Status of the Microfluidics Industry 2019 report by Yole Développement

© 2019
From Technologies to Markets
Status of the
Microfluidics
Industry
Mobinostics cartridge images - Courtesy of Boehringer Ingelheim Animal Health
Market and Technology
Report 2019
Sample

2
Sébastien CLERC
Sébastien Clerc works as a Technology & Market Analyst, Microfluidics & Medical Technologies at Yole Développement (Yole). As part of the Life
Sciences & Healthcare division, Sébastien has authored a collection of market and technology reports dedicated to topics such as microfluidics, point-
of-care, MEMS for healthcare applications and connected medical devices. In parallel, he is daily involved in custom projects such as strategic marketing,
technology scouting and technology evaluation to help academic and industrial players in their innovation processes. Thanks to his technology &
market expertise, Sébastien has spoken in more than 10 industry conferences worldwide over the last 2 years.
Sébastien Clerc graduated from Grenoble Institute of Technology (Grenoble INP - Grenoble, France) with a Master’s degree in Biomedical
Technologies. He then completed his cursus with a Master’s degree in Innovation and Technology Management in the same institute.
Contact: clerc@yole.fr
Asma SIARI
As a Technology & Market Analyst, Biotechnologies & Molecular Innovations, Medical Technologies in the Life Sciences & Healthcare division at Yole
Développement (Yole), Asma Siari is involved in the development of technology & market reports as well as the production of custom consulting
projects.
After a Master’s degree in Biotechnologies, Diagnostic Therapeutics & Management, Asma served as Research Assistant at the Moores Cancer Center
(San Diego, CA).
She is a coauthor in three scientific publications published in the Molecular Cancer Research Journal.
Asma Siari graduated with an Advanced Master’s degree in International Strategy & Marketing BtoB from EM Lyon Business School (France).
Contact: siari@yole.fr
Status of the Microfluidics Industry 2019 | Sample | www.yole.fr | ©2019
ABOUT THE AUTHORS
Biographies & contacts

3
3M, 10X Genomics,Abaxis (Zoetis), Abbott, Alere (Abbott), Achira Labs, Affymetrix (Thermo Fisher Scientific), AGC, Agilent Technologies,Akatsuki
Tech, Akonni Biosystems, Allevi, ALine, Alveo Technologies, Angle plc, Applied Microarrays, Araymond Life, Arrayit, Arrayjet, Ativa Medical, Atlas
Genetics (binx health), AutoGenomics (Prescient Medicine), AxoSim, Axxicon, Axxin, Balda AG (Stevanato Group), Base4 Innovation, BD, BGI, binx
health, Biocartis, Biocept, BioFire Diagnostics (bioMérieux), BioFluidica, Biolidics, Bionano Genomics, Bio-Rad, BioSensia (Kypha), Biosurfit, BOE,
Boehringer Ingelheim, Boehringer Ingelheim microParts, Bosch Vivalytic (Bosch Healthcare), Bronkhorst, Caliper Life Sciences (PerkinElmer),
Cambridge Consultants, CapitalBio Corporation, Capsum, Carville, CBio, CDA, Cellenion (Scienion), Celsee Diagnostics, Centrillion Technologies,
Cepheid (Danaher), CG.TEC Injection, Chemtrix, CiDRA Precision Services (IDEX), CombiMatrix (Invitae), Corium, Corning, CorSolutions,
Curetis, Cygnus Biosciences, Cytena, Cytosurge, Daktari Diagnostics, DARPA, Debiotech, Denz Bio-Medical, Dianax, DiaSorin Molecular, DNAe,
Dolomite (Syrris), Eksigent, Elveflow (Elvesys), Emulate, Enplas, Epigem, Epicore Biosystems, ExcitePCR, Fast Radius, FlexoSense, FlowJem, Fluidic
Analytics, Fluidigm, Fluigent, Fluxion Biosciences, Focus Diagnostics (DiaSorin Molcular), Formulatrix (Qiagen), GenapSys, GenePOC (Meridian
Biosciences), GeneSystems (Pall), GenMark Diagnostics, Gradientech, Great Basin Scientific (Vela Diagnostics), Gyros Protein Technologies, Helvoet,
Hemocue (Radiometer, Danaher), Hesperos, HifiBio, IDEX Health & Science, Illumina, imec, IMTAG (Heidenhain), IMT MEMS, Inanovate, Instant
Labs (Luminultra), Instrumentation Laboratory (Werfen), Intabio, IntegenX (Thermo Fisher Scientific), Invenios (Corning), Invetech, InziGn, Ion
Torrent (Thermo Fisher Scientific), IQuum (Roche), Klearia, Kloé, KURZ, LabCyte (Beckman Coulter), LexaGene, LioniX International (Magic
Micro), Little Things Factory, (Plan Optik), L’Oréal, Luminex Corporation, MakeFluidics, MBio, MedSpray, MeMed, Menarini Silicon Biosystems, Mesa
Biotech, MGI (BGI), Micralyne, MicroDrop Technologies, Microfluidic ChipShop, MicroLiquid, Micronit, Microsaic Systems, MilliDrop, Mimetas,
Minicare, MiniFAB (Schott), Mission Bio, Mobidiag, Mobinostics (Boehringer Ingelheim), Nabsys, Namocell, NanoCellect Biomedical, NanoEntek,
Nanomix, Nanopass, Nanoscribe, NanoString Technologies, NASA, Natech Plastics, NeuMoDx (Qiagen), Nokia, Nypro (Jabil), Omniome, Ontera,
OPKO Diagnostics, Oxford Nanopore Technologies, Pacific Biosciences, Parallex Bioassays, PathogenDx, PharmaFluidics, Phase Three Product
Development, Philips Innovation Services, POC Medical Systems, Precision Nanosystems, Qiagen, Qorvo, Qorvo Biotechnologies, Quantapore,
Quanterix, Quantum Biosystems, QuantuMDx, Quidel, Qvella Corporation, RAB-Microfluidics, RainDance Technologies (Bio-Rad), RedBud Labs,
Redshift Bioanalytics, Rheonix, Roche Diagnostics, Rogue Valley Microdevices, Roswell Biotechnologies, rqmicro, Samplix, Samsung, Sandstone
Diagnostics, Sanwa Biotech, SawDx, Schlumberger, Schott, Schott Nexterion, Scienion, Sciex, Sensera, Shimadzu, Siemens, Sight Diagnostics, Silex
Microsystems, SMB (Zoetis), Sophion Bioscience, Sphere Fluidics, Spinchip Diagnostics, SpinDiag, Stat-Dx (Qiagen), Stilla Technologies,
STMicroelectronics, Stratec, Surfix (LioniX), Symbient Product Development,T2 Biosystems, Talis Biomedical, TearLab, Tecan, Technicolor,
Technicolor Precision BioDevices, Tecnisco, Teledyne Dalsa, thinXXS (IDEX), Toolbox Medical Innovations, Translume, Trilobite, Trinean (Unchained
Labs), Tronics Microsystems, TSMC, TTP Group, Two Pore Guys (Ontera), uFluidix, Universal Sequencing Technology, Varioptic (Invenios, Corning),
Vaxxas, Velabs, Veredus Laboratories, Vortex Biosciences, WaferGen Biosystems (Takara Bio), Waters, Weidmann Plastics, Wi, Zimmer & Peacock, z-
microsystems, Zoetis, Zomedica Pharmaceuticals, and more.
Status of the Microfluidics Industry | Report | www.yole.fr | ©2019
COMPANIES CITED IN THIS REPORT
380+ slides of market and technology analysis
Information gathered through direct discussions with players all along the supply chain

