Starch/PVA Blended hydro gel For Wound Dressing

1. Starch/PVA Blended hydro gel For Wound Dressing
ARJUN K GOPI & SUHAIL K S – M.Sc. Biopolymer Science
CENTRE FOR BIOPOLYMER SCIENCE AND TECHNOLOGY(CBPST), KOCHI
ABSTRACT INTRODUCTION PREPARATION OF HYDROGEL HOW TO DRESS THE WOUND WITH HYDROGEL
Hydrogels are hydrophilic natured three
dimensional networks, held together by
chemical or physical bonds. Water
absorbed by hydrogel is not released
under ordinary pressure. Hydrophilic
groups such as hydroxyl (OH) and carboxyl
(COOH) on the polymer chains absorb and
store water.
This is the quality that brings about the
specific benefit of hydrogels in wound
treatment. They immediately function as
moist wound dressings. At the same
time they are capable of absorbing
contaminated exudates and safely
retaining them within the gel structure. The
absorption of secretions causes an
expansion of the cross-links in the polymer
chains, making room for the inclusion of
foreign bodies such as bacteria, detritus,
and odour molecules that
are irreversibly taken up along with the
liquid. The basic physical features of
hydrogel dressings can be specifically
modified, according to the properties
of the polymers used.
Hydrogels save the wound from fluid
loss, are capable of providing the lesion
with additional moisture, and securely
protect it against external noxae.
MATERIALS USED FOR PREPARING HYDROGEL
REFERENCES
 Hydrogels are hydrophilic natured
three-dimensional
networks, held together by chemical
or physical
bonds. Hydrophilic groups
such as hydroxyl (OH) and carboxyl
(COOH) on
the polymer chains absorb and store
water.
 The design and development of
novel membrane of
hydrogels prepared by crosslinking of
polyvinyl alcohol with heat-treated
corn-starch suspension was
attempted.
 Hydrogels save the wound from
fluid loss, are capable
of providing the lesion with additional
moisture,
and securely protect it against
external noxae.
 Provides instant cooling and
soothing relief for burns. Absorbs
wound drainage to help prevent
infection. This hydrating dressing
allows the wound to heal without
adhering to it. Breathable.
CONTACT
Fifty ml of 10% (w/v) PVA solution was taken
in a beaker. To the PVA solution, 50ml of 5%
(w/v) starch dispersion in water prepared by
heating at 100oC, was added with constant
stirring to get a homogeneous mixture.
To this mixture GA reagent (10.55ml) was
added with constant stirring. Care was taken to
eliminate entrapment of air bubbles during
mixing and the mixture was used to obtain a
membrane by the conventional solution
casting method. The membrane was dried at
room temperature.
The membrane so obtained was transparent
and was named as HT. The membrane was
washed thoroughly with distilled water to wash
off hydrochloric acid and GA, if any. Then the
membrane was dried at room temperature.
Potato starch (PS),
Ethanol
Glutaraldehyde (GA)
Polyvinyl alcohol (PVA), mol. wt. 125000.
Hydrochloric acid 35% pure
Double distilled water was used
throughout the study.
MTT dye
GA reagent was prepared by mixing
0.5ml of GA in a solution mixture of 10ml
ethanol and 0.05ml Hydrochloric acid.
 http://www.smithnephew.com/professional/p
roducts/advanced-wound-management/
intrasite-gel/
 http://www.researchgate.net
ARJUN K GOPI, M.Sc BIOPOLYMER SCIENCE,
CENTRE FOR BIOPOLYMER SCIENCE AND
TECHNOLOGY(CBPST), KOCHI
Email: arjunkgopi@gmail.com
SUHAIL K.S, M.Sc BIOPOLYMER SCIENCE,
CENTRE FOR BIOPOLYMER SCIENCE AND
TECHNOLOGY(CBPST), KOCHI
Email: suhailksiddique@gmail.com
WOUND DRESSING USING HYDROGEL
STEP 1
Remove secondary dressing. Irrigate wound
with sterile saline solution to clean wound site.
STEP 2
Remove blue protective cap from the nozzle.Swab
the snap-off tip and nozzle of the pack with a
suitable antiseptic swab. Snap the patterned tip off
the nozzle.
STEP 3
Keeping the nozzle tip clear of the wound surface,
gently press the bowl of the pack to dispense gel into
the wound. Smooth Gel over surface of wound to a
depth of approximately 5mm (0.2in.). Discard any
unused gel.
STEP 4
Cover with a secondary dressing.
STEP 5
Gel can be removed from the wound by rinsing
with sterile saline solution