Session 2.3 Gabeau
•
2 likes•576 views
1) Radiation therapy has an emerging role in the multidisciplinary management of hepatocellular carcinoma (HCC) due to advances that allow higher radiation doses to be safely delivered to small liver volumes. 2) Stereotactic body radiation therapy (SBRT) shows promise for HCC but questions remain about safety, effectiveness for bridging to transplant, and downsizing lesions. 3) A pilot study is investigating the safety and feasibility of liver SBRT for HCC.
Report
Share
Report
Share
Recommended
How is Radiation Therapy Used to Help Lung Cancer Patients?
Radiation therapy can be used to cure or palliate lung cancer depending on the cancer type and stage. For non-small cell lung cancer, conventional radiation therapy is used with surgery and chemotherapy for locally advanced stages, while stereotactic body radiation therapy is used for early stage cancers. For small cell lung cancer, conventional radiation therapy is used for limited stage disease. Palliative radiation therapy provides symptom relief for metastatic lung cancers.
Treatment Options for Cancer of the Bladder
Early stage bladder cancer is typically treated with surgery (transurethral resection) followed by chemotherapy or immunotherapy delivered directly into the bladder. Muscle-invasive bladder cancer may be treated with surgery (partial or total cystectomy), sometimes preceded or followed by chemotherapy and/or radiation. For advanced or unresectable bladder cancer, options include chemotherapy, radiation alone, or chemoradiation. Bladder preservation protocols use chemoradiation to attempt curing the cancer without surgery. Radiation is also used post-operatively or palliatively to treat symptoms.
Kupelian 1st talk planning dose hyderabad 2013 (cancer ci 2013) patrick kupel...
Kupelian 1st talk planning dose hyderabad 2013 (cancer ci 2013) patrick kupel...Dr. Vijay Anand P. Reddy
This document discusses radiotherapy treatment for localized prostate cancer. It begins by outlining prostate anatomy and imaging, including the importance of MRI. It then reviews competing treatment modalities like surgery and surveillance. A key topic is the importance of dose escalation in radiotherapy, as higher doses above 75 Gy have been shown to improve outcomes. Technique aspects covered include treatment planning with IMRT, dose constraints for organs at risk, and methods for dose escalation through conventional fractionation, hypofractionation, or stereotactic body radiosurgery. Patient-reported toxicity is also addressed.Research in India Bangalore Tech Expo 2018
This document summarizes recent developments in the treatment of head and neck cancer, focusing on the humanized monoclonal antibody nimotuzumab. A phase IIb clinical trial found that combining nimotuzumab with chemoradiation therapy significantly improved overall survival rates compared to chemoradiation alone. Specifically, the 5-year overall survival rate was 57% for patients receiving chemoradiation plus nimotuzumab, compared to only 26% for those receiving chemoradiation alone. Overall, the study demonstrates that nimotuzumab can be safely and effectively administered along with radiation therapy or chemoradiation therapy for advanced head and neck cancer.
Re-irradiation, Prostate Cancer
This document discusses salvage radiotherapy for locally recurrent prostate cancer after primary radiation. It notes that while salvage brachytherapy is commonly used, studies have shown high rates of severe toxicity and disappointing cancer control. New diagnostic techniques like MRI and PET scans, along with improved biopsy methods, now allow localization of recurrent tumors, enabling focal salvage techniques. This is expected to reduce toxicity while maintaining cancer control. The document provides selection criteria for salvage treatment, noting it may benefit carefully selected patients with pathology-proven local recurrence at least 2-3 years after primary treatment and limited tumor presentation.
Role of Radiation Therapy for Lung Cancer
Radiation therapy plays an evolving role in the treatment of lung cancer beyond just causing DNA double strand breaks.
1) Stereotactic body radiation therapy (SBRT) can provide curative treatment for early stage lung cancer with high local control rates.
2) For locally advanced lung cancer, dose escalation with conventional fractionation in RTOG 0617 did not improve overall survival, highlighting the importance of fractionation and sequencing with other therapies.
3) Radiation induces tumor cell death that can elicit anti-tumor immune responses, known as abscopal effects, especially when combined with immunotherapy like anti-CTLA4 and anti-PD1/PDL1 agents which play complementary roles.
SBRT in head and neck cancer
This document discusses stereotactic body radiation therapy (SBRT) for head and neck cancers. It provides an overview of SBRT indications, efficacy, toxicity profiles, quality of life outcomes, fractionation schedules, target definition, constraints, and the role of cetuximab. Several studies on SBRT for recurrent head and neck cancers, primary cancers metastatic to the head and neck region, and target volume delineation are summarized. Toxicities are generally low but carotid blowout syndrome remains a concern, especially for tumors adjacent to carotid arteries.
Radioterapi of lung cancer
This document provides an overview of the book "Image-guided Radiotherapy of Lung Cancer". It discusses how image-guided radiotherapy (IGRT) using techniques like PET/CT, 4D-CT, gated radiotherapy, IMRT and proton radiotherapy have introduced a new era for radiotherapy treatment of lung cancer. The book focuses on these novel IGRT approaches and provides recommendations on dose/fractionation, target volume delineation, treatment techniques and normal tissue tolerances. It aims to establish disease stage-specific guidelines to help radiation oncologists incorporate these advanced techniques into clinical practice for improved patient outcomes.
Recommended
How is Radiation Therapy Used to Help Lung Cancer Patients?
Radiation therapy can be used to cure or palliate lung cancer depending on the cancer type and stage. For non-small cell lung cancer, conventional radiation therapy is used with surgery and chemotherapy for locally advanced stages, while stereotactic body radiation therapy is used for early stage cancers. For small cell lung cancer, conventional radiation therapy is used for limited stage disease. Palliative radiation therapy provides symptom relief for metastatic lung cancers.
Treatment Options for Cancer of the Bladder
Early stage bladder cancer is typically treated with surgery (transurethral resection) followed by chemotherapy or immunotherapy delivered directly into the bladder. Muscle-invasive bladder cancer may be treated with surgery (partial or total cystectomy), sometimes preceded or followed by chemotherapy and/or radiation. For advanced or unresectable bladder cancer, options include chemotherapy, radiation alone, or chemoradiation. Bladder preservation protocols use chemoradiation to attempt curing the cancer without surgery. Radiation is also used post-operatively or palliatively to treat symptoms.
Kupelian 1st talk planning dose hyderabad 2013 (cancer ci 2013) patrick kupel...
Kupelian 1st talk planning dose hyderabad 2013 (cancer ci 2013) patrick kupel...Dr. Vijay Anand P. Reddy
This document discusses radiotherapy treatment for localized prostate cancer. It begins by outlining prostate anatomy and imaging, including the importance of MRI. It then reviews competing treatment modalities like surgery and surveillance. A key topic is the importance of dose escalation in radiotherapy, as higher doses above 75 Gy have been shown to improve outcomes. Technique aspects covered include treatment planning with IMRT, dose constraints for organs at risk, and methods for dose escalation through conventional fractionation, hypofractionation, or stereotactic body radiosurgery. Patient-reported toxicity is also addressed.Research in India Bangalore Tech Expo 2018
This document summarizes recent developments in the treatment of head and neck cancer, focusing on the humanized monoclonal antibody nimotuzumab. A phase IIb clinical trial found that combining nimotuzumab with chemoradiation therapy significantly improved overall survival rates compared to chemoradiation alone. Specifically, the 5-year overall survival rate was 57% for patients receiving chemoradiation plus nimotuzumab, compared to only 26% for those receiving chemoradiation alone. Overall, the study demonstrates that nimotuzumab can be safely and effectively administered along with radiation therapy or chemoradiation therapy for advanced head and neck cancer.
