1. Sleeve gastrectomy is associated with increased long-term risks of gastric cancer and other cancers due to induced hypergastrinemia and lifelong PPI use for common GERD.
2. Hypergastrinemia from the sleeve and PPI use more than doubles the risk of gastric cancer over time through its role as a cancer growth factor.
3. Many sleeve patients require lifelong PPIs which further increases hypergastrinemia and cancer risks due to the procedure's strong link to developing GERD.
Background: Nonalcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the developed countries. Patients with Nonalcoholic Steatohepatitis (NASH), a subset of NAFLD, are at risk for progressive liver disease and in need of effective treatment options. There is a lack of data assessing sleeve gastrectomy and their effect on NAFLD.
Objective: To assess the effects of Sleeve Gastrectomy (SG) on NAFLD.
Methods: An online search of PubMed, Medline, and Google Scholar was independently carried out by two researchers using key words like Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steato-Hepatitis, Bariatric Surgery, Obesity Surgery, Sleeve Gastrectomy and Liver Biopsy, percutaneous liver biopsy, to identify all articles. Articles were also identified from references of relevant articles. All sleeve gastrectomies that had ntraoperative and postoperative liver biopsies were included.
The Mini-Gastric Bypass:Best Treatment Type 2 Diabetes MellitusDr. Robert Rutledge
The Mini-Gastric Bypass:Best Treatment Type 2 Diabetes Mellitus
Dr K S Kular
Kular Medical Education & Research Society ,
Kular Group of Institutes ,
drkskular@gmail.com
www.kularhospital.com
Il ruolo dell'ecoendoscopia nella diagnosi delle lesioni solide pancreatiche ...Gastrolearning
Gastrolearning II modulo/4a lezione
Il ruolo dell'ecoendoscopia nella diagnosi delle lesioni solide pancreatiche
Prof. A. Larghi - Università Cattolica Sacro Cuore (Roma).
Background: Nonalcoholic Fatty Liver Disease (NAFLD) is the most common liver disease in the developed countries. Patients with Nonalcoholic Steatohepatitis (NASH), a subset of NAFLD, are at risk for progressive liver disease and in need of effective treatment options. There is a lack of data assessing sleeve gastrectomy and their effect on NAFLD.
Objective: To assess the effects of Sleeve Gastrectomy (SG) on NAFLD.
Methods: An online search of PubMed, Medline, and Google Scholar was independently carried out by two researchers using key words like Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steato-Hepatitis, Bariatric Surgery, Obesity Surgery, Sleeve Gastrectomy and Liver Biopsy, percutaneous liver biopsy, to identify all articles. Articles were also identified from references of relevant articles. All sleeve gastrectomies that had ntraoperative and postoperative liver biopsies were included.
The Mini-Gastric Bypass:Best Treatment Type 2 Diabetes MellitusDr. Robert Rutledge
The Mini-Gastric Bypass:Best Treatment Type 2 Diabetes Mellitus
Dr K S Kular
Kular Medical Education & Research Society ,
Kular Group of Institutes ,
drkskular@gmail.com
www.kularhospital.com
Il ruolo dell'ecoendoscopia nella diagnosi delle lesioni solide pancreatiche ...Gastrolearning
Gastrolearning II modulo/4a lezione
Il ruolo dell'ecoendoscopia nella diagnosi delle lesioni solide pancreatiche
Prof. A. Larghi - Università Cattolica Sacro Cuore (Roma).
Information about Obstructed Recto Sigmoid Malignancy by Dr Dhaval Mangukiya.
Details of introduction of obstructed recto sigmoid malignancy, Epidemiology, Pathophysiology, Complications, Early Presentation, Stools, History, Late Presentation, Diagnosis, Imaging, Contrast enema, Screenig, Treatment, Management, Surgical management, Surgical options etc.
https://drdhavalmangukiya.com/
http://www.youtube.com/c/DrDhavalMangukiyaGastrosurgeonSurat
https://gastrosurgerysurat.blogspot.com/
The Mini-Gastric Bypass: Best Treatment Type 2 Diabetes Mellitus
Dr K S Kular
Kular Medical Education & Research Society ,
Kular Group of Institutes ,
drkskular@gmail.com
www.kularhospital.com
Why Consider the MGB?
With the Band/Sleeve/RNY available
Why even consider the Mini-Gastric Bypass?
