Patientory Blockchain Privacy, How is it Achieved?Patientory
Patientory.com. Learn how PTOYMatrix network solves limitations currently facing electronic health record systems, primarily privacy limitations.
Your Health, at your fingertips. Visit Now Patientory.com.
HIMSS GSA e-Authentication whitepaper June 2007Richard Moore
HIMSS and the GSA, developed a pilot project to demonstrate the adoption of the GSA's secure and interoperable technical architecture for sharing medical information across multiple healthcare providers. The pilot utilized the GSA's E-Authentication Service Component program to provide digital certificates, technical architecture development support, and certificate validation services.
Seven RHIOs/Health Information Exchanges initially volunteered to participate in the project. One participant the Nevada Single Portal Medical Record HIE had to withdraw from the project due to a lack of resources.
Central Ohio HIE - Initiated by eHealth Ohio, and in conjunction with the Ohio Supercomputer Center, this project has focused on evaluating the viability of using the proposed national level user authentication process as a means of authenticating individual researchers, system developers and system administrators who will be both utilizing, creating and maintaining future health care research systems. An emerging area of software development focus, this pilot will also identify key issues faced by resource constrained development efforts.
To Get any Project for CSE, IT ECE, EEE Contact Me @ 09666155510, 09849539085 or mail us - ieeefinalsemprojects@gmail.com-Visit Our Website: www.finalyearprojects.org
Patientory Blockchain Privacy, How is it Achieved?Patientory
Patientory.com. Learn how PTOYMatrix network solves limitations currently facing electronic health record systems, primarily privacy limitations.
Your Health, at your fingertips. Visit Now Patientory.com.
HIMSS GSA e-Authentication whitepaper June 2007Richard Moore
HIMSS and the GSA, developed a pilot project to demonstrate the adoption of the GSA's secure and interoperable technical architecture for sharing medical information across multiple healthcare providers. The pilot utilized the GSA's E-Authentication Service Component program to provide digital certificates, technical architecture development support, and certificate validation services.
Seven RHIOs/Health Information Exchanges initially volunteered to participate in the project. One participant the Nevada Single Portal Medical Record HIE had to withdraw from the project due to a lack of resources.
Central Ohio HIE - Initiated by eHealth Ohio, and in conjunction with the Ohio Supercomputer Center, this project has focused on evaluating the viability of using the proposed national level user authentication process as a means of authenticating individual researchers, system developers and system administrators who will be both utilizing, creating and maintaining future health care research systems. An emerging area of software development focus, this pilot will also identify key issues faced by resource constrained development efforts.
To Get any Project for CSE, IT ECE, EEE Contact Me @ 09666155510, 09849539085 or mail us - ieeefinalsemprojects@gmail.com-Visit Our Website: www.finalyearprojects.org
Interoperability in health care information systemsAlexander Ask
A slide show from our bachelor thesis presentation. Its main focus is interoperability in health care and how interoperability issues can be addressed by open standardization.
Data Management - a top Priority for Healthcare PracticesData Dynamics Inc
The healthcare industry has become increasingly data-driven and poised to take a leap into the future, thanks to an increasingly tech-savvy and demanding patient-consumer base. While the Healthcare Data Ecosystem is presently fragmented and often, insufficient, pioneering firms see vast opportunities to be a part of the Healthcare revolution through proper management of their massive amount of Data.
Healthcare has unique data management challenges that other industries do not face, so the solutions that worked in those fields cannot simply be replicated. Challenges in healthcare data management include -
1. Data environment consolidation in acquisitions and mergers
2. Managing the rapid growth of unstructured healthcare data
3. Adhering to the strict healthcare regulations and reforms
On top of this, Healthcare organizations have to ensure that their data management solution must have a dependable & active security protocol to safeguard sensitive information of patients as per HIPAA norms. With the exponential increase in data, risk is only going to amplify.
In case of mergers & acquisitions, a sizable challenge for large healthcare corporates is the Amalgamation and Streamlining Data with the parent company’s processes. This becomes tedious and cost intensive as merging two data environments that are often radically different from each other into a single system, is difficult and tedious.
Healthcare companies need consumer-driven data strategies with patients at the forefront of their planning. How? To know, read on.
Data Dynamics is a leader in intelligent file management solutions that empower enterprises to seamlessly analyze, move, manage and modernize critical data across hybrid, cloud and object-based storage infrastructures for true business transformation.
