Life style modification by ayurveda, reflexology, hydrotherapy, homeopathy.pptxRuth Honey Solomon
This presentation gives a plentiful information on Ayurveda treatment for acne, Reflexology treatment for Hormonal Imbalance, Hydrotherapy for joint (knee) pain, Homeopathy for menstrual disorders
Clean Intermittent Self-Catheterisation is a technique which is used to empty the bladder at regular intervals. This is done by passing a catheter (small tube) into the bladder through the urethra (passage through which urine leaves the bladder). You should be taught how to do this by your continence nurse. It is not a sterile technique, but it is a clean one, so it is very important to have good hygiene standards when doing the procedure.
Best Constipation treatment in Hyderabad | Constipation surgery in Hyderabad ...HealingHandsClinic2
Constipation usually defined as when a person has a bowel movement less than 1-3 times a week. There are lot of people who suffers from regular constipation problem. Constipation on its own can be uncomfortable but it is not life-threatening. It can occur due to many reasons such as lack of fibre, physical inactivity, overuse of laxatives, not drink enough water and so on. Eating meals, going to bed, and using the bathroom at different times could increase constipation. Constipation usually resolves itself by making some lifestyle changes, without the need for any treatment.
To know more, visit: https://www.healinghandsclinic.co.in/constipation-treatment-centre/
Life style modification by ayurveda, reflexology, hydrotherapy, homeopathy.pptxRuth Honey Solomon
This presentation gives a plentiful information on Ayurveda treatment for acne, Reflexology treatment for Hormonal Imbalance, Hydrotherapy for joint (knee) pain, Homeopathy for menstrual disorders
Clean Intermittent Self-Catheterisation is a technique which is used to empty the bladder at regular intervals. This is done by passing a catheter (small tube) into the bladder through the urethra (passage through which urine leaves the bladder). You should be taught how to do this by your continence nurse. It is not a sterile technique, but it is a clean one, so it is very important to have good hygiene standards when doing the procedure.
Best Constipation treatment in Hyderabad | Constipation surgery in Hyderabad ...HealingHandsClinic2
Constipation usually defined as when a person has a bowel movement less than 1-3 times a week. There are lot of people who suffers from regular constipation problem. Constipation on its own can be uncomfortable but it is not life-threatening. It can occur due to many reasons such as lack of fibre, physical inactivity, overuse of laxatives, not drink enough water and so on. Eating meals, going to bed, and using the bathroom at different times could increase constipation. Constipation usually resolves itself by making some lifestyle changes, without the need for any treatment.
To know more, visit: https://www.healinghandsclinic.co.in/constipation-treatment-centre/
Medicated retention Enema in common gynic complaintsDr.SVL Sindhura
Matra vasti, which if translated is the medicated retention type enema , is the most successful panchakarma procedure which can be adopted in day to day clinical practice.
Anuradha e. lecture 4 Sthanik Chikitsa (Local Ayurvedic Gynaecological thera...Anuradha Roy
Ayurveda has a great potential for management of various gynaecological conditions by sthanik chikitsa or local ayurvedic therapy. A description with open end of research areas are described here.
As the spina bifida population ages, there will be many people who have never had their continence issues addressed. This leaflet is intended to help this group to look at their bowel and bladder management.
Anal Fissures are small tear near the anal opening through which the stool passes. They cause pain, bleeding or itching near the anal area. Most of the patients assume that these symptoms are related to piles or hemorrhoids or bavasir. But these symptoms can be of fissure also. Treatment for fissure starts at home itself. Use simple home remedies as described above to heal fissures. But if the problem is not resolved using the above methods then a doctor can diagnose the problem and may suggest you medicines, ointments or in rare cases surgery may be recommended. Healing Hands Clinic deals with various anorectal disorders such as piles, fissure, fistula, hernia, constipation, and others at various centers in Pune, Bengaluru, Nashik, Mumbai, and Jaipur. HHC has internationally recognized doctors and surgeons for treatment of all type of anorectal disorders.
An anal fissure or rectal fissure is a break or tear in the skin of the anal canal. Anal fissures may be noticed by bright red anal bleeding on toilet paper, sometimes in the toilet. If acute they may cause pain after defecation. but with chronic fissures pain intensity is often less.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
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Matra vasti, which if translated is the medicated retention type enema , is the most successful panchakarma procedure which can be adopted in day to day clinical practice.
