This document summarizes factors that affect tooth mortality and risk of tooth loss. It discusses several landmark studies that show supportive periodontal therapy can significantly reduce tooth loss. Common reasons for extraction include severe caries, periodontal disease, trauma, and failed root canals. Factors like furcation involvement, residual periodontal support, and mobility also impact tooth loss risk. Studies found greater loss of attachment and smoking increased risk, while regular supportive care lowered it.
Management of medically handicapped childrenDrSusmita Shah
Management of medically handicapped children such cardiovascular disease, pulmonary disease, hematological disorders, endocrine disorders, neurological disorders, Immunological disorders has been discussed in detail with all the possible evidences.
Tongue Piercing Can Lead to Gaps between TeethScott_Eckenrode
Tongue piercings have become very popular with young adults as a cool and trendy accessory. While this fashion trend can enhance a look or aesthetic, it could negatively impact an individual’s oral health, too. A case study from the University of Buffalo found that tongue piercings could cause gapped teeth.
Powerpoint of continuing education program on mid-level providers in dentistry. Focus on the training of advanced skills hygienists both in terms of ADHP and prior projects in the United States for training dental hygienists to perform skills traditionally reserved for dentists
Management of medically handicapped childrenDrSusmita Shah
Management of medically handicapped children such cardiovascular disease, pulmonary disease, hematological disorders, endocrine disorders, neurological disorders, Immunological disorders has been discussed in detail with all the possible evidences.
Tongue Piercing Can Lead to Gaps between TeethScott_Eckenrode
Tongue piercings have become very popular with young adults as a cool and trendy accessory. While this fashion trend can enhance a look or aesthetic, it could negatively impact an individual’s oral health, too. A case study from the University of Buffalo found that tongue piercings could cause gapped teeth.
Powerpoint of continuing education program on mid-level providers in dentistry. Focus on the training of advanced skills hygienists both in terms of ADHP and prior projects in the United States for training dental hygienists to perform skills traditionally reserved for dentists
Tooth Agenesis in Orthodontic Patients at Arab Population in IsraelAbu-Hussein Muhamad
Non-syndromic tooth agenesis has been occasionally described in literature and data available for its prevalence is rare in Arabs population in Israel. The purpose of the present retrospective radiographic study was to provide data concerning the prevalence of non-syndromic hypodontia in patients reporting to the Center for Dentistry,Research & Aesthetics, Jatt, Almothalat, Israel
The Importance of Oral and Dental Health in College StudentsMessiMasino
This note covers the following topics: Bacterial Diversity in the Oral Cavity, Oral-Systemic Link, Tooth Brushing, Flossing, Common Oral Hygiene Mistakes, Oral Cavity and Oropharyngeal Cancers, Oral Cavity and Oropharyngeal Cancer, Acute Dental Trauma, Controlling Bleeding and Swelling, Complications of Oral Piercings.
revision and summary of Oral diseases: a global public health challenge.
Marco A Peres, Lorna M D Macpherson, Robert J Weyant, Blánaid Daly, Renato Venturelli, Manu R Mathur, Stefan Listl, Roger Keller Celeste, Carol C Guarnizo-Herreño, Cristin Kearns, Habib Benzian, Paul Allison, Richard G Watt
Tooth loss and importance of retaining teeth for vitality, quality of life an...fdiworlddental
ORAL HEALTH FOR AN AGEING POPULATION FORUM
Tooth loss and importance of retaining teeth for vitality, quality of life and longevity
Martin Schimmel
FDI World Dental Congress 2016 Poznań
Tooth Agenesis in Orthodontic Patients at Arab Population in IsraelAbu-Hussein Muhamad
Non-syndromic tooth agenesis has been occasionally described in literature and data available for its prevalence is rare in Arabs population in Israel. The purpose of the present retrospective radiographic study was to provide data concerning the prevalence of non-syndromic hypodontia in patients reporting to the Center for Dentistry,Research & Aesthetics, Jatt, Almothalat, Israel
The Importance of Oral and Dental Health in College StudentsMessiMasino
This note covers the following topics: Bacterial Diversity in the Oral Cavity, Oral-Systemic Link, Tooth Brushing, Flossing, Common Oral Hygiene Mistakes, Oral Cavity and Oropharyngeal Cancers, Oral Cavity and Oropharyngeal Cancer, Acute Dental Trauma, Controlling Bleeding and Swelling, Complications of Oral Piercings.
revision and summary of Oral diseases: a global public health challenge.
