Spring 2010-Seminar Flier
•Download as DOC, PDF•
0 likes•203 views
The seminar will discuss the role of Wnt signaling in the pathogenesis of Alzheimer's disease. Wnt signaling is involved in critical developmental processes and adult tissue homeostasis. In the brain, Wnt signaling maintains synaptic structure and function and plays a role in long term potentiation. Exposure to beta-amyloid, a pathological feature of Alzheimer's, disrupts Wnt signaling proteins like frizzled, disheveled, and GSK-3beta, leading to neurodegeneration. Emerging evidence suggests activating Wnt signaling through Wnt ligands or related pathways could serve as a potential therapeutic approach for Alzheimer's disease.
Report
Share
Report
Share
Recommended
Plegable
The two documents discuss research into potential new treatments for prion diseases and myotonic dystrophy. The first reports that the protein folding activity of the ribosome (PFAR) plays a key role in prion propagation, and that drugs targeting PFAR show promise as antiprion medicines. The second describes how aberrant splicing in myotonic dystrophy changes a muscle enzyme and fiber types, driving muscle wasting. Both highlight the importance of understanding RNA splicing and protein synthesis defects to develop new therapies for neurodegenerative and muscle diseases.
Breast cancer
Mutations are changes in genomic sequences that can be caused by radiation, viruses, or transposons. Mutations may have no effect, prevent gene function, or alter protein production. Heredity is the passing of traits from parents to offspring, allowing variation to accumulate and lead to evolution over generations. DNA carries genetic information and is copied for each new cell, with the location of a sequence on a chromosome called a locus.
Microbiology.
Prions are proteinaceous pathogens that cause transmissible spongiform encephalopathies (TSEs) by changing their structure from a normal alpha helix form (PrPC) to an abnormal beta-pleated sheet form (PrPSc). Current treatments aim to reduce PrPC conversion through RNA interference or active DNA vaccination, but these have limitations. While RNAi risks saturating proteins and reducing long-term effectiveness, active DNA vaccination may delay but not prevent disease progression. Chemically modified oligonucleotides can also bind PrPC and prevent conversion, but their effects are very toxic. The best current option is active DNA vaccination, as it delays onset without adverse side effects like the other treatments.
Next Homework
This document lists vocabulary terms from biology and genetics chapters that are due for definitions on Monday March 9th, 2009. The terms are from chapters 2 through 8 and include diseases, genes, proteins, cells and scientific processes. Additional vocabulary from the prologue and chapter one are also included for definitions.
Splicing / Molecular Biology
This presentation is aimed at show some of the benefits of alternative splicing from the analysis of some current researchs.
DNA REPARATION ELISA OROZCO
This document summarizes research on mechanisms for repairing damaged DNA, including non-homologous end joining and homologous recombination. It discusses how enzymes act to replace lost DNA information before joining, and how further research on these enzymes may help prevent diseases like cancer via gene therapy. The document also discusses how the p53 tumor suppressor protein prevents genome mutation, and research showing statins may help prevent damage caused by mutated p53 and prevent its destruction by enzymes. Statins are said to have potential benefits for treating cancer by preventing chemotherapy resistance and metastasis. Overall, further research on DNA repair mechanisms and related proteins is said to lead to improved control of diseases through prevention, detection and treatment approaches.
Antisense therapy
This document discusses antisense therapy, which uses synthetic nucleic acid strands to bind to messenger RNA (mRNA) and inactivate genes that cause diseases. It describes first, second, and third generation antisense oligonucleotides that have improved stability and binding affinity. Various chemical modifications like locked nucleic acids and peptide nucleic acids are also discussed. The document also mentions delivery vectors like liposomes that protect antisense drugs from degradation and help target sites of disease. Examples of antisense agents targeting genes involved in cancer, HIV, and other conditions are provided.
Eukaryotic RNA processing: alternative RNA splicing
Alternative splicing is a process by which cells produce multiple protein isoforms from individual genes. Understanding the functions and interactions of alternatively spliced protein isoforms is important for understanding disease. A new study found that two proteins, PRMT1 and RBM15, regulate the differentiation of megakaryocytes, blood cells involved in platelet production, through alternative splicing. Mutations in these proteins have been linked to blood cancers. Further research on alternative splicing may help identify new disease targets and therapies.
Recommended
Plegable
The two documents discuss research into potential new treatments for prion diseases and myotonic dystrophy. The first reports that the protein folding activity of the ribosome (PFAR) plays a key role in prion propagation, and that drugs targeting PFAR show promise as antiprion medicines. The second describes how aberrant splicing in myotonic dystrophy changes a muscle enzyme and fiber types, driving muscle wasting. Both highlight the importance of understanding RNA splicing and protein synthesis defects to develop new therapies for neurodegenerative and muscle diseases.
Breast cancer
Mutations are changes in genomic sequences that can be caused by radiation, viruses, or transposons. Mutations may have no effect, prevent gene function, or alter protein production. Heredity is the passing of traits from parents to offspring, allowing variation to accumulate and lead to evolution over generations. DNA carries genetic information and is copied for each new cell, with the location of a sequence on a chromosome called a locus.
Microbiology.
Prions are proteinaceous pathogens that cause transmissible spongiform encephalopathies (TSEs) by changing their structure from a normal alpha helix form (PrPC) to an abnormal beta-pleated sheet form (PrPSc). Current treatments aim to reduce PrPC conversion through RNA interference or active DNA vaccination, but these have limitations. While RNAi risks saturating proteins and reducing long-term effectiveness, active DNA vaccination may delay but not prevent disease progression. Chemically modified oligonucleotides can also bind PrPC and prevent conversion, but their effects are very toxic. The best current option is active DNA vaccination, as it delays onset without adverse side effects like the other treatments.
Next Homework
This document lists vocabulary terms from biology and genetics chapters that are due for definitions on Monday March 9th, 2009. The terms are from chapters 2 through 8 and include diseases, genes, proteins, cells and scientific processes. Additional vocabulary from the prologue and chapter one are also included for definitions.
Splicing / Molecular Biology
This presentation is aimed at show some of the benefits of alternative splicing from the analysis of some current researchs.
DNA REPARATION ELISA OROZCO
This document summarizes research on mechanisms for repairing damaged DNA, including non-homologous end joining and homologous recombination. It discusses how enzymes act to replace lost DNA information before joining, and how further research on these enzymes may help prevent diseases like cancer via gene therapy. The document also discusses how the p53 tumor suppressor protein prevents genome mutation, and research showing statins may help prevent damage caused by mutated p53 and prevent its destruction by enzymes. Statins are said to have potential benefits for treating cancer by preventing chemotherapy resistance and metastasis. Overall, further research on DNA repair mechanisms and related proteins is said to lead to improved control of diseases through prevention, detection and treatment approaches.