Re-irradiation, Prostate Cancer
This document discusses salvage radiotherapy for locally recurrent prostate cancer after primary radiation. It notes that while salvage brachytherapy is commonly used, studies have shown high rates of severe toxicity and disappointing cancer control. New diagnostic techniques like MRI and PET scans, along with improved biopsy methods, now allow localization of recurrent tumors, enabling focal salvage techniques. This is expected to reduce toxicity while maintaining cancer control. The document provides selection criteria for salvage treatment, noting it may benefit carefully selected patients with pathology-proven local recurrence at least 2-3 years after primary treatment and limited tumor presentation.
Role of Radiation Therapy for Lung Cancer
Radiation therapy plays an evolving role in the treatment of lung cancer beyond just causing DNA double strand breaks.
1) Stereotactic body radiation therapy (SBRT) can provide curative treatment for early stage lung cancer with high local control rates.
2) For locally advanced lung cancer, dose escalation with conventional fractionation in RTOG 0617 did not improve overall survival, highlighting the importance of fractionation and sequencing with other therapies.
3) Radiation induces tumor cell death that can elicit anti-tumor immune responses, known as abscopal effects, especially when combined with immunotherapy like anti-CTLA4 and anti-PD1/PDL1 agents which play complementary roles.
SBRT in head and neck cancer
This document discusses stereotactic body radiation therapy (SBRT) for head and neck cancers. It provides an overview of SBRT indications, efficacy, toxicity profiles, quality of life outcomes, fractionation schedules, target definition, constraints, and the role of cetuximab. Several studies on SBRT for recurrent head and neck cancers, primary cancers metastatic to the head and neck region, and target volume delineation are summarized. Toxicities are generally low but carotid blowout syndrome remains a concern, especially for tumors adjacent to carotid arteries.
Radioterapi of lung cancer
This document provides an overview of the book "Image-guided Radiotherapy of Lung Cancer". It discusses how image-guided radiotherapy (IGRT) using techniques like PET/CT, 4D-CT, gated radiotherapy, IMRT and proton radiotherapy have introduced a new era for radiotherapy treatment of lung cancer. The book focuses on these novel IGRT approaches and provides recommendations on dose/fractionation, target volume delineation, treatment techniques and normal tissue tolerances. It aims to establish disease stage-specific guidelines to help radiation oncologists incorporate these advanced techniques into clinical practice for improved patient outcomes.
Adjuvant radiation based on genomic risk factors emerging scenarios
Presentation on tailoring adjuvant radiotherapy for breast cancers based on Genomic risk prediction methods - a review. Presented in MVR CANCON 2018
Low Radiation Dose effect of Tomotherapy for Hepatocellular Carcinoma
This document discusses the use of tomotherapy for treating hepatocellular carcinoma (HCC) and its advantages over other radiotherapy techniques. While tomotherapy can deliver high radiation doses to small tumor volumes with less damage to the surrounding liver tissue compared to other methods, it may still pose risks. Even low radiation doses below 10Gy delivered to the liver could potentially induce HBV reactivation or exacerbate chronic hepatitis B infection, especially in endemic areas. Further clinical studies are needed to directly compare the risks of HBV reactivation between tomotherapy and other radiotherapy modalities before tomotherapy can be widely applied in clinical practice for HCC patients. National insurance coverage and support for clinical trials are also required.
ECCLU 2011 - S. Supiot - Locally advanced prostate cancer: Multimodality trea...
ECCLU 2011 - S. Supiot - Locally advanced prostate cancer: Multimodality trea...European School of Oncology
This document discusses multimodality treatments for locally advanced prostate cancer, including combining radiotherapy with androgen deprivation therapy or chemotherapy. It reviews randomized trials showing radiotherapy plus androgen deprivation is standard treatment. It also discusses investigating neoadjuvant, concurrent, or adjuvant chemotherapy or targeted therapies with radiotherapy to better treat micrometastatic disease and modify tumor radiosensitivity or microenvironment. Several agents targeting DNA repair, angiogenesis, hypoxia, and PI3K/AKT/mTOR pathways are discussed. Improving results may involve targeting the tumor and microenvironment with surgery and radiotherapy also discussed.Post Operative RT in Carcinoma prostate
1) Post-operative radiotherapy (PORT) can reduce the risk of prostate cancer recurrence after radical prostatectomy for patients with adverse features like positive surgical margins or extracapsular extension.
2) Large randomized trials have shown that adjuvant radiotherapy (ART) within 6 months of surgery improves outcomes compared to observation or early salvage radiotherapy initiated at first signs of recurrence.
3) Salvage radiotherapy is an option for patients with rising PSA after surgery but no metastases, and can improve biochemical progression-free survival and cancer-specific survival when initiated promptly at low PSA levels.
RE-IRRADIATION IN HEAD AND NECK CANCER
Reirradiation can provide local tumor control for recurrent head and neck cancer when surgery is not possible. Modern radiation techniques like IMRT allow higher radiation doses to be safely delivered to the tumor while minimizing risks of severe toxicity. Outcomes from reirradiation include a median survival of 10-12 months and 2-year local control rates of 40-64%. Patient selection is important to balance potential benefits of local tumor control against risks of treatment-related side effects.
Oncology basics
The document discusses the surgical management of primary tumors, regional lymph nodes, and distant metastases. It covers topics like radical vs conservative surgery, lymphadenectomy, sentinel lymph node biopsy, and criteria for resection of distant metastases. It also discusses the use of chemotherapy, including neoadjuvant chemotherapy and response evaluation criteria.
IMRT in Prostate Cancer
Current Concepts in IMRT of Prostate Cancer
Hypofractionation in prostate cancer
prostate contouring
Prostate cancer updates 2021
This document discusses locally advanced high risk prostate cancer and evolving treatment options. It provides an overview of risk stratification, guidelines for biopsy from the European Association of Urology, options for imaging with multiparametric MRI, and options for treatment including radical prostatectomy, radiation therapy, and hormonal therapy. New advances in radiation therapy include stereotactic body radiation therapy and hypofractionated regimens. Advances in hormonal therapy include gonadotropin-releasing hormone antagonists and oral options like relugolix. Neoadjuvant docetaxel chemotherapy is also discussed for high risk localized disease.
Clinical Experiences of CK/HT in Hepatocellular Carcinoma
Chul-Seung Kay1,3 , Seok-Hyun Son1, Myung-Soo Kim1, Jung-Hyun Kwon2
Department of Radiation Oncology1 & 2Internal Medicine2
3Catholic Comprehensive Hospital for Advanced Cancer3
Incheon St. Mary Hospital
The Catholic University of Korea
Oligo final
Stereotactic ablative radiotherapy (SABR) is a form of external beam radiotherapy that accurately delivers a high dose of irradiation in one or few fractions to extracranial tumors. Studies have shown SABR to be safe and effective for treating oligometastatic prostate cancer lesions, with low toxicity and good local tumor control. However, larger trials like STOMP and ORIOLE that compared SABR to surveillance found no reduction in metastatic progression, possibly due to limitations in accounting for disease aggressiveness between treatment groups. SABR remains a promising option for select oligometastatic prostate cancer patients.
ABCs of Radiation Therapy for Patients, Family and Friends
Radiation therapy uses X-rays from a linear accelerator to precisely target tumors while sparing healthy tissue. Multiple low doses are given over several weeks to damage cancer cells' DNA. Daily X-rays and weekly CT scans ensure accurate positioning. Common side effects include skin reddening and swallowing pain, but risks of long-term effects are low. The goal is cure, though some treatments provide symptom relief.