Marco A Peres, Lorna M D Macpherson, Robert J Weyant, Blánaid Daly, Renato Venturelli, Manu R Mathur, Stefan Listl, Roger Keller Celeste, Carol C Guarnizo-Herreño, Cristin Kearns, Habib Benzian, Paul Allison, Richard G Watt
Tooth loss and importance of retaining teeth for vitality, quality of life an...fdiworlddental
ORAL HEALTH FOR AN AGEING POPULATION FORUM
Tooth loss and importance of retaining teeth for vitality, quality of life and longevity
Martin Schimmel
FDI World Dental Congress 2016 Poznań
KK Dental, Dr. Satwah, went to highland park's senior center to educate them about the importance of dental hygiene. Dr. Satwah performed free dental screenings on the seniors and gave them useful tips for keeping good dental hygiene.
Frequent smokers with artificial teeth will now have more reasons to break the habit. A study revealed that smoking might cause dental implants to fail even if people take great pains to maintain proper oral hygiene.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
4. Common causes of tooth loss!!
Prostheses Third molars Trauma
Failed root
canal
treatment
Orthodontic
treatment
Grade III
mobile teeth
Severe
caries
other
5. Tooth position within
dental arch
Furcation involvement
Iatrogenic factors
Residual periodontal
support
Mobility
Factors affecting tooth mortality
6. Tooth position within dental arch
Early clinical surveys have associated the prevalence
and severity of periodontal diseases with
malocclusion and irregularities of tooth position.
Ditto and hall 1954 ; Bilimora 1963; beagre and
james 1962; Geiger 1962,gould and picton 1962
Ingervall et al 1977
Buckley 1980
Griffith and addy 1981
Horup et al 1987
7. Furcation involvement
Multirooted teeth appear to be at high risk for
tooth loss during maintainence phase.
Kalkwarf and Reinhardt 1988 ; Hirschfield and
Wassermann 1978; McFall 1982
Clark et al
Burton et al
Wassermann et al
8. Iatrogenic factors
Overhanging margins and ill fitting crown margins – plaque
retention ….increased prevalence of periodontal lesions.
Lang et al 1983
Kirkstrom et al 1995
9. Residual periodontal support
Teeth with healthy periodontal support can function
either individually or as abutments for many years
without further loss of attachment.
Nyman and Lindhe 1979
Nyman and Ericcsson 1982
Teeth…… treated periodontally …….abutment in fixed
bridgework …….amount of residual periodontal support.
Bragger et al 1990
10. Mobility
2 factors contribute to tooth mobility:
- Unidirectional or multidirectional traumatic forces
- Height of periodontal supporting structures.
Persson et al1980,
Baume et al 1981
12. Ageing increased the risk of tooth loss in periodontally compromised
pts.
- Page and beck et al
- Burt et al
Ageing
13. Studies associate greater periodontal attachment loss with a
higher rate of tooth loss
- Burt et al
- Bauma et al
Loss of attachment
14. Smoking may increase the risk for loss of tooth and reduction bone height
even if the standard of oral hygiene is maintained . [Bergstorm et al ]
Study was done among 9,032 men and 14,344 women which included current cigarette smokers, and past
cigarette smokers and was found that there was an increased tooth loss among current smokers as compared
to past smokers and also the effect of smoking was seen to continue for a period of 5 years after cessation of
smoking. [ Susan et al 2016]
Smoking
15. 51 per cent of lower central incisors presented with >50 per cent loss of
attachment.
