The Indian Pharmaceutical CMO market has been analyzed and assessed with respect to APIs and finished dose formulations (solids, liquids and injectables). Strategic recommendations for the success of market participants have been provided.
Indian Pharmaceutical Export Market - Top Export Destinations for Indian Phar...Irish Pereira
By Mr. Irish Pereira. The report present snapshot of Indian Pharmaceutical industry in both domestic as well as export market. It is collation of facts pertaining to Indian pharma exports and explore key emerging trends pertaining to pharma export market. It describes key players of Indian pharma market and their export orientation as in their target export destinations, their focus therapies etc.
Fact sheet:
1) Indian Pharma Market size 2015
2) Indian pharmaceutical market segments by value
3)Patented (Innovator) Vs Generics Scenario
4)Growth drivers of Indian pharmaceutical industry
5) Indian Pharmaceutical sector – SWOT Analysis
6)PHARMEXCIL – Facilitating agency for Indian Pharma Exports
7) Indian Pharmaceutical Exports (USD bn)
8)Formulations share in Total Pharma Exports (2014-15)
9) Top 25 destination countries of India’s pharmaceutical exports during 2013-14 (INR mn)
10) Major Indian Pharma Companies (By Revenue-USD mn)
11) Pharma players and their export destinations
Sun Pharma,Dr. Reddy’s Lab,
CIPLA, Lupin, Aurobindo, Cadila Healthcare, Torrent Pharma, Wockhardt,
12) Emerging trends in Indian Pharma Market
indian Pharmaceutical industry export import overviewbipindapin
Pharmaceutical Industry-EXPORT IMPORT INDIA
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals licensed for use as medications. Pharmaceutical companies are allowed to deal in generic and/or brand medications and medical devices
Cipla ppt presentation By Ajit R. KulkarniAjit Kulkarni
It consist of History of pharmaceutical industry, company history, prominent companies in market, SWOT analysis, Findings , Learning , Growth rate , Organisational Structure , Ownership Pattern etc.
Research Report on Abbott India Ltd. on the basis of Company Profile, Management, Shareholding Pattern, SWOT Analysis, Competitive Analysis, and Way forward.
Indian Pharmaceutical Export Market - Top Export Destinations for Indian Phar...Irish Pereira
By Mr. Irish Pereira. The report present snapshot of Indian Pharmaceutical industry in both domestic as well as export market. It is collation of facts pertaining to Indian pharma exports and explore key emerging trends pertaining to pharma export market. It describes key players of Indian pharma market and their export orientation as in their target export destinations, their focus therapies etc.
Fact sheet:
1) Indian Pharma Market size 2015
2) Indian pharmaceutical market segments by value
3)Patented (Innovator) Vs Generics Scenario
4)Growth drivers of Indian pharmaceutical industry
5) Indian Pharmaceutical sector – SWOT Analysis
6)PHARMEXCIL – Facilitating agency for Indian Pharma Exports
7) Indian Pharmaceutical Exports (USD bn)
8)Formulations share in Total Pharma Exports (2014-15)
9) Top 25 destination countries of India’s pharmaceutical exports during 2013-14 (INR mn)
10) Major Indian Pharma Companies (By Revenue-USD mn)
11) Pharma players and their export destinations
Sun Pharma,Dr. Reddy’s Lab,
CIPLA, Lupin, Aurobindo, Cadila Healthcare, Torrent Pharma, Wockhardt,
12) Emerging trends in Indian Pharma Market
indian Pharmaceutical industry export import overviewbipindapin
Pharmaceutical Industry-EXPORT IMPORT INDIA
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals licensed for use as medications. Pharmaceutical companies are allowed to deal in generic and/or brand medications and medical devices
Cipla ppt presentation By Ajit R. KulkarniAjit Kulkarni
It consist of History of pharmaceutical industry, company history, prominent companies in market, SWOT analysis, Findings , Learning , Growth rate , Organisational Structure , Ownership Pattern etc.