4
 Glossary and definitions p.2
 Table of contents p.3
 Report objectives p.5
 Report scope p.6
 Report methodology p.7
 About the authors p.8
 Companies cited in this report p.9
 What we got right, What we got wrong p.10
 Who should be interested by this report p.11
 Yole Group related reports p.12
 Executive Summary p.15
 Context p.52
o Definition – our vision of microfluidics
o Microfluidics – advantages and drawbacks
o Our vision of the microfluidics market
o Examples of applications that use microfluidic products
o Why are microfluidic solutions used?
o Microfluidic applications – definitions
 Market forecasts p.62
o Market segmentation
o Market forecasts for microfluidic products and devices (units and value)
o Segment dynamics (CAGR vs. Segment size)
o How the value is spread across the supply chain
o What we got right/wrong and why
o Material mix analysis
o Conclusion
TABLE OF CONTENTS
Part 1/2
 Market trends p.87
o An increasing on-chip complexity for ever more integration and automation
o Razor and razor-blade business model
o A myriad of microfluidic players
o In-house vs. Outsourced production
o The lure of high-volume microfluidic device production
o Reaching commercial success is not an easy path
o Addressing other markets before human diagnostics, a wrong good idea?
o Road to market: comparison of applications
o Distribution networks are key for success
o Examples of distribution agreements
o A limited market for the fabs
o Is the key to success out of point-of-care?
o The market growth paradox!
o Reasons why companies choose to internalize production
o The barriers of in-house production
o Why don’t large companies work (much) with the fabs?
o A fight to acquire value
o Significant new entrants
o Towards standardized cartridge footprints?
o Having a fixed design and a secured supply chain is mandatory
o Combining the development of instrument and consumable
o Importance of multiplexing and wide assay menu
o The development of « open platform » business models
o Standardization of microfluidic devices: setting-up an ISO norm
o Success of Microfluidic technologies - Dream or reality?
o Financial analysis of publicly listed companies

5
TABLE OF CONTENTS
Part 2/2
 Microfluidic segments description p.139
o Clinical and veterinary testing
o Point-of-care testing
o Industrial, environmental, and agro-food testing
o Pharmaceutical and life science research
o Micro-reaction and flow chemistry
o Analytical devices
o Drug delivery
o Accurate dispensing
o Flow control components and modules
o Emerging applications
 Focus: Microfluidic technologies for biotech applications p.203
o Overview
o Single-cell isolation and analysis
o Cell line development
o Gene editing and therapeutics
o Supply chain and business models
 Market shares & supply chain p.266
o Different models for different volumes
o Microfluidic integrators, per material
o Microfluidic integrators: 2018 market share
o Main mergers and acquisitions since 2017 + analysis
o Fundraising since 2017 + analysis
o Microfluidic fabs: overview, geographical location, materials, ranking
o Other levels of the supply chain (design houses, prototyping houses,
materials providers, etc.)
o Analysis of recent acquisitions of microfluidic fabs
o Who’s working with who?
 Technology trends p.341
o Materials & hybrid integration
o Manufacturing processes comparison
o Reshaping processes
o Subtractive processes
o 3D printing
o Combination of manufacturing expertise
o Cost analysis: cost of goods, yield, split across the manufacturing process,
contribution of the device in the final product selling price, gross margin
analysis
o Detection methods + focus on acoustic detection methods
o Integration of complex sample prep steps
o Multiplexing: high-plex vs. low-plex
o Smartphone-based diagnostic products
o Mixing technologies
 Outlooks p.374
o Conclusions
 Yole Corporate Presentation p.380

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This new Yole Développement report provides a complete analysis of microfluidic device/product applications,
markets, and technologies:
o New major trends and evolutions in the microfluidics industry markets and business models
o Analysis of strategic moves since 2017: mergers and acquisitions, fundraising, etc.
o New microfluidic players/foundries - 2018 rankings
o Updated market data and forecast up to 2024, in value and units for microfluidic devices and products
o Supply chain description and analysis
In order to better understand how value is distributed across the supply chain, this report covers both the
microfluidic device and microfluidic-based product markets
Market trends and main players are presented for each product category via an exclusive market segmentation
An exhaustive analysis is supplied covering the materials and manufacturing processes in various microfluidic
segments
Also furnished is a presentation of new, promising applications for microfluidic technologies
REPORT OBJECTIVES

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REPORT SCOPE
Yours needs are
out of the report’
scope?
Contact us for a custom:
Other methods controlling
very small fluid volumes
Microfluidics is the science and technology that deals with the manipulation of fluids, usually in
the range of microliters (10-6) to picoliters (10-12) and/or in networks of micrometer-size
channels
Our definition of microfluidics encompasses:
Micro-fabricated devices with
channels below ~500µm in size
and/or

8
METHODOLOGIES & DEFINITIONS
Market
Volume (in Munits)
ASP (in $)
Revenue (in $M)
Yole’s market forecast model is based on the matching of several sources:
Information
Aggregation
Preexisting
information

9
WHO SHOULD BE INTERESTED IN THIS REPORT?
Financial & strategic investors:
o Realize microfluidic technologies’ potential
o See the latest moves within the industry
o Learn the sweet spots and growing applications, and
understand end-users’ objectives
R&D players:
o Understand new challenges linked to microfluidic
technologies
o Address the right market with the right technology
Healthcare & governmental organizations:
o Evaluate microfluidic technologies’ benefits
o Identify relevant companies
Diagnostics, pharmaceutical, biotechnology, industrial,
and other companies:
o Understand what is “state of the art” in microfluidic
technologies, and which solutions could bring
operational benefits
o Identify the different players across the supply chain
o Comprehend behavior evolution
o Highlight competitors and targets for collaborations
or M&A
Microfluidic foundries and device makers:
o Grasp technical requirements
o Recognize business opportunities and prospects
o Understand the evolution of the supply chain
MEMS, electronics, and optics players:
o Perceive the microfluidics market and technologies
o Interpret the requirements for market entry

11
Microfluidic
Applications
MICROFLUIDIC APPLICATIONS - DEFINITION
Microfluidic
technology is
used
everywhere
Clinical &
Veterinary
Diagnostics
Point-of-
Care
Diagnostics
Pharma &
Life Science
Research
Analytical
Devices
Industrial,
Environmental
& Agro-Food
Drug
Delivery
Micro
Reaction -
Flow
Chemistry
• Clinical and Veterinary Diagnostics
Laboratory equipment for clinical and veterinary
diagnostics
• Point-of-Care Diagnostics
Diagnostic equipment for out-of-reference laboratory, near-
patient testing (intensive care, doctor’s offices, home
testing, etc.)
• Pharmaceutical and Life Science Research
Microfluidic devices for drug discovery and screening,
genomics, proteomics, cell analysis
• Analytical Devices
Microfluidic chips and columns for mass spectrometry,
chromatography, and HPLC sample preparation
• Industrial, Environmental, and Agro-FoodTesting
Microfluidic-based tests for quality/process control and
food/water testing (pesticides, bacteria, etc.). Includes
military, security, and forensics applications.
• Drug delivery
Microfluidic devices for drug delivery, such as inhalers,
microneedles, and implantable micropumps
• Micro Reaction - Flow Chemistry
Microfluidic devices for micro reaction involved in research
or in pilot-production units

