Three things Liz's friends don't know about her:
1) She dreams of swimming the English Channel
2) She secretly thinks charades are fun
3) She is helping with research on Alzheimer's disease
With online shopping spreading quickly, China ' s e-commerce market is rapidly expanding; the e-commerce distribution bottlenecks gradual emerge. Logistics distribution has restricted the development of Taobao.It is proved that during the process of distributing activity, information processing and dispatching speed can be speeded up with computer, telecommunication and network technologies, so improving efficiency and competence greatly. Alibaba set up rookie network aimed at long-term growth. The necessary of setting up “Rookie network” as well as business models of“Rookie network” were detailed in this article. Last,the effects of Rookie Network on market was analyzed.
With online shopping spreading quickly, China ' s e-commerce market is rapidly expanding; the e-commerce distribution bottlenecks gradual emerge. Logistics distribution has restricted the development of Taobao.It is proved that during the process of distributing activity, information processing and dispatching speed can be speeded up with computer, telecommunication and network technologies, so improving efficiency and competence greatly. Alibaba set up rookie network aimed at long-term growth. The necessary of setting up “Rookie network” as well as business models of“Rookie network” were detailed in this article. Last,the effects of Rookie Network on market was analyzed.
Discussing effect of modern life including: TV, Video games, computers, mobile, diet, sports, cinema and theater. etc on epileptics by Dr: samir Mohamed Moner Al-Minshawy lecturer of neuropediatrics, Minia university Egypt
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
1. Three things her friends don’t know about Liz
Dreams of swimming the English Channel
Secretly thinks charades are fun
Is helping research in Alzheimer’s disease
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Discover the power of you
2. Three things Darren’s friends
don’t know about him
Wants to own his own business
Knows all the words to “Hello Dolly”
Worries about his Dad’s diabetes
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3. You don’t have to travel the world to change it. Start right here in Belfast.
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Part of your community for life.
4. Vous n’avez pas besoin de parcourir le monde pour le changer. Commencez ici à Montréal.
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in pharmacoresistant epilepsy treatment
Improvements in seizure control, quality of life,
and mood that you’ll see over time
Seizure Control and Quality of LIfe
The first and oly FDA-approved treatment
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Time
10. VNS Therapy is indicated for pharmacoresistant epilepsy (PRE)
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Ti m e