Research Report on Abbott India Ltd. on the basis of Company Profile, Management, Shareholding Pattern, SWOT Analysis, Competitive Analysis, and Way forward.
this is just powerpoint of the report on a pharma company this was to present in the class and for the ease to understand the research of principle of marketing in institute of business management IoBM
Active Pharma Ingredients (API) - Global Market Estimated to Reach US$ 21.9 b...Ajjay Kumar Gupta
Active Pharma Ingredients (API) - Global Market Estimated to Reach US$ 21.9 billion by 2023: Investment Opportunity for Startups and Entrepreneurs, Medications, Drugs and Pharmaceuticals, Cephalexin Monohydrate, Ampicilin Trihydrate, Ibuprofen Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economics, Production Schedule, Working Capital Requirement, Plant Layout, Process Flow Sheet, Cost of Project, Projected Balance Sheets, Profitability Ratios, Break Even Analysis
Production of active pharmaceutical ingredients is a highly sophisticated and technically demanding process. The global active pharmaceutical ingredient market is surging due to the increased demand for pharmaceutical drugs, which in turn is driven by aging population, increasing prevalence of chronic diseases such as cancer, diabetes, cardiovascular, neurological and infectious diseases among others. The global Active Pharmaceutical Ingredient market for was valued at US$ 12.9 bn in 2014 and is estimated to reach US$ 21.9 billion by 2023 at a CAGR of 6.3% from 2015 to 2023.
See more
https://goo.gl/dwgi0H
https://goo.gl/qRJmnp
https://goo.gl/t2QFiI
Contact us:
Niir Project Consultancy Services
106-E, Kamla Nagar, Opp. Spark Mall,
New Delhi-110007, India.
Email: npcs.ei@gmail.com , info@entrepreneurindia.co
Tel: +91-11-23843955, 23845654, 23845886, 8800733955
Mobile: +91-9811043595
Website :
http://www.niir.org
http://www.entrepreneurindia.co
Tags
Active Pharmaceutical Ingredients Manufacturing, Active Pharmaceutical Ingredients, API Manufacture in India, API Manufacturing, Manufacturing of Active Pharmaceutical Ingredients, API Manufacturing Industry, API Manufacturing Plant, Active Pharmaceutical Ingredient Manufacture, Manufacture of Active Pharmaceutical Ingredients, Manufacturing of Active Pharmaceutical Ingredients, Active Pharmaceutical Ingredient Manufacturing Plant, Processing of Active Pharmaceutical Ingredient, Active Pharmaceutical Ingredients Plant, Preparation of Active Pharmaceutical Ingredients (API), Active Pharmaceutical Ingredients Industry, Production of Active Pharmaceutical Ingredients (API), Active Pharmaceutical Ingredients Manufacturing Unit, Plans to Set Up API (Active Pharmaceutical Ingredients) Manufacturing Project, Active Pharmaceutical Ingredient Manufacturing Process, Active Pharmaceutical Ingredients Production, Production Process of API, Active Pharmaceutical Ingredient (API) Production, API Manufacturing Process, Business Planning for Active Pharmaceutical Ingredients Manufacturing, Business Plan for Manufacturing Active Pharmaceutical Ingredient, Start Active Pharmaceutical Ingredient (API) Production Business, Plant for Production of Active Pharmaceutical Ingredient
How Many Types of Marketing Strategies in Pharma Sector? - Ambit Bio Medixambitbiomedix12
If you are looking to many types of Marketing Strategies in Pharma Sector then Ambit Bio Medix is one of best top 10 pharma franchise companies at the best price. Here are the Many Types of Marketing Strategies in Pharma Sector.
Advances and investment in digital health is growing at an incredible rate and Contract Manufacturing Organizations and Contract Development and Manufacturing Organizations are becoming an essential part of the new pharma value chain. From wearables, to apps, to digital platforms, the data and efficiencies generated by these innovations are opening up important avenues across the pharma ecosystem. As pressure on improving drug development heats up, data, digital and technological innovations are critical to delivering the desired business and patient outcomes, promoting significantly more networking and outsourcing strategies. CMOs are evolving from service providers to strategic partners. CMOs now cover the entire value chain of pharma production, including specialized services such as R&D.
I have to try to share some knowledge about the Indian health care sector. I have put some data to get more and more knowledge which can easily understand.
this is just powerpoint of the report on a pharma company this was to present in the class and for the ease to understand the research of principle of marketing in institute of business management IoBM
Active Pharma Ingredients (API) - Global Market Estimated to Reach US$ 21.9 b...Ajjay Kumar Gupta
Active Pharma Ingredients (API) - Global Market Estimated to Reach US$ 21.9 billion by 2023: Investment Opportunity for Startups and Entrepreneurs, Medications, Drugs and Pharmaceuticals, Cephalexin Monohydrate, Ampicilin Trihydrate, Ibuprofen Manufacturing Plant, Detailed Project Report, Profile, Business Plan, Industry Trends, Market Research, Survey, Manufacturing Process, Machinery, Raw Materials, Feasibility Study, Investment Opportunities, Cost and Revenue, Plant Economics, Production Schedule, Working Capital Requirement, Plant Layout, Process Flow Sheet, Cost of Project, Projected Balance Sheets, Profitability Ratios, Break Even Analysis
Production of active pharmaceutical ingredients is a highly sophisticated and technically demanding process. The global active pharmaceutical ingredient market is surging due to the increased demand for pharmaceutical drugs, which in turn is driven by aging population, increasing prevalence of chronic diseases such as cancer, diabetes, cardiovascular, neurological and infectious diseases among others. The global Active Pharmaceutical Ingredient market for was valued at US$ 12.9 bn in 2014 and is estimated to reach US$ 21.9 billion by 2023 at a CAGR of 6.3% from 2015 to 2023.