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INTRODUCTION
Microfluidics - advantages and drawbacks
Reduced sample and reagent volumes
Shorter times for liquid displacement,
thermal transfers, and analysis
Automation and integration of complex
operations Precise liquid control
Diffusion-based mixing (due to
highly-viscous forces) takes time
Actuation is required for improving mixing steps
Better control of chemical reactions Improved safety for chemical reactions

13
INTRODUCTION
Our vision of the microfluidics market (1/3)
Example: Binx Health
analyzer
Microfluidic device: chip
(raw hardware)
Microfluidic product: cartridge with
reagents and packaging
Example: Binx Health
cartridge
Microfluidic analyzer

14
We divided microfluidic technologies into two types of components in order to better explain the microfluidics
market:
o Microfluidic device:
• A microfluidic device is defined as a micro-structured component in which a fluid will flow when it
will be used. This can be a chip, a dispensing tool, a flow control component, or other microfluidic
component types. It a the first-level packaged component.
• Microfluidic chips represent 85% (in value) of the microfluidic device market.
o Microfluidic product:
• A microfluidic product is defined as the microfluidic device packaged for sale to the end-user
• When needed, reagents and biological content are added to the device to create the product. It can
be surface functionalization with antibodies or nucleic acid probes, liquid buffers in blisters, deposition
of dry reagents, etc.
• For example, in point-of-care applications, the microfluidic product is a microfluidic device to which reagents
are added. The functionalized chip is packaged into a cartridge (often in plastic) with all the other required
elements.
• Complex cartridges can sometimes integrate tens or even hundreds of elements!
We also consider microfluidic instruments for detection (diagnostics: chip readers), for droplet generation, for
flow/pressure control, for dispensing, etc. However, these instruments are not quantified (either in volume nor in
value) in this report.
INTRODUCTION

15
INTRODUCTION
Most
microfluidic
devices are chips.
When combined
with biological
content and
packaged into
cartridges, these
chips become
products.
Chips
Other
Devices
Microfluidic product breakdown for
chips and other devices in 2018, in $B
Chips
$2.6B
Other
$0.4B
Devices
$3.0B
Products
$8.8B

19
MICROFLUIDIC SEGMENTS DESCRIPTION

20
FOCUS: MICROFLUIDIC TECHNOLOGIES FOR BIOTECH APPLICATIONS

21
MARKET SHARES AND SUPPLY CHAIN (1/2)

22
MARKET SHARES AND SUPPLY CHAIN (2/2)

24
Contact our
SalesTeam
for more
information
Chinese Microfluidics
Industry 2018
Point-of-Need Testing:
Application of Microfluidic
Technologies
Next-Generation Sequencing
& DNA Synthesis 2019
Liquid Biopsy: From Isolation to
Downstream Applications 2018
YOLE GROUP RELATED REPORTS
Yole Développement

25
Contact our
SalesTeam
for more
information
Thermo Fisher Ion 520 DNA
Sequencing Chip
System Plus Consulting

26
Contact our
SalesTeam
for more
information
Nanopore Sequencing Patent
Landscape Analysis 2019
Knowmade

The first commercially-available lab-on-a-
chip devices are now more than 20 years old.
Microfluidic device complexity has increased
ever since, leading to extremely sophisticated
cartridges performing automated, complex
sample preparation steps. Microfluidics is now
a mature technology, and today the identified
number of companies developing microfluidic-
based solutions worldwide far surpasses a
thousand (including myriad opportunistic start-
ups), and the applications are end-less. As a
consequence, Yole Développement’s (Yole)
analysts estimate that the microfluidic products
market reached $8.7B in 2018, and will grow at a
CAGR2019-2024
of 11.7%, reaching $17.4B. The two
principal applications are still point-of-care (PoC)
testing and pharmaceutical/ life science research
(including sequencing, genomics, and proteomics).
However, the dynamics per application are
evolving. While PoC devices are increasing in
complexity and integrating more and more hybrid
materials (i.e. glass + polymer, or silicon + polymer
in order to offer additional functions), we also see
high-end applications increasingly using polymer
when possible, in order to decrease costs. Glass
and silicon have a large share in these applications,
especially in sequencing, but these semiconductor
materials are increasingly integrated at the heart
of complex plastic cartridges. This is also the
case in drug delivery – even though most devices
are made of glass and silicon today, we may soon
observe the entry of polymer devices. Overall,
thanks to increased commercial adoption, all
three materials are growing nicely. In this report,
Yole’s analysts present 2017 – 2024 market data
and forecasts per application, with a detailed
material mix analysis.
STATUS OF THE MICROFLUIDICS INDUSTRY 2019
Market & Technology Report - August 2019
MICROFLUIDICS APPLICATIONS ARE GREATLY DIVERSIFYING, CREATING
NEW OPPORTUNITIES
Diversification of microfluidic technologies has led to burgeoning new applications and market growth,
driving players’ interest and M&A.
Global microfluidic devices and products market: 2019-2024 forecast
WHAT’S NEW
• Updated 2017 - 2024 market data
and forecasts (in $US and units) for
microfluidic devices and products,
along with material mix analysis
• Evolution and estimated 2018
microfluidic players’ market share at
fab level and end-product level
• Breakdown of the latest industry
moves (M&A, fundraising), market
and technology trends and evolutions,
and potential acquisition targets
• Updated information, by microfluidic
market segment
• Review of new, promising applications
for microfluidic technologies
(including a focus on biotechnology
applications)
• Comprehensive supply chain analysis
KEY FEATURES
• Provide a global view of the future for
microfluidic devices and products
• Establish an understanding of
every microfluidics application, with
an overview of the main players per
application
• Analyze microfluidic players’ dynamics
and ranking, and understand
the latest industry trends,
strategic moves, and business models’
evolutions
• Furnish 2017 and 2018 market data
for microfluidic products and devices,
along with 2019 – 2024 forecasts in
units and $US
• Explore technology, materials, and
manufacturing trends
• Explain how the supply chain
is organized and how value is
distributed across it
THE ACQUISITION WAVE CONTINUES, LEADING TO AN IMPRESSIVELY
RAPID STRUCTURATION
For the last decade, PoC has been considered
microfluidics’ greatest promise, with the potential
for rapid-testing cartridges to reach millions of
units per year.Nonetheless,the mass production of
such devices is still far from being widespread, and
companies now realize that the barriers are high on
the road to success.Just having a good technology is
not enough: financial strength, supply chain security,
regulatory, and market access are also mandatory.
In particular, numerous companies struggle to
reach the next step because of a weak commercial
network. Thus, acquisition by a larger company is
often a good way to gain access to an established
distributionnetworkandimprovedlogisticssupport.
BioFire (bioMérieux), IQuum (Roche), and Cepheid
(Danaher) are good examples of technologies
that have literally taken off after acquisition, and
we will see in the coming years whether recently-
acquired companies like GenePOC (Meridian
Biosciences) and Abaxis (Zoetis) mimic these
successes. Overall, large diagnostic companies
have acquired numerous promising or successful
microfluidic technologies through the purchase of
small and medium-size companies, to the extent
that a group of around 15 players now represents
more than 75% of the market.This is an impressive
concentration, especially given the variety of
applications. Contrarily, hundreds of start-ups with
low revenue struggle to reach commercial success
for the reasons mentioned above. In-between,
we find around 50 players with $10M – 100M
in microfluidics revenue, mostly start-ups that
have accessed the next steps and are now likely
acquisition targets.
(Yole Développement,August 2019)

