Spinal muscular atrophy is a neuromuscular disease caused by a genetic mutation that results in a lack of the survival motor neuron protein. The disease leads to degeneration of motor neurons and muscle atrophy. A potential new treatment involves using antisense oligonucleotides to modify gene splicing and increase production of the survival motor neuron protein in motor neurons. RNA structures were likely important before the evolution of DNA as some bacteria have RNA sensors that control gene expression. Discovering these ancient RNA remnants helps understand evolutionary relationships between species. Redirecting alternative splicing through antisense oligonucleotides could treat diseases caused by splicing errors like spinal muscular atrophy.

4. INTRODUCTION

5. THE SPINAL MUSCULAR ATROPHY MIGHT SOON BE TREATMENT WITH CHEMICALLY MODIFY

9. STUDENT OBSERVATION I think that antisense oligonucleotides open the possibility to improve the genetic mistake that cause some hereditary diseases.

10. THE DISCOVER OF AN ANCIENT GENETIC REMNANT FROM A TIME BEFORE DNA EXISTED

14. STUDENT OBSERVATION Structure like RNA in the C. Difficile, could be a power tool in the determination of evolutive relations between different species

18. MEDICAL UTILITY

20. THANKS