See more
https://goo.gl/dwgi0H
https://goo.gl/qRJmnp
https://goo.gl/t2QFiI
Contact us:
Niir Project Consultancy Services
106-E, Kamla Nagar, Opp. Spark Mall,
New Delhi-110007, India.
Email: npcs.ei@gmail.com , info@entrepreneurindia.co
Tel: +91-11-23843955, 23845654, 23845886, 8800733955
Mobile: +91-9811043595
Website :
http://www.niir.org
http://www.entrepreneurindia.co
Tags
Active Pharmaceutical Ingredients Manufacturing, Active Pharmaceutical Ingredients, API Manufacture in India, API Manufacturing, Manufacturing of Active Pharmaceutical Ingredients, API Manufacturing Industry, API Manufacturing Plant, Active Pharmaceutical Ingredient Manufacture, Manufacture of Active Pharmaceutical Ingredients, Manufacturing of Active Pharmaceutical Ingredients, Active Pharmaceutical Ingredient Manufacturing Plant, Processing of Active Pharmaceutical Ingredient, Active Pharmaceutical Ingredients Plant, Preparation of Active Pharmaceutical Ingredients (API), Active Pharmaceutical Ingredients Industry, Production of Active Pharmaceutical Ingredients (API), Active Pharmaceutical Ingredients Manufacturing Unit, Plans to Set Up API (Active Pharmaceutical Ingredients) Manufacturing Project, Active Pharmaceutical Ingredient Manufacturing Process, Active Pharmaceutical Ingredients Production, Production Process of API, Active Pharmaceutical Ingredient (API) Production, API Manufacturing Process, Business Planning for Active Pharmaceutical Ingredients Manufacturing, Business Plan for Manufacturing Active Pharmaceutical Ingredient, Start Active Pharmaceutical Ingredient (API) Production Business, Plant for Production of Active Pharmaceutical Ingredient
How Many Types of Marketing Strategies in Pharma Sector? - Ambit Bio Medixambitbiomedix12
If you are looking to many types of Marketing Strategies in Pharma Sector then Ambit Bio Medix is one of best top 10 pharma franchise companies at the best price. Here are the Many Types of Marketing Strategies in Pharma Sector.
Advances and investment in digital health is growing at an incredible rate and Contract Manufacturing Organizations and Contract Development and Manufacturing Organizations are becoming an essential part of the new pharma value chain. From wearables, to apps, to digital platforms, the data and efficiencies generated by these innovations are opening up important avenues across the pharma ecosystem. As pressure on improving drug development heats up, data, digital and technological innovations are critical to delivering the desired business and patient outcomes, promoting significantly more networking and outsourcing strategies. CMOs are evolving from service providers to strategic partners. CMOs now cover the entire value chain of pharma production, including specialized services such as R&D.
I have to try to share some knowledge about the Indian health care sector. I have put some data to get more and more knowledge which can easily understand.
5th Biosimilars Congregation 2014
10th September 2014, Kohinoor Continental Hotel, Mumbai, India
“Uniting industry leaders to analyse advanced commercial developments & to identify successful management strategies of Biosimilars”
This presentation was made in Pharmasource Munich 2012 and covers the aspects of Pharma API and Intermediate sourcing. The presentation covers the following sub topics
1. How the changing structure of the Pharma industry is affecting ingredients sourcing
2. Are India and China still the places to go ( and for how long) – does the Cost - Benefit stack –up?
3. Supplier Innovation and Potential gains
4. Analyzing the Asian Pharma market –
a generics hub with a competitive skill base
i may be contacted at gurmeetsingh144@hotmail.com
Polyhydroxyalkanoate are linear polyesters that are produced from fermentation of lipid or sugar by bacteria. The rising demand for biodegradable materials, increase in oil prices and policies concerning green procurement are the driving factors for investment by companies in this market.