6 yr study 29,820 BCBS plan members.
"Laparoscopic RNY and Lap Band both Fail to reduce overall health care costs in the long term."
Impact of Bariatric Surgery on Health Care Costs of Obese Persons, A 6-Year Follow-up of Surgical and Comparison Cohorts Using Health Plan Data Jonathan P. Weiner, et al. JAMA Surg. 2013;148(6)
Comparison of Revision in Roux-en-Y vs Mini-Gastric BypassDr. Robert Rutledge
Comparison of Revision in
Roux-en-Y vs
Mini-Gastric Bypass
Dr K S Kular
Kular Medical Education & Research Society
Kular Group of Institutes
drkskular@gmail.com
www.kularhospital.com
Mini Gastric Bypass: initial Experience
British Obesity Metabolic Surgery Society
4 th Annual Scientific Meeting
Jan 23-25, 2013 Glasgow
SPIRE Hospital Southampton
Department of Bariatric Surgery
M Van den Bossche, I Bailey, J Kelly
J Byrne, R Sutherland*
Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface MalignanciesMary Ondinee Manalo Igot
The prognosis of most peritoneal surface malignancies were previously dismal. However, with the incorporation of HIPEC to standard of care, we have been seeing doubling of survival for select malignancies. Appropriate patient selection is crucial.
Information about Obstructed Recto Sigmoid Malignancy by Dr Dhaval Mangukiya.
Details of introduction of obstructed recto sigmoid malignancy, Epidemiology, Pathophysiology, Complications, Early Presentation, Stools, History, Late Presentation, Diagnosis, Imaging, Contrast enema, Screenig, Treatment, Management, Surgical management, Surgical options etc.
https://drdhavalmangukiya.com/
http://www.youtube.com/c/DrDhavalMangukiyaGastrosurgeonSurat
https://gastrosurgerysurat.blogspot.com/
The Mini-Gastric Bypass: Best Treatment Type 2 Diabetes Mellitus
Dr K S Kular
Kular Medical Education & Research Society ,
Kular Group of Institutes ,
drkskular@gmail.com
www.kularhospital.com
Why Consider the MGB?
With the Band/Sleeve/RNY available
Why even consider the Mini-Gastric Bypass?
6 yr study 29,820 BCBS plan members.
"Laparoscopic RNY and Lap Band both Fail to reduce overall health care costs in the long term."
Impact of Bariatric Surgery on Health Care Costs of Obese Persons, A 6-Year Follow-up of Surgical and Comparison Cohorts Using Health Plan Data Jonathan P. Weiner, et al. JAMA Surg. 2013;148(6)
Comparison of Revision in Roux-en-Y vs Mini-Gastric BypassDr. Robert Rutledge
Comparison of Revision in
Roux-en-Y vs
Mini-Gastric Bypass
Dr K S Kular
Kular Medical Education & Research Society
Kular Group of Institutes
drkskular@gmail.com
www.kularhospital.com
Mini Gastric Bypass: initial Experience
British Obesity Metabolic Surgery Society
4 th Annual Scientific Meeting
Jan 23-25, 2013 Glasgow
SPIRE Hospital Southampton
Department of Bariatric Surgery
M Van den Bossche, I Bailey, J Kelly
J Byrne, R Sutherland*
Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface MalignanciesMary Ondinee Manalo Igot
The prognosis of most peritoneal surface malignancies were previously dismal. However, with the incorporation of HIPEC to standard of care, we have been seeing doubling of survival for select malignancies. Appropriate patient selection is crucial.
MGB is Great Look at the Data
MGB widespread persistent Confusion
Fear of Malnutrition
Need MGB Standardization Education Recognition of MGB Surgeons of Excellence
O. Glehen - HIPEC in colorectal carcinomatosisGlehen
Pr Olivier Glehen presents HIPEC in colorectal carcinomatosis in Slovenia 2013. Présentation de la CHIP dans la carcinose péritonéale d'origine colorectale.
