not supported by
flaws rigorous trials
Similar homoeopathic treatments in one condition/a group of conditions
Taylor allergic isopathic 4 RCT n / n / n / Pooled analysis of 100 mm visual Isopathic nosodes were different
from
2000**
[21] conditions nosodes/placebo y / y analogue scores 9.8 (95%CI placebo on both subjective and
4.2;15.4) mm better with isopathy objective measures
Vickers influenza-like oscillococcinum/ 7 RCT y / y / y / No evidence for preventative Oscillococcinum probably reduces
the
2000 [22] syndrome placebo y / y effect (3 trials) but reduction of duration of influenza-like syn-
dromes.
length of illness in treatment trials Further trials needed
Ernst 99 headache individualized/ 4 RCT y / p / y / one trial positive, one partially The trial data do not suggest an ef-
fect
[23] prophylaxis placebo y / n positive, 2 negative over placebo in the prophylaxis of
migraine or headache
Wiesenauer pollinosis galphimia/placebo 8 RCT,
1 CS,
p / n / n / Responder RR galphimia vs. Galphimia is significantly more ef-
fective
96**
[24,25] 2 UCS y / y placebo from 7 trials 1.25 (95%CI than placebo
1.09; 1.43)
*Disease-focused review on a variety of complementary medicine interventions including homoeopathy; **Meta-analytic overviews of researchers of
their own trials on the topic Features: 1 = comprehensive search, 2 = explicit inclusion criteria, 3 = formal quality assessment, 4 = summary of results
for each included study, 5 = meta-analysis; y = yes, p = partly, n = no, - = not applicable, ? = unclear RCT = randomized controlled trials, CCT = non-
randomized controlled trials, CS = cohort study, UCS = uncontrolled study; OR = odds ratio, RR = rate ratio
Table 1: Systematic reviews of clinical trials of homoeopathy (Continued)
5. BMC Complementary and Alternative Medicine (2001) 1:4 http://www.biomedcentral.com/1472-6882/1/4
an annotated bibliography of the available systematic re-
views. This provides an overall picture of the evidence
but for an in-depth review readers must go back to the
original reviews.
In conclusion, the available systematic reviews on home-
opathy provide little guidance for patients and doctors.
They rather reflect the ongoing fundamental controversy
on this therapy and strengthen the perception that, on
one side, positive evidence from clinical trials will not
convince skeptics, and that on the other side negative re-
sults from trials not representing actual practice will not
have any impact on homoeopaths.
Competing interest
KL, AV, GtR and DM have been involved in some of the
reviews analyzed. These were extracted and assessed by
other members of the team.
Acknowledgements
KL's work was partly funded by the NIAMS grant 5 U24-AR-43346-02 and
by the Carl and Veronica Carstens Foundation, Essen, Germany. We would
like to thank Brian Berman for his support, his help to get funding and his
patience in awaiting the completion of our work.