From Research to Revenue IV: Capturing Business Opportunities in AsiaGHBN
A full collection of the presentations made Wednesday, December 3, 2008 at Mississauga Living Arts Centre for From Research to Revenue IV: Capturing Business Opportunities in Asia.
Similar to Strategic Analysis of the Indian Pharmaceutical Contract Manufacturing MarketFinal ppt (20)
Opportunities & Challenges in West Africa's (Ghana & Nigeria) Healthcare and ...Aiswariya Chidambaram
This presentation made at the Pharma Insights Briefing session of CPhI Worldwide 2014, Paris, provides information on the market opportunities of
the fastest growing pharmaceutical markets in Africa: Ghana and Nigeria.
• Market sizing and Growth Trends
• Key Merger, Acquisition and Partnership Assessment
• Market Drivers and Challenges
• Pharmaceutical Procurement, Supply, Distribution and Retail
• SWOT and PESTLE Analysis
• Competitive Landscape Analysis
• Therapeutic Area Growth Analysis
• Strategic Recommendations
Global Generic Pharmaceutical Market - Qualitative and Quantitative AnalysisAiswariya Chidambaram
This report was presented at the Pharma Tech 2013 Conference - India A Game Changer in the Pharma Industry at Ahmedabad, India in December 2013. The presentation highlights the overview of the global generic pharmaceuticals market, with particular focus on the key market trends and challenges by therapeutic areas and geographies including the U.S, EU and India. List of key blockbuster drugs scheduled to lose patent protection between 2010 and 2020 have been included. Additionally impact of regulation on generic drugs by region and strategic recommendations for the success of market participants are also covered in this report.
This presentation which highlights the various technology innovations and developments in targeted drug delivery as well as maps its applications in different therapeutic segments was presented at the Novel Drug Delivery Systems and Clinical Trial Management 2013 Conference at Shangai, China.
Global Biopharmaceutical Contract Manufacturing Market - Qualitative and Quan...Aiswariya Chidambaram
This presentation which highlights the key market and technology trends in the global biopharmaceutical contract manufacturing market was delivered as a lecture at the In-Focus Seminar session at CPhI Worldwide 2013 held at Frankfurt, Germany.
This research service provides an in-depth analysis of the global pharmaceutical contract manufacturing market with particular focus on the finished dose formulations such as solid, liquid and semi-solid, and injectable dose formulations. Segment analysis, trends and revenue forecast for the global, U.S. and European regions have been provided in detail. Strategic recommendations for the success of market participants have also been discussed.
Briefing based on the key findings of my research on the Global Generic Pharmaceuticals Market 2010, covering the developed markets like the U.S, Germany, UK, France, Italy and Spain as well as the emerging markets such as India and China.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
SURGICAL ANATOMY OF THE RETROPERITONEUM, ADRENALS, KIDNEYS AND URETERS.pptx
Strategic Analysis of the Indian Pharmaceutical Contract Manufacturing MarketFinal ppt
1. Strategic Analysis of the Indian Pharmaceutical
Contract Manufacturing Market
Presenting Opportunities for Market Share Gain
Aiswariya Chidambaram
Senior Research Analyst - Healthcare
2. Areas of Contract Manufacturing
Indian Contract Manufacturing Market Value Chain
3. 25%
15%
20%
55%
15% 15%
0%
10%
20%
30%
40%
50%
60%
Discovery API
development
Dodage
development
APImanufacturing Dosage
manufacturing
Packaging
Extent of Outsourcing in Each Area of the Value Chain
ExtentofOutsourcing
Outsourced Core Functions
Outsourcing Trends
Increase in outsourcing of core functions
Late life-cycle outsourcing – API manufacturing represents the highest share
Drug discovery, development activities and dosage manufacturing – potential future areas
Increase in outsourcing of core functions
Late life-cycle outsourcing – API manufacturing represents the highest share
Drug discovery, development activities and dosage manufacturing – potential future areas
6. 50
25
25
3
10
5
15
7
United States
India
Raw Materials Manpower Depreciation Other Site Exp
Percentage points comparison with U.S.
Manufacturing Cost Arbitrage, India, 2010
The
United
States
China
India –
Non-
USFDA
India –
USFDA
approved
Europe
Percentage points comparison with U.S.
Cost Comparison, India, 2010
100
95
70
66
22
7
4
United States
Germany
Italy
United Kingdom
Poland
India
China
Percentage points comparison with U.S.