Antisense therapy
This document discusses antisense therapy, which uses synthetic nucleic acid strands to bind to messenger RNA (mRNA) and inactivate genes that cause diseases. It describes first, second, and third generation antisense oligonucleotides that have improved stability and binding affinity. Various chemical modifications like locked nucleic acids and peptide nucleic acids are also discussed. The document also mentions delivery vectors like liposomes that protect antisense drugs from degradation and help target sites of disease. Examples of antisense agents targeting genes involved in cancer, HIV, and other conditions are provided.
Eukaryotic RNA processing: alternative RNA splicing
Alternative splicing is a process by which cells produce multiple protein isoforms from individual genes. Understanding the functions and interactions of alternatively spliced protein isoforms is important for understanding disease. A new study found that two proteins, PRMT1 and RBM15, regulate the differentiation of megakaryocytes, blood cells involved in platelet production, through alternative splicing. Mutations in these proteins have been linked to blood cancers. Further research on alternative splicing may help identify new disease targets and therapies.
Antisense oligonucleotide therapy
This document provides an overview of antisense oligonucleotide therapy, including its definition as synthetic genetic material that binds to mRNA to prevent protein translation, mechanisms of action such as blocking ribosomes and activating RNase enzymes, applications in oncology and other therapeutic areas, examples of compounds in clinical trials, and its future potential as over 30 compounds are currently in clinical trials.
Single nucleotide polymorphism (sn ps)
Single nucleotide polymorphisms (SNPs) are variations in single nucleotides that occur at specific positions in the genome. For example, the base C may appear in most individuals at a specific position, but in some individuals the position is occupied by base A, representing a SNP. SNPs can be classified as synonymous or nonsynonymous depending on whether they change the amino acid sequence. Common human diseases like sickle cell anemia and cystic fibrosis result from SNPs. SNPs can be identified and analyzed using methods like DNA sequencing, mass spectrometry, and primer extension.
Genetic polymorphisms
This document discusses genetic polymorphisms and summarizes several research studies. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes three key points:
1) A study that used a cross-species strategy to identify 6 causal genes for Alzheimer's disease by studying interactions between human genes and neurotoxicity in the fly model.
2) Research confirming the association between a genetic variant in the PLA2R gene and membranous nephropathy through genome-wide association studies and previous Asian studies.
3) The potential medical benefits of these discoveries such as earlier diagnosis, improved treatment, and further genetic research.
Anti sense drugs
Antisense drugs work by binding to mRNA to prevent protein production from mutated genes causing genetic disorders. They are short DNA sequences that match the mRNA sequence. First generation antisense oligonucleotides used phosphorothioate modifications but had toxicity issues. Second generation ones use 2'-O-methyl and 2'-O-methoxyethyl modifications, showing better stability and less toxicity. Newer third generation modifications like PNA and LNA further increase binding affinity and stability. Effective delivery remains a challenge, with liposomes and nanoparticles being investigated to protect antisense drugs and deliver them to target tissues.
Genetic polymorphisms pptx
This document discusses genetic polymorphisms and summarizes several articles on related topics. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes findings from articles on using cross-species strategies to study human disease like Alzheimer's, identifying genes linked to membranous nephritis and autoantibodies, and discusses the medical utility of early diagnosis and improved treatment from genetic studies.
Single nucleotide polymorphism
Single Nucleotide Polymorphism (SNP)
Polymorphism is a generic term that means 'many shapes‘. It is the ability to appsear in different form .
A single nucleotide polymorphism (SNP) is a DNA sequence variation occurring when a single nucleotide - A, T, C, or G - in the genome differs between members of a species (or between paired chromosomes in an individual).
For example, two sequenced DNA fragments from different individuals, AAGCCTA to AAGCTTA, contain a difference in a single nucleotide. For a variation to be considered a SNP, it must occur in at least 1% of the population.
CHARACTERISTICS OF SNP
• In human beings, 99.9 percent bases are same.
• Remaining 0.1 percent makes a person unique.
• Different attributes / characteristics / traits
• How a person looks, diseases he or she develops.
These variations can be:
Harmless (change in phenotype)
Harmful (diabetes, cancer, heart disease, Huntington's disease, and hemophilia )
Latent (variations found in coding and regulatory regions, are not harmful on their own, and the change in each gene only becomes apparent under certain conditions e.g. susceptibility to lung cancer)
TYPES OF SNP
NON-CODING REGION
A segment of DNA that does comprise a gene and thus does not code for a protein .
CODING REGION
Regions of DNA/RNA sequences that code for proteins
Synonymous
A SNP in which both forms lead to the same polypeptide sequence is termed synonymous
(sometimes called a silent mutation).
Non synonymous
If a different polypeptide sequence is produced they are non synonymous . A non synonymous change may either be missense or nonsense, where a missense change results in a different amino acid, while a nonsense change results in a premature stop codon.
SNP Applications
• Gene discovery and mapping
• Association-based candidate polymorphism testing
• Diagnostics/risk profiling
• Response prediction
• Homogeneity testing/study design
• Gene function identification
mRNA vaccine-10
Naked mRNA Vaccines
mRNA vaccines can be delivered without any additional carriers, that is, in a naked
format. In this method, mRNA is dissolved in buffer and then injected directly.
https://www.creative-biolabs.com/vaccine/mrna-pharmacology-optimization-platform.htm
Dr. Jessica Mar to Speak
Variation occurs at all biological levels and confers robustness and phenotypic diversity. This document discusses sources of variation including physical variants in proteins and receptors, gene expression, microRNAs, structural variants in DNA like deletions and duplications, and epigenetic factors. A study uses stem cells derived from nasal biopsies of Parkinson's and schizophrenia patients and controls to establish cell lines for investigating the molecular underpinnings of neurological diseases. The variance of gene expression across patients is analyzed to identify altered gene networks in disease.
Vital breakthrough in epilepsy genetics
Foundation dedicated to innovating towards precision medicine and ultimately a cure for mutations in the SCN2a gene.
Pre-mRNA splicing and human disease
This document summarizes research on how aberrant pre-mRNA splicing can cause human disease. It notes that 25% of inherited disease-causing mutations affect splicing enhancers and silencers. The study aims to validate mutations in PINK1, a gene associated with Parkinson's disease, that create splicing silencer hexamers and are predicted to disrupt splicing. The researchers will transfect cells with PINK1 reporter constructs containing wild-type or mutant sequences and use RT-PCR and gel electrophoresis to analyze changes in splicing patterns caused by the mutations.