Kupelian 2nd talk prostate igrt hyderabad 2013 (kupelian)
1) Image guidance is crucial for prostate radiotherapy given the need for dose escalation and tighter margins with IMRT/hypofractionation.
2) Both interfraction and intrafraction prostate motion occur randomly and can be significant without image guidance.
3) Implanted fiducial markers provide accurate localization and decrease setup errors compared to soft tissue imaging.
4) While image guidance reduces systematic errors, random errors still occur daily requiring daily imaging for optimal targeting.
5) Correcting for interfraction and intrafraction motion through real-time tracking and adaptive replanning may improve outcomes by reducing toxicity and failure rates through better dose conformity.
LUNG CANCER MANAGEMENT IN LOW RESOURCE SETTINGS
The document provides information on lung cancer management in low resource settings. It discusses limited resources for setup, equipment, manpower, money and management. It also discusses potential sources of support including government, NGOs, donations and volunteers. Statistics on lung cancer prevalence and mortality are presented. The epidemiology, risk factors, diagnosis, staging and treatment of lung cancer are summarized.
Prostate Imrt
1) The study developed an intensity-modulated radiotherapy (IMRT) technique for post-operative prostate bed irradiation and compared it to the standard 4-field box technique.
2) IMRT achieved better sparing of the rectal wall and bladder wall from radiation while still providing adequate target coverage.
3) Acute gastrointestinal and genitourinary toxicity rates were lower with IMRT compared to the standard technique.
Primary Surgery vs Chemoradiotherapy for Oropahryngeal Cancer
This document summarizes a study comparing primary surgery versus chemoradiotherapy for advanced oropharyngeal cancers. The study analyzed data from 344 patients treated between 1998-2009 in Alberta, Canada. It found that patients receiving primary surgery followed by chemotherapy and radiotherapy (S-CRT) had significantly better survival rates than those receiving chemoradiotherapy (CRT) or surgery followed by radiotherapy (S-RT), with 5-year disease-specific survival rates of 71.1%, 48.6%, and 53.9% respectively. However, the role of HPV status on outcomes requires further investigation. The study generates questions about determining the optimal treatment approach for advanced oropharyngeal cancer.
CyberKnife: A New Option In the Treatment of Lung Cancer
This document summarizes the development and use of stereotactic body radiotherapy (SBRT) for early stage non-small cell lung cancer (NSCLC). It discusses how conventional radiation therapy had poor outcomes, but SBRT allows higher, more effective radiation doses to be delivered safely. Phase II data showed SBRT achieved high local control and 3-year survival rates for inoperable early stage NSCLC. Emerging data also suggests SBRT may be comparable to surgery for operable NSCLC, though more research is still needed to determine the optimal treatment approach. Overall, SBRT has significantly improved outcomes for early stage NSCLC compared to previous radiation techniques.
2022 Radiation for Common Cancers
Basic information about the use and types of radiation therapy that can be used to treat common cancers
Intra Tumoral Drug Delivery
This document describes the development of a novel intratumoral drug delivery system using interstitial chemotherapy devices. The system aims to deliver chemotherapy drugs directly into solid tumors via implantable polymeric devices to achieve higher drug concentrations and more homogeneous distribution compared to systemic chemotherapy. The document outlines the design of biodegradable polymer implants loaded with cisplatin as a model drug. In vitro studies show sustained release of cisplatin from the implants over 1 month in a rate dependent on drug loading. The system has the potential for localized treatment with fewer systemic side effects.
ECCLU 2011 - T. Wiegel - Prostate cancer: Managing of pelvic nodes - Radiatio...
ECCLU 2011 - T. Wiegel - Prostate cancer: Managing of pelvic nodes - Radiatio...European School of Oncology
The document discusses radiation treatment of pelvic lymph nodes in prostate cancer. It summarizes several key studies that have evaluated treating lymph nodes in patients with suspected lymph node involvement (cNx) or positive lymph nodes (pN+). Treating lymph nodes reduced the risk of recurrence compared to prostate-only radiation. However, whole pelvic radiation was associated with increased side effects. Newer intensity modulated radiation therapy (IMRT) techniques can reduce toxicity while adequately treating lymph node regions. An upcoming study called ART-2 aims to evaluate the benefit of radiation treatment of pelvic lymph nodes for pN+ patients after prostatectomy.Top 10 Learning Questions for Chapter 11
This document discusses key concepts relating to analyzing competitors. It provides 10 multiple choice questions and explanations about factors that influence competitors' objectives, types of competitors, steps to competitor analysis, and strategies companies use to compete. The key points covered are identifying a company's main competitors, determining their objectives, strengths, and weaknesses, and developing strategies in response to emerging competitors and new technologies.
Chapter 3 Migration
Haitian migrants risked their lives attempting to reach Florida by overcrowded boat in 1994. Many jumped overboard prematurely when the Coast Guard approached, and some undoubtedly lost their lives while others made it to shore. The migrants were fleeing extreme poverty in Haiti and seeking better opportunities elsewhere.
Student Portfolio
A sample of my student work at the Ohio State University\'s Knowlton School of Architecture.
More Related Content
What's hot
Adjuvant radiation based on genomic risk factors emerging scenarios
Presentation on tailoring adjuvant radiotherapy for breast cancers based on Genomic risk prediction methods - a review. Presented in MVR CANCON 2018
Low Radiation Dose effect of Tomotherapy for Hepatocellular Carcinoma
This document discusses the use of tomotherapy for treating hepatocellular carcinoma (HCC) and its advantages over other radiotherapy techniques. While tomotherapy can deliver high radiation doses to small tumor volumes with less damage to the surrounding liver tissue compared to other methods, it may still pose risks. Even low radiation doses below 10Gy delivered to the liver could potentially induce HBV reactivation or exacerbate chronic hepatitis B infection, especially in endemic areas. Further clinical studies are needed to directly compare the risks of HBV reactivation between tomotherapy and other radiotherapy modalities before tomotherapy can be widely applied in clinical practice for HCC patients. National insurance coverage and support for clinical trials are also required.
ECCLU 2011 - S. Supiot - Locally advanced prostate cancer: Multimodality trea...
ECCLU 2011 - S. Supiot - Locally advanced prostate cancer: Multimodality trea...European School of Oncology
This document discusses multimodality treatments for locally advanced prostate cancer, including combining radiotherapy with androgen deprivation therapy or chemotherapy. It reviews randomized trials showing radiotherapy plus androgen deprivation is standard treatment. It also discusses investigating neoadjuvant, concurrent, or adjuvant chemotherapy or targeted therapies with radiotherapy to better treat micrometastatic disease and modify tumor radiosensitivity or microenvironment. Several agents targeting DNA repair, angiogenesis, hypoxia, and PI3K/AKT/mTOR pathways are discussed. Improving results may involve targeting the tumor and microenvironment with surgery and radiotherapy also discussed.Post Operative RT in Carcinoma prostate
1) Post-operative radiotherapy (PORT) can reduce the risk of prostate cancer recurrence after radical prostatectomy for patients with adverse features like positive surgical margins or extracapsular extension.
2) Large randomized trials have shown that adjuvant radiotherapy (ART) within 6 months of surgery improves outcomes compared to observation or early salvage radiotherapy initiated at first signs of recurrence.
3) Salvage radiotherapy is an option for patients with rising PSA after surgery but no metastases, and can improve biochemical progression-free survival and cancer-specific survival when initiated promptly at low PSA levels.
