Speaker roundtable discussion organized by HBA Europe – Lyon & sponsorized by Merial : "How to Survive In the Ever-Changing Healthcare Industry" Oct 2016
Aeronautic manufacturing industry is facing huge challenge : quick ramp up, new product launch.
This has complexified program management and ability to meet target.
This presentation is based on a similar experience coming from another sector : automotive industry.
Don't hesitate to contact me for any feedback or interest
Planning is what sets for the foundation of any journey. In the realm of sales, it’s just not planning but a whole gamut of activities which finally assists you in covering that journey from an idea to an impeccable execution!
Brand Management Architects with a deep understanding of brand process management. Covering brand development processes from ideation to brand performance monitoring. Focus on consistent cross functional operations of your brands.
The product life cycle has four stages: introduction, growth, maturity, and decline. New product development practitioners and engineering managers need to understand how to approach each stage with alternative business strategies.
Aeronautic manufacturing industry is facing huge challenge : quick ramp up, new product launch.
This has complexified program management and ability to meet target.
This presentation is based on a similar experience coming from another sector : automotive industry.
Don't hesitate to contact me for any feedback or interest
Planning is what sets for the foundation of any journey. In the realm of sales, it’s just not planning but a whole gamut of activities which finally assists you in covering that journey from an idea to an impeccable execution!
Brand Management Architects with a deep understanding of brand process management. Covering brand development processes from ideation to brand performance monitoring. Focus on consistent cross functional operations of your brands.
The product life cycle has four stages: introduction, growth, maturity, and decline. New product development practitioners and engineering managers need to understand how to approach each stage with alternative business strategies.
Mastering the Product Development Process: A Comprehensive Guide to Bringing ...CIO Look Leader
Key Stages of the Product Development Process: 1. Idea Generation 2. Concept Development and Screening 3. Market Research 4. Prototype Development 5. Testing and Validation
Product development services play a pivotal role in bringing innovative ideas to life and driving business success. In this comprehensive guide, we’ll explore the intricacies of product development, from understanding the development lifecycle to the importance of market research, prototyping, coding, and quality assurance. For more information visit: www.itmindslab.com/what-is-product-development-services.
What Is It? Product Development vs. Product Management April Bright
This session will focus on the respective roles and responsibilities of the Product Manager vs. the Development Engineer from a product’s inception through its lifecycle maintenance. Attendees will learn how to leverage the cross-functional product team to deliver results, business vs. technical aspects of product development, putting the customer first and navigating the organization in order to get things done.
Product Management: Optimizing the What to DevelopTechWell
Most organizations struggle with the processes that define what software they should develop, when to do it, and how it will evolve over time—all parts of the product management role and activities. Because repeatable processes have not been established and organizations cope with conflicting priorities, teams stress needlessly over day-to-day decisions. Product management requires a fundamental company-wide understanding of its goals and opportunities coupled with the discipline to optimize development and maintenance efforts. Ernani Ferrari addresses why product management for software is crucial to maximize revenue and reduce costs in the short and long terms, explains the product manager’s role and activities, and examines how to translate company strategies into product strategies. Ernani also explores what business aspects you should consider during product planning, discusses the product artifacts you need, and outlines orchestrating product releases to improve corporate communication and overall financial results.
Future Proofing through MVP_ Pioneering the Next Generation of Products.pdfSkywindsSolutions
In this addition one sentence resounds loud and clear in the swirl of contemporary business dynamics: “Adapt or perish.” Companies must innovate, but they must also do so intelligently, given the constantly shifting environment. The MVP (Minimum Viable Product) approach to product development emerges as a guiding light in this situation, illuminating the way to a future-proof MVP Approach to product development that connects with users.
The MVP approach to product development has become a potent tool for developing goods that not only satisfy the needs of the current market but also have the adaptability to change and satisfy those of the future. And Industry-wide adoption of this agile methodology has given startups and established businesses alike a road map for navigating the complex world of product development.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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Key Stages of the Product Development Process: 1. Idea Generation 2. Concept Development and Screening 3. Market Research 4. Prototype Development 5. Testing and Validation
Product development services play a pivotal role in bringing innovative ideas to life and driving business success. In this comprehensive guide, we’ll explore the intricacies of product development, from understanding the development lifecycle to the importance of market research, prototyping, coding, and quality assurance. For more information visit: www.itmindslab.com/what-is-product-development-services.
What Is It? Product Development vs. Product Management April Bright
This session will focus on the respective roles and responsibilities of the Product Manager vs. the Development Engineer from a product’s inception through its lifecycle maintenance. Attendees will learn how to leverage the cross-functional product team to deliver results, business vs. technical aspects of product development, putting the customer first and navigating the organization in order to get things done.
Product Management: Optimizing the What to DevelopTechWell
Most organizations struggle with the processes that define what software they should develop, when to do it, and how it will evolve over time—all parts of the product management role and activities. Because repeatable processes have not been established and organizations cope with conflicting priorities, teams stress needlessly over day-to-day decisions. Product management requires a fundamental company-wide understanding of its goals and opportunities coupled with the discipline to optimize development and maintenance efforts. Ernani Ferrari addresses why product management for software is crucial to maximize revenue and reduce costs in the short and long terms, explains the product manager’s role and activities, and examines how to translate company strategies into product strategies. Ernani also explores what business aspects you should consider during product planning, discusses the product artifacts you need, and outlines orchestrating product releases to improve corporate communication and overall financial results.
Future Proofing through MVP_ Pioneering the Next Generation of Products.pdfSkywindsSolutions
In this addition one sentence resounds loud and clear in the swirl of contemporary business dynamics: “Adapt or perish.” Companies must innovate, but they must also do so intelligently, given the constantly shifting environment. The MVP (Minimum Viable Product) approach to product development emerges as a guiding light in this situation, illuminating the way to a future-proof MVP Approach to product development that connects with users.
The MVP approach to product development has become a potent tool for developing goods that not only satisfy the needs of the current market but also have the adaptability to change and satisfy those of the future. And Industry-wide adoption of this agile methodology has given startups and established businesses alike a road map for navigating the complex world of product development.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
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Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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situation in France and at Global Level on
Marketing strategy and Product definition with a focus on
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Profile ID card
➢ Market Screening to validate feasibility & to estimate market success of
the future product before GO to initiate project launch & prototype
elaboration deliverable = screening report with highlights of
environment specifities (regulatory, technological alternatives or
complementaries…) & putting in perspective an action plan for next stage
➢ Roadmap & process audit followed by a training on risk management and
lesson-learned WS
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optimize ROI Transition Management to enhance this transformation
with a cross-functional contribution as Project Director, Marketing
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