Fluoroquinolone antibiotics can cause several new adverse reactions according to reports from the FDA and EMA, including blood sugar disturbances, mental health issues like attention problems and delirium, and a small increased risk of aortic aneurysm. The document warns that fluoroquinolones should be used cautiously in elderly patients, those with renal failure, organ transplant patients, and those who have experienced the reported adverse effects. Medical professionals are instructed to stop fluoroquinolone use if any of these adverse effects present and to document individual cases. Local applications of fluoroquinolones like eye drops are considered safe.

1. ‫االدوية‬ ‫استعالمات‬ ‫مركز‬ /‫الدوائي‬ ‫الرصد‬ ‫وحدة‬
Short notes II: Fluoroquinolone’s
Updates
New Adverse reactions reportedby FDA/EMA for systemic use
Blood sugar disturbances (potential risk of hypoglycaemic coma)
Mental health S.E (attention disturbances, disorientation, agitation,
nervousness, memory impairments & delirium)
Small increased risk of aortic aneurysm & dissection
Used in caution with pt. showed the reported A.E previously, especially
Elderly
Renal failure pt.
Organ transplant pt.
IN CASE OF PRESENCEOF THESE A.E PLEASE STOP USING
FLUOROQUINOLONE & DOCUMENT YOUR CASES WITH
INDIVIDUAL CASE SAFETY REPORTS
Where is it safe to give fluoroquinolones
Local applications
Drops
Ref. ( ‫المرقم‬ ‫الدوائي‬ ‫الرصد‬ ‫وحدة‬ /‫الصيدلة‬ ‫قسم‬ ‫اعمام‬63‫بتاريخ‬8/1/2019 )