Anuradha e. lecture 4 Sthanik Chikitsa (Local Ayurvedic Gynaecological thera...Anuradha Roy
Ayurveda has a great potential for management of various gynaecological conditions by sthanik chikitsa or local ayurvedic therapy. A description with open end of research areas are described here.
As the spina bifida population ages, there will be many people who have never had their continence issues addressed. This leaflet is intended to help this group to look at their bowel and bladder management.
Anal Fissures are small tear near the anal opening through which the stool passes. They cause pain, bleeding or itching near the anal area. Most of the patients assume that these symptoms are related to piles or hemorrhoids or bavasir. But these symptoms can be of fissure also. Treatment for fissure starts at home itself. Use simple home remedies as described above to heal fissures. But if the problem is not resolved using the above methods then a doctor can diagnose the problem and may suggest you medicines, ointments or in rare cases surgery may be recommended. Healing Hands Clinic deals with various anorectal disorders such as piles, fissure, fistula, hernia, constipation, and others at various centers in Pune, Bengaluru, Nashik, Mumbai, and Jaipur. HHC has internationally recognized doctors and surgeons for treatment of all type of anorectal disorders.
An anal fissure or rectal fissure is a break or tear in the skin of the anal canal. Anal fissures may be noticed by bright red anal bleeding on toilet paper, sometimes in the toilet. If acute they may cause pain after defecation. but with chronic fissures pain intensity is often less.
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imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
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30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
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z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
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A brief information about the SCOP protein database used in bioinformatics.
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Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
This report details the geological observations and interpretations made during a field investigation of the Kaptai Rangamati road-cut section, located in southeastern Bangladesh. The purpose of this report is to document the exposed rock units, their characteristics, and the geological structures present within the road cut.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutrition is the science that deals with the study of nutrients and their role in maintaining human health and well-being. It encompasses the various processes involved in the intake, absorption, and utilization of essential nutrients, such as carbohydrates, proteins, fats, vitamins, minerals, and water, by the human body.
2. Introduction
✓ The diseases of the genital tract of woman and their
treatment have been given a lot of importance in the
ancient period.
✓ The direct communication of the peritoneum to the
exterior is through the vagina.
✓ Routes of drug administration – The Topical form of
local routes is often more convenient as well as
encouraging to the patient.
✓ This particular route of administration provides
treatment in prepared form for faster action.
4. Yoni Dhavana
Dhavana means 1] Motion, Going
2] Cleansing, Purifying
Synonyms
Yoni Seka
Achamana
Yoni Praseka
Yoni Prakshalana
Sechana
Parisechana
• This is one among 60 types of vrana chikitsa.
• Yoni prakshalana is the cleansing of yoni using required
liquid media(any kashaya).
5. Instruments
In olden days
• Bladder
• Nozzle [bamboo,metal]
Procedure of yoni dhavana
No such procedures are mentioned in the classics
so the procedures used for douching now a days
can be adopted.
6. Indications
✓ It is indicated as purva, pradhana, and paschat,
karma in all yoni rogas.
✓Vivruta yoni vyapada
✓ Yonishoola
✓ Yoni daurgandhya
✓ Yoni srava
✓ Yoni shitilata
✓ Yoni kleda
✓ Yoni kandu
✓ Yoni Paicchilya
7. ✓ Yoni arsha – as a post operative procedure for
better healing of the wound
✓ Yoni kanda
✓ Vataja artava dushti
✓ Pittaja artava dushti
✓ Kaphaja artava dushti
✓ Kunapgandhi – To remove the bad smell
✓ Upadamsha chikitsa [ all types of upadamsha] etc
✓ A special note – Use of 3 garlic clove + 3 cups of
water mixed together in a grinder and used for
vaginal infections as douches
8. Few commonly used formulations;
In pitta dosha involvement – Nalpamaradi or
panchavalkala or panchatikta kashaya is used
In kapha involvement- Aragwadadi or
Nimbadi kashaya is used
Thin discharge p/v- triphala kashaya
Sticky discharge- dashamoola or triphala
kashaya
Offensive mucopurulent discharge- candana or
lodradhi kashaya
9. Vaginal Douching
It is a procedure during which salt water or
medicated cleaning solution is used to wash
away accumulated secretions, blood or
discharges in the vagina that cause adhesions
or increase the risk of infections
Instruments
Douche set
✓ Can [metal, palstic, disposable]
✓ Rubber tube [ Catheter ]
14. Indications
✓Chronic cervicitis and vaginitis.
✓ Foul discharge from decubitus ulcers in
genital prolapse.