Snp
SNPs are found in
coding and (mostly) noncoding regions.
Occur with a very high frequency
about 1 in 1000 bases to 1 in 100 to 300 bases.
The abundance of SNPs and the ease with which they can be measured make these genetic variations significant.
SNPs close to particular gene acts as a marker for that gene.
SNPs in coding regions may alter the protein structure made by that coding region.
A SNP is defined as a single base change in a DNA sequence that occurs in a significant proportion (more than 1 percent) of a large population. Sequence genomes of a large number of people
Compare the base sequences to discover SNPs.
Generate a single map of the human genome containing all possible SNPs => SNP maps
Level of Tumor Protein Indicates Chances Cancer Will Spread AND Malfunctionin...
1) Researchers discovered a protein called CPE-delta N that is present at high levels in tumors that have metastasized. Tests measuring levels of a molecule that assists in producing CPE-delta N could predict cancer spread, even when conventional techniques suggested it was unlikely.
2) When CPE-delta N RNA levels in a tumor were more than twice the surrounding tissue, cancer was highly likely to metastasize within two years. Levels over 1 million copies indicated cancer appeared again or metastasized, while less than 250,000 copies meant no metastasis or reappearance.
3) Studies on the TDP-43 protein, which forms clumps in ALS and FTLD nerve cells, showed its
Somatic activating kras mutations in arteriovenous malformation
The document discusses a study investigating somatic activating KRAS mutations in arteriovenous malformations. The study aimed to determine if KRAS mutation is a genetic marker for arteriovenous malformation and analyze the relationship between abnormal MAPK-EPK signaling and tissue defects. The study analyzed 72 patients and found somatic activating KRAS mutations in arteriovenous malformation tissue samples. The findings suggest KRAS mutation may be a genetic factor associated with arteriovenous malformations.
Snp
This document discusses single nucleotide polymorphisms (SNPs). It defines SNPs as single base changes in DNA sequences that occur in at least 1% of a large population. The document notes that while human genomes are 99.9% identical, there are positions where some people have one nucleotide pair while others have another, which are called SNPs. SNPs are described as the most common form of genetic variation, with over 90% of human genetic variations coming from SNPs. The uses and implications of SNPs are also summarized.
synapse microarray ppt
1) Synaptogenesis is the formation of synapses between neurons, neurons and muscles, or neurons and glands. It begins prenatally and continues rapidly after birth for several years before slowing.
2) A synapse microarray consists of microwells containing neuronal cells in one compartment connected by microchannels to a second compartment containing non-neuronal cells expressing synaptic proteins. This increases synaptogenesis by precisely positioning the cells.
3) Screening chemical libraries using the synapse microarray allows for ultra-sensitive, high-throughput identification of chemicals that increase synaptogenesis. Inhibitors of histone deacetylase (HDAC) were found to increase expression of neuroligin-1, promoting
Seminario Biologia Molecular
The document discusses bone mesenchymal stem cell-derived extracellular vesicles (exosomes) encapsulated in thermosensitive hydrogels for accelerating osteogenesis and angiogenesis. Mesenchymal stem cells and exosomes released from them play an important role in bone formation. Laboratory techniques like western blot, immunofluorescence, and RT-qPCR were used to analyze protein expression and exosome uptake related to bone formation and angiogenesis. The investigation represents a breakthrough that could allow bone regeneration through exosome therapy and avoid more invasive procedures.
mRNA vaccine-9
Liposome delivery mRNA has unique advantages
https://www.creative-biolabs.com/vaccine/mrna-pharmacology-optimization-platform.htm
Snp and its role in diseases
Single nucleotide polymorphisms (SNPs) are variations in single nucleotides that occur at specific positions in the genome between individuals. There can be 10-30 million SNPs in the human genome, typically found in non-coding DNA between genes. SNPs are important for understanding an individual's response to pathogens, chemicals, drugs, and vaccines as well as realizing personalized medicine. The Human HapMap Project analyzed DNA from different populations to identify haplotypes, sets of SNPs on the same chromosome, that are associated with diseases. The project identified over 50 disease-associated genes and its data has helped find genetic contributors to conditions like diabetes, Crohn's disease, and several cancers.
Seminar presentation on snp (mulualem & janvier)
Single nucleotide polymorphisms (SNPs) are variations in a single DNA nucleotide that occur in over 1% of the population. SNPs are the most common type of genetic variation among humans, as 99.9% of human DNA sequences are identical, while the remaining 0.1% makes each individual unique. Modern techniques can efficiently determine the status of large numbers of SNPs, which promises to advance our understanding and treatment of human disease.
NETs and cardiomyocytes
Neutrophil extracellular traps and it's possible role in cardiac pathology. The experience of cocultivation of neutrophils and cardiomyocytes. The role of proteasomal proteolysis in NETs formation.
Notch signaling pathway
The Notch signaling pathway is a highly conserved cell signaling system that regulates cell differentiation, proliferation, and fate determination during embryonic and adult development. It involves transmembrane Notch receptors that are activated via cell-cell contact with Notch ligands, leading to proteolytic cleavage and release of the Notch intracellular domain which enters the nucleus to regulate gene expression. Notch signaling plays important roles in various processes including neurogenesis, cardiovascular development, and lymphocytic leukemia, where deregulation of Notch signaling can promote cancer. Inhibitors of Notch signaling such as gamma secretase inhibitors are being investigated as potential cancer therapies but have shown limited efficacy due to off-target effects.
Targetted therapies gyn oncology
This document provides a summary of a presentation on molecular signaling pathways and their implications in gynecologic oncology. The presentation discusses various oncogene and tumor suppressor pathways involved in cancer development, including EGFR, VEGFR, Wnt, TGF-β, p53, and others. It also covers DNA damage repair pathways and mechanisms of apoptosis evasion. Targeted therapy approaches for gynecologic cancers are explored, such as monoclonal antibodies (-mabs) targeting receptors and small molecule inhibitors (-nibs) targeting intracellular signaling proteins. Immunotherapy strategies like immune checkpoint inhibitors are also mentioned.
More Related Content
What's hot
Antisense oligonucleotide therapy
This document provides an overview of antisense oligonucleotide therapy, including its definition as synthetic genetic material that binds to mRNA to prevent protein translation, mechanisms of action such as blocking ribosomes and activating RNase enzymes, applications in oncology and other therapeutic areas, examples of compounds in clinical trials, and its future potential as over 30 compounds are currently in clinical trials.