STATUS OF THE MICROFLUIDICS INDUSTRY 2019
At another supply chain level, we observe an
impressive structuration. Indeed, the microfluidic
device manufacturers (“fabs”) have experienced a
strong wave of acquisitions by larger players since
2015 – the latest being MiniFAB in June 2019. Such
larger players thus acquire their own production
facilities and aim to produce for larger customers
from the diagnostics and life sciences fields,
which fabs today struggle to address. Overall,
after the recent acquisitions, the only remaining
established microfluidic fabs above $10M in
revenue and still independent are Micronit and
Microfluidic ChipShop. Last but not least, over the
past two years several large companies (leaders
in other technology fields) have decided to enter
or strengthen their position in the microfluidics
market: this is the case for Technicolor, Qorvo
Biotechnologies, and Schott. Such decisions
exemplify the attractiveness of this dynamic field,
which presents a viable opportunity for these
companies to find new growth areas. They will
soon be followed by others – in fact, we are
aware of several players that are preparing to
enter the microfluidics field, at diverse levels of
the supply chain!
MICROFLUIDIC TECHNOLOGIES ARE PENETRATING VARIOUS FLOURISHING
APPLICATIONS, WHERE THE CHALLENGES ARE BIG BUT THE POTENTIAL IS
SIGNIFICANT
Emerging applications, in particular within
the biotechnology field, can benefit from the
improvement of microfluidic technologies which
represent valuable tools for complex operations.
Today, academics and researchers are the main
users of such technologies in biotech, but we
have begun seeing an increased adoption from
pharmaceutical companies, Contract Research
Organizations (CRO), and industrial biotech
companies: for example, cell line development,
single-cell isolation/analysis, as well as cell-gene
therapies and gene editing, are all applications
where microfluidics have a role to play. In particular,
microfluidics is receiving enthusiastic response from
single-cell isolation, where there are already several
successful commercialized technologies. The other
applications mentioned above are steadily emerging,
and it is time for innovative microfluidic companies
to take the opportunity to solve the issues linked to
integration, automation, throughput increase, etc.
Indeed, most solutions used today are expensive
and low-throughput, and thus prone to human error
due to manual operations. In this report, Yole’s
analysts describe the challenges these fields face and
how microfluidic technologies, for example droplet
microfluidics, can address the bottlenecks and forge
new possibilities.
*Non-exhaustive list of companies
Single-cell isolation Cell line development Gene editing and therapeutics
Non
droplet
microfluidics
technologies
Microfluidic
technologies 
droplets
Not yet in commercial production
Still at very early stage of R&D 
Still at very early stage of R&D 
Established
application
Emerging  
application
Microfluidic players* landscape per revenue
Players* involvement in microfluidic technologies
for biotechnology applications matrix

AUTHORS
Sébastien Clerc works as a Technology
& Market Analyst, Microfluidics & Medical
Technologies at Yole Développement (Yole).
As part of the Life Sciences & Healthcare
division, Sébastien has authored a collection
of market and technology reports dedicated
to topics such as microfluidics, point-of-
care, MEMS for healthcare applications and
connected medical devices. In parallel, he
is daily involved in custom projects such as
strategic marketing, technology scouting and
technology evaluation to help academic and
industrial players in their innovation processes.
Thanks to his technology & market expertise,
Sébastien has spoken in more than 10 industry
conferences worldwide over the last 2 years.
Sébastien Clerc graduated from Grenoble
Institute of Technology (Grenoble INP -
Grenoble, France) with a Master’s degree in
Biomedical Technologies. He then completed
his cursus with a Master’s degree in Innovation
and Technology Management in the same
institute.
COMPANIES CITED IN THE REPORT (non exhaustive list)
3M, 10X Genomics, Abaxis (Zoetis), Abbott, Alere (Abbott), Achira Labs, Affymetrix (Thermo
Fisher Scientific), AGC, Agilent Technologies, Akatsuki Tech, Akonni Biosystems, Allevi, ALine, Alveo
Technologies, Angle plc, Applied Microarrays, Araymond Life, Arrayit, Arrayjet, Ativa Medical, Atlas
Genetics (binx health), AutoGenomics (Prescient Medicine), AxoSim, Axxicon, Axxin, Balda AG
(Stevanato Group), Base4 Innovation, BD, BGI, binx health, Biocartis, Biocept, BioFire Diagnostics
(bioMérieux), BioFluidica, Biolidics, Bionano Genomics, Bio-Rad, BioSensia (Kypha), Biosurfit,
BOE, Boehringer Ingelheim, Boehringer Ingelheim microParts, Bosch Vivalytic (Bosch Healthcare),
Bronkhorst, Caliper Life Sciences (PerkinElmer), Cambridge Consultants, CapitalBio Corporation,
Capsum, Carville, CBio, CDA, Cellenion (Scienion), Celsee Diagnostics, Centrillion Technologies,
Cepheid (Danaher), CG.TEC Injection, Chemtrix, CiDRA Precision Services (IDEX), CombiMatrix
(Invitae), Corium Corning, CorSolutions, Curetis, Cygnus Biosciences, Cytena, Cytosurge, Daktari
Diagnostics, DARPA, Debiotech, Denz Bio-Medical, Dianax, DiaSorin Molecular, DNAe and more.
As a Technology & Market Analyst,
Biotechnologies & Molecular Innovations,
Medical Technologies in the Life Sciences &
Healthcare division at Yole Développement
(Yole), Asma Siari is involved in the
development of technology & market reports
as well as the production of custom consulting
projects.
After a Master’s degree in Biotechnologies,
Diagnostic Therapeutics & Management,
Asma served as Research Assistant at the
Moores Cancer Center (San Diego, CA).
She is a coauthor in three scientific publications
published in the Molecular Cancer Research
Journal.
Asma Siari graduated with an Advanced
Master’s degree in International Strategy &
Marketing BtoB from EM Lyon Business School
(France).

