The document discusses robotic surgery services in the UK. It notes there are around 50 robots currently in the UK, with most located in southern regions and private practice. The NHS funds robotic-assisted laparoscopic prostatectomy (RALP) and robotic-assisted nephrectomy (RPN) procedures. It also discusses a clinical commissioning policy from NHS England that outlines criteria for funding robotic prostate cancer surgeries. Finally, it mentions that the Freeman Hospital in Newcastle was the first in the northeast to use a robotic surgery system and has now performed over 1,000 operations with robotic assistance across six surgical specialties.
This document provides an overview of brachytherapy including its principles, methods, advantages, limitations, indications, classifications, and clinical applications. Brachytherapy involves placing radioactive sources close to or inside the tumor to deliver a high dose of radiation directly to the tumor with rapid dose fall-off sparing surrounding normal tissues. It discusses various brachytherapy techniques including interstitial, intracavitary, and surface applications for treating cancers of the breast, prostate, head and neck, and soft tissue sarcomas among others.
1) The study developed an intensity-modulated radiotherapy (IMRT) technique for post-operative prostate bed irradiation and compared it to the standard 4-field box technique.
2) IMRT achieved better sparing of the rectal wall and bladder wall from radiation while still providing adequate target coverage.
3) Acute gastrointestinal and genitourinary toxicity rates were lower with IMRT compared to the standard technique.
This study compared three VMAT techniques - coplanar full arc (FA), coplanar partial arc (PA), and non-coplanar arcs (NCA) - for delivering stereotactic ablative radiation therapy (SABR) to lung tumors. Planning target volume coverage was similar for all techniques. The NCA technique provided the best conformity to the prescription dose and highest compliance with RTOG 1021 intermediate dose and organ-at-risk constraints. While the FA technique was acceptable for 70% of patients, the NCA technique best minimized doses outside the target area.
This document provides information about nasopharyngeal brachytherapy for the treatment of cancer. It discusses the anatomy of the nasopharynx, indications for brachytherapy including as a boost after external beam radiation or for localized recurrences. Several techniques for nasopharyngeal brachytherapy are described including customized moulds, Rotterdam and Massachusetts General Hospital applicators, and transnasal permanent implants. Typical dose prescriptions and fractionation schedules are provided. Results from studies show brachytherapy improves local control and survival rates compared to external beam radiation alone, especially for early stage tumors.
Evolution of Intracavitary brachytherapy for carcinoma of cervixAjeet Gandhi
The document discusses the evolution of intracavitary brachytherapy for carcinoma of the cervix over time. Key developments include changing radiation sources from radium to cesium-137 and cobalt-60, and the introduction of high-dose rate and pulsed-dose rate brachytherapy. Imaging technologies like ultrasound, CT, and MRI now allow for image-based treatment planning to better define tumor volumes and conform the radiation dose. Modern brachytherapy techniques have improved local control rates for cervical cancer and reduced toxicity compared to older methods.
This document discusses stereotactic body radiation therapy (SBRT) for head and neck cancers. It provides an overview of SBRT indications, efficacy, toxicity profiles, quality of life outcomes, fractionation schedules, target definition, constraints, and the role of cetuximab. Several studies on SBRT for recurrent head and neck cancers, primary cancers metastatic to the head and neck region, and target volume delineation are summarized. Toxicities are generally low but carotid blowout syndrome remains a concern, especially for tumors adjacent to carotid arteries.
This document summarizes three studies on imaging techniques for renal calculi:
1) A study on a new MRI contrast agent found it was successfully synthesized and showed potential as a contrast agent for bladder cancer detection with in vitro experiments.
2) A study found that contemporary CT radiation exposure for renal colic is only marginally higher than historic IVU techniques, with improved time to diagnosis.
3) A study found digital plain X-rays have good sensitivity for detecting calcium-based kidney stones larger than 5mm, especially in the upper urinary tract, but CT or ultrasound may still be needed for smaller or lower tract stones.
This document provides an overview of brachytherapy including its principles, methods, advantages, limitations, indications, classifications, and clinical applications. Brachytherapy involves placing radioactive sources close to or inside the tumor to deliver a high dose of radiation directly to the tumor with rapid dose fall-off sparing surrounding normal tissues. It discusses various brachytherapy techniques including interstitial, intracavitary, and surface applications for treating cancers of the breast, prostate, head and neck, and soft tissue sarcomas among others.
1) The study developed an intensity-modulated radiotherapy (IMRT) technique for post-operative prostate bed irradiation and compared it to the standard 4-field box technique.
2) IMRT achieved better sparing of the rectal wall and bladder wall from radiation while still providing adequate target coverage.
3) Acute gastrointestinal and genitourinary toxicity rates were lower with IMRT compared to the standard technique.
This study compared three VMAT techniques - coplanar full arc (FA), coplanar partial arc (PA), and non-coplanar arcs (NCA) - for delivering stereotactic ablative radiation therapy (SABR) to lung tumors. Planning target volume coverage was similar for all techniques. The NCA technique provided the best conformity to the prescription dose and highest compliance with RTOG 1021 intermediate dose and organ-at-risk constraints. While the FA technique was acceptable for 70% of patients, the NCA technique best minimized doses outside the target area.
This document provides information about nasopharyngeal brachytherapy for the treatment of cancer. It discusses the anatomy of the nasopharynx, indications for brachytherapy including as a boost after external beam radiation or for localized recurrences. Several techniques for nasopharyngeal brachytherapy are described including customized moulds, Rotterdam and Massachusetts General Hospital applicators, and transnasal permanent implants. Typical dose prescriptions and fractionation schedules are provided. Results from studies show brachytherapy improves local control and survival rates compared to external beam radiation alone, especially for early stage tumors.
Evolution of Intracavitary brachytherapy for carcinoma of cervixAjeet Gandhi
The document discusses the evolution of intracavitary brachytherapy for carcinoma of the cervix over time. Key developments include changing radiation sources from radium to cesium-137 and cobalt-60, and the introduction of high-dose rate and pulsed-dose rate brachytherapy. Imaging technologies like ultrasound, CT, and MRI now allow for image-based treatment planning to better define tumor volumes and conform the radiation dose. Modern brachytherapy techniques have improved local control rates for cervical cancer and reduced toxicity compared to older methods.