Single nucleotide polymorphism (sn ps)
Single nucleotide polymorphisms (SNPs) are variations in single nucleotides that occur at specific positions in the genome. For example, the base C may appear in most individuals at a specific position, but in some individuals the position is occupied by base A, representing a SNP. SNPs can be classified as synonymous or nonsynonymous depending on whether they change the amino acid sequence. Common human diseases like sickle cell anemia and cystic fibrosis result from SNPs. SNPs can be identified and analyzed using methods like DNA sequencing, mass spectrometry, and primer extension.
Genetic polymorphisms
This document discusses genetic polymorphisms and summarizes several research studies. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes three key points:
1) A study that used a cross-species strategy to identify 6 causal genes for Alzheimer's disease by studying interactions between human genes and neurotoxicity in the fly model.
2) Research confirming the association between a genetic variant in the PLA2R gene and membranous nephropathy through genome-wide association studies and previous Asian studies.
3) The potential medical benefits of these discoveries such as earlier diagnosis, improved treatment, and further genetic research.
Anti sense drugs
Antisense drugs work by binding to mRNA to prevent protein production from mutated genes causing genetic disorders. They are short DNA sequences that match the mRNA sequence. First generation antisense oligonucleotides used phosphorothioate modifications but had toxicity issues. Second generation ones use 2'-O-methyl and 2'-O-methoxyethyl modifications, showing better stability and less toxicity. Newer third generation modifications like PNA and LNA further increase binding affinity and stability. Effective delivery remains a challenge, with liposomes and nanoparticles being investigated to protect antisense drugs and deliver them to target tissues.
Genetic polymorphisms pptx
This document discusses genetic polymorphisms and summarizes several articles on related topics. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes findings from articles on using cross-species strategies to study human disease like Alzheimer's, identifying genes linked to membranous nephritis and autoantibodies, and discusses the medical utility of early diagnosis and improved treatment from genetic studies.
Single nucleotide polymorphism
Single Nucleotide Polymorphism (SNP)
Polymorphism is a generic term that means 'many shapes‘. It is the ability to appsear in different form .
A single nucleotide polymorphism (SNP) is a DNA sequence variation occurring when a single nucleotide - A, T, C, or G - in the genome differs between members of a species (or between paired chromosomes in an individual).
For example, two sequenced DNA fragments from different individuals, AAGCCTA to AAGCTTA, contain a difference in a single nucleotide. For a variation to be considered a SNP, it must occur in at least 1% of the population.
CHARACTERISTICS OF SNP
• In human beings, 99.9 percent bases are same.
• Remaining 0.1 percent makes a person unique.
• Different attributes / characteristics / traits
• How a person looks, diseases he or she develops.
These variations can be:
Harmless (change in phenotype)
Harmful (diabetes, cancer, heart disease, Huntington's disease, and hemophilia )
Latent (variations found in coding and regulatory regions, are not harmful on their own, and the change in each gene only becomes apparent under certain conditions e.g. susceptibility to lung cancer)
TYPES OF SNP
NON-CODING REGION
A segment of DNA that does comprise a gene and thus does not code for a protein .
CODING REGION
Regions of DNA/RNA sequences that code for proteins
Synonymous
A SNP in which both forms lead to the same polypeptide sequence is termed synonymous
(sometimes called a silent mutation).
Non synonymous
If a different polypeptide sequence is produced they are non synonymous . A non synonymous change may either be missense or nonsense, where a missense change results in a different amino acid, while a nonsense change results in a premature stop codon.
SNP Applications
• Gene discovery and mapping
• Association-based candidate polymorphism testing
• Diagnostics/risk profiling
• Response prediction
• Homogeneity testing/study design
• Gene function identification
mRNA vaccine-10
Naked mRNA Vaccines
mRNA vaccines can be delivered without any additional carriers, that is, in a naked
format. In this method, mRNA is dissolved in buffer and then injected directly.
https://www.creative-biolabs.com/vaccine/mrna-pharmacology-optimization-platform.htm
Dr. Jessica Mar to Speak
Variation occurs at all biological levels and confers robustness and phenotypic diversity. This document discusses sources of variation including physical variants in proteins and receptors, gene expression, microRNAs, structural variants in DNA like deletions and duplications, and epigenetic factors. A study uses stem cells derived from nasal biopsies of Parkinson's and schizophrenia patients and controls to establish cell lines for investigating the molecular underpinnings of neurological diseases. The variance of gene expression across patients is analyzed to identify altered gene networks in disease.
Vital breakthrough in epilepsy genetics
Foundation dedicated to innovating towards precision medicine and ultimately a cure for mutations in the SCN2a gene.
Pre-mRNA splicing and human disease
This document summarizes research on how aberrant pre-mRNA splicing can cause human disease. It notes that 25% of inherited disease-causing mutations affect splicing enhancers and silencers. The study aims to validate mutations in PINK1, a gene associated with Parkinson's disease, that create splicing silencer hexamers and are predicted to disrupt splicing. The researchers will transfect cells with PINK1 reporter constructs containing wild-type or mutant sequences and use RT-PCR and gel electrophoresis to analyze changes in splicing patterns caused by the mutations.
Snp
SNPs are found in
coding and (mostly) noncoding regions.
Occur with a very high frequency
about 1 in 1000 bases to 1 in 100 to 300 bases.
The abundance of SNPs and the ease with which they can be measured make these genetic variations significant.
SNPs close to particular gene acts as a marker for that gene.
SNPs in coding regions may alter the protein structure made by that coding region.
A SNP is defined as a single base change in a DNA sequence that occurs in a significant proportion (more than 1 percent) of a large population. Sequence genomes of a large number of people
Compare the base sequences to discover SNPs.
Generate a single map of the human genome containing all possible SNPs => SNP maps
Level of Tumor Protein Indicates Chances Cancer Will Spread AND Malfunctionin...
1) Researchers discovered a protein called CPE-delta N that is present at high levels in tumors that have metastasized. Tests measuring levels of a molecule that assists in producing CPE-delta N could predict cancer spread, even when conventional techniques suggested it was unlikely.
2) When CPE-delta N RNA levels in a tumor were more than twice the surrounding tissue, cancer was highly likely to metastasize within two years. Levels over 1 million copies indicated cancer appeared again or metastasized, while less than 250,000 copies meant no metastasis or reappearance.
3) Studies on the TDP-43 protein, which forms clumps in ALS and FTLD nerve cells, showed its
Somatic activating kras mutations in arteriovenous malformation
The document discusses a study investigating somatic activating KRAS mutations in arteriovenous malformations. The study aimed to determine if KRAS mutation is a genetic marker for arteriovenous malformation and analyze the relationship between abnormal MAPK-EPK signaling and tissue defects. The study analyzed 72 patients and found somatic activating KRAS mutations in arteriovenous malformation tissue samples. The findings suggest KRAS mutation may be a genetic factor associated with arteriovenous malformations.