Executive summary 15
Context 52
Definition – our vision of microfluidics
Microfluidics – advantages and drawbacks
Applications that use microfluidic products
Market forecasts 62
Market segmentation
Market forecasts for microfluidic products
and devices (units and value) and segment
dynamics
How value is spread across the supply chain
What we got right/wrong, and why
Material mix analysis
Market trends 87
An increasing on-chip complexity
Razor and razor-blade business model
In-house vs. outsourced production
The lure of high-volume microfluidic device
production
Attaining commercial success is not easy
Road to market: applications comparison
Reasons why companies choose to
internalize production
The barriers of in-house production
A fight to acquire value
Significant new entrants
The development of « open platform »
business models
Success of microfluidic technologies –
dream or reality?
Financial analysis of publicly-listed
companies
Microfluidic segments description 139
Clinical and veterinary testing
Point-of-care testing
Industrial, environmental, and agro-food
testing
Pharmaceutical and life science research
Micro-reaction and flow chemistry
Analytical devices
Drug delivery
Accurate dispensing
Flow control components and modules
Emerging applications
Focus : Microfluidic technologies for
biotech applications 203
Single-cell isolation and analysis
Cell line development
Gene editing and therapeutics
Supply chain and business models
Market shares and supply chain 266
Different models for different volumes
Microfluidic integrators, per material
Microfluidic integrators – 2018 market
share
Main MAs and fundraising since 2017
Microfluidic fabs: overview, geographical
location, materials, ranking
Other levels of the supply chain (design
houses, prototyping houses, materials
providers, etc.)
Analysis of recent microfluidic fabs’
acquisitions
Who’s working with who?
Technology trends 341
Materials and hybrid integration
Manufacturing processes description and
comparison
Cost analysis: cost of goods, yield,
split across the manufacturing process,
contribution of the device in the final product
selling price, gross margin analysis
Detection methods
Conclusions 374
TABLE OF CONTENTS (complete content on i-Micronews.com)
• Chinese Microfluidics Industry 2018
• Point-of-Need Testing: Application of Microfluidic
Technologies
• Liquid Biopsy: From Isolation to Downstream
Applications 2018
• Nanopore Sequencing 2019 – Patent Landscape
Analysis – by KnowMade
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Founded in 1998, Yole Développement (Yole) has grown to become a group of companies providing marketing, technology and strategy consulting, media and
corporate finance services, reverse engineering and reverse costing services and well as IP and patent analysis. With a strong focus on emerging applications using
silicon and/or micro manufacturing, the Yole group of companies has expanded to include more than 120 collaborators worldwide covering MEMS and image
sensors, Compound semiconductors, RF Electronics, Solid-state lighting, Displays, Software, Optoelectronics, Microfluidics Medical, Advanced Packaging,
Manufacturing, Power Electronics, Batteries Energy Management and Memory.
The “More than Moore” market research, technology and strategy consulting company Yole Développement, along with its partners System Plus Consulting,
PISEO, KnowMade and Blumorpho, supports industrial companies, investors and RD organizations worldwide to help them understand markets and follow
technology trends to grow their business.
CONSULTING AND ANALYSIS
• Market data research, marketing analysis
• Technology analysis
• Strategy consulting
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• Design and characterization of innovative optical systems
• Financial services (due diligence, MA with our partner)
More information on www.yole.fr
MEDIA EVENTS
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REPORTS
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CONTACTS
For more information about :
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• Reports Monitors: David Jourdan (jourdan@yole.fr) Fayçal Khamassi
(khamassi@yole.fr)
• Marketing Communication: Camille Veyrier (veyrier@yole.fr)
• Public Relations: Sandrine Leroy (leroy@yole.fr)

© 2019
Yole Développement
From Technologies to Market
Source: Wikimedia Commons

28©2019 | www.yole.fr | About Yole Développement
YOLE DEVELOPPEMENT – FIELDS OF EXPERTISE
Life Sciences
Healthcare
o Microfluidics
o BioMEMS Medical Microsystems
o Inkjet and accurate dispensing
o Solid-State Medical Imaging BioPhotonics
o BioTechnologies
Power
Wireless
o RF Devices Technologies
o Compound Semiconductors Emerging Materials
o Power Electronics
o Batteries Energy Management
Semiconductor
Software
o Package,Assembly Substrates
o Semiconductor Manufacturing
o Memory
o Software Computing
Photonics,
Sensing Display
o Solid-State Lighting
o Display
o MEMS, Sensors Actuators
o Imaging
o Photonics Optoelectronics
Semiconductor
Software
Power Wireless
Photonics,
Sensing
Display
Life
Sciences
Healthcare
About Yole Développement | www.yole.fr | ©2019

4 BUSINESS MODELS
o Consulting and Analysis
• Market data research,
marketing analysis
• Technology analysis
• Strategy consulting
• Reverse engineering costing
• Patent analysis
• Design and characterization
of innovative optical systems
• Financial services (due
diligence, MA with our
partner)
www.yole.fr
o Syndicated reports
• Market technology reports
• Patent investigation and patent
infringement risk analysis
• Teardowns reverse costing
analysis
• Cost simulation tool
www.i-Micronews.com/reports o Media
• i-Micronews.com website and
application
• i-Micronews e-newsletter
• Communication webcast
services
• Events:TechDays, forums,…
www.i-Micronews.com
o Monitors
• Monthly and quarterly update
• Excel database covering supply,
demand, and technology
• Price, market, demand and
production forecasts
• Supplier market shares
www.i-Micronews.com/reports

6 COMPANIES TO SERVEYOUR BUSINESS
Due diligence
www.yole.fr
Manufacturing costs analysis
Teardown and reverse engineering
Cost simulation tools
www.systemplus.fr
Market, technology and strategy
consulting
www.yole.fr
IP analysis
Patent assessment
www.knowmade.fr
Innovation and business maker
www.bmorpho.com
Design and characterization of
innovative optical systems
www.piseo.fr
Yole Group of Companies

31
OUR GLOBAL ACTIVITY
30%of our business
40%of our business
30%of our business
Greater
China office
Yole Japan
HQ in Lyon
Nantes
Paris
Nice
Vénissieux
Yole Deutschland
Frankfurt
Hsinchu
Tokyo
Yole Korea
Seoul
Palo Alto
Yole Inc.
Cornelius

ANALYSIS SERVICES - CONTENT COMPARISON
High
Technology
and Market
Report
Leadership
Meeting
QA
Service
Depth of the analysis
Breadthoftheanalysis
Meet the
Analyst
Custom
Analysis
High
Low

SERVING THE ENTIRE SUPPLY CHAIN
Our analysts
provide
market
analysis,
technology
evaluation,
and business
plans along
the entire
supply chain
Integrators, end-
users and software
developers
Device manufacturers
Suppliers: material,
equipment, OSAT, foundries…
Financial investors, RD centers

SERVING MULTIPLE INDUSTRIAL FIELDS
We work
across
multiples
industries to
understand
the impact of
More-than-
Moore
technologies
from device
to system
From A to Z…
Transportation
makers
Mobile phone
and
consumer
electronics
Automotive
Medical
systems
Industrial
and defense
Energy
management