Bauma et al
Tooth type
17. Lovdal A , Arno A, Schei O in 1961
In 1428 factory workers ….subgingival scaling every 3-6 months
after 5 year
interval
Tooth loss was significantly reduced in all pts
18. Ramford et al 1974
SRP was done in 104 pts comprising a total of 2604 teeth
After 1- 7 years of
treatment 53 teeth
were lost
32 teeth were lost
during 1st and 2nd
years after initiation
of treatment
21 teeth were lost
in a random
pattern over next 6
years
Concluded that loss of
teeth due to advanced
periodontal disease after
treatment was minimal.
19. Lindhe et al 1975
Subjects were 75 pts who had lost 50% or
more of periodontal support
Treatment
No teeth lost ……5 years
14 years…..isolated areas of recurrence
of periodontal disease
20. Ross et al 1978
180 pts who had been treated for chronic destructive periodontal disease
a total of 141 teeth were lost
one in 5 pts lost 3 teeth
10 years of
follow up
21. Loe h et al 1986
Population
First population group consisted of
565 male non dental students and
academicians between 17 and
30+years from oslo Norway
Second group consisted of 480
male tea laborers of sri lankan
population.
-17 year old Norwegian ……27.4 teeth
present out of 28 possible
-No loss of teeth….20s and 30s
-40 years of age……27.1 and the mean
mortality rate was 0.01 teeth per year
-15 year old had 27 teeth present and
the 40 year old had 25.6 teeth.
-The mean mortality rate …..0.1 and 0.3
teeth per year.
-Teeth with deep periodontal lesions
started to exfoliate in Sri Lankans as
they approached 40 years of age.
30 -35 years
follow up
22. 53% of Blacks and 29% of Whites lost at least one tooth. Blacks lost 13% of their
remaining teeth compared with 4% for Whites.
Blacks and whites with tooth loss
Drake et al 1995
Data was collected from 263 Blacks and 228
Whites by dental examinations and interviews
3 year follow
up
Stimulated saliva of blacks
………higher counts of
p.intermedia
Stimulated saliva of
whites……higher counts of
lactobacillus
23. • Hirshfield et al 1978
600 pts of 15 to 53 years with chronic periodontitis were
periodontal treated
Out of 15,666 teeth …..1,110-- periodontal reasons , 666 teeth----- questionable prognosis,
1464 teeth with furcation teeth were lost.
Follow up of 22
years
Downhill
4- 9 teeth lost
Extreme downhill
10 to 23 teeth
24. Relationship between metabolic syndrome and tooth loss
Middle aged adults , 2107
participants
5 year
follow up
Compared to those with no metabolic
components, participants with ≥3
components had an increased risk of tooth
loss Michiko furuta et al 2016
25. Life style correlation and tooth loss
Mid western
population
Tooth loss is found to be more in older age group patients with history of
smoking of more than 5 years along with systemic disease.
Thimothy et al 2013
26. Diabetes and tooth loss
100 diabetic and 100 non diabetic individuals aged 30 to 60 years
Number of mean missing teeth in diabetic individual was
found to be 6.45 % as compared to 1.43 % in control group
Charlotte Rodrigues et al
2015
27. Conclusion
Tooth risk assessment encompasses an estimation of various factors to
evaluate functional stability. Risk assessment at tooth level may be
useful in evaluating the prognosis and furcation of individual teeth and
may indicate the need for specific therapeutic measures during patient
visits. Hence prevention of tooth loss must be ensured by dentist by
advocating SPT and educating and motivating patients to take care of
their oral hygiene.
28. • Textbook of jan Lindhe 6th edition chapter 60 supportive periodontal therapy
• Textbook of clinical periodontology 11th edition chapter 79 results of periodontal therapy
• Ong, G., 1998. Periodontal disease and tooth loss. International dental journal, 48(S3),
pp.233-238.
• Bailit, H.L., Braun, R., Maryniuk, G.A. and Camp, P., 1987. Is periodontal disease the primary
cause of tooth extraction in adults?. The Journal of the American Dental Association, 114(1),
pp.40-45.
• Renvert, S. and Persson, G.R., 2004. Supportive periodontal therapy. Periodontology
2000, 36(1), pp.179-195.