Snp
This document discusses single nucleotide polymorphisms (SNPs). It defines SNPs as single base changes in DNA sequences that occur in at least 1% of a large population. The document notes that while human genomes are 99.9% identical, there are positions where some people have one nucleotide pair while others have another, which are called SNPs. SNPs are described as the most common form of genetic variation, with over 90% of human genetic variations coming from SNPs. The uses and implications of SNPs are also summarized.
synapse microarray ppt
1) Synaptogenesis is the formation of synapses between neurons, neurons and muscles, or neurons and glands. It begins prenatally and continues rapidly after birth for several years before slowing.
2) A synapse microarray consists of microwells containing neuronal cells in one compartment connected by microchannels to a second compartment containing non-neuronal cells expressing synaptic proteins. This increases synaptogenesis by precisely positioning the cells.
3) Screening chemical libraries using the synapse microarray allows for ultra-sensitive, high-throughput identification of chemicals that increase synaptogenesis. Inhibitors of histone deacetylase (HDAC) were found to increase expression of neuroligin-1, promoting
Seminario Biologia Molecular
The document discusses bone mesenchymal stem cell-derived extracellular vesicles (exosomes) encapsulated in thermosensitive hydrogels for accelerating osteogenesis and angiogenesis. Mesenchymal stem cells and exosomes released from them play an important role in bone formation. Laboratory techniques like western blot, immunofluorescence, and RT-qPCR were used to analyze protein expression and exosome uptake related to bone formation and angiogenesis. The investigation represents a breakthrough that could allow bone regeneration through exosome therapy and avoid more invasive procedures.
mRNA vaccine-9
Liposome delivery mRNA has unique advantages
https://www.creative-biolabs.com/vaccine/mrna-pharmacology-optimization-platform.htm
Snp and its role in diseases
Single nucleotide polymorphisms (SNPs) are variations in single nucleotides that occur at specific positions in the genome between individuals. There can be 10-30 million SNPs in the human genome, typically found in non-coding DNA between genes. SNPs are important for understanding an individual's response to pathogens, chemicals, drugs, and vaccines as well as realizing personalized medicine. The Human HapMap Project analyzed DNA from different populations to identify haplotypes, sets of SNPs on the same chromosome, that are associated with diseases. The project identified over 50 disease-associated genes and its data has helped find genetic contributors to conditions like diabetes, Crohn's disease, and several cancers.
Seminar presentation on snp (mulualem & janvier)
Single nucleotide polymorphisms (SNPs) are variations in a single DNA nucleotide that occur in over 1% of the population. SNPs are the most common type of genetic variation among humans, as 99.9% of human DNA sequences are identical, while the remaining 0.1% makes each individual unique. Modern techniques can efficiently determine the status of large numbers of SNPs, which promises to advance our understanding and treatment of human disease.
NETs and cardiomyocytes
Neutrophil extracellular traps and it's possible role in cardiac pathology. The experience of cocultivation of neutrophils and cardiomyocytes. The role of proteasomal proteolysis in NETs formation.
What's hot (20)
Level of Tumor Protein Indicates Chances Cancer Will Spread AND Malfunctionin...
Level of Tumor Protein Indicates Chances Cancer Will Spread AND Malfunctionin...
Somatic activating kras mutations in arteriovenous malformation
Somatic activating kras mutations in arteriovenous malformation
Similar to Spring 2010-Seminar Flier
Notch signaling pathway
The Notch signaling pathway is a highly conserved cell signaling system that regulates cell differentiation, proliferation, and fate determination during embryonic and adult development. It involves transmembrane Notch receptors that are activated via cell-cell contact with Notch ligands, leading to proteolytic cleavage and release of the Notch intracellular domain which enters the nucleus to regulate gene expression. Notch signaling plays important roles in various processes including neurogenesis, cardiovascular development, and lymphocytic leukemia, where deregulation of Notch signaling can promote cancer. Inhibitors of Notch signaling such as gamma secretase inhibitors are being investigated as potential cancer therapies but have shown limited efficacy due to off-target effects.
Targetted therapies gyn oncology
This document provides a summary of a presentation on molecular signaling pathways and their implications in gynecologic oncology. The presentation discusses various oncogene and tumor suppressor pathways involved in cancer development, including EGFR, VEGFR, Wnt, TGF-β, p53, and others. It also covers DNA damage repair pathways and mechanisms of apoptosis evasion. Targeted therapy approaches for gynecologic cancers are explored, such as monoclonal antibodies (-mabs) targeting receptors and small molecule inhibitors (-nibs) targeting intracellular signaling proteins. Immunotherapy strategies like immune checkpoint inhibitors are also mentioned.
Targetted therapies in GYn Oncolgy
This document provides a summary of a presentation on molecular signaling pathways and their implications in gynecologic oncology. The presentation discusses several key topics:
1. Hallmarks of cancer development including activation of oncogenes, inactivation of tumor suppressor genes, DNA damage repair pathways, and apoptotic factors.
2. Major signaling pathways in cancer like MAPK, PI3K/AKT/mTOR, Wnt, TGF-beta, and their roles.
3. Targeted therapy approaches for gynecologic cancers including monoclonal antibodies ("-mabs"), small molecule inhibitors ("-nibs"), drugs targeting DNA repair ("-ribs"), and immunotherapies.
4. Gen
steroid resistant nephrotic syndrome
This document discusses steroid resistant nephrotic syndrome (SRNS), including that it is a heterogeneous disease with both immune-based and genetic etiologies. Treatment strategies for SRNS vary between centers and can include calcineurin inhibitors to induce remission in immune-based cases. Recent research proposes stratifying SRNS based on disease mechanisms into monogenic, immune-mediated with circulating factors, and immune-mediated without circulating factors. A variety of immunosuppressive and targeted therapies are discussed for treating the different proposed types of SRNS.
Seminar-Spring 2010-Role of Wnt signaling in Alzheimer's disease pathogenesis
1. Wnt ligands are involved in pre- and postsynaptic protein clustering and assembly at synapses and form functional new synapses.
2. Activation of Wnt signaling protects against Aβ toxicity in Alzheimer's disease by increasing neuronal survival, decreasing apoptosis, and stabilizing β-catenin levels. Inhibition of Wnt signaling can cause neuronal damage.
3. Wnt signaling interacts and forms a crosstalk with other pathways important in Alzheimer's like M1 muscarinic acetylcholine receptor activation and PPARγ activation, which may provide neuroprotective effects against Aβ toxicity.