This document discusses stereotactic body radiation therapy (SBRT) for head and neck cancers. It provides an overview of SBRT indications, efficacy, toxicity profiles, quality of life outcomes, fractionation schedules, target definition, constraints, and the role of cetuximab. Several studies on SBRT for recurrent head and neck cancers, primary cancers metastatic to the head and neck region, and target volume delineation are summarized. Toxicities are generally low but carotid blowout syndrome remains a concern, especially for tumors adjacent to carotid arteries.
This document summarizes three studies on imaging techniques for renal calculi:
1) A study on a new MRI contrast agent found it was successfully synthesized and showed potential as a contrast agent for bladder cancer detection with in vitro experiments.
2) A study found that contemporary CT radiation exposure for renal colic is only marginally higher than historic IVU techniques, with improved time to diagnosis.
3) A study found digital plain X-rays have good sensitivity for detecting calcium-based kidney stones larger than 5mm, especially in the upper urinary tract, but CT or ultrasound may still be needed for smaller or lower tract stones.
San Antonio Breast Cancer Symposium 2007 Highlights – Radiotherapyfondas vakalis
The document summarizes several studies presented at the 2007 San Antonio Breast Cancer Symposium on radiotherapy techniques:
1) The Cambridge Breast IMRT Trial found IMRT significantly reduced hot and cold spots compared to standard radiotherapy for breast cancer.
2) A trial of 224 patients found prone positioning enabled better sparing of the heart and lungs in most cases compared to supine.
3) The START trials found hypofractionated whole breast radiotherapy schedules were as effective as standard schedules with no increase in long-term morbidity.
This document discusses the use of intensity-modulated radiation therapy (IMRT) in the treatment of cervical cancer. It provides an overview of the history and technological advances in radiation therapy for cervical cancer. It then discusses several studies comparing IMRT to conventional radiation therapy, showing benefits of IMRT such as reduced toxicity and ability to escalate dose. The document also considers integrating IMRT and brachytherapy to further optimize treatment.
1) Radiation therapy has an emerging role in the multidisciplinary management of hepatocellular carcinoma (HCC) due to advances that allow higher radiation doses to be safely delivered to small liver volumes.
2) Stereotactic body radiation therapy (SBRT) shows promise for HCC but questions remain about safety, effectiveness for bridging to transplant, and downsizing lesions.
3) A pilot study is investigating the safety and feasibility of liver SBRT for HCC.
The document discusses treatment options for locally advanced cervical cancer. It summarizes several meta-analyses and clinical trials that show concurrent chemoradiation (CCT-RT) is the standard of care, rather than neoadjuvant chemotherapy followed by surgery (NACT+Surgery). While some older trials showed a benefit of NACT+Surgery, most recent evidence suggests it does not provide benefits and adds unnecessary morbidity compared to CCT-RT. The takeaway message is that in clinical practice, only standard guidelines accepted by major organizations like NCCN and NCI should be followed, and experimental treatments belong only in clinical trials.
This document discusses the integration of intensity-modulated radiation therapy (IMRT) and brachytherapy in the treatment of cervical cancer. It notes that while IMRT and brachytherapy were once seen as competing approaches, they can be integrated to provide comprehensive adaptive radiation treatment. Several studies demonstrate the tumor shrinkage observed during both external beam radiation and brachytherapy, allowing opportunities for treatment adaptation. Overcoming technical challenges like deformable image registration will be needed to enable daily adaptive IMRT integrated with adaptive brachytherapy planning based on imaging. This has the potential to further improve outcomes for cervical cancer patients.
Research into the effectiveness of daily image guided radiotherapy on the pro...Genesis Care
This study assessed different cone beam CT (CBCT) imaging protocols for image-guided radiotherapy in prostate cancer patients. 844 CBCT images from 20 patients undergoing radiotherapy were analyzed. Daily online CBCT verification provided the best target coverage and lowest rectal dose compared to weekly online or offline protocols. Daily imaging helped improve target coverage, with one patient having inadequate coverage for 6 fractions with a weekly protocol versus just 1 fraction with daily imaging. The study concludes that daily online CBCT verification improves target coverage and reduces rectal dose for prostate cancer IGRT.
AFRICA IS CAPABLE OF USING LINEAR ACCELERATORS IN RADIOTHERAPY RATHER THAN CO...Melissa McClement
The document argues that Africa is capable of using linear accelerators rather than just cobalt units for radiotherapy. It discusses that while cobalt units are less expensive, linear accelerators provide better treatment outcomes with more precise radiation doses and smaller minimum field sizes. Linear accelerators also allow stereotactic radiotherapy and eliminate safety issues of radioactive cobalt sources. While upfront costs are higher, linear accelerators are more effective and can help increase five-year cancer survival rates in Africa.
Organ preservation in laryngopharyngeal cancersRahul Pathade
This document discusses organ preservation in laryngopharyngeal cancers. It begins with an overview of the anatomy and staging of these cancers. It then reviews past treatment approaches involving total laryngectomy and highlights studies demonstrating the benefits of organ preservation strategies using induction chemotherapy and concurrent chemoradiation. Subsequent trials showed improved larynx preservation and survival with the addition of chemotherapy to radiation compared to radiation alone. More intensive chemotherapy regimens like docetaxel, cisplatin, and 5-FU were found to further improve outcomes over standard cisplatin and 5-FU. Overall, organ preservation approaches with chemotherapy have become the standard of care for locally advanced laryngopharyngeal cancers.
A review of advances in Brachytherapy treatment planning and delivery in last decade or so, with main focus on brachytherapy for Prostate cancer, Breast cancer and Cervical cancer
Reirradiation can provide local tumor control for recurrent head and neck cancer when surgery is not possible. Modern radiation techniques like IMRT allow higher radiation doses to be safely delivered to the tumor while minimizing risks of severe toxicity. Outcomes from reirradiation include a median survival of 10-12 months and 2-year local control rates of 40-64%. Patient selection is important to balance potential benefits of local tumor control against risks of treatment-related side effects.
