This study explored increasing yields in Luffa cylindrica (smooth patola) through pruning and high density planting. Seedlings were pruned at either the 4-leaf stage (Type I) or the 2-leaf stage followed by pruning of primary branches at the 2-leaf stage (Type II). Plants were grown at various branch densities from 30 to 106,666 branches per hectare. Type I pruning resulted in earlier flowering and first harvest compared to Type II pruning, but pruning treatments did not significantly affect fruit yield or characteristics. Pruning reduced plant size and led to earlier branching, which can allow for higher density planting and increased yields per unit area.