SEMINARIO BIOMOL.pdf
This document summarizes a student's research on how a mutation in the Huntingtin (HTT) gene impacts myelination. The HTT gene codes for the huntingtin protein which is mainly active in neuronal cells. The study aims to determine how a mutation in HTT impairs myelination but not glial cell development. The methods used include western blotting, immunofluorescence staining, RNA sequencing, and quantitative PCR. The results and conclusions are not yet included but will analyze how the HTT mutation reduces myelin protein expression and myelination. This provides insights into how molecular analysis can help identify underlying damage in neurodegenerative diseases like Huntington's disease.
Association study of the GSK-3B gene with tardive dyskinesia in European Cauc...
This study investigated whether polymorphisms in the glycogen synthase kinase 3B (GSK-3B) gene are associated with tardive dyskinesia (TD) in schizophrenia patients. The researchers genotyped 8 single nucleotide polymorphisms in the GSK-3B gene in 215 schizophrenia patients, 169 of whom were European Caucasian. They found that minor alleles of all variants were associated with lower risk of TD and lower abnormal involuntary movement severity scores. Three variants (rs6805251, rs6438552, and rs9878473) showed a trend toward association with TD in European Caucasian patients. When age was included as a covariate, all variants were associated with abnormal involuntary movement severity scores at p
BIOL3200 PROPOSAL
Targeted knockdown of murine Prickle1 gene to document its role in human Progressive Myoclonic Epilepsy.
Tesi baiula monica
The document discusses research into the regulation and role of the transcription factor REST in neuronal differentiation of SH-SY5Y human neuroblastoma cells exposed to IGF-I and PMA. The key findings are: 1) IGF-I and PMA increase nuclear REST levels early in treatment but REST declines with longer exposure as neurite outgrowth increases, 2) Downregulating REST with antisense oligonucleotides enhances the effects of IGF-I and PMA on neuronal markers and neurite growth, 3) REST degradation involves the ubiquitin-proteasome system and contributes to later stage neuronal differentiation. The document also analyzes the O-glycosylation pattern of REST protein in these cells.
journal.pgen.1003895.PDF
This study identified FUS, a gene frequently mutated in ALS, as autoregulating its own expression through alternative splicing of its pre-mRNA. The study found that FUS binds to and represses the splicing of its own exon 7. This causes the production of an exon 7-skipped splice variant that triggers nonsense-mediated decay, reducing FUS protein levels. Expression of ALS-linked FUS mutants compromised this autoregulation by reducing exon 7 repression and nuclear localization of FUS. This suggests deficient FUS autoregulation could exacerbate cytoplasmic accumulation of FUS in ALS through a feed-forward loop mechanism.
1536709-wnt canonical pathway-greta brezgyte
The Wnt signaling pathway involves Wnt ligands binding to Frizzled receptors and regulating beta-catenin levels and activity. This pathway controls numerous cellular processes during development and has been implicated in diseases like cancer when dysregulated. Specifically, mutations in APC, a negative regulator of the pathway, lead to beta-catenin accumulation and are present in most colorectal cancers. Future research includes investigating epigenetic changes in this pathway and developing targeted therapies based on pathway components like APC.
Abstract Triennale
This document summarizes a thesis that uses induced pluripotent stem cells (iPSCs) as an in vitro model of Parkinson's disease. The thesis reprogrammed fibroblasts from patients with a genetic form of Parkinson's caused by SNCA gene duplication and from healthy donors into iPSCs. It then differentiated these iPSCs into dopaminergic neurons to evaluate differences in phenotype between healthy and affected cells. In particular, the thesis aims to investigate autophagy in these neurons under stress conditions, as autophagy has been linked to the clearance of alpha-synuclein, which seems impaired in Parkinson's disease.
Hunter Syndrome A Case Report
Mucopolysaccharidosis type II MPS II or Hunter syndrome is Metabolism by lysosomal accumulation with a recessive inheritance pattern associated with the X chromosome. It is caused by lack of activity of the lysosomal enzyme iduronate 2 sulfatase, encoded by the IDS gene. Plasma iduronate 2 sulfatase enzymatic activity was measured and the IDS gene in genomic DNA was analyzed by automated direct sequencing. The enzyme activity was 1.2 mol l h reference value 2 mol l h and molecular analysis detected the mutation c.1403G A p.R468Q , confirming the diagnosis of MPS II. rice field. In conclusion, there are few groups dedicated to this disease family here in Mexico, highlighting the need to form an expert team of physicians and scientists dedicated to inborn errors of metabolism to stay up to date. Miss. Parimala L | Babu M "Hunter Syndrome: A Case Report" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-1 , February 2023, URL: https://www.ijtsrd.com/papers/ijtsrd52814.pdf Paper URL: https://www.ijtsrd.com/medicine/other/52814/hunter-syndrome-a-case-report/miss-parimala-l
Environmental Factor - August 2015_ Intramural papers of the month
1) NTP research found that chronic exposure to cobalt metal dust leads to lung tumors in rodents, with mutations similar to human lung cancer. The majority of mutations consisted of specific DNA changes also common in human lung cancer.
2) NIEHS research showed bidirectional gene promoters are widespread, facilitating transcription factor binding and gene expression changes in response to stimuli.
3) A study found several non-motor symptoms can differentiate early Parkinson's patients from controls, and some symptoms differ between men and women. Understanding non-motor symptoms may help identify individuals at risk.
4) NIEHS scientists characterized the complex maturation process of the HIV reverse transcriptase enzyme, providing insights that could lead to new drug inhibition strategies.
Luisetto m et al amyotropyc lateral sclerosis and endogenous -esogenous toxic...
Luisetto m et al amyotropyc lateral sclerosis and endogenous -esogenous toxic...M. Luisetto Pharm.D.Spec. Pharmacology
1) ALS is a progressive neurodegenerative disease that affects motor neurons, leading to muscle paralysis. It was first described in 1874 but its pathogenesis remains unclear.
2) ALS may be caused by both increased toxicity from substances like RNA proteins and weakness of the motor neuron system. Genetic mutations and environmental toxins are also implicated in some cases.
3) The document proposes new experimental and drug delivery approaches to better understand disease mechanisms and improve treatment of ALS.Natalia Cucu Simp 09
The document discusses epigenetic factors that contribute to imprinting diseases. It describes how epigenetic modifications like DNA and histone methylation establish parental imprints and regulate gene expression in a parent-of-origin specific manner. Alterations in these epigenetic marks can lead to imprinting disorders like Prader-Willi syndrome and Angelman syndrome, which are associated with changes in imprinted genes on chromosome 15. The authors investigate these diseases using methods like MS-PCR to analyze DNA methylation patterns.
Development and implementation of a novel interactome platform in studies on ...