Labor Cost Arbitrage, India, 2010
Low-cost manufacturing hubs
Cost of manufacturing 60 percent lesser than the
United States
Labor is the main source of cost arbitrage
Low-cost manufacturing hubs
Cost of manufacturing 60 percent lesser than the
United States
Labor is the main source of cost arbitrage
Contract Manufacturing Market—Cost Arbitrage
7. 5
8
10
25
27
55
119
Hungary
Israel
Taiwan
Spain
China
Italy
India
Number of U.S. FDA-approved Facilities, Global, 2010
Contract Manufacturing Market—U.S. FDA-approved Facilities
India not only offers cost competitiveness, but
also ensures product quality
More than 119 U.S FDA approved facilities in
2010 – ranks second after the U.S
GMP compliant and cater to international
standards
India not only offers cost competitiveness, but
also ensures product quality
More than 119 U.S FDA approved facilities in
2010 – ranks second after the U.S
GMP compliant and cater to international
standards
8. DMF Filing Trend by DMF Type, Global, 2008-2010 DMF Filing with U.S. FDA, India, 2000 - 2010
0
100
200
300
400
500
600
700
800
2008 2009 2010(As on March10,2010)
786
710
129
236
155
8578
114
11
16 20 4
No.ofDMFsfiled
Type II Type III Type IV Type V
Year
271 294 321
455
380 365
736 760
799
1131
1021 1024
37
39
40 40
37
36
10
15
20
25
30
35
40
45
0
200
400
600
800
1000
1200
2005 2006 2007 2008 2009 2010
%ofDMFsfromIndia
No.ofDMFsfiled DMF Filed, India DMF Filed, Overall % of DMF from Ind ia
• India continues to lead in the number of DMF filings with the U.S. FDA.
• Way ahead of China as well as other Western countries
• Major companies include Dr. Reddy’s Laboratories, Aurobindo Pharma, Sun Pharmaceuticals, Lupin,
Matrix Pharmaceuticals and Orchid Pharmaceuticals.
Contract Manufacturing Market—DMF Filing
9. ChinaIndia
Europe
The United States
Bulk and Sourcing
Hub
• Good cost of RM/
early stage
intermediates
• Late lifecycle APIs
Scale Manufacturing Hub
(API and formulations)
• More than 100 U.S. FDA-
approvedplants
• High-quality managerial
Quality assurance•
Strong API and
formulations
capability
Early Stage and Launch
Hub
• R&D expertise and
investments
• Technology capability
• Facilities to support
launch
• Relationships and track
record
Source: Frost & Sullivan analysis
Existing Business Model, Global, 2010
Contract Manufacturing Market—Existing Business Model
•
10. Pre-clinical
API
Pre-clinical
Formulation
Phase-I API
Phase-II a
API
Phase-II b
API
Phase III
API
Registration
Launch
Commercial
Manufacturing
Clinical Trials
Formulations
Formulations
Development
PRE-CLINICAL DEVELOPMENT CLINICAL DEVELOPMENT COMMERCIALIZATION
FULL-SCALE SUPPLIESEARLY PHASE CUSTOM SYNTHESIS AND FORMULATIONS DEVELOPMENT
DEVELOPMENT PARTNERDEVELOPMENT PARTNER LAUNCH PARTNERLAUNCH PARTNER
LIFECYCLE AND
TRANSITION
MANAGEMENT
PARTNER
LIFECYCLE AND
TRANSITION
MANAGEMENT
PARTNER
Prior 20002000-20052005-20102010-20152015 Onwards
APIs/ Bulk
Drugs
Prior 20052005-20102010-20152015-20202020 OnwardsFormulations
Existing Business Model, Global, 2010
Contract Manufacturing Market—Emerging Business Model
11. Capacity
Reputation/
Credibility
Technical
expertise
Quality
Low
Low High
Low High
2 105 6 8
2 104 6 8
2 104 6 8
Low High
2 104 6 8
High
Personal
relationship
Communication
Timely delivery/
Speed
Approved facilities/
Regulatory support
Low
Low High
Low High
2 104 6 8
2 104 6 8
2 104 6 8
Low High
2 104 6 8
High
Cost Location
Low High
2 104 6 8
Low High
2 104 6 8
Note: Above are the key competitive factors in the selection of a CMO by Pharmaceutical/Biotech companies for contract manufacturing
services. The factors are rated on a scale of 1 to 10 with 1 = Low importance and 10 = High importance based on the end-user’s input.
Note: Above are the key competitive factors in the selection of a CMO by Pharmaceutical/Biotech companies for contract manufacturing
services. The factors are rated on a scale of 1 to 10 with 1 = Low importance and 10 = High importance based on the end-user’s input.