• Axelsson, P., Nyström, B. and Lindhe, J., 2004. The long‐term effect of a plaque control
program on tooth mortality, caries and periodontal disease in adults. Journal of clinical
periodontology, 31(9), pp.749-757.
References
Editor's Notes
Periodontal disease is considered as the main cause of tooth mortality among adults out of which one in 5 patients experience tooth loss due to inadequately maintained oral hygiene . Hence advocating proper treatment and maintainence by recall visits has shown to reduce the risk of tooth loss.
The most common causes of tooth loss includes extraction for prostheses, extraction of third molars, due to trauma, failed RCT, extraction due to orthodontic treatment, grade 3 mobile teeth, teeth extracted due to severe caries and Unexplained which includes supernumerary, retained deciduous teeth , teeth with furcation involvement…..
ingerwall et al stated that Relationship exists between crowding and increased plaque retention and gingival inflammation and if not maintained lead to increased amount of tooth loss
Clark et al conducted a study in 600 pts for a duration of 22 years and found that 83 % of pts lost 0-3 teeth during observation period and it was seen that majority of teeth were lost due to furcation involvement
Lang et al stated that Slightly subgingivally located overhanging restorations change the ecological niche providing a more favourable conditions for establishment of gram negative anerobic microbiota
Teeth treated periodontally can be maintained over decades as abutment in fixed bridgework irrespective of amount of residual periodontal support.
tooth mobility is one of the indicators for progressing periodontal disease. Studies by person et al has shown that has shown that there is variation in tooth mobility before , during and after periodontal therapy baume et al stated that there was an increased tooth mobility noticed immediately after periodontal therapy which was due to the healing phase of periodontium
The relationship between age and periodontal disease is age-associated rather than being a consequence of ageing . [ page and beck et al ]
- Over 28-year period they found that there was a trend toward greater tooth loss with increasing age. [ burt et al ]
Strongest risk factor was in areas with loss of attachment > 5mm [ Burt et al ]
Patients with advanced periodontitis had a higher chance of loosing teeth with loss of attachment accounting for > 50%. [Bauma et al]
Smokers, especially those in the age group <50 years, were a high risk group for tooth loss.
Maxillary incisors and molars presented as the next common teeth lost due to periodontal reasons.
A study was done in
Treatment was done which consisted of oral hygiene measures, SRP, extraction of untreatable teeth, periodontal surgery and prosthetic therapy . No teeth were extracted in 5 year post treatment which indicates that detailed plaque control programme along with mechanical debridement were helpful . After 14 years 61 pts who were still enrolled in the study found to have recurrence of periodontal disease in isolated areas was found and there was loss of teeth one in 3 pts during 6 to 10 years and 3 in 3 pts during 10 – 14 years period
Norweighian population was advocated with appropriate dental treatment and sri lamkan tea labourers were no advocated any form f treatment
17 year old noweigian had 27.4 teeth present out of 28 teeth …no loss of teeth was found during 20s and 30s and when they approached 40 years of age mortality rate of 0.01 teeth per year was found. The Sri Lankan 15 year old had 27 teeth present and the 40 year old had 25.6 teeth.
The mean mortality rate ranged between 0.1 and 0.3 teeth per year. Teeth with deep periodontal lesions started to exfoliated in Sri Lankans as they approached 40 years of age.
is study investigated, epidemiologically, the distribution and predictors of tooth loss in elder Blacks and Whites by following a random sample of older adults in North Carolina for three years. It was hypothesized that Blacks would be at greater risk of tooth loss and would have different risk factors for tooth loss. Blacks were at greater loss of tooth loss compared to whites …..wherein there was a more count of p.intermedia in stimulated saliva among blacks compared to whites in whom lactobacillus was found in their stimulated saliva…
Pts were catagorised as downhill and extreme downhill wherein in downhill 4 to 9 teeth were lost and in extreme downhill 10 to 23 teeth were lost.
who underwent annual dental check-ups, to evaluate tooth loss and metabolic components, including obesity, elevated triglycerides, blood pressure, fasting glucose, and reduced high-density lipoprotein.