35
o Over the course of more than 20 years, Yole Développement has grown to become a group of companies. Together with System Plus Consulting and KnowMade, we now
provide marketing, technology and strategy consulting, media and corporate finance services, reverse costing, structure, process and cost analysis services and well as
intellectual property (IP) and patent analysis. Together, our group of companies is collaborating ever closer and therefore will offer, in 2019, a collection of over 125 reports,
10 new monitors and 120 teardowns. Combining respective expertise and methodologies from the three companies, they cover:
o If you are looking for:
• An analysis of your product market and technology
• A review of how your competitors are evolving
• An understanding of your manufacturing and production costs
• An understanding of your industry’s technology roadmap and related IPs
• A clear view supply chain evolution
Our reports and monitors are for you!
o Our team of over 70 analysts, including PhD and MBA qualified industry veterans from Yole Développement, System Plus Consulting and KnowMade, collect information,
identify trends, challenges, emerging markets, and competitive environments. They turn that information into results and give you a complete picture of your industry’s
landscape. In the past 20 years, we have worked on more than 2,000 projects, interacting with technology professionals and high-level opinion makers from the main
players of their industries and realized more than 5,000 interviews per year.
WHAT TO EXPECT IN 2019?
In 2019 we will extend our offering with a new ‘monitor’ product which provides more updates on your industry during the year. The Yole Group of Companies is also building
on and expanding its investigations of the memory industry. Moreover, in parallel, the Yole Group reaffirms its commitment to a new collection of reports mixing software and
hardware and is increasing its involvement in displays, radio-frequency (RF) technology, advanced substrates, batteries and compound semiconductors. Last but not least,
System Plus Consulting is developing its teardowns service providing 120+ offers related to phones, smart home, wearables and connected devices. Discover our 2019
program right now, and ensure you get a true vision of the industry. Stay tuned!
REPORTS COLLECTION
www.i-Micronews.com
• MEMS Sensors
• RF devices technologies
• Medical technologies
• Semiconductor Manufacturing
• Advanced packaging
• Memory
• Batteries and energy management
• Power electronics
• Compound semiconductors
• Solid state lighting
• Displays
• Software
• Imaging
• Photonics

36
OUR 2019 REPORTS COLLECTION (1/4)
18 fields of excellence combined with six markets to provide a complete picture of your industry landscape
Market –Technology – Strategy – byYole Développement
Yole Développement (Yole) offers market reports including quantitative market forecasts,
technology trends, company strategy evaluation and indepth application analyses. Yole will
publish more than 55 reports in 2019, with our partner PISEO contributing to some of
the lighting reports.
Reverse Costing® – Structure, Process and Cost Analysis – by
System Plus Consulting
The Reverse Costing® report developed by System Plus Consulting provides full
teardowns, including detailed photos, precise measurements, material analyses,
manufacturing process flows, supply chain evaluations, manufacturing cost analyses and
selling price estimations. The reports listed below are comparisons of several analyzed
components from System Plus Consulting. More reports are however available, and over
60 reports will be released in 2019.The complete list is available at www.systemplus.fr.
Patent Reports – by KnowMade
More than describing the status of the IP situation, these analyses provide a missing link
between patented technologies and market, technological and business trends. They offer
an understanding of the competitive landscape and technology developments from a
patent perspective. They include key insights into key IP players, key patents and future
technology trends. For 2019 KnowMade will release over 15 reports.
The markets targeted are :
• Mobile Consumer
• Automotive Transportation
• Medical
• Industrial
• Telecom Infrastructure
• Defense Aerospace
• Linked reports are dealing with the same topic to provide
• a more detailed analysis.

37
MEMS SENSORS
o MARKET ANDTECHNOLOGY REPORT
• Status of the MEMS Industry 2019 - Update
• Status of the Audio Industry 2019 - New
• Uncooled Infrared Imagers and Detectors 2019 – Update
• Consumer Biometrics:Technologies and MarketTrends 2018
• MEMS Pressure Sensor Market and Technologies 2018
• Gas Particle Sensors 2018
o STRUCTURE, PROCESS COST REPORT
• MEMS Sensors Comparison 2019
• MEMS Pressure Sensor Comparison 2018
• Particle Sensors Comparison 2019
• Miniaturized Gas Sensors Comparison 2018
o PATENT REPORT
• MEMS Foundry Business Portfolio 2019 - New
• Miniaturized Gas Sensors 2019 - New
PHOTONIC AND OPTOELECTRONICS
• Silicon Photonics and Photonic Integrated Circuits 2019
• LiDARs for Automotive and Industrial Applications 2019 - Update
o PATENT REPORT
• Silicon Photonics for Data Centers: Optical Transceiver 2019 - New
• LiDAR for Automotive 2018
RF DEVICES ANDTECHNOLOGIES
• RF GaN Market:Applications, Players,Technology,
and Substrates 2019 - Update
• 5G’s Impact on RF Front-End Module and Connectivity
for Cell Phones 2019 – Update
• 5G Impact on Telecom Infrastructure 2019 - New
• Radar and Wireless for Automotive: Market and Technology
Trends 2019 - Update
• Passive Active Antenna Systems for Telecom
Infrastructure 2019 - New
• RF Standards and Technologies for Connected Objects 2018
• RF Front-End Module Comparison 2019 - Update
• Automotive Radar RF Chipset Comparison 2018
o PATENT REPORT
• Antenna for 5G Wireless Communications 2019 - New
• RF Front End Modules for Cellphones 2018
• RF Filter for 5G Wireless Communications: Materials and Technologies 2019
• RF GaN 2019 – Patent Landscape Analysis
Update : 2018 version still available About Yole Développement | www.yole.fr | ©2019

38
IMAGING
• Status of the CIS Industry 2019:Technology
and Foundry Business - Update
• Imaging for Automotive 2019 - Update
• NeuromorphicTechnologies for Sensing 2019 - Update
• Status of the CCM and WLO Industry 2019 – Update
• 3D Imaging Sensing 2018
• MachineVision for Industry and Automation 2018
• Sensors for RoboticVehicles 2018
• Compact Camera Modules Comparison 2019
• CMOS Image Sensors Comparison 2019
o PATENT REPORT
• Facial Gesture Recognition Technlogies in Mobile Devices 2019 - New
• Apple iPhone X Proximity Sensor Flood Illuminator 2018
MEDICAL IMAGING AND BIOPHOTONICS
• X-Ray Detectors for Medical, Industrial
and Security Applications 2019- New
• Microscopy Life Science Cameras: Market and Technology Analysis 2019
• Ultrasound technologies for Medical, Industrial
and Consumer Applications 2018
o PATENT REPORT
• Optical Coherence Tomography Medical Imaging 2018
MICROFLUIDICS
• Status of the Microfluidics Industry 2019 - Update
• Next Generation Sequencing DNA Synthesis - Technology,
Consumables Manufacturing and MarketTrends 2019 - New
• Organ-on-a-Chip Market Technology Landscape 2019 - Update
• Point-of-Need Testing Application of MicrofluidicTechnologies 2018
• Liquid Biopsy: from Isolation to Downstream Applications 2018
• Chinese Microfluidics Industry 2018
o PATENT REPORT
• Microfluidic ManufacturingTechnologies 2019 – New
• Nanopore Sequencing 2019 - New
INKJET AND ACCURATE DISPENSING
• Inkjet Printheads - Dispensing Technologies
Market Landscape 2019 - Update
• Emerging Printing Technologies
for Microsystem Manufacturing 2019 - New
• Piezoelectric Devices from Bulk to Thin Film 2019 - New
• Inkjet Functional and Additive Manufacturing for Electronics 2018
• Piezoelectric Materials from Bulk to Thin Film Comparison 2019

