This document summarizes the disadvantages of current deposition technologies for Ir/IrOx coatings on pacemaker electrodes and proposes a new Pulse Metalorganic Chemical Vapour Deposition (Pulse MOCVD) method. The Pulse MOCVD method allows for depositing biocompatible nanostructured coatings at lower temperatures with greater uniformity and less material consumption compared to existing chemical deposition and magnetron sputtering methods. The company Smart-CVD plans to commercialize the Pulse MOCVD technology by providing Ir/IrOx coating services to pacemaker electrode manufacturers and pursuing strategic partnerships.
First and foremost place for metallurgical engineering jobs is the aerospace industry. This is a field where modern day materials scientists and engineers are always sought after. Because of the extreme environments of operation, materials and metallurgical engineers can always find jobs in the aerospace and defense industry.
For more info to click here: http://www.secat.net/blog/199/Secat_-_The_Beginning_of_Something_BIG!.html
Alloy development and processing; apply deposition of protective coatings; tribological assessment of surfaces; characterisation of functional and structural materials by electron microscopy; processing and characterisation of novel photonic glasses; development of biomaterials and biomedical devices and implants; bioactive and catalytic surface studies.
For more info to click here: http://www.secat.net/blog/198/Secat_Research_Featured_In_Light_Metal_Age.html
First and foremost place for metallurgical engineering jobs is the aerospace industry. This is a field where modern day materials scientists and engineers are always sought after. Because of the extreme environments of operation, materials and metallurgical engineers can always find jobs in the aerospace and defense industry.
For more info to click here: http://www.secat.net/blog/199/Secat_-_The_Beginning_of_Something_BIG!.html
Alloy development and processing; apply deposition of protective coatings; tribological assessment of surfaces; characterisation of functional and structural materials by electron microscopy; processing and characterisation of novel photonic glasses; development of biomaterials and biomedical devices and implants; bioactive and catalytic surface studies.
For more info to click here: http://www.secat.net/blog/198/Secat_Research_Featured_In_Light_Metal_Age.html
ADVANCEMENT IN ULTRASONIC VIBRATION AND MAGNETIC FIELD ASSISTED MICROEDM PROC...IAEME Publication
Micro-machining of components has been emerged as a peak demand in the world
of micro-manufacturing. Micro-EDM is proved to be the most suitable for micro
drilling purposes. It is very essential to fabricate micro holes as well as features with
very high dimensional accuracy and precision. The major drawbacks in micro-EDM
processes are the low metal removal, tool wear and surface roughness. Researchers
have carried out several investigations to compensate the various machining problems
in the micro-EDM process. So, there evolves a need for development of more
sophisticated machining features in micro-EDM process combining with additional
techniques. This paper presents a brief review on the latest advancement in ultrasonic
vibration and magnetic field assisted techniques to improve machining efficiency and
surface qualities of machined features in micro-EDM process. Latest industrial
applications of micro-EDM have been presented
ADVANCEMENT IN ULTRASONIC VIBRATION AND MAGNETIC FIELD ASSISTED MICROEDM PROC...IAEME Publication
Micro-machining of components has been emerged as a peak demand in the world
of micro-manufacturing. Micro-EDM is proved to be the most suitable for micro
drilling purposes. It is very essential to fabricate micro holes as well as features with
very high dimensional accuracy and precision. The major drawbacks in micro-EDM
processes are the low metal removal, tool wear and surface roughness. Researchers
have carried out several investigations to compensate the various machining problems
in the micro-EDM process. So, there evolves a need for development of more
sophisticated machining features in micro-EDM process combining with additional
techniques. This paper presents a brief review on the latest advancement in ultrasonic
vibration and magnetic field assisted techniques to improve machining efficiency and
surface qualities of machined features in micro-EDM process. Latest industrial
applications of micro-EDM have been presented.
Welding is a materials joining process which produces coalescence of material...KhaldoonHusseinHamza
It is used in the manufacture of automobile bodies,
aircraft frames, railway wagons, machine frames,
structural works, tanks, boilers, general repair work
and ship building.
This presentation describes the production of silver nanowires with different processes, comparing the polyol process and their applications in different fields.
The Battery Show Japan Showcase Presentation.pdfBeneq
Battery Japan 2023
September 13-15, 2023
Atomic Layer Deposition and some of the aspects around using R2R ALD Coatings for Battery Cell Interfaces.
Presented by Dr. Andrew Cook from Beneq Oy
ADVANCEMENT IN ULTRASONIC VIBRATION AND MAGNETIC FIELD ASSISTED MICROEDM PROC...IAEME Publication
Micro-machining of components has been emerged as a peak demand in the world
of micro-manufacturing. Micro-EDM is proved to be the most suitable for micro
drilling purposes. It is very essential to fabricate micro holes as well as features with
very high dimensional accuracy and precision. The major drawbacks in micro-EDM
processes are the low metal removal, tool wear and surface roughness. Researchers
have carried out several investigations to compensate the various machining problems
in the micro-EDM process. So, there evolves a need for development of more
sophisticated machining features in micro-EDM process combining with additional
techniques. This paper presents a brief review on the latest advancement in ultrasonic
vibration and magnetic field assisted techniques to improve machining efficiency and
surface qualities of machined features in micro-EDM process. Latest industrial
applications of micro-EDM have been presented
ADVANCEMENT IN ULTRASONIC VIBRATION AND MAGNETIC FIELD ASSISTED MICROEDM PROC...IAEME Publication
Micro-machining of components has been emerged as a peak demand in the world
of micro-manufacturing. Micro-EDM is proved to be the most suitable for micro
drilling purposes. It is very essential to fabricate micro holes as well as features with
very high dimensional accuracy and precision. The major drawbacks in micro-EDM
processes are the low metal removal, tool wear and surface roughness. Researchers
have carried out several investigations to compensate the various machining problems
in the micro-EDM process. So, there evolves a need for development of more
sophisticated machining features in micro-EDM process combining with additional
techniques. This paper presents a brief review on the latest advancement in ultrasonic
vibration and magnetic field assisted techniques to improve machining efficiency and
surface qualities of machined features in micro-EDM process. Latest industrial
applications of micro-EDM have been presented.