✓ Ca of cervix, Sloughing Uterine polyps
✓ After introduction of Pessary.
✓ Pre-Operative Vaginal preparations.
✓ Post Operative Vaginal Douche.
✓ After the use of contraceptive measures.
15. Contraindications
✓ Acute genital sepsis.
✓ Pregnancy [ if douching is desirable during
pregnancy some precautions have to be taken]
✓ Menstruation
16. Types of vaginal Douch fluid
Antiseptic douch – Dettol,
Savlon,
Tincture of Iodine.
✓Vinegar or lactic acid douches – Vaginitis.
✓Alkaline Douch – Sodabicarb
✓Alum Douch
✓Salt water Douch
17. Method
In hospital practice
✓ Patient should lie on the table in lithotomy position
✓ Sterelised douch nozzle or rubber catheter is attached to
the douch can.
✓ About 2 inches portion of the nozzle or catheter is
inserted into the vagina.
✓ The douch containing fluid can be placed about 2 feet
height above the patients buttocks.
✓ Ordinarily douching for about five min is done.
✓ After withdrawal of the douch nozzle or catheter fluid
which may be retained inside the vagina should be
expelled by asking the patient to strain in sqatting position
if the condition permits/ or pt is made to cough.
18. Drawbacks
✓ Frequent douching may lead to chemical vaginitis
✓ Spread of infection into the pelvic organs.
✓ Vaginal and cervical injury.
19. Probable mode of action of Yoni Dhavana :
✓ As the name dhavana suggests cleaning it washes out
the secretions and discharges of vagina
✓ The action is mainly by the drugs used in the
preparation of the kwatha
20. Yoni-pichu
Karpasa pichuhu sidda sneha yuktaha
Apathyapathe garbhashaya mukhaparyantha sthapyate
Vaginal tampon made of cotton or gauze soaked in
taila/grita/kshara/kashaya is termed as pichu when placed
in yoni it is called yoni pichu.
The routinely used yoni pichu is sneha pichu.
21. Method of administration of yoni pichu
A swab is tied in a gauze piece (tampon).
The solution or oil is heated indirectly by keeping the
container containing oil in hot water.
The sterile pichu is dipped in the hot oil.
The vulva and vagina are cleaned with antiseptic
solutions.
Then the pichu is held with a sponge holding forceps and
kept in the vagina.
23. Yoni Daha
Yoni Kandu
Yoni Paicchilya
Yoni Kanda
Ninth month of pregnancy
Prasramsamana garbha
Rakta gulma
Apara sanga
Post-operative procedure after the extraction of
Mudha garbha.
Yoni Bhramsha in prasooti
24. In vataja yonivyapath- guduchyadi taila pichu
followed by uttarabasti
In pittaja yonivyapath- pichu of grita processed with
pittahara dravyas
In picchila yoni- udumbaradi taila is advised
In yoni srava, upapluta and pichila yoni- Dathakyadi
taila picu is advised.
26. Indications
✓ To stop oozing of blood at the end of an operation
on the vagina or cervix.
✓ To arrest secondary post-operative hemorrhage from
the vaginal walls and the cervix.
✓ To convey medication to the vagina and cervix.
✓ Pre-operative vaginal plugging before radical
vaginal hysterectomy.
✓ To control uterovaginal prolapse complicated by
decubital ulceration.
27. Method
✓ Bladder is evacuated
✓ Vulva, vagina are cleaned with antiseptic
solutions
✓ Posterior vaginal speculum is applied.
✓ A sterile long roller gauze soaked in acriflovine
glycerin, liquid paraffin or trisulfate cream is
taken.
✓ Tight plugging of vagina by the guaze is
performed by a sponge holding forceps.
✓ The end of the gauze on plugging is brought just
outside the vaginal introitus.
28. Peroid of pluging
✓This should not be prolonged for more than 24
hrs.
Care to be taken :
✓ Care of the bladder.
✓ Removal of the plug must be done very
gently.
29. Probable mode of action of Pichu
✓ Pichu helps the medicine to remain at the site for a
longer period for better action.
✓ It performs the action with the help of the drugs used
in the preparation of taila, Ghrita, etc.
✓ It diminishes the chances of infection in the genital
tract as taila is yoni vishodhana.
✓ It has vranaropaka properties.
✓ It softens the vagianl canal.
✓ Taila or sneha is vataghna
30. ✓ Tampon of oil used in the 9th month of pregnancy
may destroy pathogenic bacteria of the vagianl canal
and prevent puerperal sepsis.