39
BIOMEMS MEDICAL MICROSYSTEMS
• Medical Wearables: Market Technology Analysis 2019 - New
• Neurotechnologies and Brain Computer Interface 2018
• BioMEMS Non-Invasive Sensors: Microsystems for Life Sciences
Healthcare 2018
o PATENT REPORT
• 3D Cell Printing 2019 - New
• CirculatingTumor Cells Isolation 2019 - New
SOFTWARE AND COMPUTING
• Artificial Intelligence Computing For Automotive 2019 - New
• Hardware and Software for Artificial Intelligence (AI)
in Consumer Applications 2019 - Update
• Image Signal Processor andVision Processor Market
and Technology Trends 2019
• xPU (Processing Units) for Cryptocurrency, Blockchain, HPC
and Gaming 2019 – New
• Artificial Intelligence for Medical Imaging 2019 - New
o PATENT REPORT
• Artificial Intelligence for Medical Diagnostics - New
MEMORY
• Status of the Memory Industry 2019 - New
• MRAM Technology and Business 2019 - New
• Emerging NonVolatile Memory 2018
• Memory Comparison 2019
o PATENT REPORT
• Magnetoresistive Random-Access Memory (MRAM) 2019 - New
• 3D Non-Volatile Memory 2018
ADVANCED PACKAGING
• Fan Out PackagingTechnologies and MarketTrends 2019 - Update
• 3D TSV Integration and Monolithic Business Update 2019 - Update
• Advanced RF SiP for Cellphones 2019 - Update
• Status of the Advanced Packaging Industry 2019 - Update
• Status of the Advanced Substrates 2019 - Update
• Panel Level PackagingTrends 2019 - Update
• Automotive Packaging Market Technology Trends 2019 - New
• Trends in Automotive Packaging 2018
• Thin-Film Integrated Passive Devices 2018
• Advanced RF SiP for Cellphones Comparison 2019

40
SEMICONDUCTOR MANUFACTURING
• Nano-Imprint Technology Trends for Semiconductor
Applications 2019 - New
• Equipment and Materials for Fan Out Packaging 2019 - Update
• Equipment for More than Moore:Thin Film Deposition
Etching 2019 - New
• Wafer Starts for More Than Moore Applications 2018
• Polymeric Materials atWafer-Level
for Advanced Packaging 2018
• Bonding and Lithography Equipment Market
for More than Moore Devices 2018
• Wafer Bonding Comparison 2018
o PATENT REPORT
• Hybrid Bonding for 3D Stack 2019 – New
BIOTECHNOLOGIES
• CRISPR-Cas9 Technology: From Lab to Industries 2018
o PATENT REPORT
• Personalized Medicine 2019 – New
SOLID STATE LIGHTING
• Status of the Solid State Light Source Industry 2019 - New
• Edge Emitting Lasers (EELS) 2019 - New
• Light Shaping Technologies 2019 - New
• Automotive Advanced Front Lighting Systems 2019 - New
• VCSELs – Market and Technology Trends 2019 - Update
• IR LEDs and Laser Diodes – Technology,Applications,
and Industry Trends 2018
• Automotive Lighting 2018:Technology, Industry and MarketTrends
• UV LEDs - Technology, Manufacturing and ApplicationTrends 2018
• LiFi:Technology, Industry and MarketTrends 2018
• VCSEL Comparison 2019
o PATENT REPORT
• VCSELs 2018
DISPLAY
• Next Generation 3D Displays 2019 - New
• Next Generation Human Machine Interaction (HMI)in Displays 2019 - New
• Micro-and Mini-LED Displays 2019 - Update
• Next Generation TV Panels: New Technologies, Features and
Market Impact 2019
• Displays OpticalVision Systems forVR,AR MR 2018
o PATENT REPORT
• MicroLED Displays : Intellectual Property Landscape 2018

41
POWER ELECTRONICS
• Power SiC: Materials, Devices and Applications 2019 - Update
• Power Electronics for EV/HEV and e-mobility:
Market, Innovations and Trends 2019 - Update
• Status of the Power Electronics Industry 2019 - Update
• Discrete Power Packaging : Material Market
and Technology Trends 2019 - New
• Status of the Power ICs Industry 2019 - Update
• Status of the Passive Components for the Power Electronics
Industry 2019 - Update
• Status of the Inverter Industry 2019 - Update
• Status of the Power Module Packaging Industry 2019 - Update
• Wireless Charging Market Expectations
and Technology Trends 2018
• Power GaN 2018: Epitaxy, Devices,Applications
and Technology Trends
• Automotive Power Module Packaging Comparison 2018
• GaN-on-Silicon Transistor Comparison 2019
• SiC Transistor Comparison 2019
o PATENT REPORT
• Power SiC : Materials, Devices and Modules 2019 - New
• Power GaN : Materials, Devices and Modules 2019 – Update
BATTERY ENERGY MANAGEMENT
• Status of the Rechargeable Li-ion Battery Industry 2019 - New
• Li-ion Battery Packs for Automotive and Stationary Storage
Applications 2019 - Update
o PATENT REPORT
• Battery Energy Density Increase: Materials
and EmergingTechnologies 2019 - New
• Solid-State Batteries 2019 - New
• Status of the Battery Patents 2018
COMPOUND SEMI.
• Emerging Semiconductor Substrates:
Market Technology Trends 2019- New
• Status of the Compound Semiconductor Industry 2019 - New
• InP Materials, Devices and Applications 2019 - New
• GaAsWafer and Epiwafer Market: RF, Photonics,
LED and PV Applications 2018
o PATENT REPORT
• GaN-on-Silicon Substrate: Materials, Devices
and Applications 2019 - Update