A Prospective Study on Role of Water Soluble Contrast in Management of Small ...Kundan Singh
There is no definite protocol in management of small bowel obstruction in relation to duration and need of surgery. The aim is to study the role of gastrografin in management of small bowel obstruction.In this study patients who were diagnosed with intestinal obstruction were administered gastrografin. The patients were followed serially using x-ray at 4hrs interval for 24hrs; decision to operate was taken on non-progression of dye in two consecutive x-ray. Among 20 patients of this study 9 patients were operated on basis of gastrografin study. 11 were treated conservatively. 8 patients were of adhesive bowel obstruction. Out of which 1 was operated, 7 were treated conservatively. The sensitivity, specificity, positive and negative predictive value of gastrografin administration in this study was 100%, 89%, 92%, 100% respectively.Gas¬trografin helps in strengthening the clinical decision about the management of intestinal obstruction; it helps in early decision making regarding continuing the conservative or operative management and allows the introduction of oral intake earlier and earlier discharge from the hospital as well as reduction in operative rate.
Drs. Rossi and Shreve’s CMC Abdominal Imaging Mastery Project: May CasesSean M. Fox
Dr. Brian Shreve is an Emergency Medicine Resident and Dr. Isolina Rossi is a Surgery Resident at Carolinas Medical Center in Charlotte, NC. They are interested in medical education. With the guidance of Drs. Kyle Cunningham and Michael Gibbs, they aim to help augment our understanding of emergent abdominal imaging. Follow along with the EMGuideWire.com team as they post these monthly educational, self-guided radiology slides on:
• Splenic Laceration
• Necrotizing Pancreatitis
• Hepatic Abscess
Drs. Penzler, Ricker, and Ahmad’s CMC Abdominal Imaging Mastery Project: Dece...Sean M. Fox
Dr. Morgan Penzler is an Emergency Medicine Resident and Drs. Raza Ahmad and Ansley Ricker are Surgery Residents at Carolinas Medical Center in Charlotte, NC. They are interested in medical education. With the guidance of Drs. Kyle Cunningham and Michael Gibbs, they aim to help augment our understanding of emergent abdominal imaging. Follow along with the EMGuideWire.com team as they post these monthly educational, self-guided radiology slides. This month’s cases include:
- Gastric Perforation
- Pneumoperitoneum
- Lower GI Bleed
- Parastomal Hernia
The Mini-Gastric BypassDr Rutledge, DrR@CLOS.netFour Stories for Four Radical Ideas
20 minutes, 4 topics
5 minutes each
1. (Mis)Understanding the MGB Mechanism of action
2. MGB Paradox (Good MGB/Bad MGB)
3. MGB: BP Limb Length
4. MGB-OT to the new MGB2i
The Mystery of Bile or No Bile:“Elementary My Dear Watson!”
Why the two opposite studies of the MGB
1. Minimal Bile Reflux
2. Common Bile Reflux
Answer: 1. Skill and knowledge of the Surgeons & 2. Propper care and education of post op patients
Conclusion: Don't Do the MGB! If You Don't Know What You are Doing
Rx Lifestyle & Diet Plan
Simple Diet & Lifestyle Changes: Rx gut microbiome: Plain Yogurt / Curd / Fermented Dairy:1-2 tsps 3-6 x / Day.
Stop smoking, NSAIDs, Iron, “Supplements”, Vitamins & Medications
Before Meals, Stay upright after eating, Small meals, Limit fatty foods,
Avoid problem (junk) foods: soda, candy, fried foods, caffeinated and carbonated drinks, chocolate, citrus juices, vinegar dressings & mint, etc.
Limit or avoid alcohol, Eat slowly, small amounts, chew thoroughly and rest between bites,
Keep head up for 30-90 minutes post meals, relax for 30-90 minutes after meals.
Understanding Weight Loss After Bariatric SurgeryUnderstanding the Bilio-Pancreatic Limb Length
Statistics, Random Distribution and Too Little or Too Much of a Good Thing
The Billroth II is a good safe operation
Routinely used daily by General, Trauma and Cancer Surgeons Around the world
Studies show surgeons who are more fearful of Billroth II and cancer are the least knowledgeable about the scientific data on the Billroth II and Gastric Cancer
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
2. “Long-term PPI Use Tied to
Doubled Risk for Gastric Cancer”
• Long term Proton-pump inhibitors (PPI)
• More than doubles the Risk of Gastric Cancer,
• in a population-based study
• “Long-term use of PPIs associated with an increased
Gastric Cancer Risk
Even in subjects after H.Pylori Rx”
• http://gut.bmj.com/content/early/2017/09/18/gutjnl-2017-314605
• https://www.medscape.com/viewarticle/887863
3. Hypergastrinemia and Gastric Cancer
• Sleeve gastrectomy induces hypergastrinemia
• Gastrin has been identified as the principal effector of gastric
secretion,
• Several studies have demonstrated its role as a biomarker of
cancer risk & Growth factor for colorectal, stomach, liver, and
pancreatic cancer.