RE-IRRADIATION IN HEAD AND NECK CANCER
Reirradiation can provide local tumor control for recurrent head and neck cancer when surgery is not possible. Modern radiation techniques like IMRT allow higher radiation doses to be safely delivered to the tumor while minimizing risks of severe toxicity. Outcomes from reirradiation include a median survival of 10-12 months and 2-year local control rates of 40-64%. Patient selection is important to balance potential benefits of local tumor control against risks of treatment-related side effects.
Oncology basics
The document discusses the surgical management of primary tumors, regional lymph nodes, and distant metastases. It covers topics like radical vs conservative surgery, lymphadenectomy, sentinel lymph node biopsy, and criteria for resection of distant metastases. It also discusses the use of chemotherapy, including neoadjuvant chemotherapy and response evaluation criteria.
IMRT in Prostate Cancer
Current Concepts in IMRT of Prostate Cancer
Hypofractionation in prostate cancer
prostate contouring
Prostate cancer updates 2021
This document discusses locally advanced high risk prostate cancer and evolving treatment options. It provides an overview of risk stratification, guidelines for biopsy from the European Association of Urology, options for imaging with multiparametric MRI, and options for treatment including radical prostatectomy, radiation therapy, and hormonal therapy. New advances in radiation therapy include stereotactic body radiation therapy and hypofractionated regimens. Advances in hormonal therapy include gonadotropin-releasing hormone antagonists and oral options like relugolix. Neoadjuvant docetaxel chemotherapy is also discussed for high risk localized disease.
Clinical Experiences of CK/HT in Hepatocellular Carcinoma
Chul-Seung Kay1,3 , Seok-Hyun Son1, Myung-Soo Kim1, Jung-Hyun Kwon2
Department of Radiation Oncology1 & 2Internal Medicine2
3Catholic Comprehensive Hospital for Advanced Cancer3
Incheon St. Mary Hospital
The Catholic University of Korea
Oligo final
Stereotactic ablative radiotherapy (SABR) is a form of external beam radiotherapy that accurately delivers a high dose of irradiation in one or few fractions to extracranial tumors. Studies have shown SABR to be safe and effective for treating oligometastatic prostate cancer lesions, with low toxicity and good local tumor control. However, larger trials like STOMP and ORIOLE that compared SABR to surveillance found no reduction in metastatic progression, possibly due to limitations in accounting for disease aggressiveness between treatment groups. SABR remains a promising option for select oligometastatic prostate cancer patients.
ABCs of Radiation Therapy for Patients, Family and Friends
Radiation therapy uses X-rays from a linear accelerator to precisely target tumors while sparing healthy tissue. Multiple low doses are given over several weeks to damage cancer cells' DNA. Daily X-rays and weekly CT scans ensure accurate positioning. Common side effects include skin reddening and swallowing pain, but risks of long-term effects are low. The goal is cure, though some treatments provide symptom relief.
Kupelian 2nd talk prostate igrt hyderabad 2013 (kupelian)
1) Image guidance is crucial for prostate radiotherapy given the need for dose escalation and tighter margins with IMRT/hypofractionation.
2) Both interfraction and intrafraction prostate motion occur randomly and can be significant without image guidance.
3) Implanted fiducial markers provide accurate localization and decrease setup errors compared to soft tissue imaging.
4) While image guidance reduces systematic errors, random errors still occur daily requiring daily imaging for optimal targeting.
5) Correcting for interfraction and intrafraction motion through real-time tracking and adaptive replanning may improve outcomes by reducing toxicity and failure rates through better dose conformity.
LUNG CANCER MANAGEMENT IN LOW RESOURCE SETTINGS
The document provides information on lung cancer management in low resource settings. It discusses limited resources for setup, equipment, manpower, money and management. It also discusses potential sources of support including government, NGOs, donations and volunteers. Statistics on lung cancer prevalence and mortality are presented. The epidemiology, risk factors, diagnosis, staging and treatment of lung cancer are summarized.
Prostate Imrt
1) The study developed an intensity-modulated radiotherapy (IMRT) technique for post-operative prostate bed irradiation and compared it to the standard 4-field box technique.
2) IMRT achieved better sparing of the rectal wall and bladder wall from radiation while still providing adequate target coverage.
3) Acute gastrointestinal and genitourinary toxicity rates were lower with IMRT compared to the standard technique.
Primary Surgery vs Chemoradiotherapy for Oropahryngeal Cancer
This document summarizes a study comparing primary surgery versus chemoradiotherapy for advanced oropharyngeal cancers. The study analyzed data from 344 patients treated between 1998-2009 in Alberta, Canada. It found that patients receiving primary surgery followed by chemotherapy and radiotherapy (S-CRT) had significantly better survival rates than those receiving chemoradiotherapy (CRT) or surgery followed by radiotherapy (S-RT), with 5-year disease-specific survival rates of 71.1%, 48.6%, and 53.9% respectively. However, the role of HPV status on outcomes requires further investigation. The study generates questions about determining the optimal treatment approach for advanced oropharyngeal cancer.
CyberKnife: A New Option In the Treatment of Lung Cancer
This document summarizes the development and use of stereotactic body radiotherapy (SBRT) for early stage non-small cell lung cancer (NSCLC). It discusses how conventional radiation therapy had poor outcomes, but SBRT allows higher, more effective radiation doses to be delivered safely. Phase II data showed SBRT achieved high local control and 3-year survival rates for inoperable early stage NSCLC. Emerging data also suggests SBRT may be comparable to surgery for operable NSCLC, though more research is still needed to determine the optimal treatment approach. Overall, SBRT has significantly improved outcomes for early stage NSCLC compared to previous radiation techniques.
2022 Radiation for Common Cancers
Basic information about the use and types of radiation therapy that can be used to treat common cancers
Intra Tumoral Drug Delivery
This document describes the development of a novel intratumoral drug delivery system using interstitial chemotherapy devices. The system aims to deliver chemotherapy drugs directly into solid tumors via implantable polymeric devices to achieve higher drug concentrations and more homogeneous distribution compared to systemic chemotherapy. The document outlines the design of biodegradable polymer implants loaded with cisplatin as a model drug. In vitro studies show sustained release of cisplatin from the implants over 1 month in a rate dependent on drug loading. The system has the potential for localized treatment with fewer systemic side effects.
ECCLU 2011 - T. Wiegel - Prostate cancer: Managing of pelvic nodes - Radiatio...
ECCLU 2011 - T. Wiegel - Prostate cancer: Managing of pelvic nodes - Radiatio...European School of Oncology
The document discusses radiation treatment of pelvic lymph nodes in prostate cancer. It summarizes several key studies that have evaluated treating lymph nodes in patients with suspected lymph node involvement (cNx) or positive lymph nodes (pN+). Treating lymph nodes reduced the risk of recurrence compared to prostate-only radiation. However, whole pelvic radiation was associated with increased side effects. Newer intensity modulated radiation therapy (IMRT) techniques can reduce toxicity while adequately treating lymph node regions. An upcoming study called ART-2 aims to evaluate the benefit of radiation treatment of pelvic lymph nodes for pN+ patients after prostatectomy.What's hot (19)
Adjuvant radiation based on genomic risk factors emerging scenarios
Adjuvant radiation based on genomic risk factors emerging scenarios
Low Radiation Dose effect of Tomotherapy for Hepatocellular Carcinoma
Low Radiation Dose effect of Tomotherapy for Hepatocellular Carcinoma
ECCLU 2011 - S. Supiot - Locally advanced prostate cancer: Multimodality trea...
ECCLU 2011 - S. Supiot - Locally advanced prostate cancer: Multimodality trea...
