The document outlines six "Signals of Change" that are essential for organizations to understand to future-proof their success. The signals are: 1) Learning from the Future by using data analytics to anticipate trends, 2) Pushing decision-making to decentralized teams at the "edges", 3) Making sustainability and social purpose central to operations, 4) Restructuring supply chains to fulfill demands locally, 5) Using virtual environments to redefine how people work and interact, and 6) Applying scientific methods across industries to create sustainable innovations. The document argues that recognizing and responding to these signals will help organizations capitalize on opportunities emerging from the changing global landscape.