• Gastrin: from pathophysiology to cancer prevention and treatment.
• https://www.ncbi.nlm.nih.gov/pubmed/24469263
• Surg Endosc. 2015 Mar;29(3):723-33. The effect of duodenojejunostomy and sleeve gastrectomy on type 2 diabetes
mellitus and gastrin secretion in Goto-Kakizaki rats. Grong E
4. Gastrin and Gastric Cancer - NCBI - NIH
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239792/
• by HL Waldum - 2017 - Cited by 8 - Related articles
• Jan 17, 2017 - The role of gastrin in gastric
carcinogenesis implies caution in the long-term treatment
with inhibitors of gastric acid secretion inducing secondary
hypergastrinemia, in a common disease like
gastroesophageal reflux disease.
5. Sleeve => Increased Gastrin
=> Gastric Cancer
• SG may be associated with increased gastrin levels in both
human and rodents [13, 14]
• Gastrin levels of the SG group increased significantly compared
with those of the control group.
• Food Nutr Res. 2016 Apr 15; Metabolic and histopathological effects of sleeve gastrectomy
and gastric plication: an experimental rodent model. Gulcicek OB
7. Sleeve gastrectomy & proton pump
inhibitors after surgery
• "Proton pump inhibitors and gastric cancer: a
long expected side effect"
• "For 30 years, we have worked with the role of
gastrin and the risk of PPI treatment with
respect to gastric cancer and published more
than 200 papers and letters in this field. "
8. Sleeve gastrectomy & proton pump
inhibitors after surgery
• (Ed Note: Sleeve => Increased Gastrin Levels =>
Increased Risk of GI cancers)
• "we always have concluded that PPI treatment in
the long term would cause gastric cancer, "
• "Around 1980, it became clear that
hypergastrinemia, ... resulted in ... tumours.
9. Sleeve gastrectomy & proton pump
inhibitors after surgery
• "PPIs ... caused tumours in the rat.Ref 3 "
• " Omeprazole was accepted for use in patients with
severe diseases due to gastric acid hypersecretion.
However, PPIs were soon used in less severe
cases and are now prescribed to patients with
minor complaints from the upper abdomen (10% of
the population in the Western world)."
10. Sleeve gastrectomy & proton pump
inhibitors after surgery
• "We recall Kenneth Wormsley’s words
about the acceptance of omeprazole for
clinical use: “The first compound accepted
for use in humans after having induced
cancer in its target organ”; a taboo was
broken. "
11. Sleeve gastrectomy & proton pump
inhibitors after surgery
• "Early, it was recognised that PPIs induced
hypergastrinemia and ECL cell hyperplasia.9"
• "Recently, a study from Finland found that patients with
high gastrin values in samples from the eighties had
increased risk of gastric cancer,10"
• (Ed Note: Sleeve => Increased Gastrin Levels =>
Increased Risk of GI cancers)
• "the carcinogenic effect of H. pylori infection is best
explained by the hypergastrinemia"
12. Sleeve gastrectomy & proton pump
inhibitors after surgery
• "We conclude that the carcinogenic effect
by PPI treatment is due to
hypergastrinemia, which should have
been realised decades ago before
exposing so many patients to a risk of a
serious disease."
13. Sleeve gastrectomy & proton pump
inhibitors after surgery
• "We conclude that the carcinogenic effect by PPI
treatment "(and the Sleeve?)
• "is due to hypergastrinemia, "
• which
• "should have been realised decades ago"
• "before exposing so many patients to a risk of a
serious disease."
14. Gastroesophageal Reflux Disease After
Laparoscopic Sleeve Gastrectomy
New-onset GERD in 47%
• Obes Surg. 2018 Apr;28(4)
• Prevalence and Predictors of Gastroesophageal Reflux Disease After
Laparoscopic Sleeve Gastrectomy.