Source: Frost & Sullivan analysis.
Key Competitive Factors in the selection of a CMO
13. API Types Divi’s
Laboratory
Ltd.
Piramal
Healthcare Ltd.
Jubiliant
Organosys
Ltd.
Aurobindo
Pharma
Ltd.
Dr. Reddy’s
Laboratory
Ltd.
Small
Molecules
Controlled
Substances
Custom
Organic
Synthesis
API -
Intermediates
Cytotoxics
Process
Development
Company Service Information Comparison (continued)
15. Patent Expiry of Blockbuster Drugs WorldwidePatent Expiry of Blockbuster Drugs Worldwide
Interest of Big Pharma Leading to Increased Industry ConsolidationInterest of Big Pharma Leading to Increased Industry Consolidation
Expansion of Manufacturing CapacitiesExpansion of Manufacturing Capacities
New Product Launches/Novel Drug Delivery MechanismsNew Product Launches/Novel Drug Delivery Mechanisms
Increasing Adherence towards an Integrated Business ModelIncreasing Adherence towards an Integrated Business Model
Biologics ManufacturingBiologics Manufacturing
Contract Manufacturing Market – Emerging Trends
16. Enormous
Cost-
saving
Benefits
Manufacturing
costs reduced
by 40 – 60 %
Patent Cliff
Drugs
worth $150
billion
going off
patent
globally
Increasing
Regulatory
Support
Novel
technology,
new
pharmaceutical
hubs, SEZ
policy
Industry
Consolidation
Strategic
alliances
between Big
Pharma and
domestic
participants
Limited
Technical
Know-how
Lack of
expertise in
sterile
products,
technology
platforms
IPR
Protection
Breach of
proprietary
information
Drivers Restraints
Contract Manufacturing Market—Pushing and Pulling Forces
17. United States
Size: $55.78 B
Growth (2011 –
2016): 8.5%
Europe
Size:$36.44 B
Growth: 8.2%
Japan
Size:$8.00 B
Growth: 9.2%
India
Size:$10.00 B
Growth: 18.5%
China
Size:$26.45 B
Growth: 19.4%
Global Generic Pharmaceuticals Market – Patent Cliff
18. • Currently Indian generics represent
15% of the generics in the U.S.
• With drugs worth $67.50 billion losing
patent protection in the United States,
it is expected that Indian companies
will capture at least 30.0 per cent of
the replacement generic equivalents
Indian Generics Market – A Snapshot
48%52%
Domestic Sales and Export of Generics, India, 2010
India – primarily a branded generics market with
more than 95% generic penetration
Constitutes 20 – 22% volume share globally
Leading exporter of generics to the tune of $11
billion
Highly fragmented market – more than 20,000
registered units
Big Pharma vying to gain market shares in
domestic market
Price driven; cost pressures fuelling
consolidation
19. IndiaIndia China
Source: Frost & Sullivan analysis
Focus on:
- Late stage intermediates
- Complex synthetic APIs (Custom Synthesis)
- Dosage
Greater number of U.S FDA plants and DMF filings
Large English speaking population
TRIPS compliant product patent regime
Focus on:
- Early stage intermediates
- Large volume API manufacturing
- Expertise in fermentation
Currently lagging behind, expected to rapidly catch up
Language barriers
Better logistics & infrastructure
China – A Potential Competitor
20. In the last two years, the drive among multinationals to outsource manufacturing to Indian companies
has gained momentum. Although contract manufacturing companies should have been best
positioned for these contracts, the multinationals are preferring the Indian generic companies as
outsourcing partners.
The key reasons for this are:
•Generic facilities are capable of manufacturing products across various therapeutics segments,
unlike the pure play contract manufacturers that develop cost efficiencies through one or two
technologies at a time.
•Generic facilities are already running and manufacturing products for less regulated or emerging
markets.
•Generic companies are already in compliance with regulations in regulated and semi regulated
markets, something that is lacking in pure contract manufacturers.
•Frost & Sullivan, therefore, foresees that pure play contract manufacturers will continue to
face hurdles related to scale up and will not be able to effectively compete against the generic
companies for strategic tie-ups, as Big Pharma has being showing interest in strategic tie-ups
with Indian generic companies (which have their own brands in emerging markets)
Strategic Tie-ups between MNCs and Indian Companies
21. Source: Assocham, Frost & Sullivan analysis
Contract Research and Manufacturing Services Deals
22. Source: Assocham, Frost & Sullivan analysis
Contract Research and Manufacturing Services Deals (continued)
23. Source: Assocham, Frost & Sullivan analysis
Contract Research and Manufacturing Services Deals (continued)
26. 80%
20%
APIs and Intermediates Formulations
64%
36%
APIs and Intermediates Formulations
Percent Revenue Split, India, 2010Percent Volume Split, India, 2010
• Outsourcing of APIs for generic drugs is expected to remain high in the future.