1. The document discusses locally advanced breast cancer and the role of radiotherapy. It outlines the anatomy, target volumes, organs at risk and response assessment using tools like MRI.
2. Postmastectomy radiotherapy can reduce the risk of local recurrence by 72% and increase survival rates. The risk of local recurrence is higher with larger tumor size and more positive lymph nodes.
3. The use of neoadjuvant chemotherapy and radiotherapy after mastectomy further reduces the risk of local-regional recurrence compared to no radiotherapy, especially in patients with more advanced clinical stage.
IORT uses a high single dose of radiation delivered during surgery to treat cancer remnants after tumor removal. It has two objectives: increase local tumor control and increase the ratio of tumor control to damage of nearby healthy tissues. IORT can be delivered via two methods - IOERT uses electron beams from a LINAC and IOHDR uses radioactive sources. Treatment planning requires a multidisciplinary team to determine applicator positioning and appropriate dose to maximize tumor coverage while minimizing radiation to other organs. IORT provides local tumor control comparable to conventional fractionated radiotherapy but with faster treatment time and less damage to surrounding tissues.
1) Image guidance is crucial for prostate radiotherapy given the need for dose escalation and tighter margins with IMRT/hypofractionation.
2) Both interfraction and intrafraction prostate motion occur randomly and can be significant without image guidance.
3) Implanted fiducial markers provide accurate localization and decrease setup errors compared to soft tissue imaging.
4) While image guidance reduces systematic errors, random errors still occur daily requiring daily imaging for optimal targeting.
5) Correcting for interfraction and intrafraction motion through real-time tracking and adaptive replanning may improve outcomes by reducing toxicity and failure rates through better dose conformity.
This document discusses treatment options for larynx cancer, including radiotherapy, transoral laser surgery (TLS), and open partial laryngectomy for early glottic cancers. For locally advanced cancers, concurrent chemoradiotherapy is now the standard of care. Organ preservation approaches have improved larynx preservation rates to 85-95% for early cancers and 87.9% for advanced cancers treated with chemoradiotherapy plus cetuximab. Salvage total laryngectomy following organ preservation has acceptable morbidity and survival is not influenced by initial treatment approach.
This document summarizes recent developments in the treatment of head and neck cancer, focusing on the humanized monoclonal antibody nimotuzumab. A phase IIb clinical trial found that combining nimotuzumab with chemoradiation therapy significantly improved overall survival rates compared to chemoradiation alone. Specifically, the 5-year overall survival rate was 57% for patients receiving chemoradiation plus nimotuzumab, compared to only 26% for those receiving chemoradiation alone. Overall, the study demonstrates that nimotuzumab can be safely and effectively administered along with radiation therapy or chemoradiation therapy for advanced head and neck cancer.
Current controversies in cervical cancer management (2014)Jyotirup Goswami
Overview of the current controversies in the management of cervical cancer, including screening, prevention, staging, chemoradiation,teletherapy techniques, brachytherapy techniques
Cervix cancer is the fourth most common gynecologic cancer in women. Screening through regular pap smears can lower the risk of cervix cancer by 80%. Treatment depends on the stage - early stages may be treated with surgery or radiation while more advanced stages involve radiation with chemotherapy. Radiation uses external beam radiation to the pelvis and internal radiation through brachytherapy applicators in the cervix and vagina. Side effects result from radiation to nearby organs like the bowel, bladder, and ovaries.
Surgical Navigation - insights into wayfinding and navigation processes in th...Thomas Stüdeli
Cognitive ergonomics for minimally invasive therapies – some insights into wayfinding and navigation processes in the human body.
Farewell lecture given at Faculty of Industrial Design Engineering, Delft University of Technology, the Netherlands, 14 December 2009
Laparoscopy & its Ergonomics by Dr.Mohammad ZarinWaqas Khalil
Laparoscopic surgery poses unique ergonomic and physiological challenges compared to open surgery. Ergonomically, the laparoscopic surgeon must maintain straight line principles, triangulation, and proper instrument and body positioning to work efficiently in the confined space. Physiologically, the increased abdominal pressure from insufflation can temporarily decrease cardiac output and organ perfusion while increasing respiratory and renal stresses on the body. Proper patient positioning and understanding of these impacts are vital for the laparoscopic surgeon.
Ergonomics is vital for efficient laparoscopic surgery. The key ergonomic principles for surgeons include:
1) Maintaining straight line visibility between the surgical site, instruments, and monitor using triangulation to allow coaxial alignment of the visual and motor axes.
2) Positioning instruments at angles of 30-60 degrees for manipulation and 60 degrees for elevation to reduce strain.
3) Adopting a relaxed stance with straight back, shoulders neutral, and elbows bent to minimize fatigue.
4) Considering equipment design with articulating instruments, adjustable tables and monitors to optimize ergonomics.
San Antonio Breast Cancer Symposium 2007 Highlights – Radiotherapyfondas vakalis
The document summarizes several studies presented at the 2007 San Antonio Breast Cancer Symposium on radiotherapy techniques:
1) The Cambridge Breast IMRT Trial found IMRT significantly reduced hot and cold spots compared to standard radiotherapy for breast cancer.
2) A trial of 224 patients found prone positioning enabled better sparing of the heart and lungs in most cases compared to supine.
3) The START trials found hypofractionated whole breast radiotherapy schedules were as effective as standard schedules with no increase in long-term morbidity.
This document discusses the use of intensity-modulated radiation therapy (IMRT) in the treatment of cervical cancer. It provides an overview of the history and technological advances in radiation therapy for cervical cancer. It then discusses several studies comparing IMRT to conventional radiation therapy, showing benefits of IMRT such as reduced toxicity and ability to escalate dose. The document also considers integrating IMRT and brachytherapy to further optimize treatment.
1) Radiation therapy has an emerging role in the multidisciplinary management of hepatocellular carcinoma (HCC) due to advances that allow higher radiation doses to be safely delivered to small liver volumes.
