The document discusses how epilepsy is portrayed in modern life. While new technologies have benefited epilepsy diagnosis and treatment, they have not significantly changed public perceptions and understanding. Epilepsy is still frequently stigmatized and associated with notions of madness, evil or possession. However, Islam provided an exception through the Prophet's compassionate response in accepting and helping an epileptic woman without stigma.
الفصل الثاني - المقاطع تحت تأثير عزوم الانحناء - تصميم المنشآت الخرسانية المسلحةAhmed Gamal Abdel Gawad
حل أمثلة الفصل الثاني :
https://www.mediafire.com/?2x3mo52dv9jo6mc
المحاضرة الرابعة : المقاطع تحت تأثير عزوم الإنحناء
http://youtu.be/f5-kOqI3yGQ
المحاضرة الخامسة : تحليل المقاطع قبل التشرخ
http://youtu.be/Y1ikllWCgIU
م. أحمد جمال عبد الجواد
EEG variants, are always to be recognized while interpreting the EEG one must be aware of these. Major and most common EEG is variants are discussed in the stated presentation.
Syed Irshad Murtaza.
This lecture is all about the recognition of an abnormal EEG, its characteristics, its appearance and all about how to differentiate the abnormal activity with normal EEG background.
الفصل الثاني - المقاطع تحت تأثير عزوم الانحناء - تصميم المنشآت الخرسانية المسلحةAhmed Gamal Abdel Gawad
حل أمثلة الفصل الثاني :
https://www.mediafire.com/?2x3mo52dv9jo6mc
المحاضرة الرابعة : المقاطع تحت تأثير عزوم الإنحناء
http://youtu.be/f5-kOqI3yGQ
المحاضرة الخامسة : تحليل المقاطع قبل التشرخ
http://youtu.be/Y1ikllWCgIU
م. أحمد جمال عبد الجواد
EEG variants, are always to be recognized while interpreting the EEG one must be aware of these. Major and most common EEG is variants are discussed in the stated presentation.
Syed Irshad Murtaza.
This lecture is all about the recognition of an abnormal EEG, its characteristics, its appearance and all about how to differentiate the abnormal activity with normal EEG background.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
4. We will discuss:
• Epilepsy awareness and knowledge
•Modern technology and epilepsy
•Exercise and epilepsy
•Stress and epilepsy
•Diet and epilepsy
•Others
5. Epilepsy in modern life gained much benefit
from new technology regarding diagnostic procedures
and therapeutic modalities including: epilepsy surgery,
vagus nerve stimulation, gene therapy and alternative
medicine approaches like: yoga, relaxation techniques,
biofeedback, nutritional & herbal supplements ,
dietary measures and acupuncture.
On the other hand, modern life is still adding risk
factors for epilepsy which presents multiple
challenges to the clinicians.
7. Although رلاa رلاrevolution رلاhas رلاbeen رلاdone رلاin رلاepilepsy رلاresearch, رلا
recent رلا رلاtechnologies رلاdidn’t رلاmake رلاthis رلاparadigm رلاshift رلاin رلاperception رلا
and رلاunderstanding رلاof رلاepilepsy رلاin رلاgeneral رلاpopulation.
Epilepsy رلا has رلا frequently رلا been رلا portrayed رلا in رلا literary رلا works, رلا
films رلا and رلا television رلا (TV) رلا series, رلا often رلا relating رلا it رلا with رلا madness, رلا
evil, رلاviolent رلاbehaviors رلاor رلاpossession رلاby رلاthe رلاdivine رلاor رلاghosts. رلاThis رلا
marks رلاthe رلاawareness رلاand رلاknowledge رلاpeople رلاhave رلاabout رلاepilepsy رلا
and رلاepileptic رلاpatients. رلا
8. Epilepsy رلاhas رلاbeen رلاalways رلاstigmatized رلا(and رلاstill).
- رلا History رلا declared رلا that رلا much رلا discrimination رلا measures رلا
were رلاtaken رلاagainst رلاepileptics رلاeven رلاin رلا20th
رلاcentury.