42
OUR 2019 MONITORS COLLECTION (1/2)
Get the most updated overview of your market to monitor your strategy
Yole Développement, System Plus Consulting and KnowMade, all part of the Yole Group of Companies, are launching a collection of 10 monitors in 2019. The monitors aim to
provide updated market, technology and patent data as well dedicated quarterly analyses of the evolution in your industry over the previous 12 months. Furthermore, you can
benefit from direct access to the analyst for an on-demand QA and discussion session regarding trend analyses, forecasts and breaking news.
Topics covered will be compact camera modules (CCMs), advanced packaging, compound semiconductors, microfluidics, batteries, RF and memory.
MARKET MONITOR byYole Développement
A FULL PACKAGE:
The monitors will provide the evolution of the market in units, wafer area and revenues.
They will also offer insights into what is driving the business and a close look at what is
happening will also be covered in it.
The following deliverables will be included in the monitors:
• An Excel database with all historical and forecast data
• A PDF slide deck with graphs and comments/analyses covering the expected
evolutions
o ADVANCED PACKAGING – NEW
This monitor will provide the evolution of the advanced packaging platforms. It will
cover Fan-Out Wafer Level Packaging (WLP), Fan-Out Panel Level Packaging (PLP),
Wafer-Level Chip Scale Packaging (WLCSP), Flip Chip packaging platforms, and 2.5D
and 3D Through Silicon Via (TSV) integration. Frequency: Quarterly, starting from Q3
2019
o COMPOUND SEMI. – NEW
This monitor will describe how the compound semiconductor industry is evolving. It
will offer a close look at GaAs, InP, SiC, GaN and other compounds of interest
providing wafer volumes, revenues, application breakdowns and momentum.
Frequency: Quarterly, starting from Q3 2019
o CAMERA MODULE – NEW
This monitor will provide the evolution of the imaging industry, with a close look at
image sensor, camera module, lens and VCM. Volumes, revenues and momentum of
companies like Sony, Samsung, Omnivision and OnSemi will thus be analysed.
Frequency: Quarterly, starting from Q3 2019
o MEMORY – UPDATE
For the memory industry you can have access to a quaterly monitor, as well as an
additional service, a monthly pricing. Both services can be bought seprately:
• DRAM Service: Including a quarterly monitor and monthly pricing.
• NAND Service: Including a quarterly monitor and monthly pricing.
REVERSETECHNOLOGY MONITOR by System Plus Consulting
o SMARTPHONES – NEW
To stay updated on the latest components, packaging and silicon chip choices of the smartphone makers, System Plus Consulting has created its first Smartphone Reverse
Technology monitor. This year, get access to the packaging and silicon content database of at least 20 different flagship smartphones – more than five per quarter. Starting at the
beginning of 2019, the monitor will include an Excel database report for each phone and a quarterly comparison.

43
OUR 2019 MONITORS COLLECTION (2/2)
Get the most updated overview of your market to monitor your strategy
PATENT MONITOR by KnowMade
A FULL PACKAGE:
Starting at the beginning of the year, the KnowMade monitors include the following
deliverables:
• An Excel file including the monthly IP database of:
• New patent applications
• Newly granted patents
• Expired or abandoned patents
• Transfer of IP rights through re-assignment and licensing
• Patent litigation and opposition
• Quarterly report including a PDF slide deck with the key facts figures of the
quarter: IP trends over the three last months, with a close look to key IP players and
key patented technologies.
o GaN for Power RF Electronics
Wafers and epiwafers, GaN-on-SiC, silicon, sapphire or diamond, semiconductor
devices such as transistors, and diodes, devices and applications including converters,
rectifiers, switches, amplifiers, filters, and Monolothic Microwave Integrated Circuits
(MMICs), packaging, modules and systems.
o GaN for Optoelectronics Photonics
Wafers and epiwafers, GaN-on-sapphire, SiC or silicon; semiconductor devices such
as LEDs and lasers; and applications including lighting, display, visible communication,
photonics, packaging, modules and systems.
o Li-ion Batteries
Anodes made of lithium metal, silicon, and lithium titanate (LTO); cathodes made of
Lithium Iron Phosphate (LFP), Nickel-Manganese-Cobalt (NMC), Lithium Nickel
Cobalt Aluminium Oxide (NCA), Lithium Nickel Metal Dioxide (LiNiMO2), Lithium
Metal Phosphate (LiMPO4), and Lithium Metal Tetroxide (LiMO4); electrolytes
including liquid, polymer/gel, and solid inorganics; ceramic and other separators;
battery cells including thin film/microbattery, flexible, cylindrical and prismatic; and
battery packs and systems.
o Post Li-ion Batteries
Battery technologies including redox-flow batteries, sodium-ion, lithiumsulfur, lithium-
air, and magnesium-ion, and their supply chains, including electrodes, electrolytes,
battery cells and battery packs/systems.
o Solid-State Batteries
Supply chain including electrodes, battery cells, battery packs/systems and
electrolytes, including polymer, inorganic and inorganic/polymer, inorganic materials,
including argyrodites, LIthium Super Ionic CONductor, (LISICONs), Thio-LISICONs,
sulfide glasses, oxide glasses, perovskites, anti-perovskites and garnets.
o RF Acoustic Wave Filters
Including Surface Acoustic Wave (SAW), Temperature Compensated (TC)- SAW, Bulk
Acoustic Wave- Free-standing Bulk Acoustic Resonator (BAWFBAR), BAW-Solidly-
Mounted Resonator (BAW-SMR), and Packaging.
o RF Power Amplifiers
Including Low Noise Amplifiers, Doherty Amplifiers, Packaging, and Millimeter-Wave
technology.
o RF Front-End Modules
o Microfluidics
From components to chips and systems, including all applications.

44
I-MICRONEWS MEDIA
To meet the growing demand for market,
technological and business information,
i-Micronews Media integrates several tools
able to reach each individual contact within its
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We will ensure your company benefits from
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times and to evolve an effective
marketing plan and strategy.
Brand visibility, networking
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Today's technology makes it
easy for us to communicate
regularly, quickly, and
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Webcasts are a smart,
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#15,800+ monthly unique visitors
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#7+ key events planned for 2019
on different topics
#380 registrants per webcast on
average to gain new leads for
your business
Contact: CamilleVeyrier (veyrier@yole.fr), Marketing Communication Director

45
CONTACT INFORMATION
o CONSULTING AND SPECIFICANALYSIS, REPORT BUSINESS
• North America:
• Steve LaFerriere, Senior Sales Director forWestern US Canada
Email: laferriere@yole.fr – + 1 310 600-8267
• ChrisYouman, Senior Sales Director for Eastern US Canada
Email: chris.youman@yole.fr – +1 919 607 9839
• Japan Rest of Asia:
• Takashi Onozawa, General Manager,Asia Business Development
(India ROA)
Email: onozawa@yole.fr - +81 34405-9204
• Miho Ohtake, Account Manager (Japan)
Email: ohtake@yole.fr - +81 3 4405 9204
• Itsuyo Oshiba, Account Manager (Japan Singapore)
Email: oshiba@yole.fr - +81-80-3577-3042
• Korea: Peter Ok, Business Development Director
Email: peter.ok@yole.fr - +82 10 4089 0233
• Greater China: Mavis Wang, Director of Greater China Business
Development
Email: wang@yole.fr - +886 979 336 809
• Europe: Lizzie Levenez, EMEA Business Development Manager
Email: levenez@yole.fr - +49 15 123 544 182
• RoW: Jean-Christophe Eloy, CEO President,Yole Développement
Email eloy@yole.fr - +33 4 72 83 01 80
o FINANCIAL SERVICES (in partnership withWoodside Capital
Partners)
• Jean-Christophe Eloy, CEO President
Email: eloy@yole.fr - +33 4 72 83 01 80
• Ivan Donaldson,VP of Financial Market Development
Email: ivan.donaldson@yole.fr - +1 208 850 3914
o CUSTOM PROJECT SERVICES
• Jérome Azémar,Technical Project Development Director
Email: azemar@yole.fr - +33 6 27 68 69 33
o GENERAL
• CamilleVeyrier, Director, Marketing Communication
Email: veyrier@yole.fr - +33 472 83 01 01
• Sandrine Leroy, Director, Public Relations
Email: leroy@yole.fr - +33 4 72 83 01 89 / +33 6 33 11 61 55
• Email: info@yole.fr - +33 4 72 83 01 80
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