2) Stereotactic body radiation therapy (SBRT) shows promise for HCC but questions remain about safety, effectiveness for bridging to transplant, and downsizing lesions.
3) A pilot study is investigating the safety and feasibility of liver SBRT for HCC.
The document discusses treatment options for locally advanced cervical cancer. It summarizes several meta-analyses and clinical trials that show concurrent chemoradiation (CCT-RT) is the standard of care, rather than neoadjuvant chemotherapy followed by surgery (NACT+Surgery). While some older trials showed a benefit of NACT+Surgery, most recent evidence suggests it does not provide benefits and adds unnecessary morbidity compared to CCT-RT. The takeaway message is that in clinical practice, only standard guidelines accepted by major organizations like NCCN and NCI should be followed, and experimental treatments belong only in clinical trials.
This document discusses the integration of intensity-modulated radiation therapy (IMRT) and brachytherapy in the treatment of cervical cancer. It notes that while IMRT and brachytherapy were once seen as competing approaches, they can be integrated to provide comprehensive adaptive radiation treatment. Several studies demonstrate the tumor shrinkage observed during both external beam radiation and brachytherapy, allowing opportunities for treatment adaptation. Overcoming technical challenges like deformable image registration will be needed to enable daily adaptive IMRT integrated with adaptive brachytherapy planning based on imaging. This has the potential to further improve outcomes for cervical cancer patients.
Research into the effectiveness of daily image guided radiotherapy on the pro...Genesis Care
This study assessed different cone beam CT (CBCT) imaging protocols for image-guided radiotherapy in prostate cancer patients. 844 CBCT images from 20 patients undergoing radiotherapy were analyzed. Daily online CBCT verification provided the best target coverage and lowest rectal dose compared to weekly online or offline protocols. Daily imaging helped improve target coverage, with one patient having inadequate coverage for 6 fractions with a weekly protocol versus just 1 fraction with daily imaging. The study concludes that daily online CBCT verification improves target coverage and reduces rectal dose for prostate cancer IGRT.
AFRICA IS CAPABLE OF USING LINEAR ACCELERATORS IN RADIOTHERAPY RATHER THAN CO...Melissa McClement
The document argues that Africa is capable of using linear accelerators rather than just cobalt units for radiotherapy. It discusses that while cobalt units are less expensive, linear accelerators provide better treatment outcomes with more precise radiation doses and smaller minimum field sizes. Linear accelerators also allow stereotactic radiotherapy and eliminate safety issues of radioactive cobalt sources. While upfront costs are higher, linear accelerators are more effective and can help increase five-year cancer survival rates in Africa.
Organ preservation in laryngopharyngeal cancersRahul Pathade
This document discusses organ preservation in laryngopharyngeal cancers. It begins with an overview of the anatomy and staging of these cancers. It then reviews past treatment approaches involving total laryngectomy and highlights studies demonstrating the benefits of organ preservation strategies using induction chemotherapy and concurrent chemoradiation. Subsequent trials showed improved larynx preservation and survival with the addition of chemotherapy to radiation compared to radiation alone. More intensive chemotherapy regimens like docetaxel, cisplatin, and 5-FU were found to further improve outcomes over standard cisplatin and 5-FU. Overall, organ preservation approaches with chemotherapy have become the standard of care for locally advanced laryngopharyngeal cancers.
A review of advances in Brachytherapy treatment planning and delivery in last decade or so, with main focus on brachytherapy for Prostate cancer, Breast cancer and Cervical cancer
Reirradiation can provide local tumor control for recurrent head and neck cancer when surgery is not possible. Modern radiation techniques like IMRT allow higher radiation doses to be safely delivered to the tumor while minimizing risks of severe toxicity. Outcomes from reirradiation include a median survival of 10-12 months and 2-year local control rates of 40-64%. Patient selection is important to balance potential benefits of local tumor control against risks of treatment-related side effects.
1. The document discusses locally advanced breast cancer and the role of radiotherapy. It outlines the anatomy, target volumes, organs at risk and response assessment using tools like MRI.
2. Postmastectomy radiotherapy can reduce the risk of local recurrence by 72% and increase survival rates. The risk of local recurrence is higher with larger tumor size and more positive lymph nodes.
3. The use of neoadjuvant chemotherapy and radiotherapy after mastectomy further reduces the risk of local-regional recurrence compared to no radiotherapy, especially in patients with more advanced clinical stage.
IORT uses a high single dose of radiation delivered during surgery to treat cancer remnants after tumor removal. It has two objectives: increase local tumor control and increase the ratio of tumor control to damage of nearby healthy tissues. IORT can be delivered via two methods - IOERT uses electron beams from a LINAC and IOHDR uses radioactive sources. Treatment planning requires a multidisciplinary team to determine applicator positioning and appropriate dose to maximize tumor coverage while minimizing radiation to other organs. IORT provides local tumor control comparable to conventional fractionated radiotherapy but with faster treatment time and less damage to surrounding tissues.
1) Image guidance is crucial for prostate radiotherapy given the need for dose escalation and tighter margins with IMRT/hypofractionation.
2) Both interfraction and intrafraction prostate motion occur randomly and can be significant without image guidance.
3) Implanted fiducial markers provide accurate localization and decrease setup errors compared to soft tissue imaging.
4) While image guidance reduces systematic errors, random errors still occur daily requiring daily imaging for optimal targeting.
5) Correcting for interfraction and intrafraction motion through real-time tracking and adaptive replanning may improve outcomes by reducing toxicity and failure rates through better dose conformity.
This document discusses treatment options for larynx cancer, including radiotherapy, transoral laser surgery (TLS), and open partial laryngectomy for early glottic cancers. For locally advanced cancers, concurrent chemoradiotherapy is now the standard of care. Organ preservation approaches have improved larynx preservation rates to 85-95% for early cancers and 87.9% for advanced cancers treated with chemoradiotherapy plus cetuximab. Salvage total laryngectomy following organ preservation has acceptable morbidity and survival is not influenced by initial treatment approach.