✓ It may also soften the vaginal passage thus helps in
normal labour
31. Yoni Varti
Word meaning is wick
It is similar as vati preparation.
Vartis are elongated, having tapering ends, thick in the
middle and thin at the ends
Method of preparation of Varti:
✓ Required dravya choornas are taken.
✓ They are mixed together and triturated with the required
liquid media.
✓ Elongated tablets with thin ends are prepared
✓ These tablets are dried in the shade and used.
32.
33. Size of varti
Pradeshini anguli tulya –size of index finger
Method of Administration
✓ The site of application as well as the ends of the varti are lubricated
with oil, Ghee, Madhu, Dugdha and varti is slowly inserted inside the
vagina.
How long can it be kept in the vagina:
Acc to caraka,
✓ It should be changed repeatedly [1 to 3 hrs ]
✓ Time period may vary depending upon the type of varti.
Paschat karma
Yoni prakshalana with sukhambu
34. Indications
✓ Kaphaja Yoni vyapada- yava churna + saidhava –
bhavana with dugdha
✓ Acharana Yoni vyapada- go-pitta or matsya pitta
✓ Karnini-varti made of shodhana dravyas
✓ Yoni Shopha
✓ Yoni Kleda varti of go or matsya pitta
✓ Yoni Kandu
✓ Yoni Piacchilya
✓ Anartava
Some herbal suppository;
Garlic suppositories – antifungal
Yougurt suppositories – yeast infections
35. Suppositories :
Are special shaped solid pharmaceutical formulations
meant for insertion into body cavities other than mouth.
Used for
✓ Soothing
✓ Lubricating
✓ Antiseptic
✓ Local anesthetics
✓ Astringents
37. Probable mode of action of vartis
✓ Vartis are meant for shodhana karma.
✓ Vartis are hygroscopic they absorb the sravas
✓ Vartis show the action according to the drugs it contains.
Evenly distributed throughout the base
✓ Readily absorbable form
[ Melts at body temperature
Dissolves or disperses in the body cavity fluids
Should be completely non-toxic and non irritant to the
mucous membrane of the body cavity ]
38. Yoni Purana
Means filling something in the yoni
It may be Kalka, Choorna, Veshavara, Pinda etc
Indications
✓ Vataja Yoni Vyapat- himsra kalka
✓ Pittaja Yoni Vyapat-panchavalkala kalka
✓ Kaphaja Yoni Vyapat-shyamadi kalka
✓ Yoni Sparsha Asahatva and Yoni kandu
✓Yoni Daurgandhya
✓Yoni Kanda
✓Vataja Artava Dushti
✓Pittaja Artava Dushti
✓Kaphaja Artava Dushti
✓Kunapagandhi
39. Yoni Lepana
The medicine in the form of paste used for external
application are called lepas.
Synonyms : Lipta, Lepana, Alepa.
Acharya sushrutha has mentioned 3 types of lepa;
1.Pralepa- it is tanulepa- indicated in pitta twak
vikaras
2.Pradeha- thick- indicated in vataja twak rogas
3.Alepa- moderately thick-useful in raktha pitta
dosha rogas
40. Precautions to be taken while applying Lepa :
✓ Lepa should be immediately removed after drying.
✓ Lepa should not be applied at night.
Indications
✓ Vivruta
✓ Yoni Arsha etc
42. Topical drugs in modern pharmaceutics Ointments
These are soft semisolid preparations used for external
application to the skin or mucous membrane.
The absorption of medicament by the tissues depends upon
the following factors:
✓ Properties of drug incorporated
✓ Properties of the base used in the formulation
✓ Condition of the patients skin
✓ Site of application
✓ Duration of application
✓ Degree of friction exerted while applying the medicine
43. Creams
Are viscous semisolid ointment like preparations.
They may be oil in water or water in oil type.
Jellies
Are transparent or translucent, Non greasy semisolid
preparations meant for external application to the skin or
mucous membrane
They are used for medication or lubrication purpose
Indications
✓ Atrophic Vaginitis
✓ Non Specific Vaginitis etc
44. Yoni Dhupana
Dhupa –An aromatic vapour that are produced from
combustion of any fragrant gum resin
Indications
Garbha sanga- krishna sarpa
Apara Sanga- bhojapatra & slough of snake
Yoni Sparsha Asahatva
Yoni kandu- haridra and brihati patra
Sweta pradara
In sutika- kushta,guggulu, agaru with grita
45. Method
✓ A chair having a hole at the bottom is taken
✓ Patient is made to sit on the chair after emptying the
bladder
✓ Coal is kept below the chair
✓ Drugs used for dhupana such as agaru, guggulu etc are
sprinkled over the nirdhuma agni.