Development and implementation of a novel interactome platform in studies on ...Ewelina Maliszewska-Cyna, PhD
This document summarizes a study on developing a novel protein interaction platform to study neurodegeneration. The study cultured neuronal stem cells to form neurospheres, which were used as a model system. Lentiviral transfection was optimized to introduce target genes stably into the neurospheres. The goal was to analyze protein interactions of Alzheimer's disease proteins by co-immunoprecipitation of neurosphere cultures expressing tagged target proteins. This model aims to further the understanding of molecular mechanisms in neurodegenerative disorders like Alzheimer's disease.Notch signalling pathway.pptx
The document summarizes the Notch signaling pathway. It describes that Notch signaling involves communication between two neighboring cells through Notch receptors and ligands. When a ligand binds to a receptor on the neighboring cell, it leads to proteolytic cleavage and release of the Notch intracellular domain, which enters the nucleus and regulates transcription of target genes involved in cell proliferation and differentiation. The pathway plays important roles in development and diseases like cancer when dysregulated.
cancer
This document discusses single cell profiling of phospho-protein networks in cancer cells. It describes how the researchers used multiparameter flow cytometry to monitor phospho-protein responses to environmental cues in acute myeloid leukemia cells at the single cell level. By exposing the cancer signaling networks to potentiating inputs, they could discern unique network profiles that correlated with genetics and disease outcomes. The results revealed a dramatic remodeling of signaling networks in cancer cells and allowed for categorizing cell network phenotypes by multidimensional molecular profiles of signaling.
multiple system atrophy-newer developments
This document summarizes recent insights into multiple system atrophy (MSA). MSA is a neurodegenerative disorder characterized by parkinsonism or cerebellar ataxia along with autonomic failure. Key points include: MSA is caused by the accumulation of alpha-synuclein protein aggregates in oligodendrogltes. Diagnostic criteria have been updated and neuroimaging may help with diagnosis. Prognosis is poor with mean survival of 7-9 years. Current treatments are only symptomatic and no disease-modifying therapies exist yet, though research into targets like alpha-synuclein aggregation are promising avenues.
Similar to Spring 2010-Seminar Flier (20)
Seminar-Spring 2010-Role of Wnt signaling in Alzheimer's disease pathogenesis
Seminar-Spring 2010-Role of Wnt signaling in Alzheimer's disease pathogenesis
Association study of the GSK-3B gene with tardive dyskinesia in European Cauc...
Association study of the GSK-3B gene with tardive dyskinesia in European Cauc...
Environmental Factor - August 2015_ Intramural papers of the month
Environmental Factor - August 2015_ Intramural papers of the month
Luisetto m et al amyotropyc lateral sclerosis and endogenous -esogenous toxic...
Luisetto m et al amyotropyc lateral sclerosis and endogenous -esogenous toxic...
Development and implementation of a novel interactome platform in studies on ...
Development and implementation of a novel interactome platform in studies on ...
Recently uploaded
RHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem students
Physical pharmaceutics notes for B.pharm students
Mule event processing models | MuleSoft Mysore Meetup #47
Mule event processing models | MuleSoft Mysore Meetup #47
Event Link:- https://meetups.mulesoft.com/events/details/mulesoft-mysore-presents-mule-event-processing-models/
Agenda
● What is event processing in MuleSoft?
● Types of event processing models in Mule 4
● Distinction between the reactive, parallel, blocking & non-blocking processing
For Upcoming Meetups Join Mysore Meetup Group - https://meetups.mulesoft.com/mysore/YouTube:- youtube.com/@mulesoftmysore
Mysore WhatsApp group:- https://chat.whatsapp.com/EhqtHtCC75vCAX7gaO842N
Speaker:-
Shivani Yasaswi - https://www.linkedin.com/in/shivaniyasaswi/
Organizers:-
Shubham Chaurasia - https://www.linkedin.com/in/shubhamchaurasia1/
Giridhar Meka - https://www.linkedin.com/in/giridharmeka
Priya Shaw - https://www.linkedin.com/in/priya-shaw
Lifelines of National Economy chapter for Class 10 STUDY MATERIAL PDF
The chapter Lifelines of National Economy in Class 10 Geography focuses on the various modes of transportation and communication that play a vital role in the economic development of a country. These lifelines are crucial for the movement of goods, services, and people, thereby connecting different regions and promoting economic activities.
Walmart Business+ and Spark Good for Nonprofits.pdf
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
Gender and Mental Health - Counselling and Family Therapy Applications and In...
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Beyond Degrees - Empowering the Workforce in the Context of Skills-First.pptx
Iván Bornacelly, Policy Analyst at the OECD Centre for Skills, OECD, presents at the webinar 'Tackling job market gaps with a skills-first approach' on 12 June 2024
Chapter wise All Notes of First year Basic Civil Engineering.pptx
Chapter wise All Notes of First year Basic Civil Engineering
Syllabus
Chapter-1
Introduction to objective, scope and outcome the subject
Chapter 2
Introduction: Scope and Specialization of Civil Engineering, Role of civil Engineer in Society, Impact of infrastructural development on economy of country.
Chapter 3
Surveying: Object Principles & Types of Surveying; Site Plans, Plans & Maps; Scales & Unit of different Measurements.
Linear Measurements: Instruments used. Linear Measurement by Tape, Ranging out Survey Lines and overcoming Obstructions; Measurements on sloping ground; Tape corrections, conventional symbols. Angular Measurements: Instruments used; Introduction to Compass Surveying, Bearings and Longitude & Latitude of a Line, Introduction to total station.
Levelling: Instrument used Object of levelling, Methods of levelling in brief, and Contour maps.
Chapter 4
Buildings: Selection of site for Buildings, Layout of Building Plan, Types of buildings, Plinth area, carpet area, floor space index, Introduction to building byelaws, concept of sun light & ventilation. Components of Buildings & their functions, Basic concept of R.C.C., Introduction to types of foundation
Chapter 5
Transportation: Introduction to Transportation Engineering; Traffic and Road Safety: Types and Characteristics of Various Modes of Transportation; Various Road Traffic Signs, Causes of Accidents and Road Safety Measures.
Chapter 6
Environmental Engineering: Environmental Pollution, Environmental Acts and Regulations, Functional Concepts of Ecology, Basics of Species, Biodiversity, Ecosystem, Hydrological Cycle; Chemical Cycles: Carbon, Nitrogen & Phosphorus; Energy Flow in Ecosystems.