This document summarizes recent developments in the treatment of head and neck cancer, focusing on the humanized monoclonal antibody nimotuzumab. A phase IIb clinical trial found that combining nimotuzumab with chemoradiation therapy significantly improved overall survival rates compared to chemoradiation alone. Specifically, the 5-year overall survival rate was 57% for patients receiving chemoradiation plus nimotuzumab, compared to only 26% for those receiving chemoradiation alone. Overall, the study demonstrates that nimotuzumab can be safely and effectively administered along with radiation therapy or chemoradiation therapy for advanced head and neck cancer.
Current controversies in cervical cancer management (2014)Jyotirup Goswami
Overview of the current controversies in the management of cervical cancer, including screening, prevention, staging, chemoradiation,teletherapy techniques, brachytherapy techniques
Cervix cancer is the fourth most common gynecologic cancer in women. Screening through regular pap smears can lower the risk of cervix cancer by 80%. Treatment depends on the stage - early stages may be treated with surgery or radiation while more advanced stages involve radiation with chemotherapy. Radiation uses external beam radiation to the pelvis and internal radiation through brachytherapy applicators in the cervix and vagina. Side effects result from radiation to nearby organs like the bowel, bladder, and ovaries.
Surgical Navigation - insights into wayfinding and navigation processes in th...Thomas Stüdeli
Cognitive ergonomics for minimally invasive therapies – some insights into wayfinding and navigation processes in the human body.
Farewell lecture given at Faculty of Industrial Design Engineering, Delft University of Technology, the Netherlands, 14 December 2009
Laparoscopy & its Ergonomics by Dr.Mohammad ZarinWaqas Khalil
Laparoscopic surgery poses unique ergonomic and physiological challenges compared to open surgery. Ergonomically, the laparoscopic surgeon must maintain straight line principles, triangulation, and proper instrument and body positioning to work efficiently in the confined space. Physiologically, the increased abdominal pressure from insufflation can temporarily decrease cardiac output and organ perfusion while increasing respiratory and renal stresses on the body. Proper patient positioning and understanding of these impacts are vital for the laparoscopic surgeon.
Ergonomics is vital for efficient laparoscopic surgery. The key ergonomic principles for surgeons include:
1) Maintaining straight line visibility between the surgical site, instruments, and monitor using triangulation to allow coaxial alignment of the visual and motor axes.
2) Positioning instruments at angles of 30-60 degrees for manipulation and 60 degrees for elevation to reduce strain.
3) Adopting a relaxed stance with straight back, shoulders neutral, and elbows bent to minimize fatigue.
4) Considering equipment design with articulating instruments, adjustable tables and monitors to optimize ergonomics.
This document discusses the use of robots in surgery. It defines robots and describes different types of surgical robots including AESOP and da Vinci systems. The da Vinci system allows surgeons to perform minimally invasive procedures through small incisions using robotic arms with magnified 3D vision and improved dexterity. Robotic surgery is associated with benefits like shorter hospital stays and recovery times compared to open surgery, but also has disadvantages such as high costs and a steep learning curve.
Robotic surgery uses robotic instruments controlled by a surgeon to perform minimally invasive surgery through small incisions. The da Vinci surgical system is one such robot that has miniaturized instruments mounted on robotic arms to give surgeons improved control, vision, and precision over open surgery. It allows 3D, high-definition viewing of the surgical site from a console separate from the patient. Robotic surgery may offer benefits like less pain, blood loss, and faster recovery for patients compared to open surgery, but it also presents higher costs and legal/ethical concerns due to issues like mechanical failures.
Discover the future of cancer care at Apollo Proton Cancer Centre. Leading the way in medical oncology with advanced treatments for a brighter tomorrow.
This document summarizes recent advances in surgery presented at a conference in Athens. It discusses various topics including the role of central lymph node dissection for papillary thyroid cancer, intraoperative neuromonitoring during thyroidectomy, breast cancer axillary lymph nodes, minimally invasive pancreatic surgery, laparoscopic adrenalectomy, minimally invasive esophagectomy, and advances in pancreatic and colon cancer surgery. It also discusses the role of virtual and augmented reality in surgical training.
Laproscopic management of huge ovarian cystArsla Memon
This document summarizes a study on the laparoscopic management of huge ovarian cysts. Five patients with ovarian cysts ranging from 18 to 42 cm in diameter were treated laparoscopically. The cysts were drained of 1-12 liters of fluid under laparoscopic guidance before performing laparoscopic oophorectomy or cystectomy. There were no complications and the cysts were found to be benign. The study concludes that with proper patient selection and surgical expertise, it is possible to remove large ovarian cysts laparoscopically.
Minimally Invasive Surgery - cervical cancer.pptxAncy409947
Minimally invasive surgery such as laparoscopic and robotic radical hysterectomy can provide advantages over open radical hysterectomy for early stage cervical cancer such as fewer complications, less blood loss, and faster recovery. However, a large prospective trial found poorer oncological outcomes with laparoscopic surgery. Two key factors that may have contributed to this are the surgical learning curve effect since minimally invasive techniques were new, and cancer cell spillage risks from procedures like using a uterine manipulator or exposing the tumor. Subsequent studies found that when careful measures are taken to minimize spillage risks, like creating the vaginal cuff before laparoscopy and avoiding direct cervical handling, minimally invasive radical hysterectomy can achieve similar oncological
Brachytherapy temporary vs permanent seed placementGil Lederman
This document compares temporary and permanent prostate brachytherapy seed placement for treating prostate cancer. It finds that permanent seed placement has better outcomes than temporary seed placement using catheters. For high-risk patients, the author's institution achieves 5 and 7-year disease-free survival rates up to 25% higher than another institution using temporary seed placement via catheters. Permanent seed placement allows patients to leave the hospital quickly with minimal side effects and return to normal activities, while temporary seed placement requires multiple treatments and hospital stays with more pain and risk of complications.