Clinical Experiences of CK/HT in Hepatocellular Carcinoma
Clinical Experiences of CK/HT in Hepatocellular Carcinoma
ABCs of Radiation Therapy for Patients, Family and Friends
ABCs of Radiation Therapy for Patients, Family and Friends
Kupelian 2nd talk prostate igrt hyderabad 2013 (kupelian)
Kupelian 2nd talk prostate igrt hyderabad 2013 (kupelian)
Primary Surgery vs Chemoradiotherapy for Oropahryngeal Cancer
Primary Surgery vs Chemoradiotherapy for Oropahryngeal Cancer
CyberKnife: A New Option In the Treatment of Lung Cancer
CyberKnife: A New Option In the Treatment of Lung Cancer
ECCLU 2011 - T. Wiegel - Prostate cancer: Managing of pelvic nodes - Radiatio...
ECCLU 2011 - T. Wiegel - Prostate cancer: Managing of pelvic nodes - Radiatio...
Viewers also liked
Top 10 Learning Questions for Chapter 11
This document discusses key concepts relating to analyzing competitors. It provides 10 multiple choice questions and explanations about factors that influence competitors' objectives, types of competitors, steps to competitor analysis, and strategies companies use to compete. The key points covered are identifying a company's main competitors, determining their objectives, strengths, and weaknesses, and developing strategies in response to emerging competitors and new technologies.
Chapter 3 Migration
Haitian migrants risked their lives attempting to reach Florida by overcrowded boat in 1994. Many jumped overboard prematurely when the Coast Guard approached, and some undoubtedly lost their lives while others made it to shore. The migrants were fleeing extreme poverty in Haiti and seeking better opportunities elsewhere.
Student Portfolio
A sample of my student work at the Ohio State University\'s Knowlton School of Architecture.
Auto-Rickshaw and Share-Auto Reforms in Chennai - Raj Cherubal
Auto-Rickshaw and Share-Auto Reforms in Chennai - Raj CherubalWRI Ross Center for Sustainable Cities
- A study was conducted on auto-rickshaws and share-autos in Chennai that found they provide 22 million trips per day, compared to 54 million by buses, and play an important economic and social role.
- Reforms are needed to address issues like outdated fares, a lack of regulation and transparency, and outdated technologies. Proper regulation and integration with other transit could help formalize and improve the system.
- The Chennai Unified Metropolitan Transport Authority has been formed to regulate and integrate different transit options, but further work is still needed on policies and implementation.20 darker.pdf
E L James wrote the popular novel Fifty Shades of Grey. She is working on a sequel and new romantic thriller. The document expresses gratitude to friends and colleagues who have supported her writing career. It then shares an excerpt from Fifty Shades of Grey describing Ana's childhood memories of abuse and her current emotional state after ending her relationship with Christian Grey.
How to make the most of LinkedIn
The document provides tips for making the most of LinkedIn. It discusses how LinkedIn has shifted from mainly a recruitment site to a platform for networking, sharing information, and demonstrating expertise. It emphasizes taking the site more seriously and investing time to fully utilize its capabilities. Specific tips include choosing a good profile photo that conveys personality, crafting an engaging headline, telling your personal story to stand out from cliches, and managing privacy settings.
1.3 Learning Styles Project
This document provides summaries of titles and classroom activities that align with different learning styles. For visual-spatial learning, it recommends a resource with instructional and assessment strategies. For bodily-kinesthetic learning, it describes a teacher role-playing a train ride while reading The Polar Express. For linguistic learning, it discusses using letters and persuasive writing activities with specific book titles. The document also reflects on learning styles as strengths, assessing students' styles, and enhancing learning through style-aligned instruction. Several book titles are suggested for different learning styles, along with examples of classroom activities.
Herramientas del software educativo
El documento describe las diferentes funciones que pueden realizar los programas educativos de software. Identifica 9 funciones principales: informativa, instructiva, motivadora, evaluadora, investigadora, expresiva, metalingüística, lúdica e innovadora. Cada función describe cómo los programas educativos pueden proporcionar información a los estudiantes, guiar su aprendizaje, mantener su interés, evaluarlos, permitir la investigación, expresión, aprendizaje de lenguajes informáticos, ser entretenidos y promover la innovación pedagógica
Invisible water marking within media files using state of-the-art technology
This document summarizes an article from the International Journal of Computer Engineering and Technology. The article discusses an invisible watermarking technique for embedding secret messages within media files like images, audio and video. It proposes a software package to implement this watermarking technology for copyright protection and secure data transmission. The technique uses a binary image as a watermark and embeds it imperceptibly within a cover file. It then encrypts the watermarked file during transmission for security. The package was tested successfully and could help software companies protect data from hackers during transfer.
Technology will save our bodies and minds
The document discusses several emerging medical technologies including stem cell research, organ cloning, bionic prosthetics, and their potential benefits but also addresses ethical concerns about extending the human lifespan and the impact on overpopulation and resource demand. While advances could help treat diseases and replace failing body parts, allowing indefinite lifespan extension could strain society and the environment. The text explores both promises and perils of developing technologies that blur the line between human and machine.
Mountain Brook PPT Game for 1st Grade
This document provides a virtual tour of Mountain Brook, Alabama for students. It begins by welcoming students to Mountain Brook and explaining that they will learn about the community through pictures, videos, facts, and stories. Later, students will write about their favorite location in Mountain Brook to create a class book. The document then provides information about Mountain Brook, including its villages and schools. It shares the history and development of the city. Students view pictures of popular locations and go on a scavenger hunt to identify them. Videos of community helpers are shown. Finally, students are instructed to choose a location to write about for their class book.
Standard prestasi bm sk thn 2
Dokumen ini membahasikan Standard Prestasi Bahasa Malaysia untuk murid Tahun Dua di sekolah rendah. Ia menjelaskan falsafah pendidikan kebangsaan, matlamat, objektif, tafsiran band prestasi, deskriptor dan bukti pencapaian untuk membantu guru menilai perkembangan pembelajaran murid.
Informe de movilidad / Diciembre 2015
El Informe de Movilidad es una publicación de carácter mensual en la cual se detallan los sectores con reajustados en la liquidación de haberes. Se tratan temas relacionados a movilidad, ley 10.078, tope previsional, haber mínimo y haber medio.
A su vez se efectúa una estimación del impacto financiero que tendrá la movilidad sobre las erogaciones corrientes del sistema previsional.
NCEast Alliance 2016 State of the Region
2015 proved to be a very active year for the NCEast Alliance. The 2016 State of the Region highlights the activity and results that occurred throughout 2015.
Androscoggin County Regional Image
A slide show put together by the Androscoggin Chamber of Commerce Regional Image Committee to foster growth and advocacy from our community and community leaders and acknowledge the economic impact of L/A's tourism attractions.
Below boulevard article
Below Boulevard is a band from Sunderland returning after a year away with a new EP scheduled for early 2016. They will play their first concert of their upcoming tour in Newcastle in December ahead of the EP release. One of the lead singers, Amy, discusses the band's plans in an interview, mentioning enjoying being back home in Sunderland for the comforts of family, friends, and local shops and food. She looks forward to the band's touring plans for 2016, which will include upgraded production compared to last year and visits to new places across the UK and Ireland.
Viewers also liked (17)
Auto-Rickshaw and Share-Auto Reforms in Chennai - Raj Cherubal
Auto-Rickshaw and Share-Auto Reforms in Chennai - Raj Cherubal
Invisible water marking within media files using state of-the-art technology
Invisible water marking within media files using state of-the-art technology
Similar to Session 2.3 Gabeau
10 may sbrt
Stereotactic body radiation therapy (SBRT) is an evolution of stereotactic radiosurgery that delivers high-dose radiation to tumors in fewer fractions than conventional radiotherapy. It requires extra-ordinary care due to the precision needed to target tumors while sparing surrounding tissues from damage. SBRT has shown efficacy in treating various tumor types including lung, liver, spine, pancreas and prostate cancers with acceptable toxicity risks when proper quality assurance procedures and motion management techniques are followed.