• Contract Manufacturing of APIs and intermediates for NCE has started gaining momentum.
• Contract manufacturing of NCE formulations is expected to begin during the forecast period.
Indian Contract Manufacturing Market Overview (continued)
27. Active pharmaceutical ingredients (APIs) or bulk drugs are defined as the active part of a drug, which is responsible
for its medicinal property.
Asia Pacific, particularly India, is a favored market for API outsourcing, due to low cost benefits, complex synthetic
abilities, and GMP compliance.
Every company currently involved in the contract manufacturing segment, also has some presence in the API
segment due to the amount of manufacturing outsourced to this segment.
In terms of volume, 80-85 percent of the entire outsourcing in contract manufacturing takes place in the areas of
APIs and intermediates.
Contract manufacturing for API, which is outsourced to India, is mainly for generic formulations.
However, as the Indian contract manufacturing segment market matures, contract manufacturing for New Chemical
Entities (NCEs) will be outsourced to India.
Indian contract manufacturing organizations are already being used by many MNCs as suppliers of advanced
intermediates.
China is a major competitor in the Asian market. However, is still a supplier of low-cost off-patent molecules and
low-end intermediates.
However, the threat from the Chinese suppliers for these products and higher-end ones is only bound to increase as
the Indian contract manufacturing segment market matures.
The trend is shifting toward outsourcing the manufacturing of advanced APIs, such as biotech-based APIs,
biopharmaceuticals and advanced bulk drugs required for the production of dosage forms of new chemical entities
in high-end therapy areas, such as oncology.
Source: Frost & Sullivan analysis
APIs and Intermediates—Overview
28. • Early market growth stage
• Limited shelf-life and storage
issues
• Require high investments and
specialised technical know-how
• Increasing focus on biologics
• Expected to witness fastest growth
(29.5%, 2011 – 2017)
• More than 70% of
Indian CMOs have
expertise
• Patient compliance
and prevalence of
self-prescription.
• Low
manufacturing
costs and lower
degree of technical
change
• Expected to remain
the key segment
(25.4%, 2011 – 2017)
• Low-value business
• Majority pediatric and
baby-boomer end-
users
• High transportation
and wastage costs
• Likely to present
relatively lesser
growth prospects
(12.5%, 2011 – 2017)
Formulations —Overview
29. -
range of services control the
market
-Number of CMO’s - high
-Suppliers can forward integrate
-Volume benefits are available
- Moving up the value chain
Becoming more specialized and niche
Power of Suppliers
-End users have bargaining power
-Buyer concentration vs. industry is high
- Buyers in need due to generic penetration
and pressure on margins
Power of Buyers
-Low entry barriers in case of toll
- Government policies are supportive
- Economies of scale & scope exits
- IPR strengthening
- Technology and regulatory
strength
Threat of New Entrants
-Easy access to cheap technology
- Virtual pharma model
- Wider product range and
Threat of Substitutes
- Consolidation likely to increase
Low Impact
Medium Impact
Industry Rivalry
Traditional
Emerging
- Top participants, control the
- High toll manufacturing CMOs
- Suppliers can forward integrate
- Volume benefits are available
-
-
Power of Suppliers
- End users have bargaining power
- Buyer concentration versus industry is high
-
Power of Buyers
- Low entry barriers
Supportive Government policies-
Economies of scale and scope
-
Threat of New Entrants
- Easy access to low – cost
technology and skilled labor
-
-
Threat of Substitutes
-
Low Impact
Medium Impact
Industry Rivalry
Traditional
Emerging
-
market concentration
market
services
Contract Manufacturing Market: Porter’s Five Forces Model for Non-sterile Formulation, India, 2010
Non-sterile Formulation—Porter’s Five Forces Model
30. Contract Manufacturing Market: Porter’s Five Forces Model for Sterile Formulation, India, 2010
Power of Suppliers
- Number of suppliers is high
- Raw material cost is low
- Difficulty to forward integrate
- High competition exists
Threat of New Entrants
- High entry barriers
- Stringent and time-consuming
regulatory processes
- Rising attractiveness in terms of
market size and profitability
Threat of Substitutes
- Access to technology
- High capital investment
- Complex manufacturing process
- Availability of limited capacity
Power of Buyers
- Less bargaining power
- Average buyer concentration vs. industry
- Buyers in need due to new sterile product
approvals
- Expanding role of generic pharmaceuticals
Industry Rivalry
- Very few reliable companies
- Low competition
- Outsourcing trend is accelerating
- Competition is on the basis of
technology, quality and capacity
-
Low Impact
Medium Impact
Traditional
Emerging
Sterile Formulation—Porter’s Five Forces Model
31. Source: Frost & Sullivan analysis
Emerging Opportunity Areas
32. Innovation
Funding
Expertise
Regulatory
compliance
“Any sufficiently advanced technology is indistinguishable from magic”
– Arthur C. Clarke
Technology – The Powerful Tool
Larger companies - complex technologies such as combination drugs and controlled releases.