✓ The dhuma which is produced is given to the yoni
46.
47.
48. Probable mode of action of Dhupana
✓ The drugs used for producing dhupa such as haridra,
Guggulu,etc are disinfectant, anti microbial, antiseptic,
thus help in preventing infection.
✓ Dhupa is srotoshodhaka
✓ It is kapkaghna, Kledaghna
✓ It is also srava stambhaka
49. Absorption of drugs through the vagina:
✓ The vagina absorbs water, electrolyte, and substances of
low molecular weight.
✓ Vaginal mucosa absorbs lipophilic drugs.
✓ The vaginal wall and the tissues around are extremely
vascular.
✓ Theory of Probiotics : Probiotic supplements can help
restore a normal balance of the vaginal organisms which
could in theory reduce the chances of developing vaginal
infections. There is as yet no reliable evidence to indicate
that it really works.
50. Uttara Basti
It is given in;
Uttara Marga(upper passage- vaginal introitus or in
urinary passage)
✓After Niruha Basti- Niruhath uttaram
✓Superior in qualities- as it does snehana like anuvasana
and shodana like niruha
✓So termed as Uttar Basti
Uttara Basti Yantra
Consists of
✓ Basti Putaka
✓ Basti Netra
51. Stages Maarga /route Pushpa
vruntha/
circimferrence
of noozzle
Nirgamana
yogya/Lumen
size
Lenghth of
insertion
Young
girl/Baala
Muthra marga Malathi pushpa
vruntha(flower
stalk of
malathi)
Sarshapa
(mustard seed)
1 angula
Adult women/
yuvathi
Muthra/
yoni marga
Size of urethtal
meatus
Index
finger(kanishta
ngula)
Mudga
mudga
2 angula
4 angula
52. Basti Netra
It should be made of gold or silver etc
Should be smooth, tapering like gopuccha(cow tail)
Netra should be 10 angula in length(acc to caraka), 14
angula (acc to sushrutha).
Lumen- should pass sarshapa beeja(mustard seed)through
it or mudga or malathi vruntha according to the marga
Should have 2 karnikas
Should be inserted 4 angula in birth canal and 2 angula in
urinary passage of yuvathi
53. Basti putaka :(acc to caraka)
Can be made out of urinary bladder of animals or skin of
animals or thick cloth
Basti dravya pramana
The quantity of sneha to be given
Charaka – ½ pala
Sushruta – max - 1 prasruta
For Garbhashaya shodhana - 2 prasruta
Astanga. Hridaya – 1 shukti
54. Time of Administration
During Arthava kala as the garbhashaya will accept
the sneha very easily and pacify vata.
Advised to give within first 10 days of menstrual
cycle.
Method of administration
Purva karma:
✓ Shodhana with 2-3 niruha bastis
On the day of Basti administration
✓ Patient should be given Yavagu, dughdha, Ghrita etc
✓ Mala mootra visarjana
✓ Snehana nad swedana – Kati, Vankshana,Adhodhara
55. Pradhana Karma
Position :
✓ ThePatient is made to lie down on her back. Then she is
made to fold her legs so as to attain lithotomy position
[Urdhwajanyu].
✓ Then the uttar basti yantra is taken basti netra is
lubricated with sneha and carefully introduced into the
apathyapath.
✓ Basti putaka is compressed uniformly.
Dose: 3 - 4/Ahoratra consiquently for 3 days then after
giving rest for 3 days the procedure is again repeated for
another 3 days.
56. Paschata Karma
✓ Rest
✓ Head low position
✓ Stanik snehana and swedana
✓ Obsevation of basti pratyagaman kala
✓ Diet
57. Basti vyapat
General vyapatas in gudagata bastis should be considered
–Basti netra dosha,basti putaka dosha.
Signs of shock: once the medicine is abruptly introduced a
few may develop cervical excitement and features of
shock.
59. Time for Uttarabasti
The best period is from 6th to 12th day of postmenstruation
As it will lead to well formed bija and facilitates conception
Formulations
Bala taila in udavarthini yonivyapath
Phalasarpi/kalyanaka grita in vandyathwa
Khara vasti in gulma
Satapushpa taila in ovulatory factor causing infertility
Kshara taila in tubal block
Varunadi grita in granthi