The document discusses keys to success in rapidly changing times. It outlines 7 principles: 1) extrapolation is the best starting point for prediction, 2) improbable events will have outsized influence, 3) mindset matters more than skill sets, 4) growth mindset creates optionality, 5) think analogically, 6) develop a "barbell" risk profile, 7) pursue personal growth. It then discusses Mayo Clinic's use of social media and digital skills, highlighting innovations like Facebook Live and ways to develop deeper relationships through platforms like the Mayo Clinic Social Media Network and Connect.