• Althuwaini S
15. Sleeve Long Term Failure
• Meta-analysis on published data with at least 7
years of follow-up
• Nine cohort studies met the inclusion criteria, with a
total of 2280 patients
• At ≥7 years, the long-term weight failure rate was
estimated to be 28%; Revision 20%
• Surg Obes Relat Dis. 2018 Mar 6, Long term (7 or more years)
outcomes of the sleeve gastrectomy: a meta-analysis. Clapp B
16. Gastroesophageal reflux disease (GERD)
after sleeve gastrectomy
• “CONCLUSIONS: One year after SG,
esophageal acid exposure globally
worsened, mostly because of de novo
GERD”
• Obes Surg. 2018 Mar;28(3):838-845. Gastroesophageal
Reflux After Sleeve Gastrectomy: a Prospective
Mechanistic Study. Coupaye M
17. Surg Obes Relat Dis. 2018 Gastroesophageal reflux disease symptoms and
esophageal lesions after sleeve gastrectomy. Soricelli E
• After a mean follow-up of 66 months,
GERD symptoms and PPI intake were
recorded in 70% & 64% of patients
• Erosive esophagitis 60%, Barrett's
esophagus 13%.
• Esophageal biliary reflux was 68%.
18. Swiss Multicenter Bypass or Sleeve Study
(SM-BOSS)
• Swiss Multicenter Bypass or Sleeve Study (SM-BOSS), a 2-group
randomized trial, was conducted from January 2007 until November 2011
(last follow-up in March 2017). Of 3971 morbidly obese patients evaluated for
bariatric surgery at 4 Swiss bariatric centers, 217 patients were enrolled
• Gastric reflux worsened (more symptoms or increase in therapy) more often
after sleeve gastrectomy (31.8%) than after Roux-en-Y gastric bypass
(6.3%). The number of patients with reoperations or interventions was 16/101
(15.8%) after sleeve gastrectomy and 23/104 (22.1%) after Roux-en-Y
gastric bypass.
• JAMA. 2018 Jan 16;319(3):255-265. Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on
Weight Loss in Patients With Morbid Obesity: The SM-BOSS Randomized Clinical Trial. Peterli R
19. Prevalence of GERD symptoms, EE, and
HH was increased after LSG
• Prospective observational study. 18-month follow-up
• GERD symptoms increased from 33% to 44%
• EE from 20.1% to 33.9%
• HH from 22% to 34.8%
• Postoperative findings on symptomatic patients were as follows:
• EE was found in 64.5%,
• HH in 23%,
• Only 12.5% had normal EGD.
• Symptoms de novo were observed in 36.9% of patients, EE in 28.7%, and HH in 16.4%.
•
• J Laparoendosc Adv Surg Tech A. 2018 Jan;28(1):71-77 Laparoscopic Sleeve Gastrectomy: Endoscopic Findings and
Gastroesophageal Reflux Symptoms at 18-Month Follow-Up. Viscido G
20. Sleeve Causes GERD. And Need for PPI Rx.
• After LSG, 60% (n = 60) of patients reported
recurring GERD symptoms and
• 44% were treated with proton pomp inhibitors
(PPI).
• In 93% of these cases, GERD has developed de
novo.
• Obes Surg. 2018 Jan;28(1):130-134. doi: 10.1007/s11695-017-2795-2.
• Long-Term Outcomes of Laparoscopic Sleeve Gastrectomy-a Single-Center, Retrospective Study.
• Kowalewski PK1
21. GERD & PPIs following sleeve gastrectomy
• At 12 months postoperatively,
• sleeve gastrectomy patients had a high rate of
• overall PPI use (48%),
• new PPI use (35%), and
• persistent PPI use (79%)
• and Significantly higher when compared to gastric bypass
patients.
• Surg Endosc. 2017 Jan;31(1), GERD and acid reduction medication use
following gastric bypass and sleeve gastrectomy. Barr AC
22. HelicoBacter, Gastric & Gastric Cancer
• Helicobacter pylori infection is associated with atrophic
• gastritis, which can progress to gastric cancer in some
patients.
• Proton pump inhibitor (PPI) use has also been reported
• as a risk factor for atrophic gastritis. The risk is particularly
• high among individuals infected with H. pylori who
• are susceptible to the development of corpus atrophy
23. Sleeve, PPIs, Hyper-gastrin & Cancer
• Sleeve & PPIs => INCREASED Gastrin
• “causal effect of gastrin on neoplastic
progression in Barrett’s esophagus (BE)”