Strangers In The Night discusses a Ruby web development conference called "Gem Talk" held in Las Palmas on November 5th, 2010. The talk was given by Alberto Perdomo and covered various Ruby web servers, frameworks, and middleware that can be used to build web applications and services. It also provided an overview of the Sinatra microframework, highlighting features like routes, templates, errors and testing. Examples of real-world Sinatra applications were shown to demonstrate its use for small sites, services and modular applications.