The document summarizes evidence and guidelines for managing locally advanced rectal cancer. It discusses that neoadjuvant chemoradiation is preferred over postoperative chemoradiation based on trials showing lower local recurrence rates and less toxicity. Long-course neoadjuvant chemoradiation followed by surgery 6-8 weeks later is the standard approach. Post-treatment assessment of tumor response helps predict outcomes, with complete response indicating a good prognosis. Adjuvant chemotherapy after surgery may further improve survival based on meta-analyses of trials. Guidelines recommend a multidisciplinary, tailored approach incorporating staging, treatment response, and patient factors.
This document discusses surgical management of rectal cancer and opportunities for improvement in the United States. It notes that rectal cancer outcomes in the US are worse than in European countries that have instituted national programs. It recommends establishing a National Rectal Cancer Program in the US, based on European models, to improve adherence to evidence-based protocols, surgical quality, and ultimately patient outcomes. The program would set standards, require prospective data collection, and oversee training and accreditation of multidisciplinary teams treating rectal cancer.
Certis OncologySolutions provides pre-clinical cancer research services using a technique called Patient-Derived Orthotopic Xenograft (PDOX) mouse modeling. They have an expanding tumor bank with over 300 patient tumors and drug response data. Their facilities include a 7,000 square foot facility in San Diego with lab space. Their unique PDOX model implants patient tumor samples into mice in the same anatomical site as the original tumor to provide a more clinically relevant model for testing drug therapies. Recent studies have shown their PDOX models accurately mimic patient responses to therapies. They offer guidance on pre-clinical studies, execution of drug screening, and publishing assistance to support cancer research.
Current evidence for laparoscopic surgery in colorectal cancersApollo Hospitals
This article reviews the current evidence for laparoscopic surgery in treating colorectal cancers. It discusses several large randomized controlled trials that compared short-term and long-term outcomes of laparoscopic versus open surgery. The trials found no significant differences in cancer recurrence rates, survival rates, or number of lymph nodes retrieved between the two surgical methods. Meta-analyses of the trials validated that laparoscopic surgery is as safe and effective as open surgery for treating colorectal cancer. While the laparoscopic approach has benefits like less blood loss and shorter hospital stays, long-term oncologic outcomes are comparable to open surgery.
Robot-assisted versus open radical hysterectomy: A multi-institutional experi...flasco_org
This study compared outcomes of 491 early-stage cervical cancer patients who underwent either robot-assisted radical hysterectomy (RRH, n=259) or open radical hysterectomy (ORH, n=232) across three institutions. The study found that patients who received RRH had significantly less estimated blood loss, shorter hospital stays, and fewer intra-operative complications compared to ORH patients. Disease recurrence and survival rates were similar between the two groups. Overall, RRH resulted in improved clinical outcomes for early-stage cervical cancer patients compared to ORH.
This document discusses advances in non-invasive treatments for rectal cancer, allowing some patients to avoid colostomies and radical surgery. It describes a recent study of 36 patients with low-lying rectal cancer who received pre-operative radiation and chemotherapy, followed by surgery. For 5 patients (14%), the pre-operative treatment eliminated the cancer completely. Most patients (77%) were able to have a less invasive surgery called a low anterior resection, preserving their anus and avoiding a colostomy. The study concludes this approach may be a good alternative to more invasive surgeries for selected rectal cancer patients.
Robotic hysterectomy: A review of indications, technique, outcome, and compli...Apollo Hospitals
Hysterectomy is the second most common surgery performed on women after cesarean section. The advantages of minimally invasive hysterectomy such as reduced hospitalization, quick recovery with more rapid return to normal activities, and less postoperative morbidity are well known. Although most guidelines recommend that minimally invasive hysterectomy should be the standard of care, the gynecologists have been slow in adopting minimally invasive laparoscopic techniques to perform this operation. Since its approval in 2005 for gynecological surgeries, robot-assisted hysterectomy has been found to be feasible and safe both in benign and malignant indications. This significant difference is mainly due to ergonomics, endowrist movements of instruments, and stereoscopic three-dimensional magnified vision. The specific indications for hysterectomy where the robotic technology can benefit women are the ones with adhesions such as severe endometriosis, large uterus with large or multiple fibroids, early carcinoma cervix, and/or endometrial carcinoma. However the main benefit of this procedure was seen in the reduction of open surgery including conversions during laparoscopic hysterectomies. In the long run, we need to critically examine the long-term benefits and appropriate indications for robot-assisted hysterectomy especially in benign conditions, thus reducing the incidence of open surgery in gynecology. This review describes the operative procedure of robotic hysterectomy in eight steps.
Today, Laparoscopy is an alternative technique for carrying out many operations that have traditionally required an open approach. The benefits of minimal access surgery have been well recorded, including lower post-operative morbidity, shorter duration of hospital stay and a shorter return to work.
The document summarizes new guidelines for oncoplastic breast reconstruction developed by a multidisciplinary writing group in response to findings from the National Mastectomy and Breast Reconstruction Audit. The guidelines establish 25 quality criteria across key areas of preoperative care, surgery, and postoperative management based on audit outcomes. The criteria set standards for areas like infection control and pain management to improve clinical outcomes and patient experience based on the best available evidence. A patient version was also developed to clearly communicate expectations of care. The guidelines aim to enhance multidisciplinary care and support at each stage of a patient's breast reconstruction journey.
Radiation Treatment of Rectal and Colon Cancer :: July 2017 #CRCWebinarFight Colorectal Cancer
Michael Bassetti, MD, Ph.D. from the University of Wisconsin Carbone Cancer Center discusses all you need to know about radiation. Dr. Bassetti will talk about what radiation treatment is, how it’s used for rectal and colon cancer patients, how to prepare for treatment, how to manage side effects and more.