13 liver cancer
1. Liver cancer is a major health problem in China, being the fourth most common cause of cancer death, with high rates in Eastern and Southeastern China.
2. The main risk factors for liver cancer are chronic hepatitis B and C infections, along with aflatoxin exposure and heavy alcohol use.
3. Treatment options for liver cancer include surgical resection, liver transplantation, and percutaneous ablation techniques like radiofrequency ablation for early stage disease. Transcathelial arterial chemoembolization is often used for unresectable tumors.
CyberKnife in Hepatocellular Carcinoma
CyberKnife is an option in inoperable or medically not suitable for surgery
& in patient with progression / not tolerating systemic therapy
- Initial results are impressive with low toxicity, good response rate
Pts with small tumour, no prior treatment with good performance
treated with high dose have significantly better survival
Dose >45 Gy; 15Gy/# and small vol tumour (<50cc) have better prognosis
There is minimal toxicity with CyberKnife in liver tumours
Addition of chemotherapy along with CyberKnife will be the future
Radiotherapy in hepatocellular carcinomas
External Radiotherapy in hepatocellular carcinomas (HCC). A brief summary of the guidelines statements on radiotherapy role in hepatocellular carcinoma (hcc).
Journal club TACE vs SBRT in Hepatocellular carcinoma
This study compared outcomes of stereotactic body radiation therapy (SBRT) and transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) with 1-2 tumors. SBRT resulted in superior local control compared to TACE. There was no significant difference in overall survival between the groups. Freedom from in-liver progression was significantly higher with SBRT. Grade 3 adverse events occurred in 13% with TACE and 8% with SBRT. Larger and prospective studies are still needed to validate these findings.
MCC 2011 - Slide 26
This document summarizes a lecture on the multidisciplinary treatment of locally advanced rectal cancer. It defines locally advanced rectal cancer and discusses the goals of neoadjuvant treatment. It also addresses frequently asked questions about staging, the importance of lymph nodes, optimal radiation doses and chemotherapy regimens, the timing of surgery after chemoradiation, the type of surgery needed, and treatment of synchronous metastases.
Rectal cancer debate: Chemoradiation
1) Adjuvant chemoradiation improves local control for locally advanced rectal cancer compared to surgery alone based on multiple trials from the 1980s and 1990s.
2) Recent European trials have found no clear benefit of adjuvant chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer, with the exception of the QUASAR trial.
3) Adjuvant chemotherapy may be recommended after preoperative chemoradiation for mid-low rectal cancers with lymph node involvement (ypT3N+) or high rectal cancers with stage ypT2-3 based on trial results and expert guidelines.
Role of Radiotherapy in Primary and Metastatic Liver Tumors
Radiotherapy, specifically stereotactic body radiation therapy (SBRT), is an emerging treatment for both primary and metastatic liver tumors. SBRT can deliver very high ablative doses of radiation to tumors in a short duration while sparing surrounding healthy liver tissue due to its high conformal dosimetry and steep dose gradients. For hepatocellular carcinoma, SBRT has shown local control rates of 70-80% with acceptable toxicity. SBRT is also being investigated as an alternative to transarterial chemoembolization or radiofrequency ablation for early stage tumors. For liver metastases, SBRT has demonstrated high local control rates comparable to resection or radiofrequency ablation with minimal toxicity to the liver. Further refinement of
Role of Radiotherapy in HCC
Role of Radiotherapy in HCC. What do the guidelines say ? A comprehensive review of guidelines and other studies on role of radiotherapy in hepatocellular carcinoma.
ECCLU 2011 - A. Bex - Kidney cancer - Adjuvant and neo-adjuvant treatment
ECCLU 2011 - A. Bex - Kidney cancer - Adjuvant and neo-adjuvant treatmentEuropean School of Oncology
The document discusses adjuvant and neoadjuvant treatment options for renal cell carcinoma (RCC), including targeted therapies. It notes that localized RCC may be treated with adjuvant therapy after nephrectomy or neoadjuvant therapy to downsize tumors before surgery. Several ongoing clinical trials are investigating adjuvant targeted therapies for RCC. Neoadjuvant targeted therapies aim to downsize or downstage primary tumors but may also accelerate metastasis, and there is no way to predict individual responses. Outcomes of cytoreductive nephrectomy combined with targeted therapy in metastatic RCC depend on prognostic risk factors.23
This document summarizes various radiation therapy modalities for treating hepatic malignant tumors. It discusses external beam radiotherapy techniques like conventional radiotherapy, 3D conformal radiotherapy, stereotactic radiotherapy, and proton radiotherapy. It also covers internal radiotherapy techniques like selective internal radiotherapy using yttrium microspheres, metabolic radiotherapy with iodine-131 lipiodol, and brachytherapy. The document provides details on each technique's dosimetry, efficacy, and safety considerations.
MANAGEMENT OF HEPATOCELLULAR CARCINOMA
aggressive tumor
various treatment modality
surgery
local ablative therapy
transarterial therapy
chemotherapy radiotherapy
targetted therapy
Ca stomach
This document discusses treatment guidelines for gastric cancer. For localized disease, treatment may include endoscopic mucosal resection, limited surgical resection, or gastrectomy with lymph node dissection, followed by chemotherapy or chemoradiation. For metastatic disease, treatment includes chemotherapy, palliative surgery, or radiotherapy. Surgical techniques like subtotal or total gastrectomy with lymphadenectomy are described. The role of adjuvant and neoadjuvant chemotherapy and chemoradiation is also discussed. Simulation, target volumes, and dose constraints for radiation therapy are summarized.
management of advanced cervical cancer [Autosaved].pptx
The document summarizes current management strategies for locally advanced and metastatic cervical cancer. It discusses the following key points in 3 sentences:
Concurrent chemoradiation (CCRT) with cisplatin is considered the standard treatment for locally advanced cervical cancer (LACC). Studies have shown CCRT provides a 5-year survival advantage of 10-15% compared to radiation alone by reducing local recurrence and improving disease-free survival. Trials have investigated strategies like neoadjuvant chemotherapy (NACT) and extended field radiation but have yielded varying results with no clear consensus on improved outcomes compared to CCRT.
Radiotherapy for bladder cancers
Radiotherapy plays an important role in the management of urinary bladder cancers. It can be used as part of bladder-preserving protocols for muscle-invasive bladder cancer or as palliative treatment in elderly patients. Combined modality treatment with transurethral resection and concurrent chemoradiotherapy provides 5-year overall survival of 50-65% and bladder preservation in 38-43% of patients. External beam radiotherapy is typically delivered with a 4-field box technique to the whole pelvis at 45-50 Gy followed by a bladder boost to 60-65 Gy.
Radioembolization of Hepatic Metastases with Yttrium 90 (1) (1) FINAL
This document discusses radioembolization with Yttrium-90 as a treatment for hepatic metastases caused by colorectal cancer. It provides background on the disease, current treatment options, and rationale for using radioembolization. Radioembolization involves administering Yttrium-90 microspheres via the hepatic artery to target tumor cells. The document reviews patient selection criteria, outcomes from clinical trials showing median survival of 15.5 months, and potential adverse effects including nausea, abdominal pain and fatigue.
Metastatic liver disease (2)
This document discusses the management of metastatic liver tumors, focusing on colorectal liver metastases. Some key points:
- The liver is the most common site of metastasis from colorectal cancer. Surgical resection offers the only chance of cure or prolonged survival for resectable colorectal liver metastases, with 5-year survival rates of 40% for margin-negative resection.
