This document discusses the pros and cons of fever and antipyretic medications. It summarizes several studies that have found:
1) The use of antipyretics like NSAIDs in patients with sepsis is associated with increased mortality, while fever itself did not increase mortality.
2) In animal models, aspirin use increased mortality in infections by Streptococcus pneumoniae, though no relevant human studies were identified.
3) Overall, whether fever itself causes harm or if antipyretics should be used is still unclear. While all antipyretics lower temperature, medications reported to be dangerous may be best avoided. More research is needed on the effects of antipyretics in human infections.
This document discusses the pros and cons of fever and antipyretic medications. It summarizes several studies that have found:
1) The use of antipyretics like NSAIDs in patients with sepsis is associated with increased mortality, while fever itself did not increase mortality.
2) In animal models, aspirin use increased mortality in infections by Streptococcus pneumoniae, though no relevant human studies were identified.
3) Overall, whether fever itself causes harm or if antipyretics should be used is still unclear. While all antipyretics lower temperature, medications reported to be dangerous may be best avoided. More research is needed on the effects of antipyretics in human infections.