"Case Studies from the Field: Putting Cyber Security Strategies into Action" with Miroslav Belote, Director of Systems & Privacy Officer, JFK Health Systems
Explains about cyber security in Healthcare, Problem in Indian Scenario, Critical Infrastructure and Vulnerabilities. For more information visit: http://www.transformhealth-it.org/
Silent, Vibrant and Distributed: History of Free Software Movement in IndiaAnivar Aravind
Silent, Vibrant and Distributed: History of Free Software Movement in India Presentation by Anivar Aravind In National Conference on Free Software In Cochin Dec 2008
Localisation as a Political process: A case study on swathanthra malayalam c...Anivar Aravind
Localisation as a Political process: A case study on swathanthra malayalam computing
Presentation in International Conference on Globalisation and Language organised by Kerala University
FITT Toolbox: Standardisation in Media FormatsFITT
Standardisation is the process of developing and agreeing upon technical standards. The goals of standardisation can be to help with independence of single suppliers (commoditization), compatibility, interoperability, safety, repeatability, or quality. Standardisation is a strategic process in the technological evolution and commercialisation of products or services like ICT software and hardware. This implies at a very early stage of the technology a close collaboration between the research community, the industry and policy makers. This case shows that in the complexity of this standardisation process the involvement of the research community at an early stage is crucial to foster a rapid integration of new technology into new products.
www.FITT-for-Innovation.eu
Healthcare evolves with Data InteroperabilityDinesh V
Data Interoperability is the ability to share and work within and across organizational boundaries to advance the effective delivery of healthcare for individuals and communities.
Healthcare Interoperability: The Key to Leveraging Health TechMityung
Despite some setbacks, the digitalization of healthcare holds great promise for global health improvements. Health information technology (HIT) systems are taking over the healthcare industry.
For further information click here
https://www.mityung.com/
Healthcare IT Systems Interoperability Market Industry Analysis and Forecast ...PriyanshiSingh187645
The global demand for healthcare IT systems interoperability was valued at USD 3658.50 Million in 2023 and is expected to reach USD 10560.29 Million in 2032, growing at a CAGR of 12.5% between 2024 and 2032.
Healthcare software development has witnessed significant advancements in recent years, and one key area that has gained attention is healthcare information exchange (HIE). The exchange of patient data and health information between different healthcare systems and providers plays a crucial role in improving care coordination, patient outcomes, and overall healthcare delivery. In this blog, we will explore the benefits and challenges of healthcare information exchange in the context of healthcare software development.
Interoperability in health care information systemsAlexander Ask
A slide show from our bachelor thesis presentation. Its main focus is interoperability in health care and how interoperability issues can be addressed by open standardization.
Data Management - a top Priority for Healthcare PracticesData Dynamics Inc
The healthcare industry has become increasingly data-driven and poised to take a leap into the future, thanks to an increasingly tech-savvy and demanding patient-consumer base. While the Healthcare Data Ecosystem is presently fragmented and often, insufficient, pioneering firms see vast opportunities to be a part of the Healthcare revolution through proper management of their massive amount of Data.
Healthcare has unique data management challenges that other industries do not face, so the solutions that worked in those fields cannot simply be replicated. Challenges in healthcare data management include -
1. Data environment consolidation in acquisitions and mergers
2. Managing the rapid growth of unstructured healthcare data
3. Adhering to the strict healthcare regulations and reforms
On top of this, Healthcare organizations have to ensure that their data management solution must have a dependable & active security protocol to safeguard sensitive information of patients as per HIPAA norms. With the exponential increase in data, risk is only going to amplify.
In case of mergers & acquisitions, a sizable challenge for large healthcare corporates is the Amalgamation and Streamlining Data with the parent company’s processes. This becomes tedious and cost intensive as merging two data environments that are often radically different from each other into a single system, is difficult and tedious.
Healthcare companies need consumer-driven data strategies with patients at the forefront of their planning. How? To know, read on.
Data Dynamics is a leader in intelligent file management solutions that empower enterprises to seamlessly analyze, move, manage and modernize critical data across hybrid, cloud and object-based storage infrastructures for true business transformation.
"Case Studies from the Field: Putting Cyber Security Strategies into Action" with Miroslav Belote, Director of Systems & Privacy Officer, JFK Health Systems
Explains about cyber security in Healthcare, Problem in Indian Scenario, Critical Infrastructure and Vulnerabilities. For more information visit: http://www.transformhealth-it.org/
Silent, Vibrant and Distributed: History of Free Software Movement in IndiaAnivar Aravind
Silent, Vibrant and Distributed: History of Free Software Movement in India Presentation by Anivar Aravind In National Conference on Free Software In Cochin Dec 2008
Localisation as a Political process: A case study on swathanthra malayalam c...Anivar Aravind
Localisation as a Political process: A case study on swathanthra malayalam computing
Presentation in International Conference on Globalisation and Language organised by Kerala University
FITT Toolbox: Standardisation in Media FormatsFITT
Standardisation is the process of developing and agreeing upon technical standards. The goals of standardisation can be to help with independence of single suppliers (commoditization), compatibility, interoperability, safety, repeatability, or quality. Standardisation is a strategic process in the technological evolution and commercialisation of products or services like ICT software and hardware. This implies at a very early stage of the technology a close collaboration between the research community, the industry and policy makers. This case shows that in the complexity of this standardisation process the involvement of the research community at an early stage is crucial to foster a rapid integration of new technology into new products.
www.FITT-for-Innovation.eu
Healthcare evolves with Data InteroperabilityDinesh V
Data Interoperability is the ability to share and work within and across organizational boundaries to advance the effective delivery of healthcare for individuals and communities.