- رلاIn رلاold رلاcivilizations رلاand رلاbeliefs رلاmisunderstanding رلاabout رلا
epilepsy رلا and رلا epileptic رلا patients رلا was رلا the رلا base, رلا رلا one رلا of رلا
exceptions رلا which رلا was رلا done رلا by رلا the رلا pure رلا sunnah رلا in رلا
Islam. رلا
9. NARRATED 'ATA BIN ABI RABAH: IBN 'ABBAS
SAID TO ME, "SHALL I SHOW YOU A WOMAN OF
THE PEOPLE OF PARADISE?" I SAID, "YES." HE
SAID, "THIS BLACK LADY CAME TO THE
PROPHET AND SAID, 'I GET ATTACKS OF
EPILEPSY AND MY BODY BECOMES
UNCOVERED; PLEASE INVOKE ALLAH FOR ME.'
THE PROPHET SAID (TO HER), 'IF YOU WISH,
BE PATIENT AND YOU WILL HAVE (ENTER)
PARADISE; AND IF YOU WISH, I WILL INVOKE
ALLAH TO CURE YOU.' SHE SAID, 'I WILL
REMAIN PATIENT,' AND ADDED, 'BUT I BECOME
UNCOVERED, SO PLEASE INVOKE ALLAH FOR
ME THAT I MAY NOT BECOME UNCOVERED.' SO
HE INVOKED ALLAH FOR HER.
SAHIH BUKHARI" VOLUME 7, BOOK 70,
NUMBER 555
12. Photosensitive Epilepsy (PSE)
• It is a good example for effect of technology, it’s a form of reflex
epilepsy in which seizures can be triggered by flickering or
intermittent light stimulation, occurring in 1/4000 of the population,
common in childhood and more in girls. With age, it can disappear but
75% stay photosensitive for life.
• Seizures vary from brief absence seizures to tonic–clonic seizures,
May preceded by “aura” and this can serve as a warning. Flashing
lights or rapidly changing or alternating images (as in clubs, around
emergency vehicles, in action movies or television programs, cinema,
theatre…….. etc.) are examples especially in luminance contrast. Red
color is a good trigger. The photoparoxysmal response in EEG helps
in diagnosis. Treatment remains the removal of the offending stimulus
with drug therapy (as sodium valproate).
13.
14. *Television is the most common source of seizures in PSE
especially in a dark room, at close range and with flickering.
Some patients self-induce seizures by waving their fingers in
front of their eyes with TV watching.
*For protection:
• The room should be well-lit.
• light source is placed on top of or behind the TV to balance the
screen brightness.
• Flat screen or LCD (liquid crystal display) units don’t flicker at
all.
• Sitting away (2.5 meters).
• Use a remote control or cover one eye to reduce flickering.
• Take a five-minute break every 30 minutes.
15.
16. • Seizures triggered by VGs were reported, not only in photosensitive,
but also in nonphotosensitive epileptic children.....Preventive
measures concerning the characteristics of images VGs (flash rate,
choice of colours, patterns, and contrast).
• Playing video games on a LCD TV screen
• No playing with the feeling of tiredness
• Taking a 5-minute break away every 15 minutes
• Switching off immediately with dizziness , blurring of vision, muscle
twitching and being uncomfortable in any way .
18. • It is recommended that computer screens have a refresher
frequency of at least 73 Hz or use LCD screen, the
computer screen should not show any glare, which can
result in a flickering.
• The risk of a seizure depends on the material being
viewed. Some software, especially games, cartoons and
web designs contain flickering images.
• Use an anti-glare screen to reduce fatigue and discomfort
• Take regular breaks away (5 minutes every 15 minutes).
20. Going to cinema and theatre is safe with epilepsy.
Films with special effects (including laser and
flashing lights) could potentially trigger seizures in
people with photosensitive epilepsy. Think carefully
about where is the seat.