- Factors associated with poorer prognosis include short disease-free interval, multiple tumors, bilobar involvement, large tumor size, and elevated CEA levels.
- Preoperative imaging with CT, MRI, and ultrasound is used to evaluate resectability and tumor extent. Laparoscopy can help identify unresectable disease.
SBRT_upperGI_malignancies
This document summarizes a presentation on the role of stereotactic body radiation therapy (SBRT) in treating upper gastrointestinal malignancies. It begins with an introduction to SBRT and its differences from conventional radiation therapy. It then discusses SBRT's role in treating metastatic liver lesions, primary liver malignancy, cholangiocarcinoma, and pancreatic malignancy. The document reviews the linear quadratic model for predicting SBRT effects and the risk of radiation-induced liver disease. It outlines the evolution of radiation therapy for liver malignancies including the emergence of SBRT, which allows higher ablative doses to be delivered to tumors while sparing more normal liver tissue.
Controversias en cancer de pulmón oligometastásico (tratamiento sistémico vs ...
This document discusses controversies around treating oligometastatic non-small cell lung cancer (NSCLC) with systemic therapy versus surgery. It reviews evidence that local ablative therapies like surgery and stereotactic body radiotherapy (SBRT) may cure a minority of patients with oligometastatic NSCLC, especially those with few metastases, longer disease-free intervals, and complete resection of metastases. However, the evidence is limited and does not allow for clear recommendations. The decision to use local ablative therapies depends on a case-by-case clinical judgment weighing factors like patient health, number/location of metastases, and whether ablation can render all visible disease.
Similar to Session 2.3 Gabeau (20)
Journal club TACE vs SBRT in Hepatocellular carcinoma
Journal club TACE vs SBRT in Hepatocellular carcinoma
Role of Radiotherapy in Primary and Metastatic Liver Tumors
Role of Radiotherapy in Primary and Metastatic Liver Tumors
ECCLU 2011 - A. Bex - Kidney cancer - Adjuvant and neo-adjuvant treatment
ECCLU 2011 - A. Bex - Kidney cancer - Adjuvant and neo-adjuvant treatment
management of advanced cervical cancer [Autosaved].pptx
management of advanced cervical cancer [Autosaved].pptx
Radioembolization of Hepatic Metastases with Yttrium 90 (1) (1) FINAL
Radioembolization of Hepatic Metastases with Yttrium 90 (1) (1) FINAL
Controversias en cancer de pulmón oligometastásico (tratamiento sistémico vs ...
Controversias en cancer de pulmón oligometastásico (tratamiento sistémico vs ...
More from Albert Einstein Cancer Center
Advances Agenda Slide 2016
The document discusses four topics related to developing new medical technologies and immunotherapies: 1) macrophage-tumor cell communication in tumor progression, 2) new technologies for cervical (pre)cancer screening in low- and middle-income countries, 3) designing novel immunotherapies for autoimmune diseases, and 4) development of novel immunotherapies targeting new immune checkpoints.
Nciccwithsocialmedia
This document provides a list of 69 National Cancer Institute (NCI) designated cancer centers in the United States. It includes the center name and social media presence for each, such as Twitter, Facebook, YouTube, etc. The majority of centers have a presence on Twitter (58 centers) and Facebook (57 centers). Fewer centers maintain accounts on other platforms like Flickr, Pinterest, Vine and podcasts. The document also provides totals at the bottom for each social media platform.
000 agenda
This document contains summaries of several topics related to immunobiology and cancer, including lymph formation and functions, inhibition of tumor-induced T cell anergy, generating cytolytic memory T cells, STAT3 activation in diffuse large B cell lymphoma, microbial control of intestinal innate immunity, spatiotemporal dynamics of Rho GTPases in cancer invasion, the role of macroH2A1 in cancer and senescence, epigenetic regulation of cancer by DNA methylation enzymes, targeting epigenetics in anticancer approaches, bladder cancer as a model for translational medicine, biology and treatment of prostate cancer, and personalized cancer medicine.
The Biosketch format, SciENcv and the paper
The document provides information about the new NIH biosketch format called SciENcv. It discusses how SciENcv allows researchers to create, edit, and maintain their own biosketch data. Using SciENcv, researchers can generate a biosketch that is pre-populated with information from their eRA Commons profile and automatically formatted for NIH grants. The document reviews how to set up a SciENcv profile, import publications and grants, and download a biosketch for inclusion in NIH applications. Researchers must use the new SciENcv format for all applications submitted to NIH on or after May 25, 2015.
Using MyNCBI & My Bibliography
The document provides instructions for creating and linking MyNCBI and eRA Commons accounts, adding publications to My Bibliography, linking publications to relevant grants and awards, ensuring publications comply with the NIH Public Access Policy, and assigning delegates. Key steps include registering for a MyNCBI account, linking it to an existing eRA Commons profile, searching for and adding publications to My Bibliography, associating publications with applicable grants and awards, designating publication compliance status, and allowing delegates access to view and manage accounts. The document outlines NIH requirements and guidelines for using these tools to properly track research outputs and funding sources.
Using MyNCBI & My Bibliography
The document provides instructions for using MyNCBI and MyBibliography to comply with NIH requirements. It describes how to create a MyNCBI account and link it to an eRA Commons account. It explains how to add publications to MyBibliography and link them to relevant grants/awards. It also discusses how to ensure publications are compliant with the NIH Public Access Policy and how delegates can view a PI's MyBibliography. The document is intended to help users correctly set up and utilize MyNCBI features by an October 2014 deadline.
The Biosketch format, SciENcv and the paper
The document provides guidance on using the new NIH biosketch format called SciENcv. It explains that SciENcv allows researchers to create and maintain their biosketch online by automatically populating sections from their eRA Commons profile and linked publications. The document outlines how to create a biosketch using SciENcv, including leveraging existing data, writing the required sections, and downloading the biosketch for inclusion in grant applications. Researchers must use the new biosketch format for all applications submitted to NIH on or after May 25, 2015.
Using My NCBI & My Bibliography
The document provides instructions for using MyNCBI and linking publications to grants and awards in order to comply with NIH public access policy requirements. It describes how to create a MyNCBI account and link it to an eRA Commons account. It explains how to add publications to My Bibliography and link them to relevant grants or awards. It also discusses designating a delegate and changing a publication's compliance status. The document provides resources for further information on public access policy and using MyNCBI and My Bibliography.
Nih public access_policy
The document discusses the NIH Public Access Policy, which requires that peer-reviewed articles resulting from NIH funding be made publicly available through PubMed Central. It explains what a PMCID is, who the policy applies to, and why researchers need to comply. It provides details on the different methods for getting a PMCID and setting up citation management tools like RefWorks to properly cite articles with PMCIDs or NIHMSIDs. Noncompliance could impact future NIH funding.
Guide for My Bibliography and Compliance
The document discusses the NIH public access policy, which requires researchers receiving NIH funding to submit final peer-reviewed manuscripts to PubMed Central. It outlines the policy requirements, explains the four methods of compliance, and provides tips on how to locate PMCID numbers, configure EndNote, and get help from the library to ensure compliance. Potential issues like determining the appropriate manuscript version and locating NIHMS IDs are also addressed.
Nciccwithsocialmedia
The document lists the names of various cancer centers along with their social media presence on platforms such as Twitter, Facebook, LinkedIn, YouTube, Flickr, Google+, Pinterest, blogs and websites. For each center, it indicates whether or not they have a presence on each social media platform and provides the URL for their main website. Most centers have a presence on Twitter, Facebook, and their own website, while presence on other platforms like YouTube, Flickr and Pinterest is more varied between centers.
