Шалтгаан, ангилал:
Tuberculous meningitisdevelops most commonly as a complication of
progressive primary infection in infants and young children, and from chronic
reactivation bacillemia in adults with immune deficiency caused by aging, alcoholism,
malnutrition, malignancy, human immunodeficiency virus (HIV) infection, or drugs (such as
tumor necrosis factor-alpha inhibitors).
Uptodate: Tuberculous meningitis: Clinical manifestations and diagnosis,
Fig 2 - uploaded by Rabindra N Padhy
4.
Children with MTB,especially that aged 0 to 4, have a higher incidence of TBM.
This infection is more prevalent in the developing world, with a higher incidence of MTB in
children. By contrast, in the developed world, TBM is more often seen in adults who
experience the reactivation of TB.
TBM - Tuberculous meningitis
● Children 6 mo to 6 yr old
● TBM develop within months after primary MBT
Valori H. Slane et al. Tuberculous Meningitis, NIH
5.
In a 2022meta-analysis including 52 studies and more than 12,000 patients from 28
countries, central nervous system tuberculosis (TB) constituted 13.9 percent of all cases
of meningitis and 4.5 percent of all TB cases.
In the United States in 2018, tuberculous meningitis accounted for about 1 percent
of TB cases and 4 percent of extrapulmonary TB disease.
Navarro-Flores A et al. Global morbidity and mortality of central nervous
system tuberculosis: a systematic review and meta-analysis.
6.
Navarro-Flores A etal. Global morbidity and mortality of central nervous
system tuberculosis: a systematic review and meta-analysis.