Sulfonamides are the first antimicrobial agents effective against bacterial infections by inhibiting the folate synthase enzyme. They are classified as short, intermediate, or long acting depending on their duration of action and include drugs like sulfadiazine, sulfamethoxazole, and sulfamethopyrazine. Common uses include treating meningitis with sulfadiazine, ocular infections with sulfacetamide, and burns with silver sulfadiazine or mafenide. Adverse effects can include hepatitis, crystalluria, and hypersensitivity reactions.

1. SULFONAMIDES
Presented By-
ABHISHEK PRAJAPATI

2. INTRODUCTION
 Sulfonamides are the first antimicrobial agents
effective against pyrogenic bacterial infection.
 Domagk Prontosil Red dye
 responsible for antibacterial activity

3. antibacterial activity

4. CLASSIFICATION OF SULFONAMIDES
 Short Acting - Sulfadiazine
 Intermediate acting – Sulfamethoxazole
 Long acting – Sulfamethopyrazine
Sulfadoxine.
 Special Purpose Silver sulfadiazine
Sulfacetamide
Mafenide
Sulfasalazine

5.  All Sulfonamide are Bacteriostatic in Nature
 Sulfonamide are inhibit folate synthase enzyme.
 Sulfonamide rapidly absorbed fromGIT.
 Sulfonamide freely cross the Placenta
C.I. in Pregnancy

6. USES OF SULFONAMIDE
 Sulfadiazine use in Menengitis.
 Sulfacetamide use in occular infection.
 Silver Sulfadiazine specially use in burnsurface .
 Mafenide – it is also called pseudosulfonamide.
It is use only topically for burn dressing to prevent
infection.
 Sulfasalazine – ( Prodrug ) use in Ulcerative colitis &
rheumatoid arthritis

7.  Sulfadoxine & Sulfamethopyrazine
These are Ultra long acting drugs
High plasma protein binding
Renal excreation slow
 Both are use in combination of Pyrimethamine in
treatment of Malaria.
(Chloroquine resistance P. falciparum Malaria )

8. ADVERSE EFFECT
 Hepatitis
 Crystalluria
 Hypersensitivity reaction
 Hepatitis
 Haemolysis
 Kernicterus
 Steven Johnson syndrome