Water Pollution: Water Quality standards, Introduction to Treatment & Disposal of Waste Water. Reuse and Saving of Water, Rain Water Harvesting. Solid Waste Management: Classification of Solid Waste, Collection, Transportation and Disposal of Solid. Recycling of Solid Waste: Energy Recovery, Sanitary Landfill, On-Site Sanitation. Air & Noise Pollution: Primary and Secondary air pollutants, Harmful effects of Air Pollution, Control of Air Pollution. . Noise Pollution Harmful Effects of noise pollution, control of noise pollution, Global warming & Climate Change, Ozone depletion, Greenhouse effect
Text Books:
1. Palancharmy, Basic Civil Engineering, McGraw Hill publishers.
2. Satheesh Gopi, Basic Civil Engineering, Pearson Publishers.
3. Ketki Rangwala Dalal, Essentials of Civil Engineering, Charotar Publishing House.
4. BCP, Surveying volume 1
Level 3 NCEA - NZ: A Nation In the Making 1872 - 1900 SML.ppt
The History of NZ 1870-1900.
Making of a Nation.
From the NZ Wars to Liberals,
Richard Seddon, George Grey,
Social Laboratory, New Zealand,
Confiscations, Kotahitanga, Kingitanga, Parliament, Suffrage, Repudiation, Economic Change, Agriculture, Gold Mining, Timber, Flax, Sheep, Dairying,
BÀI TẬP DẠY THÊM TIẾNG ANH LỚP 7 CẢ NĂM FRIENDS PLUS SÁCH CHÂN TRỜI SÁNG TẠO ...
BÀI TẬP DẠY THÊM TIẾNG ANH LỚP 7 CẢ NĂM FRIENDS PLUS SÁCH CHÂN TRỜI SÁNG TẠO ...Nguyen Thanh Tu Collection
https://app.box.com/s/qhtvq32h4ybf9t49ku85x0n3xl4jhr15LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UP
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
What is Digital Literacy? A guest blog from Andy McLaughlin, University of Ab...
What is Digital Literacy? A guest blog from Andy McLaughlin, University of Aberdeen
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...Nguyen Thanh Tu Collection
https://app.box.com/s/y977uz6bpd3af4qsebv7r9b7s21935vdHow to Make a Field Mandatory in Odoo 17
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
-------------------------------------------------------------------------------
Find out more about ISO training and certification services
Training: ISO/IEC 27001 Information Security Management System - EN | PECB
ISO/IEC 42001 Artificial Intelligence Management System - EN | PECB
General Data Protection Regulation (GDPR) - Training Courses - EN | PECB
Webinars: https://pecb.com/webinars
Article: https://pecb.com/article
-------------------------------------------------------------------------------
For more information about PECB:
Website: https://pecb.com/
LinkedIn: https://www.linkedin.com/company/pecb/
Facebook: https://www.facebook.com/PECBInternational/
Slideshare: http://www.slideshare.net/PECBCERTIFICATION
Recently uploaded (20)
RHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem students
RHEOLOGY Physical pharmaceutics-II notes for B.pharm 4th sem students
Mule event processing models | MuleSoft Mysore Meetup #47
Mule event processing models | MuleSoft Mysore Meetup #47
Lifelines of National Economy chapter for Class 10 STUDY MATERIAL PDF
Lifelines of National Economy chapter for Class 10 STUDY MATERIAL PDF
Walmart Business+ and Spark Good for Nonprofits.pdf
Walmart Business+ and Spark Good for Nonprofits.pdf
Gender and Mental Health - Counselling and Family Therapy Applications and In...
Gender and Mental Health - Counselling and Family Therapy Applications and In...
Beyond Degrees - Empowering the Workforce in the Context of Skills-First.pptx
Beyond Degrees - Empowering the Workforce in the Context of Skills-First.pptx
Chapter wise All Notes of First year Basic Civil Engineering.pptx
Chapter wise All Notes of First year Basic Civil Engineering.pptx
Level 3 NCEA - NZ: A Nation In the Making 1872 - 1900 SML.ppt
Level 3 NCEA - NZ: A Nation In the Making 1872 - 1900 SML.ppt
BÀI TẬP DẠY THÊM TIẾNG ANH LỚP 7 CẢ NĂM FRIENDS PLUS SÁCH CHÂN TRỜI SÁNG TẠO ...
BÀI TẬP DẠY THÊM TIẾNG ANH LỚP 7 CẢ NĂM FRIENDS PLUS SÁCH CHÂN TRỜI SÁNG TẠO ...
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UP
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UP
What is Digital Literacy? A guest blog from Andy McLaughlin, University of Ab...
What is Digital Literacy? A guest blog from Andy McLaughlin, University of Ab...
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...
Spring 2010-Seminar Flier
- 1. Department of Pharmacology Pharmacology and Neuroscience Graduate Program Seminar ROLE OF WNT SIGNALING IN ALZHEIMER’S DISEASE PATHOGENESIS Presented by: Nisha Rizvi Tuesday, April 20, 2010 – 3:00 p.m. Med-Micro SCLF II Conference Room 825 North Rutledge Springfield, Illinois Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by abnormal deposition of extracellular β-amyloid plaques and intracellular hyperphosphorylated tau tangles. Many theories related to the pathogenesis of AD have been proposed and are being studied extensively. One of them suggests that a dysfunctional Wnt signaling pathway, at least in part, may be associated with altered transcriptional regulation of target genes leading to metabolic defects and activation of apoptotic signals for progressive and selective death of specific neuronal cell populations. Wnt pathway is a critical mediator of intercellular signaling events through highly conserved family of secreted proteins involved in multiple developmental events during embryogenesis and adult tissue homeostasis. It is extensively being studied for its involvement in the pathogenesis of a number of diseases like diabetes, cancer, schizophrenia and Alzheimer’s disease. In the mature nervous system, expression of Wnt signaling suggests its role in maintenance of synaptic structure, function and plasticity. It modulates both pre- and postsynaptic protein clustering important for neurite growth and establishment of new functional synapses which may contribute to long term potentiation (LTP). Neuronal exposure to Aβ induces alteration in expression and/or activity of various canonical and non-canonical Wnt proteins such as the frizzled (Fz)/ low density lipoprotein receptor-related protein (LRP) complex, disheveled (Dsh), glycogen synthase kinase-3β (GSK-3β), and β-catenin ultimately leading to neurodegeneration. Also, recent studies report that Wnt signaling interacts with peroxisome proliferator-activated receptor γ (PPARγ) and muscarinic acetylcholine receptor (mAChR) pathways together eliciting neuroprotection. Thus, there is growing evidence that Wnt signaling is a putative target for Aβ-dependent synaptotoxicity and its activation by Wnt ligands, PPARγ or M1 mAChR agonists could serve as a potential therapeutic strategy in Alzheimer’s disease.