Healthcare Interoperability: The Key to Leveraging Health TechMityung
Despite some setbacks, the digitalization of healthcare holds great promise for global health improvements. Health information technology (HIT) systems are taking over the healthcare industry.
For further information click here
https://www.mityung.com/
Healthcare IT Systems Interoperability Market Industry Analysis and Forecast ...PriyanshiSingh187645
The global demand for healthcare IT systems interoperability was valued at USD 3658.50 Million in 2023 and is expected to reach USD 10560.29 Million in 2032, growing at a CAGR of 12.5% between 2024 and 2032.
Healthcare software development has witnessed significant advancements in recent years, and one key area that has gained attention is healthcare information exchange (HIE). The exchange of patient data and health information between different healthcare systems and providers plays a crucial role in improving care coordination, patient outcomes, and overall healthcare delivery. In this blog, we will explore the benefits and challenges of healthcare information exchange in the context of healthcare software development.
Information Privacy and Security: The Value and Importance of Health Information Privacy, security of health data, potential technical approaches to health data privacy and security.
HARMAN Digital Transformation and Technology SolutionsHarman DTS
Partner with HARMAN Digital Transformation Solutions (DTS) to build products and solutions that address real customer needs in real-time, and accelerate business growth.
This presentation talks about the context of developing the Electronic Health records for India. the guidelines as mentioned in the GOI site is described vividly with examples, for better understanding.
N.B: Please download the ppt first, for the animations to work better.
Digital health is about electronically connecting up the points of healthcare so that health information can be shared securely.
This is the first step to understanding how digital health can help deliver safer, better and quality healthcare.
“My Health Record” is the new name of the digital health record system.
This is a presentation I delivered at AIIM 2010 in Philadelphia. It presents a holistic look at the make up of a patient record and the challenges in moving to a digital environment.
COMPETIVENESS AND PERFORMANCE COMPETIVENESS AN.docxdonnajames55
COMPETIVENESS AND PERFORMANCE
COMPETIVENESS AND PERFORMANCE
Competiveness and Performance Effectiveness for Health Care IT Systems
Teresa Pride
Strayer University
February 25, 2018
Dr. Renita Ellis
HSA 315 Health Information Systems
Information technology (IT) has undergone significant improvements thereby requiring organizations to integrate these technologies to remain competitive. Considerably, health institutions are striving to improve primary care delivery, a facet that can be attained by incorporating the use of IT in service delivery. Information technology systems enable these institutions to streamline their processes based on its ability to improve the communication aspect of the system. Enhanced communication between employees and management simplify the organization’s operations as information can be shared in real time. Notably, healthcare institutions have priorities that must be addressed adequately to ensure that both the patients and stakeholders are satisfied with the organization’s service delivery system. Based on this, the institutions ought to retain IT management personnel to sustain its processes. This paper discusses the responsibilities and characteristics of the Chief Information and Chief Technology Officers. Additionally, the paper outlines how technologies can be used to improve healthcare processes, approaches to prevent misuse of information by upholding data privacy, strategies for organizations to train providers in using IT, and best practices for efficient IT alignment with strategic planning initiatives.
Characteristics and Roles of a CTO and a CIO
Often people confuse the two important senior leadership roles within the health care organization, the Chief Information Officer and Chief Technology Officer (Wager, Lee and Glaser 2013). Despite this, they have distinct tasks that must be performed to ensure the smooth running of the healthcare organization. Primarily, the CTO ensures that the institution’s services are tailored to meet the needs of the consumers. Notably, technological innovations are continually evolving thereby the organizations should retain an individual who is conversant with the new changes whenever they occur. In this regard, the CTO has the responsibility of advising top-level executives on strategic decisions regarding technology (Stephens, Ledbetter, Mitra & Ford, 2011). Additionally, the CTO identifies, evaluates and examines high return and high-risk IT systems with the potential of its application within the organization. As a result, the CTO must assess and monitor technologies for use in better service delivery in the future. The CTO’s focus is the client whereby he/she uses technology to foster collaboration amid suppliers and management to promote the organization’s services (Stephens, Ledbetter, Mitra & Ford, 2011). As the CTO works in the external environment, he/she can comprehend what is working in other institutions and apply it within the organization.