NCICC with socialmedia
The document lists 66 cancer centers and their social media presence across several platforms. It shows that over half of the centers (58%) have a Twitter account, while slightly under half (53%) have a Facebook presence. Fewer have LinkedIn (3%), YouTube (35%), or Flickr (8%) accounts. About a third (32%) do not have any listed social media presence. Most centers link to their main website from the document.
04.2 kurland pc
1. Most cancer cells rely on aerobic glycolysis, known as the Warburg effect, which is an inefficient way to generate ATP but facilitates the production of biomass needed for cell proliferation.
2. Understanding the Warburg effect could allow researchers to stage and "fingerprint" tumors based on their metabolic profiles and capacity for invasiveness and proliferation.
3. Targeting metabolic pathways and symbiotic relationships involved in biomass production and that support proliferation, such as lactate transport between hypoxic and oxygenated tumor cells, may provide approaches for combination anti-cancer therapies using metabolic inhibitors.
03.1 libutti pc
The document outlines the vision and strategies for a new cancer care center. The center aims to provide outstanding cancer care for patients while advancing scientific understanding of cancer through translational research. It will establish a multidisciplinary, disease-based care model and develop new treatments to reduce cancer deaths and suffering. The center plans to expand clinical services and research collaborations, build a biospecimen repository, and pursue affiliations and outreach to support its growth.
02.3 gabeau mac
1. Radiation therapy has an emerging role in the multidisciplinary management of hepatocellular carcinoma (HCC) due to advances that allow higher radiation doses to be safely delivered to small liver volumes.
2. Stereotactic body radiation therapy (SBRT) shows promise for HCC but questions remain about safety, effectiveness for bridging to transplant, and downsizing lesions.
3. A pilot study is investigating the safety and feasibility of liver SBRT for HCC.
02.2 kaubisch pc
This document discusses treatment options for hepatocellular carcinoma (HCC), including both potentially curative treatments like surgery and transplantation as well as palliative treatments. It describes staging systems for HCC and the Barcelona Clinic Liver Cancer (BCLC) treatment algorithm. Promising targeted agents discussed include sorafenib, which demonstrated improved survival in phase III trials, and other multi-kinase inhibitors in phase II trials. Ongoing challenges include integrating treatment modalities and evaluating new targets as the number of potential agents increases.
02.1 kinkhabwala
This document discusses strategies for treating hepatocellular carcinoma (HCC) including:
1) Developing individualized treatment approaches using tumor biology and molecular targets.
2) Creating multimodality treatment algorithms combining locoregional therapies with molecular targets.
3) Developing novel locoregional therapies.
It describes the Montefiore Einstein Liver Center's integrated care system for liver disease and cancer, including divisions for transplantation, hepatology, and research. The center aims to standardize protocols and share resources to improve outcomes for HCC patients.
01.5 belbin aecc advances 2010 for web
This document discusses research on new epigenetic biomarkers for oropharyngeal cancer. Specifically, it finds that differential DNA methylation can predict tumor behavior and identify new therapeutic targets. A 150-CpG and 125-CpG signature was found to accurately predict aggressive disease within 24 months and nodal metastasis at diagnosis, respectively. Further validation of these predictive signatures in external patient populations could lead to a clinically useful test for treatment selection.
01.4 steidl pc for upload
The document summarizes research on targeting cancer stem cells in acute myeloid leukemia (AML). It discusses how AML stem cells (leukemia stem cells or LSCs) differ from normal stem cells in their ability to self-renew and initiate leukemia. The research aims to understand the molecular mechanisms that drive LSC function and identify transforming events involved in LSC formation and maintenance. Preclinical studies show that the transcription factor PU.1 regulates genes like JunB that are important for LSC function. The document also discusses using a small molecule drug called Eltrombopag to stimulate megakaryopoiesis in MDS/AML patients without activating LSCs, as a potential treatment for thrombocytopenia.
01.3 klampfer pc
Tumor stroma, including macrophages and other cells, actively influence cancer through soluble factors that alter signaling in tumor cells. Specifically, this document discusses:
1) Colon cancer cells stimulate macrophages to release IL-1β which mediates crosstalk between tumor cells and macrophages.
2) IL-1β inhibits TRAIL-induced apoptosis in tumor cells through NFkB and Wnt signaling pathways.
3) Vitamin D3 can inhibit IL-1β release from macrophages and restore TRAIL-induced apoptosis in a VDR-dependent manner.
More from Albert Einstein Cancer Center (20)
Recently uploaded
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Knee anatomy and clinical tests 2024.pdf
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
The Electrocardiogram - Physiologic Principles
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Journal Article Review on Rasamanikya
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
A Classical Text Review on Basavarajeeyam
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Top 10 Best Ayurvedic Kidney Stone Syrups in India
we have mentioned the best 10 ayurvedic Kidney Stone Syrups. You can check all these products and choose the best one for yourself.
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
It includes regulation of combination products and medical devices. FDA and industry liaisons.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Adhd Medication Shortage Uk - trinexpharmacy.com
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
share - Lions, tigers, AI and health misinformation, oh my!.pptx
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Physiology of Special Chemical Sensation of Taste
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Novas diretrizes da OMS para os cuidados perinatais de mais qualidadeProf. Marcus Renato de Carvalho
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Non-respiratory Functions of the Lungs.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The Best Ayurvedic Antacid Tablets in India
Treat the symptoms of indigestion, heartburn and stomach reflux with the 10 Best Ayurvedic Antacid Tablets in India.
Top-Vitamin-Supplement-Brands-in-India List
Swisschem Dermacare provides the Top 10 Vitamin Supplement Brands in India. To know more about us give us call at our official number
Recently uploaded (20)
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
REGULATION FOR COMBINATION PRODUCTS AND MEDICAL DEVICES.pptx
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Session 2.3 Gabeau
- 1. Role of Radiation Therapy in Multidisciplinary Management of Hepatocellullar Carcinoma Darlene Gabeau, M.D., Ph.D. Assistant Professor Department of Radiation Oncology Department of Radiation Oncology
- 2. HCC : Standard Treatment Algorithm Barcelona Clinic Liver Cancer System Llovet, J. M. et al. J. Natl. Cancer Inst. 2008 100:698-711
- 3. HCC : Standard Treatment Algorithm Barcelona Clinic Liver Cancer System Llovet, J. M. et al. J. Natl. Cancer Inst. 2008 100:698-711
- 4. HCC: Limitations of Standard Modalities Survival 50 - 70% Local Control <25%
- 5. HCC: Limitations of Standard Modalities Survival 50 - 70% Local Control <25% Survival 50 - 80%
- 6. HCC: Limitations of Standard Modalities Survival 50 - 70% Local Control <25% Survival 50 - 80% Ablation Survival 10 - 50%
- 7. HCC: Limitations of Standard Modalities Survival 50 - 70% Local Control <25% Survival 50 - 80% Ablation Survival 10 - 50% TACE Survival 30 - 60%
Editor's Notes
- 2 2 Click and type your text here
- 2 2 Click and type your text here
- 2 2 Click and type your text here
- 2 2 Click and type your text here
- 2 2 Click and type your text here
- 2 2 Click and type your text here
- 2 2 Click and type your text here
- 2 2 Click and type your text here
- 2 2
- 2 2
- 2 2
- 2 2
- 2 2
- 2 2
- 2 2
- 2 2
- 2 2 Click and type your text here
- 2 2 Click and type your text here
- 2 2
- 2 2
- 2 2
- 2 2
- 2 2
- 2 2 Click and type your text here
- 2 2 Click and type your text here
- 2 2 Click and type your text here