Digital version thesis Salvage for radiorecurrent prostate cancer, Max PetersMax Peters
This document discusses salvage therapy for prostate cancer recurrences after primary radiotherapy. It notes that patients undergoing radiotherapy are at risk of recurrent disease, which is often confined to the prostate and eligible for salvage treatment. Traditionally, salvage modalities targeted the entire prostate due to difficulties assessing localized recurrences, but this resulted in significant toxicity rates. Recent advances in MRI and biopsy techniques allow for focal salvage treatments targeting only the recurrent tumor area, maintaining cancer control while decreasing toxicity. Focal salvage Iodine-125 brachytherapy appears able to provide durable disease control with minimized toxicity. However, dose constraints are needed for organs at risk to prevent complications, and constraints developed for primary radiotherapy may not apply
Robotic surgery has advantages over conventional and laparoscopic surgery for gynecological procedures. The da Vinci surgical system allows for precision in complex surgeries through its three-dimensional view and wristed instruments. Robotic surgery results in less blood loss, quicker recovery times, and fewer complications compared to open surgeries. While further research is still needed, robotic surgery has become a common method for hysterectomies and myomectomies to treat conditions like fibroids and cancer. The case study describes a large fibroid removed robotically with minimal blood loss and fast recovery for the patient.
Certis Oncology Solutions provides pre-clinical oncology research using Patient-Derived Orthotopic Xenograft (PDOX) mouse models. They establish PDOX models through microsurgery from patient tumor samples and test various drug therapies simultaneously in mice to provide treatment data to oncologists. Their PDOX models metastasize reliably and have a high tumor establishment success rate, providing more accurate pre-clinical data than traditional PDX models. Certis is expanding their tumor bank and testing facilities while publishing numerous studies showing PDOX models closely match patient tumor responses to therapies.
Similar to Superspecialiation_UK_Upload_Linkedin (20)
3. Robotic Systems in the UK
• Around 50 robots in the UK (2 private) – 66 in DE
• South more than North – (Private Practice)
• NHS England funds RALP/RPN
• Further funding for RARC questionable
No new centers to offer procedures
5. Clinical Commissioning
Policy: Robotic-Assisted
Surgical Procedures for
Prostate Cancer
Reference: NHS England B14/P/a
OFFICIAL
1 Executive summary
Policy Statement
NHS England will commission robotic assisted surgical techniques for the treatment
of prostate cancer (i.e., radical prostatectomies for prostate cancer) in accordance
with the criteria outlined in this document.
In creating this policy NHS England has reviewed this clinical condition and the
options for its treatment. It has considered the place of this treatment in current
clinical practice, whether scientific research has shown the treatment to be of benefit
6. Multidisciplinary Programme
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you can opt out of receiving cookies. Ok, I understand
23.11.2015
Da Vinci Robot carried out 1000th operation in Newcastle
In July 2012, the Freeman Hospital in Newcastle was the first in the North East to start using the £2m robot in prostate cancer surgery. The Trust has since purchased a second
Da Vinci robot which is being used across other surgical specialities including gynaecology, ear, nose and throat, lung, colorectal and pancreatic surgery.
The robots have how carried out 1,000 operations making Freeman Hospital the only centre in the UK using robotic surgery across six surgical specialities. The extraordinary
technology has helped save hundreds of lives and, with greater precision and smaller incisions than is possible for a surgeon, dramatically reduced recovery times for patients.
1000th operation da Vinci team L-R: Emma Dickson, Sister Catherine Birnie, Sara Cross, Laura Waterworth, Professor Naeem Soomro, Paul Renforth, Rajan
Veeratterapillay and Senior Sister Maggie Birkbeck
Professor Naeem Soomro, Associate Medical Director and Consultant Urologist at Freeman Hospital, says: "We are delighted to have reached such a tremendous milestone in
such a relatively short space of time. We are now expanding this technique across other surgical specialities where we can offer robotic surgery to benefit many more patients all
the time.
“Minimally invasive surgery is certainly the way forward – it’s so much better for the patient both in terms of how we surgically treat them, and enabling them to be back on their
Newcastle Hospitals - Da Vinci Robot carried out 1000th oper... http://www.newcastle-hospitals.org.uk/news/news-item-21472...
We use cookies on this website to make your visit an easier and faster experience. If you continue to use our site, we'll assume that you are happy to receive cookies from our site. However,
you can opt out of receiving cookies. Ok, I understand
23.11.2015
Da Vinci Robot carried out 1000th operation in Newcastle
In July 2012, the Freeman Hospital in Newcastle was the first in the North East to start using the £2m robot in prostate cancer surgery. The Trust has since purchased a second
Da Vinci robot which is being used across other surgical specialities including gynaecology, ear, nose and throat, lung, colorectal and pancreatic surgery.
The robots have how carried out 1,000 operations making Freeman Hospital the only centre in the UK using robotic surgery across six surgical specialities. The extraordinary
technology has helped save hundreds of lives and, with greater precision and smaller incisions than is possible for a surgeon, dramatically reduced recovery times for patients.
1000th operation da Vinci team L-R: Emma Dickson, Sister Catherine Birnie, Sara Cross, Laura Waterworth, Professor Naeem Soomro, Paul Renforth, Rajan
Veeratterapillay and Senior Sister Maggie Birkbeck
Professor Naeem Soomro, Associate Medical Director and Consultant Urologist at Freeman Hospital, says: "We are delighted to have reached such a tremendous milestone in
such a relatively short space of time. We are now expanding this technique across other surgical specialities where we can offer robotic surgery to benefit many more patients all
the time.
“Minimally invasive surgery is certainly the way forward – it’s so much better for the patient both in terms of how we surgically treat them, and enabling them to be back on their
Newcastle Hospitals - Da Vinci Robot carried out 1000th oper... http://www.newcastle-hospitals.org.uk/news/news-item-21472...
7. N.B. FOR IN-HOUSE USE ONLY – NOT TO BE RETURNED TO BAUS – Operational from 01/01/2014
BAUS%&%Complex%operations%database%
Total%Cystectomy%for%Malignant%Disease%–%Operation%–%2014%
Patient%Details: %
Date%of%Birth%
Patient%NHS%Number %
Sex Patient%Hospital%Number
% Male% % Female%
Consultant%% % % % % % Centre
Q1%Date%of%diagnosis%of%bladder%cancer%% % %
%%%%%%(date&histological&diagnosis)&
%
Q2%Indication%for%Cystectomy%
%
%
% %
%
Q3/ 4/ 5%Pre&Operative%Clinical%categories:%% %
Q6%Urethral%Biopsy%performed If%yes
%
Q7%Pre&Operative%Imaging
% %
Q8%Serum%Creatinine%%% Q9%Serum%eGFR%%% % % Q10%pre&op%Hb%% %
%%%%%%%%% % %%%%% % % %
%
Q11%Patient%offered%Pre&operative%% % Q12%Patient%received%Neoadjuvant%Chemotherapy%
Neoadjuvant%Chemotherapy%
%
If%NO %
%
Q13%Status%Upper%tracts%
Q14%Date%of%Operation%% % % %% Q15/ 16%Grade%of%Main%Operating%Surgeon
Was%procedure%performed%jointly%with%another%consultant?
