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Similar to Seminar 2016#Shri Sonwane Similar to Seminar 2016#Shri Sonwane (15) Seminar 2016#Shri Sonwane2. INTRODUCTION
Morphine is derived from dried extract from the capsules of poppy plant
known as papaver somniferum.
It is a colourless prismatic substance having M.P: 247ºc.
Mol.formula:- C17H19NO3
Mol.wt:- 285.4
It is slightly soluble in water,ether,chloroform but soluble in alcohol & alkali
solution.
Phenanthrene(opium) alkaloid.
closely related compouds are codein,thebaine.
3. MOA & PHARMACOLOGICAL ACTIONS
Analgesics
Sedative
Papillary Constriction
Antitussive property
Respiratory depression
Heat regulation
Delayed Gatric emptying time & decrease peristaltic
movement
6. USES
Analgesic.
Used as pre-anesthetic medication.
Producing Sleep & Sedation.
Used as Anti-tussive.
For treatment of Diarrhoea.
10. 2.IR Spectrum:-
Frequency cm-1 Assignment
3480,3350 Free OH
3210 Bonded OH
2940,2920 CH (stretch)
2840 CH3-NH
1650 C7= C8 (Alkene)
1605 C=C (Aromtic)
1250,1090 C4-O-C5
760 Monosubstituted
aromatics.
11. 3.NMR Spectra
Group CHEMICAL SHIFT (PPM)
H2 (aromatic)
H1 (aromatic)
H7
H8
H5
H9
H14
N-CH3
2H10
S=siglet,
d=doublet,
Morphine HCL
6.76 (d)
6.68 (d)
5.75 (d)
5.40 (d)
5.06 (d)
4.37 (m)
4.20 (d)
3.00 (s)
2.16
m=multiplet,
q=quartet
Morphine
6.42 (Abq)
4.63 (d)
2.30 (s)
12. 4.Mass Spectum
m/e Relative Intensity %
285
286
284
268
216
215
174
171
162
161
153
152
131
129
123
127
124
116
115
100.0(base)
26.1 M+1
17.2 M-1
13.3
11.1
33.3
18.9
11.1
5.8
11.0
13.3
22.2
24.4
14.4
31
27.8
43.3
16.6
74
m/e Relative Intensity %
109
103
94
91
82
81
77
70
65
60
59
58
57
56
55
54
53
52
51
22.2
16.7
26.7
21.7
22.2
42.
32.2
46.6
22.2
12.2
50
28.9
46.6
23.3
80
16.6
47.8
1.5
35.6
13. REFERENCES
www.Sciencedirect.com
“Organic Chemistry of Natural Product”- by Gurudep
Chatwal,Vol-1
“Organic Chemistry of Natural Product”- by
O.P.Agarwal,Vol-1
Elementary Organic Spectroscopy by Y.R Sharma
pg.no:256-276
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