This document summarizes the struggles of several indigenous individuals during the colonial period in North America: 1) Martin Ocelotl was an Aztec priest in Mexico who predicted the arrival of Europeans. He was sentenced to death for heresy but released, then banned from Mexico and imprisoned in Spain. 2) Isabel Moctezuma was the daughter of the Aztec ruler Moctezuma II. She was married multiple times and had children with both indigenous and Spanish men. She received a large inheritance before dying in 1550. 3) Opechancanough was a chief of the Powhatan Confederacy who led attacks against English colonists before being killed in 1646.