9. Caseload and Outcome
cancer, Gleason grade ≤6, and
clinically meaningful differen
homogenous group. Because
between surgeon experience
by the ability of individual su
capable surgeon who was u
therefore contribute to the be
ing curve), weperformed add
the sample to patients who
100 total surgeries and to pa
at least 250 total surgeries. C
results were unduly influenc
geons, we restricted the ana
completed the median num
Because there were some di
levels of surgeon experience,
addition, because it is possib
affected by differences in the
hormonal therapy before pat
cal recurrence, we performed
Fig. 2. The surgical learning curve for cancer control after radical pros-
tatectomy. Predicted probability (black curve) and 95% confidence
intervals (gray curves) for freedom from biochemical recurrence (BCR)
at 5 years after radical prostatectomy are plotted against increasing
surgeon experience. Probabilities are for a patient with typical cancer
severity (mean prostate-specifi c antigen level, pathologic stage, and
grade) treated in 1997 (approximately equal numbers of patients were
cancer, Gleason grade ≤6, and
clinically meaningful differen
homogenous group. Because
between surgeon experience
by the ability of individual su
capable surgeon who was un
therefore contribute to the be
ing curve), weperformed addi
the sample to patients whos
100 total surgeries and to pat
at least 250 total surgeries. C
results were unduly influence
geons, we restricted the anal
completed the median numb
Because there were some dif
levels of surgeon experience, w
addition, because it is possibl
affected by differences in the i
hormonal therapy before pati
cal recurrence, we performed
Fig. 2. The surgical learning curve for cancer control after radical pros-
tatectomy. Predicted probability (black curve) and 95% confidence
intervals (gray curves) for freedom from biochemical recurrence (BCR)
at 5 years after radical prostatectomy are plotted against increasing
surgeon experience. Probabilities are for a patient with typical cancer
severity (mean prostate-specifi c antigen level, pathologic stage, and
grade) treated in 1997 (approximately equal numbers of patients were
Vickers, J Natl Cancer Inst 2007;99:1171–7
10. Effect of Surgeon Experience on Cancer Control
There were1256 biochemical recurrencesamong the 7765 patients
in this study. Median follow-up for patients without recurrence
was 3.9 years. Only a small proportion of patients died without
experiencing abiochemical recurrence, resulting in a5-year overall
survival probability of 95%. This finding suggests that adjustment
for competing risk would have a minimal effect on any of our
analyses.
high (concordance index of
able model provides good c
model, greater surgeon exper
of prostate cancer recurrence
Figure 2 shows the 5-yea
chemical recurrence plotted
providesthe learning curve fo
prostatectomy. T here was a d
trol with increasing surgeon e
but no large change in recurr
rience. T o illustrate the asso
and outcome, wecompared th
wastreated by asurgeon with
tectomy (one with 10 prior o
was treated by a more exper
operations). We chose this d
because this number of prio
(275) for patientsand isalso t
the learning curve started to
of recurrence at 5 years were
for patients treated by surg
10.7% (95% CI = 7.1% to 15
with 250 prior operations, w
difference of 7.2% (95% C
needed to harm of 14; that
a surgeon with 10 as oppose
will experience a recurrence
We conducted a number
robustness of our findings
migration might haveaffected
Fig. 1. Probability of freedom from biochemical recurrence after radical
prostatectomy. The data are stratifi ed by surgeon experience (i.e., the
number of prior surgeries) at the time of the patient’s radical prostatec-
tomy, shown as numbers next to each curve.
Effect of Surgeon Experience on Cancer Control
T here were 1256 biochemical recurrencesamong the7765 patients
in this study. Median follow-up for patients without recurrence
was 3.9 years. Only a small proportion of patients died without
experiencing abiochemical recurrence, resulting in a5-year overall
survival probability of 95%. This finding suggests that adjustment
for competing risk would have a minimal effect on any of our
analyses.
high (concordance index of 0
able model provides good co
model, greater surgeon experi
of prostate cancer recurrence
Figure 2 shows the 5-yea
chemical recurrence plotted
providesthelearning curvefo
prostatectomy. T here wasa d
trol with increasing surgeon e
but no large change in recurre
rience. T o illustrate the asso
and outcome, wecompared th
wastreated by asurgeon with
tectomy (one with 10 prior o
was treated by a more exper
operations). We chose this d
because this number of prio
(275) for patientsand isalso th
the learning curve started to
of recurrence at 5 years were
for patients treated by surg
10.7% (95% CI = 7.1% to 15
with 250 prior operations, w
difference of 7.2% (95% CI
needed to harm of 14; that
a surgeon with 10 as opposed
will experience a recurrence a
We conducted a number o
robustness of our findings (
migration might haveaffected
Fig. 1. Probability of freedom from biochemical recurrence after radical
prostatectomy. The data are stratifi ed by surgeon experience (i.e., the
number of prior surgeries) at the time of the patient’s radical prostatec-
tomy, shown as numbers next to each curve.
Caseload and Outcome
Vickers, J Natl Cancer Inst 2007;99:1171–7
12. Problems with Superspecialisation
• Nobody wants to do general urology any more
• Long travelling times for patients
• Needs working Hub and Spoke system (aftercare)
• What happens if somebody gets sick
• Jealousy from the non specialized surgeons
• 150 Cases – influencing patient selection?
• Don’t be a one trick Pony!
13. Summary
• Existing robotic systems not used efficiently
• Attempt to Increase outcomes/efficiency through
Centralisation
Multispecialty programs
Superspecialisation