22. • It is more beneficial to use natural light or old-
fashioned light bulbs. Energy-saving bulbs are
small fluorescent tubes. Older strip fluorescent
light tubes flicker more and should be exchanged
regularly.
24. Electromagnetic fields (EMFs) emitted by mobile
phones had been shown to increase cortical
excitability and modulate inter-hemispheric
synchronization of temporal and frontal resting EEG
rhythms.
Inhabitants living nearby mobile base stations are at
risk for developing neuropsychiatric problems and
some changes in the performance of neurobehavioral
functions either by facilitation or inhibition.
25. Although that exposure wasn’t above accepted international
guidelines, studies had reported increased prevalence of adverse
neurobehavioral symptoms , such as headache, memory changes,
dizziness, tremors, depression, sleep disturbances and more significant
increases in the frequency of seizures in epileptic patients if living at
distances <500 m from base stations which suggesting that current
guidelines may be inadequate in protecting health. Other studies added
the dose response relationship, duration exposure and other variables,
such as sociodemographic data.
Future research should address critical and neglected issues such
as investigation of repeated, intensive and chronic exposures, especially
in in highly sensitive populations such as epileptic children to provide
safe rules for the use of mobile
26. Finally, research related to the effects on health of using mobile
phones is inconclusive. So until there is more evidence, it is sensible for
everyone, whether they have epilepsy or not, to restrict their mobile
phone use to short and essential calls only.
-People with epilepsy who use mobile phones often should carefully
monitor their seizure frequency.
-Mobile phones should be kept away from vagus nerve stimulation
devices.
-Children with epilepsy should be discouraged from using mobile
phones.
28. Although microwave ovens are recommended as
a safe cooking alternative for epileptic patients but
hand burns in complex partial seizures are reported.
The use of gloves and heating foods (not boiling
liquids) is recommended.
30. Both physical (work related) and mental stress are
commonly believed to precipitate seizures in some patients
with epilepsy. Stress itself may also be associated with other
seizure-provoking factors such as sleep deprivation.
Stressful life events as wars can be provocative factors for
the occurrence of seizures. Typical absence seizures are
more likely to be provoked by stress then other types of
seizures.
33. Epileptic patients have previously been discouraged from
participation in sports dx- for fear of inducing seizures or increasing its
frequency. Although there are rare cases of exercise-induced seizures,
studies have shown that it improves both physical and psychosocial
outcomes.
The majority of sports are safe provided adequate seizure control
and preparation of family and trainers. Contact sports including football
don’t induce seizures.
Water sports and swimming are safe if seizures are well
controlled and direct supervision is present with exception for those who
have bathing epilepsy or hot-water epilepsy.
Additional care must be taken in sports involving heights such as
gymnastics, or horseback riding. Sports such as hang-gliding, diving are
not recommended, given the risk of severe injury or death, if a seizure
were to occur during the activity.
34. Generally, most sports are safe as long as
patients avoid overexertion, dehydration and
hypoglycemia. If a seizure occurs, it is most likely to
be after the exercise (15 minutes to three hours later)
and can occur suddenly without warning.
36. • Travelling by cars and trains: Patients should sit away from
watching fast moving or jerking shapes on roads, also light
reflection on rapidly moving vehicles which can trigger seizures in
PSE.
• Air travel increases seizures frequency. Provided that seizures are
controlled with medication, epileptic Patients can travel by air.
• Epilepsy is thought to be one of the essential contraindication for
driving a motor vehicle on public roads. There is a tendency
toward a greater liberalization of driving standards for people with
epilepsy.
37.
38. Foods that thought to be seizure triggers in some patients include:
artificial colors, preservatives especially Propionate in addition towheat,
cows milk and cheese (but not sheep cheese), tomatoes, tea, grapes and
other salicylate-containing foods; chocolate, pork, banana, amine-
containing foods and other glutamate containing foods (Egger et al,
1989). ).