Foray into therapeutic segments, which have difficult manufacturing processes and less competition.
Focus on cost, quality of manufacturing and complex chemistry skills.
Commoditized generic market - focus on complex technologies and can command premium pricing.
Indian Companies Focussed on Complex Technologies
33. Therapeutics
Development of RNA-i based therapeutics
Development of anti-sense based therapeutics
Recombinant protein therapeutics
Monoclonal antibodies
Government
Regulatory bodies like EMEA to drive new
product and technology introduction
Increase in approval rates of new
biopharmaceuticals and biosimilars.
Globalization
Consolidations, mergers, acquisitions
Opening and expansion of Asian markets
Global capital markets
CMOs moving up the value chain
– consolidating horizontal spread,
expanding vertical spread
“A-one-stop-shop” offered by
CMOs, promoting a complete
portfolio of products and
comprehensive range of services.
Shift from a purely transactional
relationship to a risk-sharing model
aligned with customer priorities
Large CMOs moving into niche
areas of manufacturing.
Development of virtual pharma
Transition from “small molecule
blockbuster” model to
biopharmaceutical model
“ The best way to predict the future is to create it” – Peter Drucker
What Can be Expected in the Future?
Customer-centric range of
services
Staying ahead of industry
curve by building brand
preference
Strengthened relationship
for longevity
34. Reacting to
Change
Anticipating
Change
Leading
the
Change
• Develop drugs for key indications.
• Customize according to customer needs and
preferences.
• Comply with new government policies.
• Analyze prospects for market globalization.
• Research customer needs, preferences and
expectations.
• Monitor new technological developments to
predict future.
• Foresee capacity requirements.
• Pioneer new and better technologies.
• Introduce innovative products, that open new
market opportunities and spur creation of whole
new industries.
• Seek to set industry standards.
• React and respond as needed.
• Defend and protect company’s
position in the market.
• Plan ahead for future changes.
• Invest in R&D.
• Instill competitive capabilities.
• Improve product line.
• Strengthen distribution.
• Seize the offensive.
• Be the agent of industry
change.
• Influence rules of the game.
• Force rivals to follow.
Strategic
Posture Actions Strategy
“ Change is the law of life. And those who look only to the past or present are certain to miss the future.” – John F.
Kennedy
Source: Frost and Sullivan
Facing the Change – Strategic Recommendations
35. • Outsourcing of non-core activities such as manufacturing of intermediates and APIs to low-cost
destinations such as India is gaining momentum for pharma MNCs as they focus on their core R&D and
brand building business.
• Indian companies have strengthened their presence in the market and developing technical expertise in
niche segment (sterile drugs, cytotoxics, lyophilization, etc.) that offer higher margins and higher entry
barriers. Acquisition of foreign facilities would accelerate growth and foster better relationships with
innovator companies, though generating adequate return from such investments can be difficult.
• In the long run, companies, which provide integrated drug development, research, clinical trial and
manufacturing outsourcing services, will prove to be one stop shops catering to all the needs of the
innovator companies resulting in long-term partnerships and better customer franchise.
• The domestic market offers significant opportunities for CRAMS providers, as increasingly larger
domestic companies are outsourcing manufacturing and packaging services to these participants in
order to focus on marketing and sales, and new drug development. Their ability to offer value-added
services such as drug delivery systems, combination drugs further leverages their value proposition.
• Overall, the outlook for Indian CRAMS appears to be healthy, supported by increasing outsourcing of
manufacturing and high-end research activities.
Conclusion
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Email: AiswariyaC@frost.com
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AISWARIYA CHIDAMBARAM
Senior Research Analyst - Healthcare
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