Modernizing Legacy Systems in Healthcare: A Comprehensive GuideLucy Zeniffer
Modernizing Legacy Systems in Healthcare: A Comprehensive Guide" offers practical insights into upgrading outdated healthcare technology. Exploring strategies, challenges, and benefits, this guide empowers healthcare professionals with the knowledge to navigate the complexities of system modernization. From enhancing efficiency to improving patient care, it provides a roadmap for embracing innovation in healthcare IT infrastructure.
A framework for secure healthcare systems based on big data analytics in mobi...ijasa
In this paper we introduce a framework for Healthcare Information Systems (HISs) based on big data
analytics in mobile cloud computing environments. This framework provides a high level of integration,
interoperability, availability and sharing of healthcare data among healthcare providers, patients, and
practitioners. Electronic Medical Records (EMRs) of patients dispersed among different Care Delivery
Organizations (CDOs) are integrated and stored in the Cloud storage area, this creates an Electronic
Health Records (EHRs) for each patient. Mobile Cloud allows fast Internet access and provision of EHRs
from anywhere and at any time via different platforms. Due to the massive size of healthcare data, the
exponential increase in the speed in which this data is generated and the complexity of healthcare data
type, the proposed framework employs big data analytics to find useful insights that help practitioners take
critical decisions in the right time. In addition, our proposed framework applies a set of security
constraints and access control that guarantee integrity, confidentiality, and privacy of medical information.
We believe that the proposed framework paves the way for a new generation of lower cost, more efficient
healthcare systems.
Mesa rendonda "Redes Sociales en el Ámbito de la Salud" - Sevilla, 12 abril 2011. Patrocinada por el Observatorio para la Calidad de la Formación en Salud y la Caedra Telefónica de la Universidad de Sevilla
Perceptions and attitudes toward virtual-reality medical training: The Ann My...Francisco J Grajales III
Medical education is a discipline where science, practice and art meet to with one common goal - to improve the quality of life of patients and save lives. Since Socrates and Galen’s time, medical professionals have gathered together to interact and share their knowledge and practical experience to become better health professionals. Today, the Social Web has changed how humans interact, think, learn and simulate. Unfortunately however, medical training remains dispersed, often varying significantly even within the same geographical regions.
Second Life (SL) is the most prevalent 3-D virtual reality world on the Internet. With over 18 million users and a resident population that logged 124 million user hours during Q1 2009, SL has applications that extend from virtual reality to real-life, particularly in the field of medical education. The Ann Myers Medical Centre (AMMC) is a virtual hospital and collaborating centre founded by Dr. Ann Buchanan to explore real life health professional training using 3-D worlds. Constructed in 2006, the AMMC allows medical personnel from around the world to present clinical cases, interact, comment on novel emerging public health problems (i.e. swine flu) and perform real-life clinical teaching in the form of presentations, medical simulations or grand rounds -all foundations of interdisciplinary medical training.
Using an audience response system, presenters and audience members will collectively explore perceptions and attitudes toward virtual-reality medical training, including challenges and barriers. Presenters will also provide a live tour and simulation of a typical “grand rounds teaching session" with the virtual attendance of medical professionals from around the globe.
E-Government and E-Health Strategies by Mrs. Veronica Boateng,Director, Application Systems Ghana Information and Communications Technology Directorate (GICTeD)
eHealth : the promise of ICT for improving health in Africa, by Prof. S. Yunkap KwankamExecutive DirectorInternational Society for Telemedicine and eHealth (ISfTeH)
Public Health Informatics in Africa Examples from IDRC supported projects in ...Francisco J Grajales III
Public Health Informatics in Africa Examples from IDRC supported projects in Africa By Mrs Ramata Molo Thioune, IDRC Senior Program Officer-Dakar/Senegal
Quality and safety of health information on the Internet: Who decides and how? Role of standards, consumer education and media literacy by Dr.Gunther Eysenbach
Quality and safety of health information on the Internet: Who decides and ho...Francisco J Grajales III
Quality and safety of health information on the Internet: Who decides and how? Role of standards, consumer education and media literacy by Dr.Gunther Eysenbach
Quality and safety of health information on the Internet: Who decides and ho...Francisco J Grajales III
Quality and safety of health information on the Internet: Who decides and how? Role of standards, consumer education and media literacy by Dr.Gunther Eysenbach
Quality and safety of health information on the Internet: Who decides and ho...Francisco J Grajales III
Quality and safety of health information on the Internet: Who decides and how? Role of standards, consumer education and media literacy by Dr.Gunther Eysenbach
Quality and safety of health information on the Internet: Who decides and ho...Francisco J Grajales III
Quality and safety of health information on the Internet: Who decides and how? Role of standards, consumer education and media literacy by Dr.Gunther Eysenbach
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).