References
1. Eisenberg DM, Davis RB, Ettner SL, et al: Trends in alternative
medicine use in the United States, 1990-1997. Results of fol-
low-up national survey JAMA 1998, 280:1569-1575
2. Fisher P, Ward A: Complementary medicine in Europe BMJ
1994, 309:101-111
3. Malik IA, Khan NA, Khan W: Use of unconventional methods of
therapy by cancer patients in Pakistan Eur J Epidemiol 2000,
16:155-160
4. Vandenbroucke JP: Homoeopathy trials going nowhere Lancet
1997, 350:824
5. Schulte J: Effects of potentization in aqueous solutions Br Hom
J 1999, 88:155-160
6. Linde K, Vickers A, Hondras M, et al: Systematic reviews of com-
plementary therapies – an annotated bibliography Part 1: acu-
puncture. BMC Complementary and Alternative Medicine 2001, 1:3
7. Cucherat M, Haugh MC, Gooch M, Boissel JP: Evidence of clinical
efficacy of homeopathy. A meta-analysis of clinical trials Eur J
Clin Pharmacol 2000, 56:27-33
8. Linde K, Clausius N, Ramirez G, et al: Are the clinical effects of
homeopathy placebo effects? A meta-analysis of randomised
placebo-controlled trials Lancet 1997, 350:834-843
9. Walach H: Unspezifische Therapie-Effekte. Das Beispiel
Homöopathie PhD thesis, Psychologisches Institut, Albert-Ludwigs-Uni-
versität Freiburg, 1997
10. Lutz C: Quantitative Meta-Analyse empirischer Ergebnisse
der Homöopathieforschung Diplomarbeit, Psychologisches Institut,
Albert-Ludwigs-Universität Freiburg, 1993
11. Kleijnen J, Knipschild P, ter Riet G: Clinical trials of homoeopathy
BMJ 1991, 302:316-323
12. Hill C, Doyon F: Review of randomized trials of homoeopathy
Rev Epidém et Santé Publ 1990, 38:139-147
13. Ernst E: Classical homoeopathy versus conventional treat-
ments: a systematic review Perfusion 1999, 12:13-15
14. Linde K, Melchart D: Randomized controlled trials of individu-
alized homeopathy: a state-of-the art review J Alt Complement
Ther 1998, 4:371-388
15. Barnes J, Resch KL, Ernst E: Homoeopathy for post-operative il-
eus: a meta-analysis J Clin Gastroenerol 1997, 25:628-633
16. Ernst E, Barnes J: Are homoeopathic remedies effective for de-
layed-onset muscle soreness? A systematic review of place-
bo-controlled trials Perfusion 1998, 11:4-8
17. Jacobs JWG, Rasker JJ, van Riel PLCM, Gribnau FWJ, van de Putte
LBA: Alternatieve behandelingswijzen by reumatische aan-
doeningen; een literatuuronderzoek Ned Tijdschr Geneeskd
1991, 135:317-322
18. Linde K, Jobst K: Homoeopathy for asthma (Cochrane Review)
In: The Cochrane Library, Issue 4, 1998. Oxford: Update Software.
19. Lüdtke R, Wilkens J: Klinische Wirksamkeitsstudien zu Arnica
in homöopathischen Zubereitungen In: Karl und Veronica
Carstens-Stiftung, Jahrbuch Band 5 (1998). Edited by Albrecht H, Frühwald
M. Essen: KVC Verlag 199997-112
20. Ernst E, Pittler MH: Efficacy of homoeopathic Arnica. A sys-
tematic review of placebo-controlled clinical trials Arch Surg
1998, 133:1187-1190
21. Taylor MA, Reilly D, Llewellyn-Jones RH, McSharry C, Aitchison TC:
Randomised controlled trials of homoeopathy versus place-
bo in periennial allergic rhinitis with overview of four trial se-
ries BMJ 2000, 321:471-476
22. Vickers AJ, Smith C: Homoeopathic Oscillococcinum for pre-
venting influenza and influenza-like syndromes (Cochrane
Review) In: The Cochrane Library, Issue 1, 2000. Oxford: Update Soft-
ware.
23. Ernst E: Homeopathic prophylaxis of headaches and mi-
graine? A systematic review J Pain Symptom Manag 1999, 18:353-
357
24. Wiesenauer M, Lüdtke R: A meta-analysis of the homeopathic
treatment of pollinosis with Galphimia glauca Forsch Komple-
mentärmed 1996, 3:230-236
25. Lüdtke R, Wiesenauer M: Eine Metaanalyse der homöopa-
thischen Behandlung der Pollinosis mit Galphimia glauca
Wien Klin Wochenschr 1997, 147:323-327
26. Ernst E, Resch KL: Clinical trials of homoeopathy: a re-analysis
of a published review Forsch Komplementärmed 1996, 3:85-90
27. Ernst E: Are highly dilute homoeopathic remedies placebos?
Perfusion 1998, 11:291-292
28. Jonas WB, Linde K: Homeopathy and rheumatic disease Rheum
Dis Clin North America 2000, 26:117-123
29. Linde K, Scholz M, Ramirez G, Clausius N, Melchart D, Jonas WB: Im-
pact of study quality on outcome in placebo-controlled trials
of homeopathy J Clin Epidemiol 1999, 52:631-636
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