Welding is a materials joining process which produces coalescence of material...KhaldoonHusseinHamza
It is used in the manufacture of automobile bodies,
aircraft frames, railway wagons, machine frames,
structural works, tanks, boilers, general repair work
and ship building.
This presentation describes the production of silver nanowires with different processes, comparing the polyol process and their applications in different fields.
The Battery Show Japan Showcase Presentation.pdfBeneq
Battery Japan 2023
September 13-15, 2023
Atomic Layer Deposition and some of the aspects around using R2R ALD Coatings for Battery Cell Interfaces.
Presented by Dr. Andrew Cook from Beneq Oy
Emerging semiconductor substrates are expected to grow at a 24% CAGR from 2018 – 2024.
More information on https://www.i-micronews.com/products/emerging-semiconductor-substrates-market-technology-trends-2019/
IDEAS company presentation given at the IEEE NSS/MIC 2022. The topic of this presentation was recent products from IDEAS in radiation detection and imaging.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
1. Chief Executive Officer
LLC “Smart-CVD”
VLADIMIR VOLOBUEV
NOVOSIBIRSK 2013
Biocompatible nanostructured
coatings for cardiac implants
2. Pacemaker with electrodes Tip of electrode
Scheme of crossing
ELECTRODE-HEART MUSCLE
Method Disadvantages
Chemical
deposition
- Poor adhesion
- Uneven coating thickness
- Low reproducibility of Technology
- Instability of coating composition
- High consumption of noble metal
Magnetron
spattering
- Needing for a "high vacuum“
- High consumption of noble metal
- High power consumption
Disadvantages of present deposition technologies of
Ir/IrOx coatings for tip of pacemaker electrodes
3. VLADIMIR VOLOBUEV SMART-CVD
- deposition of Ir/IrOx nanostracturated coatings by Pulse Metalorganic
Chemical Vapour Deposition (Pulse MOCVD) method
Advantages of PULSE MOCVD method
Obtaining of film materials with different morphology and layers
structure
Deposition of coatings on various materials
Forming of high-melting-point materials layers under the
temperature much lower than their melting temperatures
(Tdeposition (Ir/IrOx from Ir(aa)3)=350-450 C; Tmelting(Ir)= 2447 С)
Lack of coatings flaking-off
Deposition layer uniformity and homogeneity (of composition)
Possibility of coatings deposition of target thick
Minimum consumption of noble-metals
Possibility of coatings deposition on geometric complex-shaped
details
4. 4
Commercialization
Services for deposition Ir/IrOx coatings on electrodes
customers
Strategic partnerships and production pacing
electrodes
Potential
customers
• Pacemaker electrodes manufactures:
Russian – Elestim
Cardio, Kardioelektronika, IMZ
All world -
Medtronic, Biotronik, Guidant/Boston
Scientific, Vitatron
• Manufacturers of components for pacemaker
electrodes - Heraeus
Market
of coatings for
pacemaker electrodes
• 320 mln.USD*
Perspective
markets
• Stents and medical wire – 500 mln.USD
* - BCC Research
VLADIMIR VOLOBUEV SMART-CVD
5. Last, first and middle names Successful collaboration with:
Chief Executive Officer
– Volobuev Vladimir
Master of Economics and Management
Business education in USA, Netherlands
Strategic Venture Management
Unikon
HuaFu
Derzgava
Head manager of chemical division
- Morozova Natal'ya Borisovna
Doctor of Chemistry, senior researcher, NIICh SB
RAS
Ultramet Inc.
Intel
Air Products and Chemicals Inc.
EADS
Airbus
R&D production facility «Astrophysics»
Construction engineer
- Igumenov Igor Konstantinovich
Doctor of Chemistry, Professor, Head of laboratory,
NIICh SB RAS
Fellow of American Electrochemical society
Scientific adviser
- Gel'fond Nikolaj Vasil'evich
Doctor of Chemistry, Deputy Director for Science,
NIICh SB RAS
Project engineering manager
– Filatov Egor Sergeevich
• PHD, researcher, NIICh SB RAS
VLADIMIR VOLOBUEV SMART-CVD
6. VLADIMIR VOLOBUEV SMART-CVD
1) Partners
- technology companies engaged in the
development of equipment and devices for medicine
- pacemaker electrodes manufactures
2) Investment
100 thousand USD – 1-st round
200 thousand USD – 2-nd round
volobuev.vv@sygma.ru
